直线偏振光近红外线（超激光）合并神经阻滞治疗带疱疹的疗效观察

目的：观察直线偏振光近红外线仪照射合并神经阻滞对带状疱疹的治疗效果。方法：70例带状疱疹患者随机分为两组,I组在神经阻滞的基础上给予直线偏振光近红外线照射,Ⅱ组只采用单纯神经阻滞疗法。以VAS评价两组的疗效,比较观察两组治疗后疼痛缓解及皮损改善的显效率,好转率,无效率和有效率。结果：两组治疗前后VAS均有显著性差异（P＜0．01）;疼痛缓解的显效率和有效率两组无显著性差异（P＞）．05）。皮损改善的显效率Ⅰ组为15％,Ⅱ组26．7％,两组之间有显著性差异（P＜0．05）。结论：直线偏振光近红外线治疗仪照射合并神经阻滞优于单纯神经阻滞,前者在治疗带状疱疹皮损改善中的较好的效果。     

直线偏振光近红外线照射合用神经阻滞提高治痛效果的量化评估

目的：为提高治痛优秀率，对直线偏振光近红外线照射合用神经阻滞方法治疗疼痛性疾病，与单一神经阻滞进行比较。方法：选择2003—06／2004-11延边大学医学院附属医院麻醉疼痛科就诊的慢性疼痛患者130例。其中面肌痉挛21例、下肢感觉异常10例、带状疱疹后神经痛8例、膝痛18例、肩手综合征3例、椎间盘突出13例、颈椎病6例、网球肘10例、耳鸣1例、肩关节周围炎19例、腰痛症10例、腕、距小腿（踝）关节痛2例、肋间神经痛9例。随机分为2组，直线偏振光近红外线照射合用神经阻滞组和神经阻滞组，每组65例。直线偏振光近红外线照射合用神经阻滞组采用隔天1次作神经阻滞，并在不实施神经阻滞的时间隔天1次照射直线偏振光近红外线；根据不同的疾病选择相应的部位进行照射，其参数为输出80％-100％，照射周期2s／开、4s／关，照射时间为10～30min，次数介于3～12次。神经阻滞组采用单一神经阻滞疗法。全部病例用统一表格记录观察项目并以目测类比评分法测痛记分（优为0-2分，良为3～8分，差为9～10分）。主要比较两组的优、良及无效情况、优良率为优＋良，采用t检验进行显著性分析。结果：130例患者全部完成治疗无退出，均进人结果分析。①直线偏振光近红外线合用神经阻滞组优占88％（57／65），良占11％（7／65），无效占1．5％（1／65），优良率99％。神经阻滞组优占72％（47／65），良占23％（16／65），无效占4．6％（3／65）。优良率97％。②两组的优秀率进行比较差异显著（88％，72％，P〈0．05）。但对有效率（良）、优良率、无效率进行比较的结果，无显著差异（P〉0．05）。结论：直线偏振光近红外线合用神经阻滞方法使直线偏振光近红外线作用更加强化，更好的发挥赋活机体刺激作用。疼痛病治疗采用神经阻滞并用超激光疼痛治疗仪照射疗法，可明显提高优秀率，能获得最佳效果。     

超激光与神经阻滞治疗慢性软组织损伤性疼痛的研究

目的：评价超激光疼痛治疗仪复合阻滞在慢性软组织损伤疼痛治疗中的作用。方法：选择疼痛门诊慢性软组织损伤性疼痛患者90例,随机分为3组,单纯神经阻滞组为组Ⅰ30例,单纯超激光照射为组Ⅱ30例,神经阻滞后加超激光照射为组Ⅲ30例,3组进行疗效对比观察。结果：3种治疗方法均有明显疗效,治疗后组Ⅰ与组Ⅱ的VAS值及下降率、显效率、有效率、总有效率差异无显著意义（P＞0．05）,组Ⅲ与组Ⅰ、组Ⅱ相比VAS值及下降率、显效率、总有效率差异均有显著意义（P＜0．05）,组Ⅲ的神经阻滞治疗疗效少于组Ⅰ、组Ⅱ相比VAS值及下降率、显效率、总有效率差异均有显著意义（P＜0．05）,组Ⅲ的神经阻滞治疗次数少于组Ⅰ,组Ⅲ的超激光照射治疗次数少于组Ⅱ,而复发率明显低于组Ⅰ、组Ⅱ（P＜0．05）。结论：超激光照射治疗慢性软组织损性疼痛是有效的,但如与神经阻滞复合应用效果更好,且不易复发,是治疗慢性软组织损伤性疼痛有效的方法之一。     

直线偏振光近红外线照射合用神经阻滞提高治痛效果的量化评估

目的:为提高治痛优秀率,对直线偏振光近红外线照射合用神经阻滞方法治疗疼痛性疾病,与单一神经阻滞进行比较。方法:选择2003-06/2004-11延边大学医学院附属医院麻醉疼痛科就诊的慢性疼痛患者130例。其中面肌痉挛21例、下肢感觉异常10例、带状疱疹后神经痛8例、膝痛18例、肩手综合征3例、椎间盘突出13例、颈椎病6例、网球肘10例、耳鸣1例、肩关节周围炎19例、腰痛症10例、腕、距小腿(踝)关节痛2例、肋间神经痛9例。随机分为2组,直线偏振光近红外线照射合用神经阻滞组和神经阻滞组,每组65例。直线偏振光近红外线照射合用神经阻滞组采用隔天1次作神经阻滞,并在不实施神经阻滞的时间隔天1次照射直线偏振光近红外线;根据不同的疾病选择相应的部位进行照射,其参数为输出80%～100%,照射周期2s/开、4s/关,照射时间为10～30min,次数介于3～12次。神经阻滞组采用单一神经阻滞疗法。全部病例用统一表格记录观察项目并以目测类比评分法测痛记分(优为0～2分,良为3～8分,差为9～10分)。主要比较两组的优、良及无效情况、优良率为优+良,采用t检验进行显著性分析。结果:130例患者全部完成治疗无退出,均进入结果分析。①直线偏振光近红外线合用神经阻滞组优占88%(57/65),良占11%(7/65),无效占1.5%(1/65),优良率99%。神经阻滞组优占72%(47/65),良占23%(16/65),无效占4.6%(3/65)。优良率97%。②两组的优秀率进行比较差异显著(88%,72%,P<0.05)。但对有效率(良)、优良率、无效率进行比较的结果,无显著差异(P>0.05)。结论:直线偏振光近红外线合用神经阻滞方法使直线偏振光近红外线作用更加强化,更好的发挥赋活机体刺激作用。疼痛病治疗采用神经阻滞并用超激光疼痛治疗仪照射疗法,可明显提高优秀率,能获得最佳效果。     

直线偏振光近红外线照射联合中医针刺治疗肩周炎的疗效观察及护理

目的:探讨直线偏振光近红外线照射联合针刺治疗肩周炎的临床疗效及护理方法。方法:将48例肩周炎的患者采取随机数字法分为观察组26例和对照组22例,观察组采用直线偏振光近红外线照射疼痛治疗仪结合针刺治疗,对照组采用常规的综合康复训练,治疗前后采用VAS、FIM及肩关节JOA评分方法观察各组治疗效果并进行比较。结果:治疗后两组患者VAS评分均较治疗前均有所下降,FIM及肩关节JOA评分均较治疗前明显改善(P0.05);治疗后观察组FIM、JOA评分高于对照组(P0.05),优良率为高于对照组(P0.05)。结论:直线偏振光近红外线照射联合针刺可有效改善肩周炎患者的疼痛的症状;此治疗方案损伤较小、安全可靠、方法简便,是治疗肩周炎比较实用的治疗方法。     

经皮神经电刺激和红外偏振光联合应用对老年带状疱疹后神经痛的影响

目的：探讨经皮神经电刺激（TENS）和红外偏振光联合应用对老年带状疱疹后神经痛的疗效。方法：将45例PHN患者随机分为3例，每组15例。Ⅰ组使用TENS；Ⅱ组使用红外偏振光治疗仪；Ⅲ组联合应用以上两种治疗方法。各组治疗每日1次，每次各30min，10次一个疗程。使用疼痛视觉模拟评分法（VAS）评估疼痛缓解程度；使用汉密顿抑郁量表（HAMD）和汉密顿焦虑量表（HAMA）进行治疗前后心理测验。结果：治疗后VAS评分Ⅲ组和Ⅰ组与Ⅱ组相比较，差异具有显著性（P＜0．05），HAMD和HAMA量表治疗前后各组自身对照差异显著（P＜0．05），3组之间差异无显著性（P＞0．05）。结论：TENS和红外偏振光治疗仪治疗应用对老年PHN止痛效果好，可改善患者抑郁，焦虑症状，无任何副作用。     

超激光与神经阻滞治疗慢性软组织损伤性疼痛的临床研究

目的评价超激光疼痛治疗仪复合神经阻滞在慢性软组织损伤疼痛治疗中的作用。方法选择疼痛门诊慢性软组织损伤性疼痛患者90例,随机分为单纯神经阻滞(Ⅰ组),单纯超激光照射组(Ⅱ组)和神经阻滞后加超激光照射组Ⅲ组。结果3种治疗方法均有明显疗效,无显著差异(P＞0.05),Ⅲ组神经阻滞治疗次数少于Ⅰ组,超激光射治疗次数少于Ⅱ组,复发率明显低于Ⅰ、Ⅱ组(P＞0.05)。结论超激光照射治疗慢性软组织损伤性疼痛是有效的,但如与神经阻滞合用效果更好。     

蛛网膜下腔阻滞联合椎旁阻滞治疗带状疱疹神经痛的临床疗效

目的 评价蛛网膜下腔阻滞联合椎旁神经阻滞治疗急性带状疱疹神经痛的疗效.方法 急性带状疱疹神经痛患者共36 例,随机分为三组,其中A 组12 例行蛛网膜下腔阻滞+椎旁神经阻滞治疗,B 组12 例行单纯蛛网膜下腔阻滞治疗,C 组采用单纯椎旁神经阻滞治疗.以视觉模拟评分(VAS)评定治疗效果.结果 分别于治疗前、治疗后3 d、7 d 及14 d记录三组患者VAS 评分,结果 发现三组患者治疗后3 d、7 d 及14 d VAS 评分均较治疗前逐渐降低,但A 组在治疗后3 d、7 d 及14 d VAS 评分与B 组及C 组相比差异有统计学意义(P ＜0.01),其中A 组治疗后VAS 评分均低于B 组及C 组(P ＜0.01).结论 蛛网膜下腔阻滞联合椎旁神经阻滞治疗能够很好地缓解急性带状疱疹患者的疼痛.     

不同直线偏光近红外线照射治疗带状疱疹疗效观察

目的观察直线偏光近红外线照射交感神经节和脊 (脑 )神经根部与传统照射星状神经节 (下半身脊神经根 )+ 局部照射两种方法对带状疱疹的治疗效果 . 方法 68例带状疱疹病人随机分为两组 , Ⅰ组采取直线偏光近红外线照射交感神经节和脊 (脑 )神经根 , Ⅱ组采取星状神经节或脊神经 + 局部照射 . 以口述描绘评分法 (VRS)评价治疗后的优良率和治疗次数 . 结果两组治疗后的优良率有极显著差异 (P< 0.01), 治疗次数有显著差异 (P< 0.05). 结论直线偏光近红外线照射交感神经节和脊 (脑 )神经根的方法明显优于传统的星状神经节 (或脊神经根 )+ 局部照射的方法治疗带状疱疹 .     

带状疱疹后神经痛综合物理治疗与药物治疗的疗效比较

目的：探讨综合物理治疗对带状疱疹后神经痛的治疗作用。方法：将42例带状疱疹后神经痛患者随机分为两组，Ⅰ组采用经皮电神经刺激联合窄谱中波紫外线治疗，Ⅱ组采用药物治疗。采用目测类比评分法（VAS）评估疼痛缓解程度。结果：治疗后两组VAS评分均明显降低，Ⅰ组降低幅度明显大于Ⅱ组，其差异具有显著性意义愀0．01）。结论：经皮电神经刺激联合窄谱中波紫外线治疗带状疱疹后神经痛能较好地缓解，疗效较常规药物好。     

带状疱疹的早期综合治疗

目的:通过对带状疱疹的早期诊断及早期综合治疗,观察其对急性期疼痛缓解及后遗痛预防的疗效.方法:36例带状疱疹急性期病例随机分成治疗组及对照组,治疗组采用抗病毒药物、曲马多、加巴喷丁、局部神经阻滞及超激光照射治疗.对照组采用抗病毒药物、布洛芬缓释胶囊、局部神经阻滞及超激光照射治疗.采用VAS评分及睡眠影响指数(SIS)对疼痛程度及患者生活质量进行评价.结果:治疗前,治疗组VAS及SIS平均为6.81±1.76及6.62±1.86,对照组VAS及SIS平均为6.57±1.45及6.43±1.75;治疗五周后,治疗组VAS及SIS平均为1.38±1.47及1.02±1.71,对照组VAS及SIS平均为2.27±0.92及2.00±0.65.治疗组后遗痛的发生率为4.8%,对照组为13.3%.结论:带状疱疹的早期诊断及综合治疗不仅可以减轻急性症状,还可减少带状疱疹后神经痛(PHN)的发生率.     

THE PROBLEM OF THE ETIOLOGY OF HERPES ZOSTER

Attempts were made to produce lesions in. animals by the injection of material obtained from the vesicles and involved skin of nine cases of herpes zoster. All the cases, with the exception of one (Case II), were characteristic cases of idiopathic herpes zoster and the question of their being cases of so called zosteriform herpes or symptomatic herpes zoster can hardly be raised. As regards Case II, if this case occurred alone, there might be some doubt as to its nature on account of the mildness of the symptoms and the small area of skin involvement. Taken in connection with Cases III and IV, however, which occurred in the same ward and in patients who were quite closely in contact with Patient II, it seems fairly reasonable to assume that they were all of the same character. Cases of herpes zoster have been extremely rare in this hospital and the occurrence of three cases in the same ward within a very short period of time suggests very strongly a transference of infection from one case to the other. That Case II was not one of herpes simplex also seems fairly certain from the negative results obtained by inoculation of rabbits'' eyes with vesicle material. In making the animal experiments we employed various methods which were suggested largely by the technique used by previous observers, especially by those who have reported results which were considered positive. In making inoculations into the corneas the technique recommended by Lipschütz was employed as far as possible. Young rabbits were used and the material was obtained from fresh vesicles early in the disease and inoculated with as little delay as possible. The material injected into rabbits'' eyes was obtained from seven cases and twenty-four rabbits were used. In judging of the results obtained in this kind of experimentation great caution must be observed. Our experience convinces us that slight opacities occurring along the lines of scarification and mild conjunctivitis cannot be held to indicate the effect of a specific virus. As regards the interpretation of the microscopic changes found, we were quite familiar with the appearance of intranuclear inclusion bodies as seen in the lesions of experimental herpes simplex and the filterable virus (Virus III) indigenous to rabbits described by Rivers and Tillett (5). We also had no difficulty in imding intranuclear inclusions in the sections of skin removed from patients. It is not likely, therefore, that these structures were overlooked in our study of the sections. Briefly stated, although the material studied was satisfactory and in spite of the fact that a considerable number of animals were used for each case, we have been unable to confirm the observations of Lipschütz regarding the experimental production of specific lesions in the corneas of rabbits. We realize that this is only negative evidence and therefore not of conclusive importance in view of Lipschütz''s observations. It indicates, however, that the production of specific lesions in rabbits'' eyes with material from herpes zoster vesicles is extremely difficult and that successful results may be a matter of chance, depending, possibly, on peculiar susceptibility on the part of the rabbits. In view of the fact, however, that a careful analysis of the positive results reported by other observers shows that the conclusions were based on insufficient evidence, we believe that further work is necessary before the successful inoculation of the rabbits'' corneas with herpes zoster virus can be accepted as fully demonstrated. To make the evidence convincing specific lesions should be obtained with a fair degree of regularity and the virus should be successfully transmitted through at least two generations. Apparently the latter was not attempted by Lipschütz. Intracerebral inoculations into three rabbits with material from two cases (Nos. I and IV) were made. Two rabbits were also inoculated intraspinally with material from one case (No. IV). None of these animals showed any reaction. In the case of one of the animals inoculated into the brain (Case I) although this rabbit showed no symptoms, we thought it conceivable that the susceptibility of the species for the virus might be so slight that no obvious lesion had been produced. Nevertheless it was thought that the virus might possibly remain alive at the seat of inoculation and by repeated transfers become adapted to the rabbit. This phenomenon has been observed by Noguchi with vaccine virus, and by Rivers and Tillett with the rabbit virus isolated by these workers. This possibility was tested by us by making serial corneal and brain inoculations. Corneal transfers were carried through fourteen animals in series, and brain transfers through ten. No specific lesions developed in any of the animals. The work of Teague and Goodpasture suggested that the skin might be rendered more susceptible to infection by previous treatment with tar. Material from two cases (Nos. I and VIII) was inoculated into the tarred skin of guinea pigs and rabbits. The material was injected intracutaneously and also rubbed into the scarified skin. No reaction was obtained in any of the animals. Finally, the transmission of herpes zoster to monkeys was attempted. Blanc and Caminopetros, and Bastai and Busacca, as discussed in the review of the literature, inoculated monkeys (Macacus) in various ways, without success. It was thought possible that although monkeys of the genus Macacus might be refractory, monkeys of another genus might prove susceptible. Consequently, besides the inoculation of two Macacus monkeys, attempts were made to infect five vervets. Moreover, in view of the fact that the virus of vaccinia and the rabbit virus of Rivers and Tillett could be successfully cultivated in the testicle, intratesticular inoculations were employed. The testicles were removed at varying periods following inoculation. Numerous sections of these testicles were made and examined, but in no instance were any lesions found which could be interpreted as specific. No cells containing intranuclear inclusion bodies were found. These experiments, therefore, have also led to purely negative results. This report of our work is made at the present time because a considerable amount of literature has been published which gives the impression that herpes zoster has been successfully transmitted to animals. Although the observations of Lipschütz are suggestive, it is important that they be confirmed by further investigations. Until herpes zoster can be regularly transmitted to animals and cross-immunity tests be carried out, the relation of the virus of herpes zoster to that of herpes simplex remains a matter of speculation. In view of the fact that herpes simplex can be easily and regularly transmitted to rabbits, whereas in the hands of a large number of investigators similar experiments with herpes zoster are completely negative, it does not seem likely that the etiological agent concerned in these two diseases can be absolutely identical. The question of the identity or non-identity of herpes zoster and varicella is even more difficult to answer, because at present neither of these infections is readily transmissible to animals. The work of Kundratitz is extremely interesting. His observations, aside from indicating a close immunological relationship between herpes zoster and varicella, are important in that they seem to show the presence of a transmissible virus in the vesicles of herpes zoster. The only question that arises is whether the cases of herpes zoster from which Kundratitz was able to make successful transfers were true cases of idiopathic herpes zoster.     

带状疱疹后三叉神经痛临床及病理分析

目的：探讨带状疱疹后三叉神经痛的临床及病理特点。方法：对34例带状疱疹后三叉神经痛进行临床分析,7例行Dandy氏手术并取病理检查。结果：发病年龄50～60岁20例（59%）。右侧21例（62%）。累及三叉神经I支24例（71%）。并发角膜溃疡12例,角膜炎10例。疱疹后三叉神经痛24例的病理所见,三叉神经感觉根肿胀、轴突变性、节段性脱髓鞘,神经纤维内见淋巴细胞及中性粒细胞浸润。结论：带状疱疹后三叉神经痛是带状疱疹病毒感染所致的三叉神经感觉根急、慢性炎症所致。该病多发生于中老年人,右侧I支较多,易并发角膜溃疡及角膜炎。Dandy氏手术是治疗带状疱疹引起的顽固性三叉神经痛的有效方法。     

前列地尔治疗带状疱疹的疗效观察

目的:观察前列地尔注射液(alprostadil,PGE1)治疗带状疱疹的疗效和安全性.方法:40例带状疱疹患者随机均分为2组,对照组给予泛昔洛韦、维生素B1、弥可保、奇曼丁口服,并给予炉甘石洗剂外敷;治疗组在对照组治疗的基础上,加用静脉注射前列地尔注射液7天.结果:治疗组的VAS评分在治疗后1d、3d、5d、7d、14d、30d与对照组比较有显著性差异(P<0.05),两组QS、QL评分在治疗后3d、5d、7d、14d比较有显著性差异(P<0.05);治疗组疱疹止疱、结痂、脱痂时间均早于对照组(P<0.05).结论:前列地尔注射液治疗带状疱疹安全、有效.     

神经肽Y及P物质在带状疱疹后神经痛中的临床意义研究

目的:探讨血清神经肽Y(neuropeptide Y,NPY)及P物质(substance P,SP)在预防带状疱疹后神经痛的意义,为治疗、预防带状疱疹后神经痛(herpes zoster neuralgia,PHN)提供依据。方法:收集带状疱疹患者50例,在入院时、出院时用视觉模拟评分法(visual analogue scale,VAS)疼痛评分及血清中NPY、SP的浓度检测,于出院1月后随访是否发生PHN。采血检测20例健康志愿者血清NPY、SP的浓度为对照。结果:50例带状疱疹患者中9例发生了PHN,发生率18%。带状疱疹患者治疗后及志愿者血清NPY、SP浓度与治疗前比显著降低;不同疼痛程度组血清NPY及SP浓度比较差异均有统计学意义;发生PHN与未发生PHN的NPY及SP浓度比较显著增高。结论:NPY及SP在带状疱疹后神经痛的发生、发展过程中有重要作用,对二者检测可能对预测PHN的发生有重要价值。     

激光点灼治疗带状疱疹的效果

目的探讨激光点灼治疗带状疱疹的效果。方法急性带状疱疹病人62例，随机分为2组。A组32例，给予激光点灼＋阿昔洛韦治疗；B组30例，给予阿昔洛韦＋可由软膏治疗。比较两组疼痛减轻时间、皮疹结痂时间、痊愈时间及有无遗留带状疱疹后神经痛。结果A组疼痛减轻时间、结痂时间及痊愈时间较B组明显缩短（t＇=284．0、265．2、165．4．P〈0．01）．无遗留神经痛。结论激光点灼治疗带状疱疹安全，操作简单，无副作用，可明显缩短疗程。     

RELATION OF VARICELLA TO HERPES ZOSTER : I. STATISTICAL OBSERVATIONS.

Varicella most frequently occurs in individuals under 10 years of age, while zoster as a rule is observed in persons beyond that age. The number of cases of varicella exhibits a markedly constant seasonal variation. The variations in the prevalence of herpes zoster are not regular and do not parallel those of varicella.     

神经根脉冲射频对带状疱疹后神经痛的干预效果观察

目的:探讨神经根脉冲射频对带状疱疹后神经痛的干预效果。方法:选择2015年8月至2016年8月之间在我院进行治疗的带状疱疹后神经痛病人74例,按照随机数字的方法分为对照组和治疗组,每组37例,对照组使用常规药物治疗方法,观察组在对照组病人治疗方案基础上使用神经根脉冲射频进行治疗,对治疗的效果进行分析和评价。结果:完成治疗后,对照组与观察组病人的疼痛情况,睡眠质量,情绪情况与每晚睡眠时间与治疗前相比,均有改善,观察组病人的改善程度高于对照组病人,数据差异均具有统计学意义(P <0.05),观察组的治疗效果显著优于对照组,数据差异具有统计学意义(z=3.685, P <0.05),在治疗过程中,两组病人的各类不良反应发生率的数据差异均不具有统计学意义(P> 0.05)。结论:使用神经根脉冲射频对带状疱疹后神经痛病人进行干预,可以显著减轻病人疼痛,改善病人睡眠质量,提高治疗效果,而不良反应发生率并未增加,是值得推广的一种治疗方法。     

草乌甲素治疗带状疱疹性疼痛疗效观察

目的:评价草乌甲素(bulleyaconitine A,BLA)治疗带状疱疹性疼痛的疗效。方法:带状疱疹性疼痛病人30例,随机分为对照组和试验组,两组均在入院后给予相同的基础综合治疗,试验组在综合治疗的同时加用草乌甲素片,观察记录:两组病人分别在治疗前、治疗后第1天、第3天、第5天、第7天、第30天的以下指标:疼痛数字评分(numerical rating scale,NRS);睡眠评分(athens insomnia scale,AIS);抑郁自评量表(self-rating depression scale,SDS);病人的不良反应;带状疱疹后神经痛的发生率。结果:1与治疗前比较,两组病人各时点NRS、AIS及SDS评分均明显降低,差异有统计学意义(P<0.05);两组相比较,试验组NRS评分、AIS评分及SDS评分下降程度均明显高于对照组,组间差异均有统计学意义(P<0.05)。2两组均未见不良反应。3对照组有2例病人发生后神经痛,试验组无病人发生后神经痛。结论:1基础综合治疗能有效缓解带状疱疹性疼痛、改善病人睡眠质量及减轻病人抑郁状态。2联合草乌甲素疗效更为显著,且未见明显不良反应。