共查询到20条相似文献,搜索用时 15 毫秒
1.
Lehnhardt S Thorsten Winterer J Strecker R Hogerle S Herget G Geens V Laubenberger J Uhrmeister P 《Investigative radiology》2002,37(11):594-599
RATIONALE AND OBJECTIVE: The aim of this study was to demonstrate and measure perfusion deficits caused by central bronchogenic carcinoma and to compare magnetic resonance angiography (MRA) perfusion data with data of perfusion scintigraphy. The diagnostic value of 2D MRA in detection of malignant pulmonary artery stenosis in comparison with conventional DSA was investigated. MATERIALS AND METHODS: Eighteen patients were included in the study. MRA, conventional pulmonary angiograms, and pulmonary perfusion scintigrams were performed. MRA and DSA were compared and MR pulmonary perfusion data were assessed and compared with scintigraphical data. RESULTS: Perfusion defect could be demonstrated and localized in all patients. A quantitative perfusion deficit and a side dependent perfusion ratio could be evaluated. There was statistically significant correlation between MR perfusion and scintigraphically acquired data. 2D MRA showed a high correlation for detection and grading of stenosis compared with angiograms. CONCLUSIONS: Pulmonary perfusion could be demonstrated by using an ultrafast 2D projection MR DSA sequence. This technique allows measurement and quantification of pulmonary perfusion abnormalities in patients with malignant stenosis with statistically significant correlation to perfusion scintigraphy. The diagnostic potency in the evaluation of malignant pulmonary artery stenosis compared with conventional DSA could be shown. 相似文献
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Peter Hedera Song Lai Jonathan S. Lewin E. Mark Haacke Dee Wu Alan J. Lerner Robert P. Friedland 《Journal of magnetic resonance imaging : JMRI》1996,6(5):718-725
Imaging of activated brain areas based on changes of blood deoxyhemoglobin levels is now possible with MRI. Acetazolamide (ACZ) increases cerebral blood flow (CBF) without changing cerebral oxygen consumption; this results in signal changes observed in gradient echo MR images from the areas with an increase in CBF. We assessed signal changes after ACZ application in seven healthy subjects with a conventional 1.5-T MRI scanner. The susceptibility-sensitized three-dimensional fast low-angle shot (FLASH) sequence was used to visualize signal changes induced by ACZ. We analyzed anatomic localization of different ranges of detected signal changes. ACZ caused significant signal changes in the gray matter and at the edge of the cerebral cortex, the latter corresponding to draining surface veins. No significant differences were seen among different brain areas within the same slice. Using the maximum intensity projection technique, we were able to partially separate signal changes originating in draining veins from signal originating in the gray matter microvasculature. Signal changes from the microvessels reflect cerebrovascular reserve. Blood-oxygen-level-dependent (BOLD) based MRI can evaluate CBF reserve with high spatial and temporal resolution. To assess cerebrovascular reserve, it is necessary to separate signal changes originating in large vessels from signal from brain microvasculature. 相似文献
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An ultrafast MR sequence was used to measure changes in signal intensity during the first pass of intravascular contrast through the pulmonary circulation. From this, mean transit time, relative blood volume, and relative blood flow were calculated. Data were collected in an isogravitational plane in six healthy subjects. A slight but significant gradient in transit time was present, with faster times at the lung apex. A significant decrease in blood volume, compared with the lung base, was also seen in the apex. Significant decreases in blood volume and blood flow, compared with central portions of the lung, were seen in the lung periphery. Six additional subjects were imaged along a gravitational plane. A significant gradient in transit time was seen, with faster transit in dependent regions of the lung. MRI is able to evaluate regional differences in pulmonary perfusion with high spatial and temporal resolution. Magn Reson Med 46:166-171, 2001. 相似文献
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核素肺灌注显像对搏动性双向Glenn术肺血流的评估 总被引:1,自引:0,他引:1
目的探讨核素肺灌注显像定性定量评估搏动性双向Glenn术肺血流情况。方法11例肺血少、复杂先天性心脏病患者均接受搏动性双向Glenn术。术前经上肢静脉、术后分别由上下肢静脉注射显像剂,示踪剂在肺内达到平衡后,取前后位及后前位行肺灌注显像,每个体位采集5×105放射性计数。若肾脏显影,则勾划两肾感兴趣区,分别计算术前和术后两肺与双肾放射性计数。结果在搏动性双向Glenn术后两肺放射性计数比值差异无显著性,两肺血基本对称。右向左分流指数较术前明显下降。结论核素肺灌注显像能无创性定性定量评估搏动性双向Glenn术前后肺血流情况,并观察疗效。 相似文献
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Cascini G Falcone C Greco C Bertucci B Cipullo S Tamburrini O 《La Radiologia medica》2008,113(8):1157-1170
Purpose
The aim of the study was to assess the reliability of whole-body magnetic resonance imaging (WB-MRI) in detecting skeletal metastasis and to compare the results with those of bone scintigraphy (BS).Materials and methods
Thirty-three patients (21 women, 12 men, median age 58 years, range 27–78) were enrolled. Histological proof of malignancy was obtained in all cases. The primary tumour was unknown in 1 patient. BS and WB-MRI were performed as staging procedures in 15 patients, during the follow-up in 6 and to investigate pain in 9 and neurological symptoms in 3. Bone metastases were recorded for 8 different skeletal segments (ribs, skull, cervicothoracic spine, lumbosacral spine, clavicle-scapula-sternum, pelvis, upper extremities and lower extremities) in all patients, for a total of 264 examined areas.Results
Bone metastases were detected in 18 patients (55%). In 15/33 patients, WB-MRI and BS were concordantly negative. BS revealed focal metastatic uptake in 72%, whereas WB-MRI was positive in 89%. Results differed in seven patients. WB-MRI was positive but BS was negative in five cases. Two patients with negative WB-MRI had focal and intense uptake in the ribs on BS. Out of 264 examined areas, bone metastases were detected in 34 (13%). WB-MRI revealed tumour spread in 26/34 areas (76%) and BS in 21/34 areas only (62%).Conclusions
WB-MRI is a reliable method for screening patients with suspected skeletal metastases, although BS still remains a useful tool. WB-MRI is also advantageous because it reveals extraskeletal and soft tissue metastases. 相似文献9.
Mana Ishibashi Yoshio Tanabe Hidenao Miyoshi Eiji Matusue Toshio Kaminou Toshihide Ogawa 《Japanese journal of radiology》2009,27(9):371-374
Splenosis represents the heterotopic autotransplantation of splenic tissue after either splenic trauma or surgery. Intrathoracic
splenosis is a rare condition resulting from concomitant rupture of the spleen and the left hemidiaphragm. We report a case
of splenosis in a 41-year-old male patient who had experienced severe thoracoabdominal injury including rupture of the spleen
and left hemidiaphragm and post-traumatic splenectomy 20 years previously. Abnormal opacities in the cardiac region were noted
on a chest radiograph at an annual checkup. Computed tomography (CT) of the chest demonstrated multiple, well-circumscribed
pleura-based nodules at the posterior base of the left hemithorax and the left subdiaphragmatic area. On magnetic resonance
imaging (MRI), the lesions were hypointense on T1-weighted images and hyperintense on T2-weighted images. After administration
of superparamagnetic iron oxide (SPIO), the lesions showed decreased signal intensity but remained slightly hyperintense relative
to liver parenchyma on T2-weighted images. 99mTc-labeled Sn colloid scintigraphy revealed multiple areas of increased activity consistent with the lesions on the CT and
MRI scans. In addition to the history of splenic trauma and left hemothorax, SPIO-enhanced MRI and radionuclide scintigraphy,
which can demonstrate phagocytic ability in the ectopic splenic tissue, were useful for confirming the diagnosis. 相似文献
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Prediction of postoperative pulmonary function using perfusion magnetic resonance imaging of the lung 总被引:4,自引:0,他引:4
Iwasawa T Saito K Ogawa N Ishiwa N Kurihara H 《Journal of magnetic resonance imaging : JMRI》2002,15(6):685-692
PURPOSE: To assess semiquantitatively the regional distribution of lung perfusion using magnetic resonance (MR) perfusion imaging.MATERIALS AND METHODS: Subjects were 20 consecutive patients with bronchogenic carcinoma, who underwent MR imaging (MRI) and radionuclide (RN) perfusion scans for preoperative evaluation. Three-dimensional (3D) images of whole lungs were obtained before and 7 seconds after bolus injection of contrast material (5 ml of Gd-DTPA). Subtraction images were constructed from these dynamic images. Lung areas enhanced with the contrast material were measured and multiplied by changes in signal intensity, summed for the whole lung, and the right-to-left lung ratios were calculated. The predicted postoperative forced expiratory volume in 1 second (FEV1) was estimated using MR and RN perfusion ratios.RESULTS: The correlation between perfusion ratios derived from the MR and RN studies was excellent (r = 0.92). Sixteen of 20 patients underwent surgery, and 12 patients had postoperative pulmonary function tests. The predicted FEV1 derived from the MR perfusion ratio correlated well with the postoperative FEV1 in the 12 patients (r = 0.68).CONCLUSION: Perfusion MRI is suitable for semiquantitative evaluation of regional pulmonary perfusion. 相似文献
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Nuclear magnetic resonance: principles of blood flow imaging 总被引:1,自引:0,他引:1
C M Mills M Brant-Zawadzki L E Crooks L Kaufman P Sheldon D Norman W Bank T H Newton 《AJR. American journal of roentgenology》1984,142(1):165-170
Nuclear magnetic resonance (NMR) imaging with spin-echo techniques defines vascular structures with superb anatomic detail. Contrast agents are not necessary as there is intrinsic contrast between flowing blood and the vascular wall. The signal intensity from blood within the vessel lumen varies with the sequence of gradient and radiofrequency pulses used to generate the image as well as with the velocity of blood flow. Appropriate imaging techniques can optimize anatomic detail, distinguish slow from rapidly flowing blood, and serve to identify marked impairment or complete obstruction of flow in an artery or vein. Some examples of these principles in the intracranial circulation are illustrated. 相似文献
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Kitajima M Hirai T Shigematsu Y Fukuoka H Sasao A Okuda T Morioka M Kai Y Yamashita Y 《Japanese journal of radiology》2010,28(10):746-753
Purpose
The purpose of this study was to evaluate whether cerebral perfusion from bypassed arteries can be demonstrated on regional perfusion imaging (RPI) using arterial spin labeling. We then compared cerebral perfusion on RPI and digital subtraction angiography (DSA) in moyamoya patients who underwent extracranial-intracranial bypass surgery. 相似文献13.
增强MR肺灌注扫描诊断肺动脉栓塞的初步研究 总被引:3,自引:0,他引:3
目的应用增强MR肺灌注扫描技术(MRPP)与增强MR肺动脉造影(MRPA)、核素肺灌注扫描相对照,初步探讨此项成像技术诊断肺动脉栓塞的敏感性及特异性。方法14例最终明确诊断为肺动脉栓塞患者,均行增强MRPA及MRPP。5例患者同时拥有核素肺通气一灌注扫描结果。3例经溶栓治疗后复查MRPA及MRPP。通过在上、中下肺野和异常区域内设置感兴趣区(ROI),测量信号强度(SI)、时间一信号曲线,获取灌注高峰期信号强度变化率。结果14例肺动脉栓塞患者,MRPA发现共62支肺动脉闭塞,MRPP共发现55个肺灌注异常区与之相吻合。符合率为88.71%,14例中MRPP显示有25个肺段合并有段及段以远的肺动脉栓塞。5例同时拥有核素扫描结果的患者,核素显示37个段灌注缺损,MRPP显示33个段,敏感度为89.19%,3例经溶栓治疗后复查MRPA和MRPP,均见受累肺动脉明显改善,肺灌注缺损区明显减少。正常灌注与灌注缺损区及低灌注区的信号强度变化率(TROS)差异有统计学意义(t=22.882,P〈0.01)。结论MRPP能够显示肺动脉栓塞的灌注缺损区和低灌注区。时间一信号曲线显示肺动脉栓塞区对比剂无灌注高峰期,信号曲线波动幅度小,信号强度变化率减低。MRPP对段及段以远的肺动脉栓塞的显示有较高的研究价值。MRPP联合MRPA可进一步提高MR诊断肺动脉栓塞的敏感度。 相似文献
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Fink C Ley S Risse F Eichinger M Zaporozhan J Buhmann R Puderbach M Plathow C Kauczor HU 《Investigative radiology》2005,40(2):72-79
RATIONALE AND OBJECTIVES: The effect of breathholding on pulmonary perfusion remains largely unknown. The aim of this study was to assess the effect of inspiratory and expiratory breathhold on pulmonary perfusion using quantitative pulmonary perfusion magnetic resonance imaging (MRI). METHODS AND RESULTS: Nine healthy volunteers (median age, 28 years; range, 20-45 years) were examined with contrast-enhanced time-resolved 3-dimensional pulmonary perfusion MRI (FLASH 3D, TR/TE: 1.9/0.8 ms; flip angle: 40 degrees; GRAPPA) during end-inspiratory and expiratory breathholds. The perfusion parameters pulmonary blood flow (PBF), pulmonary blood volume (PBV), and mean transit time (MTT) were calculated using the indicator dilution theory. As a reference method, end-inspiratory and expiratory phase-contrast (PC) MRI of the pulmonary arterial blood flow (PABF) was performed. RESULTS: There was a statistically significant increase of the PBF (delta = 182 mL/100 mL/min), PBV (delta = 12 mL/100 mL), and PABF (delta = 0.5 L/min) between inspiratory and expiratory breathhold measurements (P < 0.0001). Also, the MTT was significantly shorter (delta = -0.5 sec) at expiratory breathhold (P = 0.03). Inspiratory PBF and PBV showed a moderate correlation (r = 0.72 and 0.61, P < or = 0.008) with inspiratory PABF. CONCLUSION: Pulmonary perfusion during breathhold depends on the inspiratory level. Higher perfusion is observed at expiratory breathhold. 相似文献
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Michaely HJ Schoenberg SO Ittrich C Dikow R Bock M Guenther M 《Investigative radiology》2004,39(11):698-705
PURPOSE: To differentiate healthy kidneys from diseased kidneys, we propose a combined magnetic resonance (MR) examination that includes measurements of renal arterial blood flow and parenchymal perfusion. MATERIALS AND METHODS: A total of 130 kidneys (patients/healthy volunteers: 83/47) were examined using renal artery MR flow measurements and renal parenchymal perfusion measurements, as well as contrast-enhanced MR angiography. Cine phase-contrast-flow measurements were performed using an ECG-gated fast low angle shot pulse sequence; perfusion was measured with an arterial spin labeling flow-sensitive alternating inversion recovery technique. Contrast-enhanced MR angiography was performed with a fast 3D gradient echo sequence in a single breath hold. For evaluation, kidneys were divided into groups based on nephrologic diagnosis of the patient. Recursive partitioning and Wilcoxon rank-sum tests were used to separate the different groups. RESULTS: Significant differences in mean renal artery flow and parenchymal perfusion were found in kidneys with renal artery stenosis as well as parenchymal disease as compared with healthy kidneys. Using a classification tree derived from the recursive partitioning, a specificity of 99% and sensitivity of 69% with a positive/negative predictive value of 97%/84% was achieved for the separation of healthy kidneys from kidneys with vascular, parenchymal or combined disease. The overall accuracy was 88%. CONCLUSION: The combination of cine PC flow measurements and MR perfusion measurements offers a comprehensive assessment of both renovascular and renoparenchymal disease and provide a noninvasive approach to differentiate between these kidneys and normal kidneys. 相似文献
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Correction of structural defects of the heart associated with cyanotic heart disease often requires rerouting of systemic venous return into the pulmonary arteries and pulmonary venous return into the ventricles. Preliminary experience suggests that magnetic resonance imaging, through its superior depiction of the resultant complex anatomy, provides important supplemental information to echocardiography. Together, these noninvasive techniques may lessen the present need for repeat catheterization in children with surgically corrected cyanotic heart disease. 相似文献
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Multiphasic perfusion computed tomography in hyperacute ischemic stroke: comparison with diffusion and perfusion magnetic resonance imaging 总被引:6,自引:0,他引:6
Na DG Ryoo JW Lee KH Moon CH Yi CA Kim EY Lee SJ Yi BY Kim JH Byun HS 《Journal of computer assisted tomography》2003,27(2):194-206
PURPOSE: The purpose of this study was to compare multiphasic perfusion computed tomography (CT) with diffusion and perfusion magnetic resonance imaging (MRI) in predicting final infarct volume, infarct growth, and clinical severity in patients with hyperacute ischemia untreated by thrombolytic therapy. METHOD: Multiphasic perfusion CT was performed in 19 patients with ischemic stroke within 6 hours of symptom onset. Two CT maps of peak and total perfusion were generated from CT data. Diffusion-weighted imaging (DWI) and perfusion MRI were obtained within 150 minutes after CT. Lesion volumes on CT and MRI were compared with final infarct volume and clinical scores, and mismatch on CT or MRI was compared with infarct growth. RESULTS: The lesion volume on the CT total perfusion map strongly correlated with MRI relative cerebral blood volume (rCBV), and that on the CT peak perfusion map strongly correlated with MRI relative cerebral blood flow (rCBF) and rCBV (P < 0.001). The lesion volume on unenhanced CT or DWI moderately correlated with final infarct volume, but only lesion volume on unenhanced CT weakly correlated with baseline clinical scores (P = 0.024). The lesion volumes on the CT peak perfusion map and MRI rCBF similarly correlated with final infarct volume and clinical scores and more strongly than those on mean transit time (MTT) or time to peak (TTP). DWI-rCBF or CT mismatch was more predictive of infarct growth than DWI-MTT or DWI-TTP mismatch. CONCLUSION: Multiphasic perfusion CT is useful and of comparable utility to diffusion and perfusion MRI for predicting final infarct volume, infarct growth, and clinical severity in acute ischemic stroke. 相似文献
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G Sommer B Noorbehesht N Pelc R Jamison A J Pinevich L Newton B Myers 《Investigative radiology》1992,27(6):465-470
RATIONALE AND OBJECTIVES. This study assesses the ability of a cardiac-gated phase-contrast magnetic resonance imaging (MRI) technique to measure renal blood flow (RBF) noninvasively in humans. METHODS. In nine normal volunteers, total RBF in the renal arteries and in the left renal vein was estimated by MRI and correlated with RBF determined by the clearance of para-aminohippuric acid (CPAH) and the hematocrit level. RESULTS. Correlation of RBF estimated from left renal vein flow, with RBF by CPAH-hematocrit, yielded r = .86 (P less than .003). Repeated measurement of RBF by MRI demonstrated a high degree of reproducibility, with coefficients of variation ranging from 4.8% to 8.9%. However, the MRI measurements of arterial flow did not significantly correlate with the standard measurements. CONCLUSIONS. Reproducible noninvasive measurement of normal RBF is possible with the phase-contrast MRI technique used to measure renal venous blood flow. 相似文献