慢性浅表性胃炎605例的超声与胃镜检查对照研究

慢性浅表性胃炎６０５例的超声与胃镜检查对照研究陈晓玲西安解放军４５１医院特诊科关键词慢性浅表性胃炎，胃镜检查，声象图慢性浅表性胃炎临床多见。１９９０年９月～１９９２年５月，作者采用上海长征医院研制的胃超声快速显象液，对临床初诊为慢性胃炎的２６５５例做...     

对慢性浅表性胃炎52例临床观察分析

慢性浅表性胃炎在临床上是常见病多发病,占消化内科专科门诊的30%左右.现回顾分析我院消化科2005～2007年诊治的52例慢性浅表性胃炎临床资料,现报道如下.     

胃得宁、甲氰咪胍、颠茄片联合治疗慢性浅表性胃炎165例临床观察

目的探讨胃得宁、甲氰咪胍、颠茄片联合用药对于慢性浅表性胃炎临床症状的改善情况。方法慢性浅表性胃炎病患165例,治疗前48h内停服一切药物,随机分为服用胃得宁、甲氰咪胍、颠茹片联合用药组（55例）为治疗组,胃得宁、颠茄片纽（55例）为对照纽1,甲氰咪胍、颠茄片组（55例）为对照组2,连服用2周,观察病患的症状缓解情况。结果三组患者治疗期间依从性良好,症状积分评价有统计学意义（P〈0．05）;治疗组总有效率（96．36徇明显高于对照组1（67．27％）和对照组2（60．005）,且差异有显著性（P〈O．05）。结论治疗组上腹胀痛、嗳气、恶心等症状较对照组相比明显好转,未观察到不起反应发生。证明短期服用胃得宁、甲氰咪胍辅以颠茄片,能显著改善慢性浅表性胃炎的症状。可做临床优先选用药物。     

萎胃复元汤治疗慢性萎缩性胃炎临床疗效分析

目的：探讨萎胃复元汤治疗慢性萎缩性胃炎的临床疗效,为临床提高治疗慢性萎缩性胃炎的临床疗效和患者的生活质量提供理论依据。方法选择2013年5月1日~2014年4月30日在我院中医科治疗的慢性萎缩性胃炎患者56例,随机平均分成治疗组和对照组两组,每组28例患者,对照组给予患者口服吗丁啉、多酶片及猴菇菌片的西药治疗,治疗组给予患者口服中药萎胃复元汤的中药治疗,治疗4w以后,比较两组患者的临床症状改善时间、治疗有效率及不良反应率。结果治疗组患者的临床症状改善时间为7.92 d、治疗有效率为96.43%、不良反应率为7.14%,显著优于对照组,且<0.05差异有统计学意义。结论萎胃复元汤可以迅速改善慢性萎缩性胃炎的临床症状,提高治疗的有效率,且可以减少不良反应,是一种安全高效的治疗方式。     

儿童注意缺陷多动障碍的脑电活动研究进展

儿童注意缺陷多动障碍(attention deficit hy-peractivity disorder,ADHD)是与其年龄不相适应、以注意力不集中、多动和冲动行为为特征的心理行为性疾病,在学龄儿童中广泛存在[1]。目前临床颇为常见,近年来已占儿保门诊病例的第一或第二位。儿童ADHD的现患率在不同国家存在一定差异,其巨大波动可能受ADHD在精神障碍疾病诊断和统计手册(diagnostic and statistical manual ofmental disorders,DSM-IV)中的定义、抽样、资料收集方法、对象的选择和共患疾病等因素的影响等。以美国DSM-IV为诊断标准,美国学龄儿童ADHD现患率为3%~5%,我国为3%~10%,美国男童患病率是女童的4~9倍,我国男童患病率则是女童的3倍[2]。EEG作为一种非侵入性检测手段被应用于ADHD的研究,已取得了一些成果,为ADHD病因的明确、类型划分及治疗提供了一定的理论依据。本文就ADHD的EEG研究进展作一综述。1ADHD儿童的EEG变化机制EEG记录的是大脑神经元的整体电活动的综合,反映大脑调节行为,以频率的周期性、节律性为突出表现。脑电活动起源...     

镇冲降逆止呕方对家兔胃电活动的影响

目的 观察镇冲降逆止呕方对麻醉家兔浆膜胃电活动的影响.方法 采用胃电电极与RM6240生物采集系统,描记胃电曲线,记录各组给药前10min及给药后10、20、30、40min的胃电活动.结果 镇冲降逆止呕方能减弱家兔胃电活动的振幅和频率,且呈现出一定的剂量依赖关系,灌胃给药6 ml/kg后,胃电活动的振幅和频率分别从给药前的(0.78±0.11)mV 、(3.29±0.37)次/ min 降为(0.58±0.09)mV 、(2.58±0.26)次/ min,与生理盐水组比较,差异有显著性(P＜0.05).结论 镇冲降逆止呕方能明显减弱家兔的胃电活动.     

Lgr5在慢性浅表性胃炎中的表达

 目的：探讨富含亮氨酸重复序列的G蛋白偶联受体5（Lgr5）在慢性浅表性胃炎中的表达及其临床意义。方法：将30只Wistar大鼠随机分为空白组、模型组和对照组。采用0.02%氨水合并饥饱失常法对大鼠进行慢性浅表性胃炎造模,模型复制成功后,采用免疫组化、Western blotting和RT-PCR检测各组中Lgr5的mRNA及蛋白的表达水平。结果：Lgr5主要在细胞的胞膜和胞浆中表达,模型组中Lgr5 mRNA和蛋白表达水平高于对照组和空白组大鼠（P＜0.01）,对照组和空白组中Lgr5表达水平差异不显著(P＞0.05)。结论：持续的炎症刺激导致Lgr5表达增加,Lgr5可能是一种炎性的促肿瘤因子。     

Mannan-binding lectin in children with chronic gastritis

The involvement of mannan-binding lectin (MBL) insufficiency in the pathogenesis of chronic gastritis (CG) in children was investigated. Blood samples were collected from 78 paediatric patients suffering from CG associated with Helicobacter pylori infection (group Hp(+)) and from 41 with the disease not associated with such an infection (group Hp(-)). Control group consisted of 77 children. The frequency of mbl-2 gene mutations and serum protein concentrations did not differ significantly in both groups as compared with controls. An expression of mbl-2 gene in gastric biopsies of CG patients was demonstrated. It was found to be stronger in H. pylori-infected children. The results presented in this paper suggest that MBL deficit/dysfunction probably does not contribute to an increased risk of CG (both associated and not associated with H. pylori infection) in children. However, MBL opsonic effect and/or the lectin pathway of complement activation may be taken into account as possible host defence mechanisms in gastric patients.     

Ultrastructural changes of gastric superficial epithelium cells in chronic Helicobacter gastritis

Electron-microscopic investigations were carried out in 22 specimens of biopsy material from pyloric and fundal parts of the stomach in patients with chronic Helicobacter gastritis. In 6 cases of normal mucosa Helicobacter pylori (HP) was absent both in the antrum and fundus. In chronic antral gastritis HP was found in both regions. Variants of HP adhesion to the epithelium and its interactions were studied. It is demonstrated that HP may penetrate into intercellular spaces and cell cytoplasm. Cell reciprocal reaction to adhesion and invasion was accompanied by hyperplasia of the microvilli, clasmatosis and "selfsanation" phenomenon. Differences between ultrastructural changes in the antrum and fundus were considered.     

慢性胃炎患儿T细胞和红细胞免疫功能的检测

应用流式细胞术（ＦＣＭ） 直接免疫荧光染色法和免疫粘附花环法, 检测了４１ 例慢性胃炎患儿外周血Ｔ 淋巴细胞亚群（ 包括ＣＤ３ ＋ ,ＣＤ４ ＋ 和ＣＤ８ ＋） 的变化和红细胞免疫功能（ＲＢＣＣ３ｂＲＲ,ＲＢＣＩＣＲ） ,以观察慢性胃炎患儿的免疫功能在治疗前后的变化。结果显示：慢性胃炎患儿治疗前各项免疫指标除ＲＢＣ－ ＩＣＲ 外,均低于对照组（ Ｐ＜ ０ ．０１） ;治疗后各项免疫指标均有显著提高,而ＲＢＣ－ ＩＣＲ 则有所下降（ Ｐ ＜ ０ ．０１） 。本研究提示,慢性胃炎患儿一旦确诊,就应及时正规治疗,以免患儿长期缺乏必需的营养素而致免疫功能紊乱。     

Significance of some growth factors in the pathogenesis of chronic gastritis in children

Gastric biopsy specimens taken from 44 children aged 7 to 15 years who had a clinical diagnosis of chronic gastritis (CG) were studied. In Helicobacter pylori (Hp)-associated CG (n = 24), there were accelerated cell regeneration processes in the antral and fundal mucosae as compared with the rate of proliferation and apoptosis in Hp-unassociated CG (n = 20). The increased proliferation of gastric mucosal (GM) elements has been shown to be associated with the high density of EGFR, in Hp-associated CG in particular, which is generally observed in the insufficient level of TGFR-beta. The authors have ascertained the important role and heterodirectional functional load of EGFR and NGFR-beta in the pathogenesis of CG. This disease is characterized by the maximum EGRF expression that is directly correlated with the rate of cell regeneration processes and the activity of an inflammatory process. Moreover, the rate of proliferation and apoptosis are associated with the increased expression of EGRF on the other hand and with the inadequate reperesenation of TGFR-beta on the GM cell membranes, which is particularly prominent in children with Hp-associated CG.     

Superoxide dismutases in chronic gastritis

Human gastric diseases have shown significant changes in the activity and expression of superoxide dismutase (SOD) isoforms. The aim of this study was to detect Mn‐SOD activity and expression in the tissue of gastric mucosa, primarily in chronic gastritis (immunohistochemical Helicobacter pylori‐negative gastritis, without other pathohistological changes) and to evaluate their possible connection with pathohistological diagnosis. We examined 51 consecutive outpatients undergoing endoscopy for upper gastrointestinal symptoms. Patients were classified based on their histopathological examinations and divided into three groups: 51 patients (archive samples between 2004–2009) with chronic immunohistochemical Helicobacter pylori‐negative gastritis (mononuclear cells infiltration were graded as absent, moderate, severe) divided into three groups. Severity of gastritis was graded according to the updated Sydney system. Gastric tissue samples were used to determine the expression of Mn‐SOD with anti‐Mn‐SOD Ab immunohistochemically. The Mn‐SOD expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa. In patients with normal histological finding, positive immunoreactivity of Mn‐SOD was not found. Our results determine the changes in Mn‐SOD expression occurring in the normal gastric mucosa that had undergone changes in the intensity of chronic inflammatory infiltrates in the lamina propria.