Primary gastric burkitt lymphoma: a rare cause of intraabdominal mass in childhood

Primary gastric lymphoma in the pediatric population is rare and the role of Helicobacter Pylori (H. Pylori) in its pathogenesis is unclear. In this report, we describe a case of non-Hodgkin’s lymphoma (Burkitt’s type) coexisting with H. pylori and discuss the potential relationship between H. Pylori and gastric Burkitt lymphoma.     

Acute leukemia in burkitt lymphoma

Burkitt lymphoma uncommonly presents as acute leukemia. We describe the clinical course and findings of a 14-year-old female with Burkitt lymphoma who presented with acute leukemia, splenomegaly and an abdominal mass. She responded initially to prednisone alone and later achieved full remission with combination chemotherapy. Established morphologic criteria and clinical course were consistent with the diagnosis of Burkitt lymphoma (1), although B-cell determinants were not present on her tumor cells.     

Cytogenetic studies on four cases of non-endemic burkitt lymphoma

Cytogenetic studies carried out on four children with non-endemic Burkitt lymphoma showed: 1) Two with the typical translocation t(8;14)(q24;q32); 2) one with a variant t(2;8)(p11;q24); and 3) one with apparently normal chromosomes 8 and 14. Additional chromosomal variation was present in all four patients. Two were shown to have a duplication of part of the long arm of chromosome 1 (1q23→1q32 and 1q23→1q42). Epstein Barr virus studies on two patients showed that one was positive and the other negative. A comparison of these results with other non-endemic cases in the literature has been made revealing a wider range of chromosomal variation than has been hitherto reported for endemic cases. The finding that chromosome 8 is also involved in the variant translocations in Burkitt lymphoma suggests that its changes may contribute more to the tumour development than the 14q +.     

Primary epidural burkitt lymphoma in a child: case presentation and literature review

Primary spinal epidural Burkitt lymphoma, presenting with signs of spinal cord compression, is very uncommon in childhood. Previously reported pediatric cases with isolated epidural Burkitt lymphoma had a high mortality, and survivors usually suffered serious neurologic sequelae. The authors present a 13-year-old female with isolated epidural Burkitt lymphoma with favorable outcome, and review the pediatric literature.     

Malignant lymphoma in childhood

Summary Twenty-nine cases of malignant lymphoma in childhood excluding the leukaemic involvement, seen over a period from 1959 to 1971 have been reviewed. Males (82.8%) were more commonly affected than females (17.2%). One case of lymphosarcoma and four cases of reticulum cell sarcoma were extranodal in origin while ten, thirteen, and one case of lymphosarcoma, Hodgkin’s 3 disease and reticulum cell sarcoma respectively were of nodal origin. In the majority of cases, the age of onset was 2–4 years and 10–12 years in lymphosarcoma, 6–8 years in Hodgkin’s 3 disease and 10–14 years in reticulum cell sarcoma. The age of onset, clinical features and histological patterns have been discussed. From the Department of Pathology and Bacteriology, S.P. Medical College, Bikaner.     

Rectal localization of Burkitt's lymphoma]

BACKGROUND: Rectal tumors are rare in childhood and among them malignant tumors are even less common. Only eight cases of primary rectal lymphomas were reported in children, with various presenting signs and histology. Burkitt's lymphomas are among these cases. CASE REPORT: A five-year-old child presented with hematochezia and unusual constipation. The rectal examination showed a voluminous intra rectal mass. Radiographic and pathologic examinations led to the diagnostic of Burkitt's lymphoma with medullary involvement. Complete remission was obtained after initial chemotherapy but a local relapse occurred and the child died eight months later. CONCLUSION: Hematochezia associated with unusual constipation impose a rectal examination. Early diagnosis of a rectal tumor may allow patients survival.     

Autopsy diagnosis of endemic burkitt lymphoma as the primary etiology of acute renal failure in children

Two cases of Burkitt lymphoma are reported who presented atypically with acute renal failure and significant proteinuria as initial features of the lymphoma. The cases underscore the need for high index of suspicion for Burkitt lymphoma in any child with rapidly enlarging kidneys and acute renal failure of obscured origin in parts of the world where Burkitt lymphoma is endemic.     

Primary lymphoma of brain in childhood

Primary brain lymphoma is exceedingly rare during the first decade of life. We report an unusual case, not only being one of the youngest presented, but also because of the unusual CT features exhibited.     

Primary central nervous system burkitt lymphoma with non-immunoglobulin heavy chain translocation in right ventricle: case report

Primary central nervous system Burkitt lymphoma (PCNSBL) is rare. Few cases of primary central nervous system involvement with sporadic Burkitt lymphoma have been reported and its treatment is now controversial. Here, the authors report a case of a 14-year-old boy suffering from non-immunoglobulin heavy chain (IgH) translocation PCNSBL. To the authors' knowledge, this is the second case report describing primary Burkitt lymphoma involving cerebral ventricles. After receiving combination treatment with surgery, stereotactic radiosurgery, and a chemotherapy regimen including high-dose methotrexate, the patient had a disease-free survival of 18 months.     

Histoplasmosis mimicking childhood non-Hodgkin lymphoma

Cell surface markers are becoming increasingly important in the diagnosis of malignant lymphoid diseases. We present a case of pulmonary histoplasmosis with a pleural effusion. The differential diagnosis included non-Hodgkin lymphoma because the pleural fluid cells were cytologically identical to convoluted lymphoblasts; the cells also formed rosettes with sheep erythrocytes at 37 degrees C, suggesting that they were malignant thymus-derived lymphoblasts. Since cultures of pleural fluid were negative for bacteria and fungi, the correct diagnosis of histoplasmosis was made only after conventional histology identified Histoplasma capsulatum organisms in pleural nodules. Thus, until we have a better understanding of the significance of cell surface markers, we should continue to rely on conventional histology for the diagnosis of lymphomas.     

Lymphoblastic lymphoma: Late relapse in childhood

This report describes two children with lymphoblastic lymphoma who relapsed more than 2^1/2 years from diagnosis. Relapses occurred at seven and 20 months after completion of treatment. Their therapy consisted of an intensive pulse chemotherapy program combined with radiation therapy. Initial relapse after two years' treatment has been extremely rare in patients receiving contemporary chemotherapy programs, and two-year survival without disease has been considered a cure. These cases illustrate that late relapses can occur after intensive chemotherapy and that two-year disease-free survival must not be interpreted as a complete cure.     

Non-Hodgkin's lymphoma in childhood presenting as thyroid enlargement

The authors report a case of a 10-year-old girl with early involvement of the thyroid gland by non-Hodgkin's lymphoma, an uncommon site of presentation of childhood lymphomas. In pediatrics, thyroid enlargement is more often caused by lymphocytic thyroiditis. The good response to therapy, in spite of the advanced stage of the disease, is noted.