养血生发胶囊联合胱氨酸及多维元素片治疗斑秃的疗效观察

目的:观察养血生发胶囊联合胱氨酸及多维元素片(金施尔康)治疗斑秃的疗效。方法:将63例斑秃患者分为两组,治疗组33例口服养血生发胶囊2.0 g,每日2次,胱氨酸片100 mg,每日3次,金施尔康片,每日1次;对照组30例口服养血生发胶囊2.0 g,每日2次。两组疗程均为3个月。结果:治疗组有效率90.91%,明显优于对照组(有效率为56.67%),且无明显不良反应。结论:口服养血生发胶囊联合胱氨酸及金施尔康治疗斑秃疗效高、安全性好。     

复方甘草酸苷联合胱氨酸治疗斑秃疗效观察

目的观察复方甘草酸苷联合胱氨酸治疗斑秃的疗效。方法将145例患者随机分为治疗组和对照组,治疗组85例给予口服复方甘草酸苷片75mg,3次／d,胱氨酸片100mg,3次／d,3个月为1个疗程。对照组60例给予口服斑秃丸1次5．0g,3次,d,胱氨酸片100mg,3次／d,疗程同治疗组。治疗1个疗程后判定疗效。结果治疗组和对照组总有效率分别为84．71％和58．33％,2组比较差异有统计学意义（p〈0．01）,治疗组疗效优于对照组。结论复方甘草酸苷片联合胱氨酸治疗斑秃的疗效高,安全性好,值得临床推广。     

吡美莫司软膏外用治疗斑秃33例疗效观察

目的观察吡美莫司软膏外用治疗斑秃的临床疗效。方法治疗组33例斑秃患者采用吡美莫司软膏外用,2次/d,同时口服胱氨酸片2片,3次/d;对照组32例予口服胱氨酸片,用法同治疗组。两组治疗时间均为12周,治疗结束后1个月判定疗效。结果治疗组痊愈15例,显效16例,好转2例,无效0例,有效率93.94%;对照组分别为6例、17例、7例、2例和71.88%,两组有效率差异有统计学意义(P<0.05)。结论吡美莫司软膏治疗斑秃疗效满意。     

胱氨酸联合薄芝注射液治疗斑秃的疗效观察

目的观察胱氨酸联合薄芝注射液治疗斑秃的临床疗效。方法将120例斑秃患者随机分为3组,治疗组40例,口服胱氨酸片100㎎,3次∕d,同时肌注薄芝注射液,每次4ml,隔日1次;对照Ⅰ组40例,每天服用胱氨酸片;对照Ⅱ组40例,肌注薄芝注射液,每次4ml,隔日1次。3组均外擦生姜,疗程均为3月。结果治疗组、对照Ⅰ组、对照Ⅱ组有效率分别为90.00%,62.50%和70.00%,治疗组与两对照组比较差异均有统计学意义(P<0.05)。结论胱氨酸联合薄芝注射液治疗斑秃,疗效明显,安全实用,值得临床推广应用。     

复方甘草酸苷治疗斑秃疗效观察

目的观察复方甘草酸苷治疗斑秃的疗效和安全性。方法78例患者随机分为两组,治疗组44例,口服复方甘草酸苷片3片,3次/d;对照组34例,口服胱氨酸100mg,谷维素20mg,维生素B120mg,均3次/d。两组均外用自制生发酊,2次/d。连续用药3个月,疗程结束后随访3个月。结果治疗组痊愈20例,显效13例,好转10例,无效1例,痊愈率45.45%,有效率75.00%,分别与对照组比较(23.53%,52.88%)差异有显著性(χ2=4.45,4.53,P均<0.05)。结论复方甘草酸苷治疗斑秃疗效好,副作用少,耐受性好。     

中西药综合治疗斑秃临床疗效观察

目的观察中西药联合治疗斑秃的临床疗效。方法将80例患者随机分为2组,治疗组40例采用口服胱氨酸片、复方甘草酸苷片、活力舒口服液及配合外擦中药复方当归生发酊;对照组40例,仅口服相同剂量的胱氨酸片、复方甘草酸苷片。治疗2个月后分析对比2组患者临床疗效。结果治疗组总有效率为95.0%,明显高于对照组的75.0%,2组比较差异有统计学意义(P0.05)。结论中西药联合口服及外擦治疗斑秃比单纯的西药口服治疗效果好。     

复方甘草酸苷治疗斑秃55例疗效观察

目的探讨复方甘草酸苷片(美能)治疗斑秃的疗效和安全性。方法97例斑秃患者随机分为两组,治疗组55例,口服美能片75mg,3次/d,同时服用养血生发胶囊4粒,2次/d;对照组42例,单用养血生发胶囊,用法同治疗组。两组疗程均为3个月。观察和记录患区毛发再生情况。结果治疗组与对照组有效率分别为76.36%和52.38%,差异有显著性(χ2=6.102,P<0.05)。结论美能联合养血生发胶囊治疗斑秃的疗效较好。     

脉管复康片联合复方甘草酸苷和米诺地尔外用治疗斑秃疗效观察

目的观察脉管复康片联合复方甘草酸苷和米诺地尔外用治疗斑秃的临床疗效。方法将86例斑秃患者随机分为2组,治疗组47例,给予口服脉管复康片2.4 g,3次/d,复方甘草酸苷片50 mg,3次/d,2%米诺地尔溶液外搽患处,3次/d;对照组39例,给予口服复方甘草酸苷片50 mg,3次/d,2%米诺地尔溶液外搽患处,3次/d。疗程共4周。结果治疗组和对照组痊愈率比较差异有统计学意义(P0.01),有效率比较差异有统计学意义(P0.01),均未见明显不良反应。结论脉管复康片联合复方甘草酸苷和米诺地尔治疗斑秃疗效好。     

304nm高能紫外线联合复方甘草酸苷片治疗斑秃42例临床观察

目的评价304nm中波高能紫外线联合复方甘草酸苷片治疗斑秃的临床疗效和安全性。方法将入选的84例斑秃患者随机分为两组,各42例。全部患者予304nm中波高能紫外线照射,2次/周,治疗组还予口服复方甘草酸苷片50mg,对照组还予口服胱氨酸片100mg,均为3次/d,治疗8周后评价临床疗效。结果治疗组有效率为73.81%,对照组有效率为52.38%,两组比较差异有统计学意义(P0.05)。二者均无严重的不良反应。结论 304nm中波高能紫外线联合复方甘草酸苷片治疗斑秃疗效好,且无明显不良反应。     

甘草锌颗粒联合养血生发胶囊治疗轻症斑秃105例疗效观察

目的观察并分析甘草锌颗粒联合养血生发胶囊治疗轻症斑秃的疗效。方法将183例轻症斑秃患者随机分为治疗组和对照组,治疗组105例,对照组78例。治疗组与对照组均服用养血生发胶囊,4粒/次,2次/d,同时治疗组服用甘草锌颗粒,5g/次,3次/d,治疗组与对照组均于服药2个月内观察疗效。结果治疗组与对照组治愈率为35.24%和12.82%,两组比较差异有统计学意义(P0.005),总显效率治疗组为83.81%,对照组为52.56%,两组比较差异有统计学意义(P0.005)。结论甘草锌颗粒联合养血生发胶囊治疗轻症斑秃疗效显著。     

Alopecia Areata

Alopecia areata is a common form of non-scarring alopecia that appears equally in males and females of any age, although children and adolescents are more commonly affected. The disorder is usually characterized by limited alopecic patches on the scalp, but more severe forms may affect the entire scalp (alopecia totalis) or body (alopecia universalis). Characteristic nail changes may also accompany hair loss. Alopecia areata has been linked with certain human leukocyte antigen (HLA) class II alleles, indicating a probable autoimmune etiology. Current research implicates T lymphocytes in the pathogenetic mechanism of disease. Other autoimmune diseases are also linked with alopecia areata. The diagnosis of alopecia areata is usually made clinically, although a biopsy is diagnostic for this condition. Treatment is challenging and aims at the regrowth of hair in affected individuals. Intralesional corticosteroid injections are widely used in mild disease. Topical anthralin and minoxidil may also be clinically efficacious. Topical sensitizers, such as squaric acid dibutlyester and diphenylcyclopropenone, are sometimes employed. Various therapies for the disease may have efficacy in different patients, making a universal treatment algorithm difficult to implement. Patients should be handled on an individual basis, with the final outcome based on the cosmetic regrowth of hair. Maintenance therapy is also important in patients that do achieve acceptable regrowth, necessitating a highly motivated patient and good rapport with the treating physician.     

Alopecia Areata Symposium

Abstract: No dermatologic disorder poses so little threat to health and physical cotnfort and yet is so emotionally devastating as alopecia areata. Fortunately, the rate of spontaneous remission is high; nevertheless, management is problematic because of the considerable cosmetic disability imposed by extensive and visible hair loss, and the unpredictability of response to accepted therapeutic agents. Indeed, opinions vary as to whether or not any of the currently employed therapeutic modalities is effective, and there is remarkable diversity in approach to the patient with this problem.
This symposium includes two lengthier articles on alopecia areata as well as several shorter commentaries on management by dermatologists with a special interest in this disorder.