An attempt to use cordarone in the treatment of rhythm disorders in patients with circulatory insufficiency

Anti-arrhytmic activity of cordarone was studied in 68 patients with circulatory failure (CF) and heart rhythm disorders with the aid of the 48-hour monitoring of the ECG. Cordarone was administered after the maintenance therapy with digoxin (the mean concentration of digoxin in the plasma 1.38 +/- 0.09 ng/ml) at an average dose of 300 mg/day. Cordarone suppressed supraventricular premature heart beat by 80.2%, ventricular premature heart beat (VPHB) by 76.4%, group VPHB by 82.9% and runnings of ventricular tachycardia by 86.6%. Antiarrhythmic activity of cordarone was more remarkable at the early stages of CF. The concentration of digoxin in the plasma did not exceed the mean therapeutic one. Therefore, cordarone possesses a high antiarrhythmic activity, with its efficacy being significantly higher in patients with moderately pronounced CF. At the same time cordarone influences to a less measure the quality of ventricular rhythm disorders in patients with severe CF and apparently does not avert the cases of sudden death in such patients.     

Evaluation of the effectiveness of calcium antagonists combined with digoxin and furosemide in hypertension complicated by circulatory insufficiency in elderly patients

Clinical, hemodynamic and neurohumoral data are available supporting the validity of a differentiated approach to administration of combined treatment with furosemide, digoxin and calcium antagonists nifedipine and verapamil in advanced-aged patients with hypertension complicated by circulatory disorders. The choice of the drugs should be based on the criterion of per hour diuresis following a single dose of the combination.     

Effects of ethmozine and ethacizin on the central hemodynamics, peripheral vascular tonus and tissue oxygenation in patients with ventricular rhythm disorders and cardiac insufficiency

Daily monitoring of the ECG, catheterization of the pulmonary artery, tetrapolar chest rheography, occlusion plethysmography and polarography were employed to study the antiarrhythmic efficacy and the effects on the central and peripheral circulation of the new antiarrhythmic etmozine and etacyzine. Twenty-two patients with a frequent chronic ventricular premature heart beat (PHB) and clinically marked circulatory failure (CF) were entered into the study. Intake of etmozine (600 to 800 mg daily) and etacyzine (100 to 300 mg daily) over 5 to 6 days exerted a positive antiarrhythmic effect in 52.6 and 83.3% of the patients, respectively. Etmozine did not produce any adverse hemodynamic action, whereas etacyzine brought about an insignificant increase in the stroke and minute volumes of the heart (12.3 and 9.8%, respectively). However, the lack of an increase in the heart rate (HR), diastolic pressure in the pulmonary artery and regional vascular resistance (RVR), and no significant rise of the preload (systolic pressure in the right atrium) and afterload (elevation of the mean arterial blood pressure and RVR) attest to the fact that etacyzine has a negligible adverse hemodynamic action in CF patients. Intravenous injection of etmozine does not elicit any changes in the RVR or in the venous tone. Meanwhile intravenous injection of etacyzine leads to a significant reduction in the RVR (23.3%). The treatment with both etmozine and etacyzine given in courses promotes the improvement of the microcirculation and tissue oxygen metabolism in patients presenting with CF. More pronounced positive shifts in the microcirculation were achieved with etacyzine. Apparently, this bears on a more demonstrable arteriolodilatation effect of the drug.(ABSTRACT TRUNCATED AT 250 WORDS)     

电子束CT诊断致心率不齐性右室发育不良合并三尖瓣关闭不全1例

螺旋CT由于受心跳运动影响，对于心肌的检查效果不理想，而电子束CT由于扫描速度快，心电门控触发，不受心跳影响，故对于心肌的检查具有很大的优势，现将本院发现的1例少见心肌病报告如下。