共查询到20条相似文献,搜索用时 15 毫秒
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《Lung cancer (Amsterdam, Netherlands)》1994,10(5-6):350
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Peter Broderick Tina Bagratuni Jairam Vijayakrishnan Steven Lubbe Ian Chandler Richard S Houlston 《BMC cancer》2006,6(1):243
Background
The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variation in other BER pathway genes such as NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 also contribute to CRC susceptibility. 相似文献9.
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Announcement
Breast Cancer Research non-peer-review research depository 相似文献11.
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Background
Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and pro-apoptotic genes is recognised as a critical factor in cancer development. 相似文献16.
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《癌症》2015,(3):147-148
The"Collaborative Innovation Center for Cancer Medicine,"co-established by Sun Yat-sen University,Fudan University,Peking Union Medical College and the National Institute of Biological Sciences,follows a national initiative to improve medical sciences and technologies for cancer care in China.The purpose is to establish a leading international center for innovation to conduct competitive and large-scale outstanding research with a multidisciplinary team of oncology 相似文献
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Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan 总被引:2,自引:0,他引:2
K.-C. Lai W.-C. Chen L.-B. Jeng S.-Y. Li M.-C. Chou F.-J. Tsai 《European journal of surgical oncology》2005,31(10):1135-1140
AIMS: To assess gastric cancer risk and clinical-pathological factors associated with genetic polymorphisms of MK, IL-4, p16, p21 and p53 genes. METHODS: A retrospective study was conducted for 123 patients who had recently developed primary gastric cancer. Clinical data and pathological findings were collected, genetic polymorphisms of MK, IL-4, p16, p21 and p53 genes were analysed, and the associations of genetic polymorphisms with gastric cancer carcinogenesis were evaluated. RESULTS: There was significant association of genetic polymorphisms between gastric cancer and control groups in p53 genes. After further stratification of the cancer group into different clinical-pathologic parameters, there were significant associations in the sex and LN involvement groups in MK gene; alcohol consumption group in p16 gene; age and cell differentiation groups in p21 gene; age and tumour location groups in p53 gene; but we fail to find any significant association with IL-4 gene polymorphisms. CONCLUSIONS: Genetic susceptibility testing is a tool to evaluate the association of genetic polymorphisms with gastric cancer carcinogenesis. 相似文献
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Gloria D. Coronado Mary A. O’Connell Jennifer Anderson Helena Löest Dana Ogaz Beti Thompson 《Journal of cancer education》2010,25(1):32-35
Students from racially/ethnically diverse backgrounds are underrepresented in graduate programs in biomedical disciplines.
One goal of the Minority Institution/Cancer Center partnership between New Mexico State University (NMSU) and the Fred Hutchinson
Cancer Research Center (FHCRC) is to expand the number of underrepresented students who are trained in cancer research. As
part of the collaboration, a summer internship program has been organized at the FHCRC. The program runs for 9 weeks and involves
mentored research, research seminars, coffee breaks, social activities, and a final poster session. This study examined the
graduate school attendance rates of past interns, explored interns’ perceptions of the training program, and identified ways
to improve the program. Thirty undergraduate students enrolled at NMSU participated in the internship program from 2002 to
2007 and telephone interviews were conducted on 22 (73%) of them. One-third of the students were currently in graduate school
(32%); the remaining were either working (36%), still in undergraduate school (27%), or unemployed and not in school (5%).
Students rated highly the following aspects of the program: mentored research, informal time spent with mentors, and research
seminars. Students also reported the following activities would further enhance the program: instruction on writing a personal
statement for graduate school and tips in choosing an advisor. Students also desired instruction on taking the GRE/MCAT, receiving
advice on selecting a graduate or professional school, and receiving advice on where to apply. These findings can inform the
design of internship programs aimed at increasing rates of graduate school attendance among underrepresented students. 相似文献
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