3cm单孔胸腔镜下解剖性肺段切除术的疗效及安全性分析

目的探究3 cm单孔胸腔镜下解剖性肺段切除术的疗效及安全性。方法将该院2015年6月‐2017年6月收治的100例早期非小细胞肺癌(NSCLC)患者按随机数表法分为观察组(n=50)和对照组(n=50),观察组采用3 cm单孔胸腔镜下解剖性肺段切除术治疗,对照组采用传统的单孔肺叶切除术,比较两组手术疗效及术后并发症发生率。结果(1)观察组术后胸液引流天数及住院时间均显著短于对照组,术中出血量及术后胸液引流量均显著低于对照组,差异具有统计学意义(P0.05);(2)观察组术后并发症发生率4.00%(2/50),显著低于对照组的14.00%(7/50),差异具有统计学意义(P0.05)。结论 NSCLC患者应用3 cm单孔胸腔镜下解剖性肺段切除术,可显著减少术中出血量及术后胸液引流量,缩短术后胸液引流天数及住院时间,改善患者预后,且术后并发症产生风险较低。     

单孔胸腔镜行肺叶切除术对非小细胞肺癌的治疗效果评价

目的 探究非小细胞肺癌采用单孔胸腔镜行肺叶切除术的治疗效果。方法 随机选取2021年1月—2023年8月丹阳市人民医院收治的110例非小细胞肺癌患者作为研究对象,以随机数表法分组,其中观察组(55例)行单孔胸腔镜行肺叶切除术,对照组(55例)行三孔胸腔镜行肺叶切除术,对两组手术指标、术后疼痛评分和并发症情况进行分析。结果 观察组胸管总引流量少于对照组,胸管拔除时间和术后住院时间短于对照组,差异有统计学意义(P均<0.05)。两组淋巴结清扫数量比较,差异无统计学意义(P>0.05)。观察组术后疼痛评分比对照组低,差异有统计学意义(P<0.05)。观察组并发症总发生率(7.27%)低于对照组(21.82%),差异有统计学意义(χ²=4.680,P<0.05)。结论 非小细胞肺癌以胸腔镜行肺叶切除术治疗时,选择单孔操作术式可减轻创伤和术后疼痛程度,减少手术并发症,缩短康复时间。     

单孔胸腔镜肺叶切除术治疗老年非小细胞肺癌患者60例的回顾性研究

目的 回顾性研究单孔胸腔镜肺叶切除术治疗老年非小细胞肺癌(NSCLC)患者的临床效果.方法 回顾性分析本院2016年1月至2019年12月收治的60例老年NSCLC患者的临床资料,依据不同治疗术式分为单孔组(n=32)与三孔组(n=28).单孔组行单孔胸腔镜肺叶切除术治疗,三孔组行三孔胸腔镜肺叶切除术治疗,比较两组手术相关指标(手术时间、术中失血量、淋巴结清扫量、术后引流量、胸腔引流时间、住院时间)及术前、术后3 d血清C反应蛋白(CRP)、降钙素原(PCT)水平.结果 两组术中失血量、淋巴结清扫量、术后引流量、胸腔引流时间比较差异无统计学意义,但单孔组手术时间长于三孔组,住院时间短于三孔组(P<0.05);术后3 d,单孔组血清CRP、PCT水平均低于三孔组(P<0.05).结论 与三孔胸腔镜肺叶切除术比较,单孔胸腔镜肺叶切除术治疗老年NSCLC患者手术效果一致,且安全性高,但可明显减轻术后炎性反应,缩短康复进程.     

单孔与两孔胸腔镜肺大泡切除术对自发性气胸患者术后疼痛程度及复发率的影响

目的 探讨单孔与两孔胸腔镜肺大泡切除术对自发性气胸患者术后疼痛程度及复发率的影响.方法 回顾性分析本院胸外科2017年5月至2020年5月收治的100例自发性气胸患者的临床资料,根据不同的治疗方式分为对照组和观察组,各50例.对照组行胸腔镜肺大泡切除术双孔治疗,观察组行胸腔镜肺大泡切除术单孔治疗.比较两组手术相关指标、手术前后疼痛情况、术后不良反应发生率及术后3个月复发率.结果 观察组手术时间短于对照组,手术总出血量、胸管引流量少于对照组,胸管引流时间、住院时间短于对照组,差异均有统计学意义(P<0.05).术前,两组视觉模拟评分(VAS)比较差异无统计学意义;术后3 d,两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).观察组术后不良反应发生率低于对照组,差异有统计学意义(P<0.05).两组术后复发率比较差异无统计学意义.结论 单孔胸腔镜肺大泡切除术治疗自发性气胸患者效果优于双孔胸腔镜肺大泡切除术,可缩短手术时间及住院时间,减少手术出血量,降低疼痛程度,且安全性较高,值得临床推广运用.     

单孔胸腔镜下肺叶切除术治疗早期非小细胞肺癌的临床效果观察

目的观察单孔胸腔镜下肺叶切除术治疗早期非小细胞肺癌的临床效果。方法从本院2015年1月至2018年12月接受的早期非小细胞肺癌患者中,抽取68名作为研究对象,随机将其分为对照组与观察组,均34例。对照组实施三孔胸腔镜下肺叶切除术进行治疗,观察组实施单孔胸腔镜下肺叶切除术进行治疗,观察两组手术情况以及术后并发症发生情况。结果观察组术中出血量、术后并发症发生率均显著低于对照组(P0.05);胸管留置时间和住院时间均显著短于对照组(P0.05);两组手术时间无明显差异(P0.05)。结论在早期非小细胞肺癌临床治疗中实施单孔胸腔镜下肺叶切除术治疗能够有效降低术中出血量和术后并发症的发生,缩短胸管留置时间和住院时间。     

单孔、单操作孔与三孔胸腔镜肺癌根治术的临床研究

目的比较单孔、单操作孔与三孔胸腔镜肺癌根治术的临床效果及围术期的影响,探讨单孔法及单操作孔技术的实用性。方法选取2016年1-12月期间行胸腔镜肺癌根治术的患者91例,分为单孔组(n=22)、单操作孔组(n=28)及三孔组(n=41),比较三组手术时间、术中出血量、淋巴结清扫数目、术后引流胸液总量、胸管停留时间、术后疼痛VAS评分、术后住院时间和术后并发症情况。结果三组在术中出血量、淋巴结清扫数目、引流胸液总量、术后住院天数、停留胸管时间及术后并发症方面差异无统计学意义(P0.05)。单孔组及单操作孔组在术后疼痛评分方面优于三孔组(P0.05),而两者间差异无统计学意义(P0.05);单操作孔组的手术时间较三孔组、单孔组延长(P0.05),而三孔组与单孔组间差异无统计学意义(P0.05)。结论单孔法、单操作孔法与三孔法胸腔镜手术具有相类似的临床效果,在胸腔镜手术治疗非小细胞肺癌中是安全、可行的。     

胸腔镜下全胸腺切除治疗早期胸腺瘤的临床疗效分析

目的探析对早期胸腺瘤患者实施胸腔镜下全胸腺切除治疗的临床疗效。方法选取2018年6月至2019年7月本院收治的早期胸腺瘤患者22例为研究对象,所有患者均实施经剑突下单孔胸腔镜下全胸腺切除手术,观察患者在实施手术治疗后的并发症发生率、术中出血量、住院时间、引流管引流时间、手术时间、术后呼吸机辅助时间、ICU住院时间及住院费用。结果治疗后,患者乳糜胸发生率为0.00%(0/22),肺部感染发生率为9.09%(2/22),膈肌麻痹发生率为4.55%(1/22),心律失常发生率为4.55%(1/22),并发症总发生率为18.18%(4/22);患者术中出血量(88.10±60.64)mL、住院时间(6.02±4.25)d、引流管引流时间(4.38±3.22)d、总引流量(502.13±421.66)mL、手术时间(110.28±46.76)min、术后呼吸机辅助时间(13.56±2.98)h、ICU住院时间(1.52±1.48)d、住院费用(4.32±4.19)万元。结论通过对早期胸腺瘤患者实施经剑突下单孔胸腔镜下全胸腺切除手术治疗,能缩短手术时间,减少术中出血量,缩短患者住院时间、引流管引流时间、术后呼吸机辅助时间、ICU住院时间,减少患者住院费用和并发症发生率,有利于患者预后恢复,值得临床推广应用。     

单孔胸腔镜在自发性气胸治疗中的应用研究

目的 探讨单孔胸腔镜在自发性气胸治疗中的应用效果。方法 随机选择河源市人民医院2020年6月—2022年6月收治的自发性气胸患者50例为研究对象,依据随机数表法随机分为单孔胸腔镜组(n=22)与电视胸腔镜手术(video-assisted thoracoscopic surgery, VATS)组(n=28)。单孔胸腔镜组采用单孔胸腔镜下肺大疱切除术治疗,VATS组采用电视胸腔镜下肺大疱切除术治疗。记录两组患者围术期指标,术后24 h和术后72 h疼痛视觉模拟(VAS)评分,术后引流量、术后引流时间和术后住院时间,术后并发症发生情况。结果 单孔胸腔组术中出血量(18.98±4.35)mL少于VATS组(27.37±5.16)mL,且手术时间(25.13±4.82)min短于VATS组(34.07±6.57)min,差异有统计学意义(t=6.107、5.347,P<0.05)。单孔胸腔组术后24、72 hVAS评分(3.16±0.58)分、(2.74±0.38)分低于VATS组(4.25±0.71)分、(3.41±0.45)分,差异有统计学意义(t=5.830、5.589,P<...     

单孔胸腔镜模块化肺癌根治术的临床应用效果及价值探讨

目的分析单孔胸腔镜模块化肺癌根治术的临床应用效果。方法选取我院2016年1月至2017年8月收治的原发性非小细胞肺癌患者130例,按照手术类型分为单孔组(n=65)和三孔组(n=65),分别行单孔、三孔胸腔镜模块化肺癌根治术治疗,观察比较两组患者各手术指标情况。结果单孔组患者术后引流总量、术后胸管置管时间、术后住院时间、术后24 h疼痛评分均少于三孔组患者(P0.05)。结论单孔胸腔镜模块化肺癌根治术的临床应用效果显著,能有效缩短患者康复时间,改善术后疼痛。     

微创胸腔镜手术对改善纵膈肿瘤预后的影响

目的研究微创胸腔镜手术对改善纵膈肿瘤预后的影响。方法选取2016年7月至2017年5月我院收治的纵膈肿瘤患者55例作为研究主体,根据治疗术式不同分为对照组(n=27,传统开胸纵隔切除术)和观察组(n=28,微创胸腔镜手术)。比较2组手术情况及术后并发症发生率。结果 2组患者手术均顺利,无手术死亡情况。观察组手术时间、术中出血量、术后胸管引流时间、镇痛药物使用时间、术后住院时间均低于对照组(P0.05)。观察组住院费用略高于对照组,但组间对比无统计学意义(P0.05);且观察组术后轻微声嘶、发热以及切口局部渗液并发症发生率明显低于对照组(P0.05)。结论与开胸纵隔切除术疗效比较,微创胸腔镜手术医治纵膈肿瘤疗效更突出,且手术安全性较高,术后并发症发生率低,有利于患者术后恢复。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.