咪达唑仑-丙泊酚序贯给药在机械通气病人程序化镇静中的应用

[目的]探讨咪达唑仑-丙泊酚序贯给药在机械通气病人程序化镇静中的应用效果。[方法]选择在重症监护病房(ICU)需机械通气且预计镇痛、镇静超过72h的危重病病人42例,在持续泵入芬太尼镇痛的基础上,随机分为咪达唑仑组(M组)、丙泊酚组(P组)、咪达唑仑-丙泊酚序贯组(M-P组),以Ramsay评分3分～4分为镇静目标,密切观察3组病人镇静效果、镇静药物总量、费用、停药后清醒时间(即每日唤醒计划实施情况)及停药后躁动情况,镇静前、镇静后1h、镇静期间平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO2)的变化。[结果]在镇静过程中,咪达唑仑-丙泊酚序贯镇静能够达到单用丙泊酚或咪达唑仑的镇静疗效,可避免单用咪达唑仑镇静停药后苏醒时间过长的缺点,同时较单用丙泊酚组费用低。[结论]在程序化镇静中实施咪达唑仑-丙泊酚序贯给药,配合精心护理,不仅能有效避免苏醒时间长、躁动等不安全因素,还提高了病人的安全性和适应性。     

丙泊酚在重症监护室术后患者中的应用

目的观察丙泊酚在重症监护室（ICU）外科术后对患者的镇静效果及作用。方法 2006年7月-2008年7月,对行外科手术后在ICU观察室采用丙泊酚镇静的45例患者的镇静效果、停药苏醒时间及给药前后呼吸、循环参数的变化进行观察,并与治疗前进行比较。结果丙泊酚镇静起效快,镇静治疗后大多数患者开始血压有所下降（P〈0.05）但不久恢复正常,所有患者心率、呼吸频率、血氧饱和度无明显变化（P〉0.05）,停药后苏醒快。结论丙泊酚是外科术后患者较理想的镇静剂,但应根据患者情况调整给药速度、剂量及时间。     

咪达唑仑-丙泊酚序贯给药在机械通气病人程序化镇静中的应用

[目的]探讨咪达唑仑一丙泊酚序贯给药在机械通气病人程序化镇静中的应用效果。[方法]选择在重症监护病房（ICU）需机械通气且预计镇痛、镇静超过72h的危重病病人42例,在持续泵入芬太尼镇痛的基础上,随机分为咪达唑仑组（M组）、丙泊酚组（P组）、咪达唑仑-丙泊酚序贯组（M—P组）,以Ramsay评分3分～4分为镇静目标,密切观察3组病人镇静效果、镇静药物总量、费用、停药后清醒时间（即每日唤醒计划实施情况）及停药后躁动情况,镇静前、镇静后1h、镇静期间平均动脉压（MAP）、心率（HR）、血氧饱和度（SpO：）的变化。[结果]在镇静过程中,咪达唑仑-丙泊酚序贯镇静能够达到单用丙泊酚或咪达唑仑的镇静疗效,可避免单用咪达唑仑镇静停药后苏醒时间过长的缺点,同时较单用丙泊酚组费用低。[结论]在程序化镇静中实施咪达唑仑一丙泊酚序贯给药,配合精心护理,不仅能有效避免苏醒时间长、躁动等不安全因素,还提高了病人的安全性和适应性。     

术前应用普瑞巴林对瑞芬太尼致术后痛觉过敏的影响

目的:探讨术前应用普瑞巴林对瑞芬太尼致术后痛觉过敏的影响。方法:选择择期腹腔镜胆囊切除术患者80例,ASA分级Ⅰ～Ⅱ级,年龄25～60岁,采用随机、双盲的方法分为两组,每组40例:普瑞巴林组(P组)和安慰剂对照组(C组)。P组在术前2h口服普瑞巴林150mg,C组术前2h口服安慰剂作为对照。术中静脉泵注丙泊酚和瑞芬太尼,间断静脉注射维库溴铵维持麻醉。记录手术时间、麻醉时间、恢复室观察时间、术中平均BIS值;苏醒时间、意识恢复时间和拔管时间;Ramsay镇静评分;患者意识恢复时的数字疼痛评分(NRS);麻醉药物用量;术后PCA芬太尼用量;并发症。结果:(1)两组术中丙泊酚总量、瑞芬太尼总量、苏醒时间、意识恢复时间、拔管时间比较无明显差异(P>0.05);(2)P组的Ramsay镇静评分(1.71±0.51)比C组(2.53±0.47)明显降低(P<0.05),意识恢复时NRS评分(2.86±0.88)比C组(6.23±1.03)明显降低(P<0.05);(3)P组患者术后1h(114.28±43.59)、2h(158.65±58.72)、4h(213.81±62.45)、8h(341.08±94.47)的PCA泵芬太尼用量比C组1h(185.93±49.77)、2h(225.64±60.85)、4h(285.49±59.14)、8h(395.44±87.99)显著减少(P<0.05);(4)P组术后24h的头晕发生率(25%)比C组(10%)明显增高(P<0.05),躁动发生率(7.5%)则比C组(37.5%)显著降低(P<0.05)。结论:术前应用普瑞巴林可有效抑制瑞芬太尼所致的术后痛觉过敏。     

连续性静-静脉血液滤过患者延长美罗培南静脉输注时间的药代动力学研究

目的 探讨连续性静-静脉血液滤过(CVVH)患者延长美罗培南静脉输注时间的药代动力学特点.方法 10例CVVH患者给予美罗培南500 mg静脉输注,输注时间3h,6h给药1次.第4次开始给药前即刻(0 h)及给药后0.25、0.5、1、1.5、2、3、4、5、6h(下一次给药前即刻)留取血液标本,用高效液相色谱法测定血药浓度,并绘制血药浓度-时间曲线.结果 CVVH患者延长美罗培南输注时间至3h的药物峰浓度(Cmax)达(25.05±5.64)mg/L,至6h达谷浓度(Cmin)为(13.03± 3.01)mg/L,血药浓度曲线下面积(AUC)为(118.42±26.78)mg· h-1· L-1,药物清除半衰期(T1/2)为(3.74±0.55)h,药物平均滞留时间(MRT)为(4.99±0.84)h,药物表观分布容积(Vd)为(22.85±9.85)L,药物清除率(CL)为(4.49±1.32)L/h.10例患者血药浓度大于最低抑菌浓度(MIC)的时间占给药间隔时间的百分比(％T＞MIC)均达到100％(MIC 8 mg/L).结论 CVVH患者应用美罗培南500 mg,6h给药1次,延长输注时间至3h,可达到满意的药效学指标.     

超重患者行无痛胃镜麻醉中舒芬太尼和丙泊酚最佳给药时间间隔的临床观察

目的探讨行无痛胃镜检查的超重患者选择舒芬太尼联合丙泊酚进行麻醉期间的最佳给药间隔时间。方法前瞻性选取2019年6月至2019年12月于首都医科大学附属北京友谊医院择期行无痛胃镜的超重患者(体重指数为25～29. 9 kg/m2) 90例,ASA分级为Ⅰ级或Ⅱ级,采用随机数字表法将患者分为舒芬太尼和丙泊酚同时给药组(A1组)、舒芬太尼给药1 min后丙泊酚给药组(A2组)、舒芬太尼给药2 min后丙泊酚给药组(A3组),每组各30例。三组患者入室后静脉推注舒芬太尼0. 05～0. 1μg/kg,根据需要静脉推注丙泊酚每10秒推3 ml直至意识消失。记录各组患者给药后意识丧失所需时间、丙泊酚用量和手术后患者苏醒时间以及术中发生体动、呼吸抑制和心动过缓的情况。结果与A1组比较,A2组和A3组患者的丙泊酚用量(A1组112. 33±9. 26 mg,A2组93. 17±6. 76 mg,A3组99. 00±4. 81 mg)较少(P 0. 05),其中A2组患者的丙泊酚用量最少(P 0. 05);与A3组比较,A1组和A2组患者的意识消失时间(A1组28. 90±1. 47 s,A2组27. 73±1. 53 s,A3组30. 80±1. 86 s)较短(P 0. 05),其中A2组患者的意识消失时间最短(P 0. 05);与A1组比较,A2组和A三组患者的苏醒时间(A1组8. 38±0. 43 s,A2组6. 88±0. 54 s,A3组7. 30±0. 78 s)较短(P 0. 05),其中A2组患者的苏醒时间最短(P 0. 05);与A1组比较,A2组和A3组患者的体动发生例数(A1组16. 667%,A2组3. 333%,A3组26. 667%)较少(P 0. 05),A2组患者的体动发生例数最少(P 0. 05);三组患者的围手术期呼吸抑制(A1组10. 000%,A2组3. 333%,A3组10. 000%)和心动过缓(A1组13. 333%,A2组6. 667%,A3组10. 000%)发生率比较,差异均无统计学意义(P 0. 05)。结论在预充氧充分的情况下,舒芬太尼联合丙泊酚在超重患者行无痛胃镜麻醉中给药时间间隔应控制为1 min。     

丙泊酚和瑞芬太尼对术后神志清楚机械通气重症患者器官功能的保护作用

目的:研究丙泊酚和瑞芬太尼应用于术后神志清楚机械通气重症患者的镇静和镇痛时对患者器官功能的保护作用。方法:将45例择期行腹部手术的重症患者随机分为A组、B组和C组,每组15例。3组均用微量注射泵持续输注丙泊酚和瑞芬太尼,丙泊酚用量均为2 mg/(kg·h),而A、B、C组瑞芬太尼用量分别为0.05、0.1、0.15μg/(kg·min)。监测各组患者用药前后呼吸、循环参数以及血糖和皮质醇浓度变化,并评价镇静、镇痛效果。结果:给药后,3组患者均达到良好的镇痛、镇静效果(P0.05),且患者的心率(HR)、平均动脉压(MAP)、呼吸率(RR)和脉搏血氧饱和度(SpO2)均得到显著改善(P0.05)。结论:对术后神志清楚的机械通气重症患者应用丙泊酚和瑞芬太尼进行镇静镇痛,可降低机体一系列的应激反应,保护患者心肺等器官功能。在丙泊酚剂量不变的情况下,瑞芬太尼以0.1μg/(kg·min)持续静脉输注较为适宜。     

瑞芬太尼在重症监护病房机械通气患者镇痛镇静中的应用研究

目的 观察瑞芬太尼对重症监护病房(ICU)机械通气患者镇痛、镇静治疗的效果,对机械通气时间、血流动力学的影响以及药物不良反应.方法 60例肿瘤术后需有创机械通气超过24 h的患者按随机数字表法分为芬太尼组(30例)及瑞芬太尼组(30例),分别给予芬太尼和瑞芬太尼持续静脉泵入镇痛、镇静,疼痛的评估选择面部表情评分法(FPS),镇静的评估选择Ramsay评分法(RS),必要时加用丙泊酚镇静治疗.两组患者在治疗期间执行每日唤醒策略,分别记录两组用药前后的FPS、RS和生命体征,加用丙泊酚及每日中断药物以唤醒的病例数,机械通气时间、住ICU时间、住ICU费用,以及不良反应发生情况.结果 两组患者均可达到满意的镇痛、镇静目标.两组间镇痛、镇静深度总体无明显差异,但用药30 min时芬太尼组FPS(分)明显高于瑞芬太尼组(3.70±1.20比2.70± 1.17,P＜0.05);两组间仅用药30 min时瑞芬太尼组平均动脉压(MAP,mm Hg,1 mm Hg=0.133 kPa)较芬太尼组明显下降(72.9±6.9比77.6±9.1,P＜0.05),其余生命体征无明显差异.芬太尼组有更多的患者需要加用丙泊酚镇静(19例比8例),并需中断药物(12例比4例,均P＜0.05);而瑞芬太尼组用药30 min和1、6、24 h时自主呼吸频率(RRs,次/min)均较芬太尼组明显降低(7.0±2.8比10.4±3.5,5.4±3.4比10.6±3.6,5.4±3.0比7.2±3.1,6.1±3.0比9.2±3.4,均P＜0.05).瑞芬太尼组机械通气时间(h)、住ICU时间(h)均较芬太尼组明显缩短(73.6±26.7比94.9±37.3,125.9±37.1比150.8±50.9,均P＜0.05),但住ICU费用(万元)则无明显差异(6.06±2.29比5.83±2.38,P＞0.05).瑞芬太尼组出现低血压的患者数比芬太尼组多(8例比2例,P＜0.05).结论 瑞芬太尼用于ICU机械通气患者与经典治疗效果相当,且起效迅速,能缩短机械通气时间,减少镇静剂的用量,无严重不良反应.     

精神病患者机械通气治疗左心衰竭时丙泊酚的疗效观察

目的:探讨丙泊酚对精神病患者机械通气治疗急性左心功能衰竭时治疗效果.方法:将精神病合并急性左心衰行机械通气的38例随机分成两组:丙泊酚组(n=18):持续静滴丙泊酚0.5～1.0 mg/(kg·h):对照组(n=20):间断用度冷丁50～100 mg静脉注射;观察镇静效果达Ramsay分级Ⅲ～Ⅳ级时间、动态监测给药前、后的生命体征、循环参数的变化.结果:丙泊酚的镇静效果优于对照组,治疗后1 h,两组血流动力学指标均较治疗前有显著改善.与对照组比较,丙泊酚组心脏指数显著升高,肺动脉压、肺毛细血管楔压轻度下降、外周血管阻力有所下降,有统计学差异(P<0.05);丙泊酚组平均动脉压较对照组有所下降,但无统计学意义,P>0.05.结论:精神病患者机械通气治疗急性左心衰时使用丙泊酚镇静效果好,并对血流动力学影响有益.     

比较低分子肝素两种静脉给药方式在连续性肾脏替代治疗中的应用

目的比较低分子肝素两种静脉给药方式在连续性肾脏替代治疗(continuous renal replace-ment therapy,CRRT)中的抗凝效果及安全性。方法选择重症急性肾衰竭伴或不伴多器官功能衰竭需行CRRT治疗应用低分子肝素抗凝的患者,按照给药方式不同分为A组(间断静脉给药)和B组(持续静脉给药),进行自身交叉对照,A组:首次剂量30～40IU/kg,每4h给药一次,每次剂量依次递减10%。B组:首次剂量15～25IU/kg,维持量5～10IU/(kg·h);治疗结束前1h停药;生色底物法测定抗Xa因子活性,检测治疗前后凝血功能、血肌酐和尿素氮等指标。结果17例连续性静静脉血液滤过治疗(continuous veno-venous hemofiltration,CVVH)患者入选,A组和B组的法安明总剂量分别为(8117.65±788.38)IU和(7976.47±898.28)IU,差异无统计学意义(t=0.597,P0.05),实际治疗时间分别为(11.72±0.53)h和(11.82±0.50)h,差异无统计学意义(t=0.549,P0.05)。两组各有1例临床显性出血,治疗前后血肌酐和尿素氮下降率差异均无统计学意义(均P0.05)。两组抗Xa因子活性均在CVVH治疗2h达到高峰,其中A组抗Xa因子水平显著高于B组[(0.65±0.17)IU/mlvs(0.51±0.15)IU/ml,t=3.730,P0.05],其他时间点差异均无统计学意义(均P0.05)。两组治疗结束时活化部分凝血活酶原时间(activated partial thromboplastin time,APTT)均较治疗前延长[A组:(38.79±6.26)比(33.54±9.12),t=2.270,P0.05;B组:(36.24±5.21)比(32.36±6.22),t=2.370,P0.05]。结论低分子肝素无论采用间断静脉给药还是采用持续静脉给药均可安全有效地应用于CVVH治疗,持续静脉给药方式能够保持抗Xa因子水平相对稳定,间断静脉给药方式可能导致患者凝血功能较大波动。     

Determination of creatine kinase isoenzyme MB activity in serum using immunological inhibition of creatine kinase M subunit activity. Activity kinetics and diagnostic significance in myocardial infarction.

This is a new method for the determination of creatine kinase isoenzyme MB activity in serum. The method uses direct activity measurement of creatine kinase B subunit activity after blocking of CK-M subunit activity by inhibiting antibodies. The test takes no longer than 15 min. The method yields an intra-serial C.V. of 2.0-12.9%, and a C.V. from day to day of 5.5%. The detection limit is 3.4 U/l creatine kinase MB. In the 95 cases with proven myocardial infarction several types of creatine kinase MB activity kinetics could be determined. The percentage of creatine kinase MB of peak CK-total is 6-25%, with a mean of 11.1%. The amount of creatine kinase MB with respect to total CK activity after reinfarction is higher than the amount after initial infarction.     

Dissociable correlates of two classes of retrieval processing in prefrontal cortex

Although substantial evidence suggests that the prefrontal cortex (PFC) implements processes that are critical for accurate episodic memory judgments, the specific roles of different PFC subregions remain unclear. Here, we used event-related functional magnetic resonance imaging to distinguish between prefrontal activity related to operations that (1) influence processing of retrieval cues based on current task demands, or (2) are involved in monitoring the outputs of retrieval. Fourteen participants studied auditory words spoken by a male or female speaker and completed memory tests in which the stimuli were unstudied foil words and studied words spoken by either the same speaker at study, or the alternate speaker. On "general" test trials, participants were to determine whether each word was studied, regardless of the voice of the speaker, whereas on "specific" test trials, participants were to additionally distinguish between studied words that were spoken in the same voice or a different voice at study. Thus, on specific test trials, participants were explicitly required to attend to voice information in order to evaluate each test item. Anterior (right BA 10), dorsolateral prefrontal (right BA 46), and inferior frontal (bilateral BA 47/12) regions were more active during specific than during general trials. Activation in anterior and dorsolateral PFC was enhanced during specific test trials even in response to unstudied items, suggesting that activation in these regions was related to the differential processing of retrieval cues in the two tasks. In contrast, differences between specific and general test trials in inferior frontal regions (bilateral BA 47/12) were seen only for studied items, suggesting a role for these regions in post-retrieval monitoring processes. Results from this study are consistent with the idea that different PFC subregions implement distinct, but complementary processes that collectively support accurate episodic memory judgments.     

俯卧位通气对高海拔地区肺复张治疗无效急性呼吸窘迫综合征患者氧合的影响

目的 探讨俯卧位通气对高海拔地区肺复张术(RM)治疗无效急性呼吸窘迫综合征(ARDS)患者的治疗作用.方法 从海拔2260m的地区医院筛选RM治疗无效的41例ARDS患者[平均氧合指数( PaO2/FiO2)较RM前升高＜20％视为RM无效],依不同病因分为肺内源性ARDS组(ARDSp组)和肺外源性ARDS组(ARDSexp组),每组再按信封法随机分为俯卧位组和仰卧位组,即ARDSp俯卧位组(11例)、ARDSp仰卧位组(9例)、ARDSexp俯卧位组(10例)、ARDSexp仰卧位组(11例).在通气前及通气1、2、3、4h监测动脉血氧分压( PaO2)、PaO2/FiO2、静态顺应性(Cst)、气道阻力(Raw)的变化.结果 通气lh时,ARDSexp俯卧位组PaO2/FiO2( mm Hg,l mm Hg=0.133 kPa)即较通气前显著升高(157.4±40.6比129.3±48.7,P＜0.05),并随通气时间延长呈持续增高趋势,4h达峰值(219.1 ±41.1);且ARDSexp俯卧位组通气3h内PaO2/FiO2较其他3组显著增高,另3组间则差异无统计学意义.ARDSp俯卧位组、ARDSexp俯卧位组通气4h时PaO2/FiO2均较相应仰卧位组显著增高(208.8±39.7比127.4±47.1,219.1±41.1比124.9±50.8,均P＜0.05).4组通气前后Cst无显著改变,各组间差异也无统计学意义.ARDSp俯卧位组通气4h时Raw(cmH2O·L-1·s-1)较通气前显著降低(6.8±1.7比10.7±1.8,P＜0.05),且明显低于其他3组;其他3组各时间点Raw组内及组间比较差异均无统计学意义.结论 俯卧位通气作为ARDS机械通气重要策略之一,可以改善RM无效高原ARDS患者的氧合,为抢救患者赢得宝贵的时间.     

Digital imaging among medical facilities

The Department of Veterans Affairs (VA) in the USA operates a network of 172 medical centres which all utilize a hospital information system (HIS) which has been developed and is currently maintained by the VA. During the past several years, an image management and communication module has been developed, installed and clinically utilized at the Washington DC and Maryland VA Medical Centres. This image management and communication system, referred to as the decentralized hospital computer program (DHCP) imaging system, is fully integrated with a commercial picture archiving and communication system (PACS). The system is utilized to capture, archive, and display all images generated within the hospital including radiology, nuclear medicine, pathology, endoscopy, bronchoscopy, and dermatology, intraoperative photographs, ECG data, and a limited number of paper documents. The ultimate goal of the project is to have all patient text and image data available at any clinical workstation to any authorized user anywhere within the network of medical centres. Clinical requirements for an imaging workstation include ease of use, rapid and reliable access to the complete set of patient information, and images which are of acceptable quality to meet the requirements of the user and the subspecialty. Patient confidentiality and data security must be safeguarded at all times. Integration of the images with the remainder of the patient's database was found to be critical to the success of the project. The experience at the Washington and Maryland facilities suggests that an imaging system that is successfully integrated with a hospital information system can provide substantial clinical and economic benefits both within and among medical centres. Clinical acceptance and utilization of the system has been excellent, particularly in diagnostic radiology where DHCP Imaging has been interfaced to a commercial PAC system. Based upon this initial experience, the VA has begun to deploy the system throughout its large network of medical centres.     

Myocardial elastography at both high temporal and spatial resolution for the detection of infarcts

Myocardial elastography is a novel method for noninvasively assessing regional myocardial function, with the advantages of high spatial and temporal resolution and high signal-to-noise ratio (SNR). In this paper, in-vivo experiments were performed in anesthetized normal and infarcted mice (one day after left anterior descending coronary artery [LAD] ligation) using a high-resolution (30 MHz) ultrasound system (Vevo 770, VisualSonics Inc., Toronto, ON, Canada). Radiofrequency (RF) signals of the left ventricle (LV) in longitudinal (long-axis) view and the associated electrocardiogram (ECG) were simultaneously acquired. Using a retrospective ECG gating technique, 2-D full field-of-view RF frames were acquired at an extremely high frame rate (8 kHz) that resulted in high-quality incremental displacement and strain estimation of the myocardium. The incremental results were further accumulated to obtain the cumulative displacements and strains. Two-dimensional and M-mode displacement images and strain images (elastograms), as well as displacement and strain profiles as a function of time, were compared between normal and infarcted mice. Incremental results clearly depicted cardiac events including LV contraction, LV relaxation and isovolumetric phases in both normal and infarcted mice, and also evidently indicated reduced motion and deformation in the infarcted myocardium. The elastograms indicated that the infarcted regions underwent thinning during systole rather than thickening, as in the normal case. The cumulative elastograms were found to have higher elastographic SNR (SNR(e)) than the incremental elastograms (e.g., 10.6 vs. 4.7 in a normal myocardium, and 6.0 vs. 2.4 in an infarcted myocardium). Finally, preliminary statistical results from nine normal (m = 9) and seven infarcted (n = 7) mice indicated the capability of the cumulative strain in differentiating infracted from normal myocardia. In conclusion, myocardial elastography could provide regional strain information at simultaneously high temporal (>/=0.125 ms) and spatial ( approximately 55 microm) resolution as well as high precision ( approximately 0.05 microm displacement). This technique was thus capable of accurately characterizing normal myocardial function throughout an entire cardiac cycle, at the same high resolution, and detecting and localizing myocardial infarction in vivo.     

手转胎头术失败的原因与分娩结局临床分析

目的 探讨手转胎头术失败的原因与分娩结局.方法 选择2008年1月至2010年12月于我院住院分娩的持续性枕横位、枕后位产妇198例,根据行手转胎头术后结果分为成功组126例、失败组72例.比较两组分娩结局,对比分析失败原因.结果 失败组胎儿体质量≥3500 g的发生率[76.4％(55/72)]明显高于成功组[31.7％(40/126)],差异有统计学意义(x2=30.177,P=0.001)、失败组宫缩乏力发生率[58.3％(42/72)]高于成功组[38.1％ (48/126)],差异有统计学意义(x2=7.569,P=0.006)、失败组骨盆临界或轻度狭窄发生率[38.9％ (28/72)]高于成功组[23.8％(30/126)],差异有统计学意义(x2 =5.030,P=0.002)、失败组手转胎头时机不当(宫口开大＜6 cm、胎头位于坐骨棘上及宫口开大8～10 cm、胎头位于坐骨棘下≥2 cm)发生率[61.1％(44/72)]高于成功组[38.9％(49/126)],差异有统计学意义(x2=9.084,P=0.003).失败组母儿并发症(产后出血、产褥病率、胎儿窘迫、新生儿窒息)发生率高于成功组(x2 =9.586,P=0.002、x2=9.334,P=0.002、x2=5.910,P=0.015、x2=5.240,P=0.022)、失败组剖宫产发生率[72.2％(52/72)]明显高于成功组[34.1 ％(43/126),x2=26.641,P=0.001)].结论 手转胎头术能使难产变顺产,降低剖宫产率,减少母儿并发症,但须积极预防、处理导致手转胎头术失败的原因,对矫正失败后继续矫正及试产应慎重.