Cheilitis glandularis: a pediatric case report

Cheilitis glandularis is a rare disorder, usually affecting the lower lip of adults. This case involved both lips of an adolescent male. A familial history of the condition may have contributed to the involvement of both lips, and may reinforce the importance of hereditary tendency in the development of cheilitis glandularis. Emotional disturbance and poor oral hygiene also had a role in the disorder in this case, which was successfully treated with surgery.     

Cheilitis glandularis

Cheilitis glandularis is an uncommon lesion affecting the lower lip. Its origin remains obscure, although it is hypothesized that chronic irritation secondary to prolonged solar exposure causes hypertrophy of the labial salivary glands and eventual enlargement and ectropion of the lower lip. Although carcinoma of the lower lip has been reported in association with it, cheilitis glandularis is still considered a benign process that is adequately managed with conservative surgery. A case is presented and its surgical management is described.     

Cheilitis glandularis

Background. Glandular cheilitis (GC) is a rarely recognized disease of the accessory salivary glands of the lips, particularly of the lower lip. Clinically, three variants have been described: cheilitis glandularis simplex, cheilitis glandularis suppurativa, and cheilitis glandularis apostematosa. Most cases are diagnosed as the simple form of glandular cheilitis, which is characterized by enlarged excretory ducts, induration, and enlargement of the salivary glands as well as production of a rather mucopurulent saliva. Case reports. Two patients are described who revealed the characteristic changes of cheilitis glandularis simplex (case 1, 75-year-old male patient; case 2, 83-year-old female patient). In case 1 the patient developed a retention cyst of the upper lip probably as a consequence of GC. Diagnosis. Histologically, ectasia of glandular ducts and chronic sialadenitis are typical features. Therapy formerly consisted of antibiotics and locally applied corticosteroids; an optimal oral hygiene, however, is mandatory. Advanced stages have to be treated surgically. Glandular cheilitis has been considered a precancerous lesion, although no definite scientific proof has ever been presented. Cheilitis granulomatosa, cheilitis exfoliativa, and self-induced changes (Munchausen syndrome) have to be considered in the differential diagnosis of glandular cheilitis.     

Cheilitis glandularis: clinico-histopathological diagnostic criteria

Oral Diseases (2011) 17 , 335–339 Objectives: To present a combination of clinical and histopathological criteria for diagnosing cheilitis glandularis (CG), and to evaluate the association between CG and squamous cell carcinoma (SCC). Materials and Methods: The medical literature in English was searched from 1950 to 2010 and selected demographic data, and clinical and histopathological features of CG were retrieved and analysed. Results: A total of 77 cases have been published and four new cases were added to the collective data. The clinical criteria applied included the coexistence of multiple lesions and mucoid/purulent discharge, while the histopathological criteria included two or more of the following findings: sialectasia, chronic inflammation, mucous/oncocytic metaplasia and mucin in ducts. Only 47 (58.0%) cases involving patients with a mean age of 48.5 ± 20.3 years and a male‐to‐female ratio of 2.9:1 fulfilled the criteria. The lower lip alone was most commonly affected (70.2%). CG was associated with SCC in only three cases (3.5%) for which there was a clear aetiological factor for the malignancy. Conclusions: The proposed diagnostic criteria can assist in delineating true CG from a variety of lesions with a comparable clinical/histopathological presentation. CG in association with premalignant/malignant epithelial changes of the lower lip may represent secondary, reactive changes of the salivary glands.     

Cheilitis glandularis: an unusual histopathologic presentation

Cheilitis glandularis (CG) is an uncommon disease that usually affects the lower lip of adults. It is characterized by enlargement and eversion of the lip in association with excretory duct dilatation. The presence of minor salivary gland hyperplasia is controversial. Three types of CG have been described in the literature; the classification is based on the common clinical and histopathologic findings (ie, simple, superficial, and deep). This report is of an unusual case of CG simplex for which the initial histopathologic diagnosis was papillary cystadenoma, a neoplastic process. The lesion was completely excised, and final microscopic review of a larger specimen revealed chronic sclerosing sialadenitis, dilated salivary secretory ducts with oncocytic change and periductal inflammation, and foci of adenomatous hyperplasia consisting of enlarged ducts exhibiting squamous epithelial metaplasia and hyperplasia with papillary architecture. The latter proliferative pattern is an unusual finding in what is otherwise clinically diagnosed as CG.     

Concurrent anomalies: cheilitis glandularis and double lip. Report of a case

Double lip and cheilitis glandularis are uncommon anomalies involving the minor salivary glands of the lip. A unique case of concurrent double lip and cheilitis glandularis is presented. The development, diagnosis, and treatment of both lesions are reviewed. Their concurrent development in this patient appears to be unrelated.     

Cheilitis glandularis: An unusual presentation in a patient with HIV infection

Cheilitis glandularis is a rare disorder of unknown etiology characterized by inflammation of the minor salivary glands of the lower lip. The present report details the features of a patient who presented with cheilitis glandularis and was subsequently found to also have undiagnosed HIV infection.     

左上唇涎石病1例

涎石病是涎腺常见的疾病,主要累及大涎腺,小涎腺较少见。本文报道1例左上唇涎石病,并结合相关文献对其进行复习。     

Trichofolliculoma of the upper lip: report of a case

A trichofolliculoma occurring in the mid-philtrum of the upper lip of a 17-year-old boy is reported. It presented as an asymptomatic, 10 mm deep sinus and histology showed keratin-filled cysts or sinuses lined by stratified squamous epithelium.     

Actinic granuloma affecting the upper lip: a rare and challenging clinical entity

Actinic granuloma is a rare dermatological condition that can be difficult to diagnose, and the opinion of specialist dermatologists and histopathologists might be needed to confirm diagnosis. Our patient's lesion was not diagnosed until 3 years after initial presentation. We are aware of only 18 reported cases since 1982, and to our knowledge this is the first reported to affect the upper lip. The condition is slow to improve, and the most effective treatment remains unclear. We used intralesional steroid injections, but a small area has yet to resolve 9 years after presentation.     

Papillary cystadenoma arising from the upper lip: a case report

We report a rare case of a papillary cystadenoma arising from the upper lip. This tumor was not distinctly encapsulated and had proliferated replacing the ductal epithelium. Mast cells were found not only in the stroma but also in the oncocytic epithelial layer. There was a strong immunoreaction with mitochondrial antibody in the epithelial layer. Only one case (0.9%) of papillary cystadenoma has occurred among the 110 benign intraoral salivary gland tumors seen in our hospital from 1966 through September 2003.     

Chondroid syringoma of the upper lip: report of a case

The case of a 38-year-old white man with a chondroid syringoma in the left side of the upper lip is reported. Histochemical study of the lesion showed that the morphologic distributions of the neutral mucosubstances, sulfated acid mucopolysaccharides, and elastic fibers in the reported case were similar to those of mixed salivary gland tumor. The recently reported ultrastructural and immunohistochemical features of chondroid syringoma are also discussed in an effort to clarify its histogenesis.     

上唇皮肤混合瘤1例报告

上唇皮肤混合瘤临床少见,表现为上唇皮下无症状肿块,手术切除预后良好。本文报道1例上唇皮肤混合瘤病例并复习相关文献,以期提高对唇部皮肤混合瘤的认识。     

Glomangioma: rare case of a painful lump in the upper lip

Glomus tumours in the lip are extremely rare with only 13 cases, including this one, recorded in the English language that we know of. We report a 45-year-old woman with a firm, mildly painful lump in her upper lip. Excisional biopsy examination and histopathological analysis showed it to be a subtype of glomus tumour called a glomangioma.