Relationship between lifestyle and serum lipid and lipoprotein levels in middle-aged Japanese men

Cross-sectional associations between lifestyle factors [cigarette smoking, alcohol intake, overall obesity indicated by body mass index (BMI), eating breakfast, snacking between meals, considering nutritional balance, coffee drinking, physical exercise, and hours of work and sleep] and serum lipid and lipoprotein levels were examined in 1580 middle-aged Japanese men in Osaka, Japan. From stepwise regression analyses, significant correlates with low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and Log triglyceride levels were, in the order of relative importance: BMI, alcohol intake (negative), and age for LDL cholesterol level; BMI (negative), cigarette smoking (negative), alcohol intake, considering nutritional balance, and physical exercise for HDL cholesterol level; and BMI, cigarette smoking, working hours (negative), considering nutritional balance (negative), alcohol intake, and coffee drinking (negative) for Log triglyceride level. The cumulative percentages of variation for LDL cholesterol, HDL cholesterol and Log triglyceride levels were 4.2%, 15.4% and 14.7%, respectively. From stepwise regression analyses, excluding BMI as a factor in the model, snacking between meals emerged as a significant factor for LDL cholesterol level and HDL cholesterol level (negative). The cumulative percentage of variation for each serum lipid and lipoprotein level was decreased (1.5% for LDL cholesterol, 6.8% for HDL cholesterol, and 3.1% for Log triglyceride). These results suggest that BMI has the strongest association with serum lipid and lipoprotein levels and that good daily lifestyles may have an anti-atherogenic effect by altering serum lipid and lipoprotein levels in middle-aged Japanese men.     

Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes

The aim of the authors of this study was to clarify the relationships among apolipoprotein E (ApoE) genotype, blood pressure, lipid profile, serum leptin, and adiponectin in healthy postmenopausal women. The study was conducted between March 2011 and December 2012 on 266 participants aged 50–65 years from the Institute of Rural Health in Lublin, Poland. Results showed that women had four combinations of genotypes: ?2/?3, ?3/?3, ?3/?4, and ?4/?4. Carriers of different genotypes did not differ in terms of age, body mass index (BMI), blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, and adiponectin levels. Mean low-density lipoprotein (LDL) cholesterol levels were higher in ε4 carriers compared to non-carriers. Fasting serum leptin concentrations were higher in homozygotes ?4/?4. Leptin correlated positively with BMI in all study groups and with LDL in ?2/?3, ?3/?3, and ?3/?4. Adiponectin correlated negatively with triglycerides in ?2/?3, ?3/?3, and ?3/?4 and positively with HDL in ?2/?3 carriers. Adipokines were not associated with blood pressure. Multiple regression analyses demonstrated associations among leptin, ApoE ?4/?4, BMI, and LDL, and among adiponectin, BMI, and triglycerides. In healthy postmenopausal women ?4/?4 genotype was associated with lower leptin levels. Homozygosity ?4/?4 was associated with a more atherogenic lipid profile and possibly dysregulation of leptin and adiponectin signaling in lipid metabolism.     

中老年人血清瘦素与脂联素水平及其相关危险因素研究

目的 探讨相对健康的中老年人血清瘦素与脂联素水平与心脑血管疾病危险因素的相关性.方法 从"广州生物库队列研究"中收集1515名相对健康的50岁及以上的中老年人个人资料及病史、体格检查并测定血清空腹血糖、血脂、瘦素和脂联素的水平.结果 (1)广州市1515名的血清瘦素水平(x-±s)男女性分别为(3.90±2.36)ng/ml和(12.17±2.01)ng/ml;脂联素水平男女性分别为(5.33±2.78)mg/L和(7.18±2.58)mg/L.(2)男女性血清瘦素和脂联素水平均随年龄增长而升高;在调整BMI后,男性瘦素水平仍随年龄增长而显著升高(趋势检验P＜0.001),而女性其脂联素水平也随年龄增长而显著升高(趋势检验P＜0.05).(3)在调整年龄后,男女性血清瘦素和脂联素水平均与吸烟状态无明显相关(P=0.09～0.76).(4)血清瘦素水平,男女性均随腰围、BMI、SBP、LDL-C和TG增加而显著升高(P=0.04,＜0.001),同时还随男性的DBP和空腹血糖升高及HDL-C降低而显著升高(P=0.03～0.02).(5)血清脂联素水平男女性均随腹围以及TG升高而下降(P=0.003,＜0.001),而男性血清脂联素水平还随BMI与空腹血糖升高及HDL-C水平下降而下降(P=0.05,＜0.001),女性则随SBP和TC上升而下降(P=0.05～0.006).结论 广州市相对健康的中老年人血清瘦素和脂联索水平男性比女性低;男性瘦素水平和女性脂联素水平同年龄增加呈显著相关.血清瘦素升高和脂联素下降与传统心脑血管危险因素上升有关.     

Association of lifestyle with serum lipid levels: a study of middle-aged Japanese men

Cross-sectional associations between lifestyle and serum lipid levels were examined in 1591 Japanese male office workers aged 35 to 59 years in Osaka, Japan. From multiple linear regression analyses, significant correlates with low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and Log triglyceride levels and the ratio of LDL cholesterol to HDL cholesterol were, in the order of relative importance: BMI, alcohol intake (negative) and age for LDL cholesterol level; BMI (negative), cigarette smoking (negative), alcohol intake, consideration for nutritional balance, hours of brisk walking, hours of walking at an ordinary pace and physical exercise for HDL cholesterol level; BMI, cigarette smoking, consideration for nutritional balance (negative), hours of work (negative), alcohol intake and coffee drinking (negative) for Log triglyceride level; and BMI, alcohol intake (negative), cigarette smoking, consideration for nutritional balance (negative), age, hours of brisk walking (negative) and the frequency of snack intake between meals for the ratio of LDL cholesterol to HDL cholesterol. Our data suggest that obesity, cigarette smoking and snack intake between meals are atherogenic whereas alcohol consumption, consideration for nutritional balance and walking long hours, especially at a brisk pace, are anti-atherogenic in middle-aged Japanese men.     

青少年体重指数与血清瘦素等生化指标之间的关系

目的研究青少年肥胖程度与血清瘦素、胰岛素、血糖及血脂等的相关性,为成年期疾病的早期预防提供相关依据。方法随机选取83名中学生,其中肥胖学生47名,正常学生36名。测定血清瘦素、胰岛素、血糖及血脂等指标,计算胰岛素抵抗指数（HOMA-IR）。结果除血糖外,血清各项检测指标肥胖组均高于正常组（P值均〈0.05）;83名中学生BMI和血清瘦素及其他各项指标均呈显著正相关（P值均〈0.05）。女生只有三酰甘油、胰岛素和胰岛素抵抗指数与瘦素水平显著正相关。结论BMI对血清瘦素水平影响最明显,对糖、脂代谢的影响相对较小;肥胖组存在明显的高瘦素血症（瘦素抵抗）、高胰岛素血症、胰岛素抵抗（IR）和轻微的脂代谢异常。     

Low-density lipoprotein subclass distribution pattern and adiposity-associated dyslipidemia in postmenopausal women

OBJECTIVE: A predominance of small, dense low-density lipoprotein (LDL) particles (subclass pattern B) is associated with increased risk for coronary heart disease and is characterized by elevated triglycerides and depressed high-density lipoprotein (HDL) cholesterol concentrations. The present analysis was undertaken to assess the impact of LDL subclass distribution pattern and adiposity on serum lipids in postmenopausal women. METHODS: Anthropometric measurements and fasting lipid data were obtained from 254 postmenopausal women 70 years of age or younger, not receiving sex hormone replacement, who were participating in a clinical trial designed to assess the influence of hormone replacement regimens on coronary heart disease risk markers. RESULTS: The prevalence of LDL subclass pattern B was 32%. Triglyceride levels were higher and HDL cholesterol lower (both p<0.001) in women with pattern B vs. pattern A, but total and LDL cholesterol levels did not differ. LDL subclass pattern contributed independently to the variance in HDL cholesterol (p<0.001) and log(e) triglyceride (p<0.001) concentrations explained by anthropometric variables (waist circumference or body mass index). Compared to women with LDL subclass pattern A and waist circumference below the median value of 83.0 centimeters, those with pattern B and waist > or =83.0 centimeters had markedly lower HDL cholesterol levels [44.0 (41.6-47.4) vs. 57.2 (54.1-60.3) mg/dL, mean (95% CI)] and increased triglyceride concentrations [geometric mean 147.8 (131.6-165.7) vs. 95.4 (88.2-102.5) mg/dL]. CONCLUSIONS: These data suggest that adiposity and LDL subclass distribution pattern are independent determinants of plasma triglyceride and HDL cholesterol concentrations in postmenopausal women.     

Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age

Limited evidence suggests that serum iron and hepcidin concentrations are dysregulated in obesity and inflammation. The objective of the present study was to compare C-reactive protein, interleukin-6, circulating levels of hepcidin, serum lipids, and iron status in obese vs. normal-weight women of childbearing age. Healthy women aged 18–30 years were recruited for the study (n = 47: 25 obese and 22 normal weight). Fasting blood samples were obtained to measure serum lipids (total cholesterol, HDL, LDL cholesterol, triglycerides, non-HDL cholesterol), complete blood count, serum iron, total iron-binding capacity, transferrin saturation, serum ferritin, hepcidin, C-reactive protein, and interleukin-6. Obese women had significantly higher mean serum C-reactive protein (p < 0.001), interleukin-6 (p < 0.001), hepcidin (p = 0.024), triglycerides (p < 0.001) and total cholesterol/HDL ratio (p < 0.001) but lower HDL (p = 0.001) and serum iron/hepcidin ratio (p = 0.011) compared with normal-weight women. BMI correlated positively with inflammatory markers, triglycerides, LDL and total cholesterol/HDL ratio, and negatively with HDL and serum iron/hepcidin ratio. Serum iron correlated negatively with ferritin in the obese group (p = 0.030) but positively in normal weight women (p = 0.002). BMI and ferritin were the only predictors of serum iron/hepcidin ratio accounting for 23% of the variation among subjects. Studies are needed to examine anti-inflammatory dietary approaches that can improve iron biomarkers in obese women.     

不同糖耐量水平人体的脂联素、内皮素-1与胰岛素抵抗的相关性

目的探讨不同糖耐量水平人体的脂联素(APN)和内皮素-1(ET-1)与胰岛素抵抗的关系。方法选择70例正常对照(对照组)、55例糖耐量受损(IGT组)和65例新诊断早期2型糖尿病患者(T2DM早期组),测定受试者空腹状态下的血清空腹血糖(FPG)、空腹胰岛素(FINS)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血清APN、血浆ET-1及服糖后2 h血糖水平;测量身高、体重,计算体质指数(BMI);计算胰岛素抵抗指数(HOMA-IR)。结果 IGT组、T2DM早期组分别与正常对照组相比,HOMA-IR、ET-1、LDL均显著升高,而APN、HDL均显著降低,T2DM早期组更明显(均P0.01)。血清APN水平与HOMA-IR、BM(I体重指数)、FBG、LDL显著负相关,与HDL显著正相关(P0.01)。血浆ET-1与HOMA-IR、BMI、FBG、LDL显著正相关,与HDL显著负相关(P0.01)。APN与ET-1显著负相关(r=-0.517,P0.01)。结论人体血清APN和血浆ET-1的水平与胰岛素抵抗、体重指数、脂代谢均密切相关。APN和ET-1水平可作为2型糖尿病发病危险性和疾病进展的预测指标。     

Fiber intakes and anthropometric measures are predictors of circulating hormone, triglyceride, and cholesterol concentrations in the women's health trial

The unhealthy eating patterns and obesity among women in the U.S. are indicated by changes in biomarkers, such as insulin, lipoproteins, and estradiol, that are risk factors for breast cancer and cardiovascular diseases. This article models the inter-relations among diet, serum insulin, estradiol, and sex hormone binding globulin (SHBG) concentrations, plasma LDL and HDL cholesterol, and net triglyceride concentrations, using the data at baseline and 12 mo on 379 and 615 postmenopausal women in the Control and Intervention groups, respectively, of the Women's Health Trial: Feasibility Study in Minority Populations. Subjects in the Intervention group received detailed advice over a period of 1 y for reducing fat intakes and increasing the consumption of whole grains and fruits and vegetables. The main findings were that there were significant differences between the Control and Intervention groups in the changes from baseline to 12 mo in LDL and HDL cholesterol and SHBG concentrations. Second, using a comprehensive random effects modeling framework, the ratio of fiber to energy intake was significantly associated (P < 0.05) with lower insulin and triglyceride levels, and with a higher HDL cholesterol concentration in the Intervention group. Third, the subjects' waist-to-hip ratio and BMI were significantly associated with insulin, SHBG, LDL and HDL cholesterol, and triglyceride concentrations. Fourth, insulin levels were significantly negatively associated with SHBG and HDL cholesterol, and positively associated with LDL cholesterol, triglyceride, and estradiol concentrations. Overall, weight loss, especially around the waist, and increased fiber intakes are likely to be beneficial for lipid, cholesterol, and hormone profiles of U.S. women.     

脂联素基因多态性与新疆地区汉族2型糖尿病的相关性研究

目的研究脂联素(APN)基因45T/G单核苷酸多态性(SNPs)与新疆地区汉族人2型糖尿病(T2DM)的相关性。方法采用聚合酶链反应-限制性内切酶片段长度多态性技术(PCR-RFLP),比较新疆地区汉族人正常糖耐量组(NGT)和T2DM组APNSNP45基因型与等位基因分布频率差异;比较相同人群不同基因型和不同人群相同基因型T2DM相关体测与生化指标的差异。结果 T2DM组APNSNP45TG+GG基因型及G等位基因分布频率均高于NGT组(P﹤0.005);NGT组TG+GG基因型者血清甘油三酯(TG)、总胆固醇(CH)和低密度脂蛋白(LDL)水平显著高于TT基因型者(P﹤0.005),相同基因型人群之间,T2DM组收缩压(SBP),体重指数(BMI),腰臀比(WHR),空腹血糖(FBG),胰岛素抵抗指数(LOG(HOMA-IR)),TG,CH及LDL均高于NGT组(P﹤0.05);胰岛β细胞功能指数(LOG(HOMA-β))和高密度脂蛋白(HDL)水平均低于NGT组(P﹤0.005)。结论 APNSNP45T/G多态位点与新疆地区汉族T2DM相关,携G等位基因者发生T2DM的可能性增加,且G等位基因与汉族血脂代谢异常及胰岛素抵抗有关。     

Plasma leptin and the cholesterol saturation of bile are correlated in obese women after weight loss

Increased cholesterol secretion is a major alteration of biliary function in obese subjects Leptin is a regulator of food intake and is increased in plasma of subjects with low energy expenditure and high adiposity. We investigated the relationship between leptin and the cholesterol saturation of bile in obese women before and after weight reduction by energy restriction (5.02 MJ/d). We studied women (n = 14) with a body mass index (BMI) > or = 30 kg/m(2) who were 35.4 +/- 2.3 y old and who did not have a history of gallstones. They were studied by ultrasound to ensure absence of stones or sludge. BMI, gallbladder bile composition, plasma leptin, serum lipids and lipoproteins cholesterol levels were recorded at baseline and after 6 wk of weight reduction. There were decreases in BMI (33.9 +/- 3.1 to 31.1 +/- 3.6 kg/m(2), P < 0.0001) and leptin levels (16.7 +/- 9.7 to 10.0 +/- 6.7 micro mol/L, P < 0.05) during weight loss. After the experimental period, there were positive correlations between plasma leptin levels and BMI (r = 0.71, P < 0.004); leptin levels and the cholesterol saturation index (CSI) (r = 0.53, P < 0.05); the CSI and LDL cholesterol (r = 0.73, P < 0.003); and negative correlations between leptin levels and HDL cholesterol (r = -0.54, P < 0.05) and LDL cholesterol (r = -0.57, P < 0.03). We have shown relationships among HDL cholesterol, CSI and leptin. This could be useful in understanding the pathophysiology of cholesterol gallstone formation in obese people.     

Relationship between plasma adiponectin levels and metabolic risk profiles in Taiwanese children

OBJECTIVE: Adiponectin, a novel adipokine with antiinflammatory and insulin-sensitizing properties, has an important role in glucose metabolism and is negatively correlated with body fat amount in adults. The purpose of this study was to evaluate the association of plasma adiponectin level with metabolic risk profiles and insulin resistance status among Taiwanese children. RESEARCH METHODS AND PROCEDURES: We enrolled 1,248 children (608 boys and 640 girls) to ascertain their demographic, anthropometric, and cardiovascular risk factors distribution in Taipei. We measured plasma insulin, adiponectin, and leptin levels by radioimmunoassay (Linco Research Inc, St. Charles, MO). We calculated an insulin resistance index (IRI) using the Homeostasis Model Assessment model and also calculated an insulin resistance syndrome (IRS) summary score for each individual by adding the quartile ranks from the distribution of systolic blood pressure, serum triglyceride, high-density lipoprotein-cholesterol (HDL-C) (inverse), and insulin levels. RESULTS: In general, the boys had larger BMI, higher systolic blood pressure, serum total cholesterol, and triglyceride, and lower plasma leptin and adiponectin levels than girls. Plasma adiponectin levels were correlated negatively with BMI, leptin, insulin, IRI, and IRS summary score but positively correlated with HDL-C in both boys and girls. In multivariate regression analyses, adiponectin was negatively associated with insulin (girls only), IRI (girls only), and IRS score, and positively associated with HDL-C in both genders even after adjusting for age, BMI, plasma leptin level, and other potential confounders. DISCUSSION: These data suggest that plasma adiponectin levels were negatively associated with metabolic risk profiles that may have played a protective role in the development of insulin resistance among Taiwanese school children.     

胰岛素抵抗与结直肠癌关系的临床研究

目的 探讨胰岛素抵抗(IR)与结直肠癌(CRC)发病的关系,为CRC病因学探索及CRC的预防研究提供思路.方法 收集新诊断的312例CRC患者的临床资料作为病例组,选择286名健康体检者作为对照组.比较两组人群间空腹血糖(FPG)、空腹胰岛素水平(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、体质指数(BMI)、腰臀比(WHR)、糖尿病家族史、结直肠癌家族史、吸烟、饮酒等生活行为以及血脂、血脂联素水平等方面的差异.结果 CRC组BMI、CRC家族史比例均高于对照组,差异有统计学意义(P＜0.05,P＜0.01),且CRC组和对照组lnHNS、lnHOMA-IR分别为(2.92±0.51)、(2.46±0.45) mU/L和(1.49±0.51)、(1.02±0.41),差异有统计学意义(P＜0.05,P＜0.01),而CRC组脂联素水平[(10.1±2.9)mg/L]明显低于对照组[(13.2±2.6)mg/L],差异有统计学意义(P＜0.05);两组间FPG、甘油三酯、总胆固醇以及糖尿病家族史、吸烟率、饮酒率、合并高血压比例等方面的差异均无统计学意义(P＞0.05).多因素回归分析显示,年龄、性别、糖尿病家族史、高血压、吸烟、饮酒及血脂、FPG、BMI、WHR、脂联素未进入方程,对CRC未见显著影响;HNS与CRC (OR=4.37,95％ CI=3.21～7.23)、HOMA -IR与CRC(OR=6.68,95％ CI=3.79～9.53)、CRC家族史与CRC(OR=2.31,95％ CI=1.83～5.64)之间的关系有统计学意义(P＜0.05).结论 IR与CRC存在一定的相关性,是CRC患病的独立危险因素.     

抗阻训练对肥胖儿童身体成分血脂及血清瘦素的影响

了解8周抗阻训练对肥胖儿童身体成分、血脂及血清瘦素的影响,为改善肥胖儿童的健康水平以及寻求更好的减肥方法提供理论依据.方法 根据WHO推荐的身高标准体重法,选取晋中市18名肥胖儿童(男、女各9名)进行8周抗阻训练,然后对运动前后身体成分[体重、体质量指数(BMI)、肌肉量及躯干肌肉量、身体脂肪量、身体各部位脂肪量及身体脂肪比率]、血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)]及血清瘦素水平进行比较.结果 肥胖儿童抗阻训练后血清瘦素、TG、LDL水平均下降(P值均<0.05),HDL水平上升(P<0.01);男性肥胖儿童抗阻训练后体重,BMI,身体脂肪量,左右上肢及躯干脂肪量均下降(P值均<0.05),肌肉量及躯干肌肉量均增加(P值均<0.05);女性肥胖儿童抗阻训练后BMI,身体脂肪量,右下肢、右上肢及躯干脂肪量均下降(P值均<0.05),肌肉量及躯干肌肉量增加(P值均<0.01).结论 8周抗阻训练可以降低肥胖儿童BMI、身体脂肪量和血清瘦素水平,增加肌肉质量,改善血脂紊乱.     

Low-Density Lipoprotein Subclass Distribution Pattern and Adiposity-Associated Dyslipidemia in Postmenopausal Women

Objective: A predominance of small, dense low-density lipoprotein (LDL) particles (subclass pattern B) is associated with increased risk for coronary heart disease and is characterized by elevated triglycerides and depressed high-density lipoprotein (HDL) cholesterol concentrations. The present analysis was undertaken to assess the impact of LDL subclass distribution pattern and adiposity on serum lipids in postmenopausal women.

Methods: Anthropometric measurements and fasting lipid data were obtained from 254 postmenopausal women 70 years of age or younger, not receiving sex hormone replacement, who were participating in a clinical trial designed to assess the influence of hormone replacement regimens on coronary heart disease risk markers.

Results: The prevalence of LDL subclass pattern B was 32%. Triglyceride levels were higher and HDL cholesterol lower (both p<0.001) in women with pattern B vs. pattern A, but total and LDL cholesterol levels did not differ. LDL subclass pattern contributed independently to the variance in HDL cholesterol (p<0.001) and log_e triglyceride (p<0.001) concentrations explained by anthropometric variables (waist circumference or body mass index). Compared to women with LDL subclass pattern A and waist circumference below the median value of 83.0 centimeters, those with pattern B and waist ≥83.0 centimeters had markedly lower HDL cholesterol levels [44.0 (41.6–47.4) vs. 57.2 (54.1–60.3) mg/dL, mean (95% CI)] and increased triglyceride concentrations [geometric mean 147.8 (131.6–165.7) vs. 95.4 (88.2–102.5) mg/dL].

Conclusions: These data suggest that adiposity and LDL subclass distribution pattern are independent determinants of plasma triglyceride and HDL cholesterol concentrations in postmenopausal women.     

血清趋化素、瘦素、脂联素浓度与学龄前单纯性肥胖儿童糖脂代谢的关系

目的 研究血清趋化素、瘦素、脂联素水平与3~6岁学龄前期儿童单纯性肥胖及代谢的关系,为学龄前单纯性肥胖儿童临床监测及治疗效果提供依据。方法 选取2019年1月—2020年5月于大连市妇幼保健院儿童保健门诊体检的3~6岁儿童为研究对象,获取单纯性肥胖儿童41例作为研究组,另获取同年龄、同时期儿童43例作为对照组。测量其身高和体重,并计算身高别体重;测定血清趋化素、瘦素、脂联素、空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c),同时计算胰岛素抵抗指数。结果 单纯性肥胖组的FINS、胰岛素抵抗指数(HOMA-IR),LDL-c,血清趋化素,瘦素明显高于对照组,差异有统计学意义(t=3.288、2.927、4.939、3.078、5.456,P＜0.05),HDL-c,脂联素明显低于对照组,差异有统计学意义(t=-5.179、-3.145,P＜0.05)。而两组FPG、TG、TC差异无统计学意义(t=0.391、0.768、-0.266,P＞0.05); 趋化素与身高别体重、FINS、HOMA-IR、 LDL-c、瘦素呈正相关(r=0.339、0.416、0.227、0.376、0.266,P＜0.05),与HDL-c、脂联素呈负相关(r=-0.410、-0.309,P＜0.05)。瘦素与身高别体重、FINS、HOMA-IR、 LDL-c、趋化素呈正相关(r=0.492、0.375、0.279、0.269、0.266,P＜0.05),与HDL-c、脂联素呈负相关(r=-0.467、-0.326,P＜0.05)。脂联素与身高别体重、FINS、HOMA-IR,LDL-c、趋化素、瘦素呈负相关(r=-0.296、-0.351、-0.278、-0.229、-0.309、-0.326,P＜0.05),与HDL-c呈正相关(r=0.234,P=0.032)。结论 血清趋化素、瘦素、脂联素水平与学龄前单纯性肥胖儿童糖脂代谢密切相关,这些指标对于识别、监测、干预学龄前单纯性肥胖儿童有着重要意义。     

膳食脂质对中老年高胆固醇血症患者血清胆固醇的影响

对１６７名中老年高胆固醇血症患者的膳食脂质摄入情况及血清总胆固醇（ＴＣ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）和低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）水平进行分析测定,结果表明：膳食脂质摄入及身体质量指数（ＢＭＩ）对血清胆固醇水平有重要影响;ＢＭＩ、膳食胆固醇和饱和脂肪酸与ＴＣ和ＬＤＬ－Ｃ水平呈正关联,ＨＤＬ－Ｃ及其与ＴＣ的比值与单不饱和脂肪酸呈正关联,而与ＢＭＩ呈负关联,提示减少膳食胆固醇和饱和脂肪摄入、     

职业紧张对石油工人血脂代谢的影响

目的 探讨职业紧张对石油工人血脂代谢的影响,为其健康管理提供理论依据。方法 选取2017年4月-2018年4月参加职业健康体检的某石油企业在岗工人作为研究对象,共2241名工人纳入本次研究。采用中文版《工作内容问卷》评估职业紧张水平;采集工人空腹状态肘静脉血,检测血清总胆固醇（TC）、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平。结果 石油工人血脂异常率为52.03%,其中血清TC异常率27.49%,血清TG异常率29.41%,血清HDL-C异常率12.23%,血清LDL-C异常率22.80%。采用多因素logistic回归分析显示:调整年龄、性别、BMI等混杂因素后,与低紧张型工作状态下工人相比,高紧张型工作状态的工人发生血清TC异常、LDL-C异常的风险更高（P<0.05,OR值分别为1.35、1.42）,高社会支持状态下发生血清LDL-C异常风险降低（P<0.05,OR=0.77）。结论 职业紧张是石油工人血清TC、LDL-C异常的危险因素,社会支持是石油工人血清LDL-C异常的保护因素。     

单纯性肥胖儿童血清瘦素水平与血糖及血脂变化的关系

目的 研究单纯性肥胖儿童血清瘦素水平与血糖、胰岛素抵抗及血脂异常的关系。方法 采用放射免疫分析法、酶法对42对7-10岁肥胖及健康对照儿童进行血清瘦素、胰岛素水平及血糖、血脂水平的测定。结果 肥胖及对照儿童瘦素水平分别为2．74-45．125μg/L和0．53-10．18μg/L,经对数转换后肥胖组平均水平非常显著高于体重正常组。血清瘦素水平与体重指数(BMI)、腰臀围比(WHR)及体脂百分比均呈显著正相关关系。83％的肥胖儿童有瘦素抵抗,肥胖瘦素敏感组与体重正常组的血糖、胰岛素及血脂水平均差异无显著性,而肥胖瘦素抵抗组总胆固醇、甘油三酯(TG)、低密度脂蛋白胆固醇及胰岛素水平均显著高于体重正常组,肥胖瘦素敏感与瘦素抵抗儿童年龄、性别分布及BMI、WHR的差异无显著性,但瘦素抵抗组TG显著高于瘦素敏感组,高密度脂蛋白胆固醇显著低于瘦素敏感组。结论 肥胖儿童即存在瘦素抵抗,瘦素抵抗与代谢综合征及心血管疾病的危险因素密切相关,可作为筛查高危肥胖儿童的有用指标。     

An epidemiological study on the familial aggregation and the sequential changes of serum lipids and apolipoproteins in school children in a rural area of Awaji Island

An epidemiological survey on serum lipids and apolipoproteins in school children in Goshiki-cho, Awaji-Island was carried out from 1985 to 1988 and their relations to blood pressure, anthropometric values, nutritional intake and a family history of hypertension were investigated. Parent-child and sibling-sibling correlations of the values were also analyzed. The results obtained were as follows: 1. During a 3-year follow-up from 11 to 14 years of age, serum levels of apo AI, apo AII, apo B and LDL cholesterol decreased at 12 years of age in both males and females. A tracking phenomenon was observed in serum levels of lipids and apolipoproteins. 2. Males at 10-14 years of age with a family history of hypertension (FH+) showed significantly higher systolic blood pressure and erythrocyte Na/K ratios than those without such a family history (FH-). The FH+ group (both males and females) had lower serum HDL cholesterol and higher levels of apo B, LDL cholesterol and triglyceride. 3. Significantly positive correlations were observed between apo AI levels of mother-son pairs and between those of elder and younger brother pairs. A positive correlation was observed between apo B levels of elder brother-younger sister pairs. Serum levels of total, HDL and LDL cholesterol in school children were closely correlated with the levels of the respective cholesterols in parents. Similar correlations were observed between sibling-sibling pairs.