Application of commercial MOSFET detectors for in vivo dosimetry in the therapeutic x-ray range from 80 kV to 250 kV

The purpose of this study was to investigate the dosimetric characteristics (energy dependence, linearity, fading, reproducibility, etc) of MOSFET detectors for in vivo dosimetry in the kV x-ray range. The experience of MOSFET in vivo dosimetry in a pre-clinical study using the Alderson phantom and in clinical practice is also reported. All measurements were performed with a Gulmay D3300 kV unit and TN-502RDI MOSFET detectors. For the determination of correction factors different solid phantoms and a calibrated Farmer-type chamber were used. The MOSFET signal was linear with applied dose in the range from 0.2 to 2 Gy for all energies. Due to fading it is recommended to read the MOSFET signal during the first 15 min after irradiation. For long time intervals between irradiation and readout the fading can vary largely with the detector. The temperature dependence of the detector signal was small (0.3% degrees C(-1)) in the temperature range between 22 and 40 degrees C. The variation of the measuring signal with beam incidence amounts to +/-5% and should be considered in clinical applications. Finally, for entrance dose measurements energy-dependent calibration factors, correction factors for field size and irradiated cable length were applied. The overall accuracy, for all measurements, was dominated by reproducibility as a function of applied dose. During the pre-clinical in vivo study, the agreement between MOSFET and TLD measurements was well within 3%. The results of MOSFET measurements, to determine the dosimetric characteristics as well as clinical applications, showed that MOSFET detectors are suitable for in vivo dosimetry in the kV range. However, some energy-dependent dosimetry effects need to be considered and corrected for. Due to reproducibility effects at low dose levels accurate in vivo measurements are only possible if the applied dose is equal to or larger than 2 Gy.     

Design of apparatus for precise x-ray dose chamber calibrations

An apparatus for precision calibration of ion chambers in the x-ray region from 16 to 320 kV is described. The development of a fast-acting shutter with "opening" and "closing" times of less than 3-ms eliminates the requirement for operating time corrections. Controls from outside the radiation room permit changing x-ray filters and alternately positioning both test and standard ion chambers in the x-ray beam. Thus, the remote controls eliminate the need to enter the x-ray room in the course of a series of calibrations. The potential advantages resulting from the capabilities of this apparatus are described in this Technical Report.     

Monte Carlo modelling of radiotherapy kV x-ray units.

To obtain accurate information for absorbed dose calculations in water for kilovoltage x-rays, the photon spectrum, planar fluence and the angular distribution of the photons at the collimator exit of the x-ray unit have to be known. The only way to obtain this information is by Monte Carlo (MC) simulation. Compared with the situation for high-energy photons and electrons, where in recent years numerous papers have been devoted to MC modelling of complete clinical accelerator units, there is a lack of similar work for kV x-ray units. A reliable MC model for a kV x-ray unit would allow the output information to be used in a treatment planning system for regular and irregular treatment fields. Furthermore, with MC simulation, perturbation factors of dose-measuring devices, such as those specified in codes of practice, can be calculated. In this work, the MC code EGS4/BEAM was used to build realistic models of two complete x-ray units. The tungsten target, exit window, collimator, additional filtration and applicator were taken into account. For some aspects of the work, a comparison was made with the simulations from another MC code, MCNP4B. The contribution to the characteristic radiation from electron impact ionization and from the photoelectric effect of reabsorbed bremsstrahlung photons was studied. Calculated and measured photon fluence spectra in air and half-value layers for a Philips MCN410 tube were compared for several anode voltages and additional filtrations. Results from the two codes agreed well, and the agreement with measured spectra was found to be good for energies above 50 keV but rather less good below that energy. For a Siemens Stabilipan 2 Th300 x-ray tube, HVLs and dose distributions in water were compared with measurements for several clinical x-ray qualities. For most of the combinations of radiation qualities and applicators, good agreement was obtained, although there were also some cases where the agreement was not so good. Electron contamination and photon build-up at the water surface were studied using MC simulation. The influence of depth on the photon spectral distribution was investigated. Both EGS4/BEAM and MCNP4B, in their default versions, handle inadequately the production of characteristic x-rays. This was found to have only a minor influence on the calculated dosimetric quantities. Simulations with MCNP4B required the use of several variance reduction techniques in order to obtain results within reasonable calculation times.     

Synchronized tumour tracking with electromagnetic transponders and kV x-ray imaging: evaluation based on a thorax phantom

Intrafractional organ motion remains a source of error in conformal radiotherapy of dynamic targets such as tumours of the lung or of the prostate. The purpose of this work was to devise a method for the continuous and routine measurement of intrafractional organ motion. The method consists of a combination of an electromagnetic (EM), internal marker-based tracking system with the on-board kilovoltage x-ray imaging system of a modern treatment machine. The EM system continuously tracks the target, while x-ray images can be acquired simultaneously if demand arises. An image processing algorithm has been developed to automatically localize and track the EM markers in the x-ray images. We have demonstrated simultaneous target tracking using the EM system and x-ray imaging of a mobile target inside a programmable thorax phantom. The target motion was very well reproduced by both systems. The comparability of the target locations reported by both systems was established (better than 0.25 mm up to target velocities of 3 cm s(-1)). One immediate use of the synchronized system was shown: the generation of a 4D cone beam computed tomography data set using the EM system for the measurement of motion. In conclusion, we have developed a system for the routine measurement of intrafractional motion that continuously provides the 3D position of the target with the ability to acquire images of the treatment field only when needed, thereby eliminating avoidable imaging dose to the patient.     

The effect of total x-ray irradiation on the thalamus

Summary A study was made of the functional condition of the hypothalamic area in cats following a total x-ray irradiation dose of 600 r. The functional condition of the sympathetic hypothalamic centers was measured in terms of the change in the skin potential of the sweat secreting surface of the cat's paw following electrical stimulation of the hypothalamus.The excitability of the hypothalamic centers rose considerably after irradiation. The increased excitability was still present during the following 24 hours, and in most cases even after 3 days. Just before death, the excitability of the autonomic centers was reduced.Analogous phasic changes of hypothalamic excitability were observed in a number of animals following their total irradiation with a dose of 50 r; these disappeared within 2 weeks after irradiation, and no radiation sickness developed.Presented by Active Member of the AMN SSSR V. V. Parin     

Kinetics of bone marrow cells during fractionated x-ray irradiation

The harmful action of fractionated x-ray irradiation (12 rad daily, total dose 250, 500, 750, 1000, or 1500 rad) on hematopoiesis was studied in guinea pigs. The dynamics of the changes in erythro- and myelopoiesis after irradiation was phasic in character. In the first phase activation of proliferative processes was manifested as an increase in the mitotic index, shortening of the mitotic cycle of cells of the erythroid and myeloid series, and their more rapid differentiation, so that as a result a sufficient number of cells entered the blood stream and maintained a near-normal number of erythrocytes and leukocytes in peripheral blood. In the second phase weakening of proliferative processes was observed in the bone marrow, the mitotic index was reduced, the duration of the mitotic cycle was increased, and differentiation of cells of the erythroid and myeloid series was slowed, with the development of anemia and leukopenia in the peripheral blood.Department of Pathophysiology, Tomsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR I. V. Toroptsev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 2, pp. 228–230, February, 1977.