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1.
电解可脱性弹簧圈栓塞治疗大脑后交通动脉瘤   总被引:4,自引:2,他引:2       下载免费PDF全文
目的 讨论以电解可脱性弹簧圈血管内栓塞治疗后交通动脉瘤的疗效及技术要点。方法对42例后交通动脉瘤患者用电解可脱性弹簧圈进行动脉瘤囊内栓塞,术后早期处理出血。结果42个动脉瘤中38个瘤腔完全闭塞,3个95%闭塞,1个被90%闭塞。术后41例临床痊愈,1例死亡,死亡率2.4%。术中并发脑血管痉挛1例;术后弹簧圈末端逸出1例。1例复发者经二次补充GDc栓塞而治愈。全组出现与栓塞技术相关的并发症2例。术后随访3~50个月均无再出血。结论对后交通动脉瘤采用电解可脱性弹簧圈进行血管内囊内栓塞疗效可靠;早期栓塞及有效的术后处理是提高治愈率的重要方法。  相似文献   

2.
目的探讨血管内栓塞治疗前交通动脉瘤的方法,技术特点及疗效。方法回顾性分析应用血管内栓塞治疗的54例破裂前交通动脉瘤患者的临床资料。结果54例中成功栓塞53例,其中32例100%栓塞,19例95%栓塞,2例90%栓塞;3例出现严重血管痉挛;2例死于脑疝及严重血管痉挛继发脑梗塞。随访6~24个月,无术后再出血病例。结论血管内栓塞是治疗前交通动脉瘤的一种微创、相对安全而有效的方法。  相似文献   

3.
目的探讨颅内动脉瘤破裂出血后在其破口周围所形成的假性动脉瘤与真性动脉瘤(TAN-FAN)复合体的血管内栓塞时机及并发症防治方法。方法采用电解可脱性弹簧圈对58例TAN—FAN复合体进行血管内栓塞。结果58例TAN—FAN复合体中24例(41.4%)为出血后7天内进行栓塞,20例(34.5%)为出血后7天~2周内进行栓塞,14例(24.1%)为出血后2周~1个月内进行栓塞。58个动脉瘤均被成功栓塞,其中真性动脉瘤腔100%闭塞者46个,95%闭塞者9个,90%闭塞者3个;13例A型与31例B型假性动脉瘤腔均未行弹簧圈填塞,14例C型中11例仅用弹簧圈疏松填塞假性动脉瘤腔,另3例用3D-GDC仅栓塞真性动脉瘤腔部分。术中并发动脉瘤破裂1例;并发脑血管痉挛2例;并发脑梗死3例。1例复发者经二次补充GDC栓塞而治愈。其治疗结果根据Glasgow预后评分:Ⅰ级43例,Ⅱ级11例,Ⅲ级3例,全组死亡1例,死亡率1.7%。术后随访3~60个月均无再出血。结论对动脉瘤破裂后形成的TAN—FAN复合体应早期进行血管内栓塞;只有根据TAN—FAN复合体不同的类型采用不同的栓塞方法进行个体化治疗,并具有丰富的动脉瘤栓塞经验,才能最大限度的降低并发症。  相似文献   

4.
目的总结以电解可脱性弹簧圈(GDC)血管内栓塞治疗颅内动脉瘤的技术要点、并发症及其防治经验。方法采用GDC对168例颅内动脉瘤患者进行动脉瘤囊内栓塞。结果成功栓塞168个动脉瘤,其中100%闭塞的144个,95%闭塞的14个,90%闭塞的10个;全组6例死亡,死亡率3.6%。术中并发动脉瘤破裂3例,脑血管痉挛9例,脑梗死2例,术后弹簧圈末端逸出2例;3例复发者经二次补充GDC栓塞而治愈。随访5~54个月,全组术后均无再出血。结论动脉瘤的血管内治疗应根据病情进行个体化设计,并采用与之相应的栓塞技术才能最大限度的提高动脉瘤栓塞的治愈率、降低并发症。  相似文献   

5.
1993年6月至1996年3月,作者应用血管内技术治疗脑动静脉畸形(AVMs)18例。其中2例完全闭塞,8例闭塞70%~90%,5例闭塞50%~70%,3例闭塞少于50%。2例栓塞后出现轻度神经功能缺失。栓塞后1周,4例位置表浅的AVM进行了手术治疗。2例位于深部的AVM栓塞后1个月进行了γ-刀治疗。18例患者中,14例得到随访,12例临床症状减轻或缓解,1例癫痫发作较栓塞前频繁,1例栓塞后6个月发生颅内再出血。脑AVM经血管内栓塞治疗,可使部分患者治愈,对于大型及重要功能区的AVM,血管内栓塞治疗可为手术及放疗提供条件。  相似文献   

6.
目的:探讨椎基底动脉分支远端动脉瘤的治疗方法与策略。方法33例患者经全脑血管造影术证实为椎基底动脉分支大脑后动脉、小脑上动脉、小脑前下动脉与小脑后下动脉之远端动脉瘤,分别为8例、6例、9例、10例。其中血管内栓塞治疗29例,直接行开颅动脉瘤夹闭术2例,数字减影血管造影(DSA)与磁共振成像(MRI)三维影像融合数据输入神经导航,在神经导航指引下行开颅动脉瘤灼闭手术1例,1例因血管内栓塞治疗失败未进行手术治疗。结果所有病例无手术相关死亡,2例患者行弹簧圈栓塞术,术后1 d 患者再出血死亡,1例栓塞未成功又未行手术患者病情好转出院,余30例患者未发生术后再出血。结论椎基底动脉分支远端动脉瘤多数手术治疗难度大,应首选血管内栓塞治疗。  相似文献   

7.
显微手术和介入治疗急性期颅内动脉瘤破裂的对比性研究   总被引:12,自引:6,他引:6  
目的 比较显微外科手术和血管内介入治疗急性期颅内动脉瘤破裂的疗效和相关并发症。方法 82例破裂性颅内动脉瘤,均在蛛网膜下腔出血急性期(72h以内)行外科治疗,其中行显微手术瘤颈夹闭40例,血管内电解可脱性弹簧圈栓塞治疗42例。对两组疗效和并发症进行对比分析。结果 显微手术组,完全夹闭率92.5%,手术相关并发症4例,死亡2例。弹簧圈栓塞组,完全闭塞率71.4%,栓塞组相关并发症6例,死亡1例。在前循环动脉瘤中,栓塞组完全闭塞率与手术组完全夹闭率相比较,显微手术组结果优于栓塞组。临床随访6个月,两者预后良好者均达95.0%。结论 显微瘤颈夹闭术和血管内栓寒治疗均是颅内动脉瘤治疗的有效方法。  相似文献   

8.
目的:探讨颈段脊髓血管畸形的临床及影像学特征,研究血管内治疗的方法和效果,方法:选择1991年1月至2000年6月收治的21例颈段脊髓血管畸形患者,分析其临床表现和血管造特征,所有病例均行血管内栓塞治疗。结论:其中3例于术后6个月-2年,因病灶巨大,行第2次治疗,栓塞材料选用真丝微粒或线段10例,NBCA胶3例,线段和NBCA胶联合应用8例,病灶闭塞90%以上7例,闭塞80%-90%8例,60%-80%4例,60%以下2例,临床症改善15例,无变化5例,例术后3个月死亡,结论:血管内栓塞是颈段脊髓血管畸形有效的治疗方法。  相似文献   

9.
目的 探讨血管内介入治疗椎动脉夹层动脉瘤的安全性与有效性.方法 回顾性分析30例患者30个夹层动脉瘤行血管内介入治疗的临床资料,其中8例单纯弹簧圈栓塞,10例支架辅助弹簧圈栓塞,3例单支架置入,9例载瘤动脉闭塞.结果 术后对30例中的22例进行随访脑血管造影,随访时间为1~8个月,平均6个月.其中17例完全栓塞患者无复发;近完全栓塞3例中2例动脉瘤稍增大,部分栓塞2例动脉瘤复发,这4例患者均行二次手术,其中3例行支架置入,1例行动脉瘤栓塞.结论 血管内介入治疗椎动脉夹层动脉瘤是一种安全有效的方法.  相似文献   

10.
目的总结白塞病并发动脉瘤的外科手术和腔内治疗经验。方法对1977年6月至2006年3月收治的12例白塞病患者并发21个动脉瘤进行回顾性分析。腹主动脉瘤3个,升主动脉瘤1个,髂动脉瘤4个,髂动脉吻合口假性动脉瘤1个,股总动脉瘤3个,股浅动脉瘤2个,腘动脉瘤2个,椎动脉瘤1个,锁骨下动脉瘤2个。颈动脉瘤1个和肠系膜上动脉瘤1个。21个动脉瘤中,行外科手术14个,包括动脉瘤切除、人工血管或自体大隐静脉移植术12个,动脉瘤切除、病变动脉结扎术2个;行支架型人工血管腔内修复术6个;1个升主动脉瘤因患者全身情况差,行保守治疗。结果围手术期死亡患者2例,其中1例行外科手术,1例行腔内修复术。术后吻合口假性动脉瘤1例(1个),其他部位新动脉瘤形成7个,下肢血管移植物闭塞2例,但患肢无明显缺血坏死。6例患者随访3-293个月,随访中位时间28个月,1例死于肺癌。结论白塞病动脉瘤一旦发生,需积极处理。术前、术后积极免疫抑制治疗可降低外科手术和腔内修复术后并发症发生。因术后有吻合口和其他部位假性动脉瘤复发及血管移植物闭塞可能,需长期随访、及时处理。  相似文献   

11.
OBJECT: The goal of this study was to delineate the angioanatomical features that determine whether a patient with an unruptured middle cerebral artery (MCA) aneurysm is treated using endovascular coil placement or surgical clipping. METHODS: Thirty consecutive patients harboring 34 unruptured MCA aneurysms were evaluated. Patients with unruptured aneurysms are managed prospectively according to the following protocol: the primary treatment recommendation is endovascular packing with Guglielmi detachable coils (GDCs). Surgical clipping is recommended after failed attempts at coil placement or in the presence of angioanatomical features that contraindicate that type of endovascular therapy. Of 34 unruptured MCA aneurysms, two (6%) were successfully embolized and 32 (94%) were clipped. Of these 32 surgically treated aneurysms, in 11 (34%) an attempt at GDC embolization had failed, whereas in 21 (66%) primary clipping was performed because of unfavorable angioanatomy. Of the 13 aneurysms treated endovascularly, two (15%) were successfully excluded, whereas GDC treatment failed in 11 (85%). An unfavorable dome/neck ratio (< 2) and an arterial branch originating at the aneurysm base were the reasons for embolization failure. CONCLUSIONS: Careful evaluation of the angioanatomy of unruptured aneurysms allows selection of the most appropriate treatment. However, for unruptured MCA aneurysms, surgical clipping appears to be the most efficient treatment option. Series of unruptured aneurysms are ideal for comparing treatment results.  相似文献   

12.
目的观察个体化血管内介入治疗椎动脉夹层动脉瘤(VADA)的临床效果。方法回顾性分析38例VADA患者(43枚动脉瘤)。其中10例(10枚)动脉瘤破裂出血,对6枚采用动脉瘤填塞及载瘤动脉闭塞术,4枚以单支架辅助弹簧圈栓塞。对未破裂33枚动脉瘤均行载瘤动脉重建术,以单支架辅助弹簧圈栓塞3枚,双支架辅助弹簧圈栓塞25枚,三支架辅助弹簧圈栓塞5枚。结果血管内介入治疗所有43枚VADA均获成功,对28枚实现完全及次全栓塞、15枚实现部分栓塞。术后随访12个月,34例(38枚动脉瘤)接受全程复查,其中21枚治愈、11枚改善、6枚稳定,未见复发,无新发脑出血或脑缺血症状;改良Rankin量表(mRS)评分0~1分30例,2分2例,3分1例,4分1例。结论根据具体情况采用个体化血管内介入治疗VADA安全、有效,且预后较好。  相似文献   

13.
Of 43 cavernous sinus aneurysms diagnosed over 6 1/2 years, 23 fulfilled indications for treatment; of these 19 were treated, eight surgically and 11 with interventional radiological techniques. Six small and two giant aneurysms were treated surgically: four were clipped, two were repaired primarily, and two were trapped with placement of a saphenous-vein bypass graft. Seven large and four giant aneurysms were treated with interventional radiological techniques: in five cases the proximal internal carotid artery (ICA) was sacrificed; one aneurysm was trapped with detachable balloons; and five were embolized with preservation of the ICA lumen. The mean follow-up period was 25 months. At follow-up examination, three patients in the surgical group were asymptomatic, two had improved, and three had worsened. Three of these patients had asymptomatic infarctions apparent on computerized tomography (CT) scans. At follow-up examination, four radiologically treated patients were asymptomatic, five had improved, two were unchanged, and none had worsened. One patient had asymptomatic and one minimally symptomatic infarction apparent on CT scans; both lesions were embolic foci after aneurysm embolization with preservation of the ICA. It is concluded that treatment risk depends more on the adequacy of collateral circulation than on the size of the aneurysm. A multidisciplinary treatment protocol for these aneurysms is described, dividing patients into high-, moderate-, and low-risk groups based on pretreatment evaluation of the risk of temporary or permanent ICA occlusion using a clinical balloon test occlusion coupled with an ICA-occluded stable xenon/CT cerebral blood flow study. Radiological techniques are suggested for most low-risk patients, while direct surgical techniques are proposed for most moderate- and high-risk patients.  相似文献   

14.
目的总结颅内后循环动脉瘤的特点,探讨其血管内介入治疗的临床疗效。方法回顾性分析40例行血管内介入治疗的颅内后循环动脉瘤患者的临床和影像学资料、介入治疗过程,观察期效果及术后随访结果。结果 40例患者共发现42个后循环动脉瘤,均完成血管内介入治疗,其中8个行单纯弹簧圈栓塞,28个行支架辅助栓塞,1个行Onyx胶栓塞,5个动脉瘤及载瘤动脉同时闭塞。术后即刻DSA造影显示动脉瘤完全栓塞30个,近全栓塞6个,部分栓塞6个。术后6个月随访DSA造影显示动脉瘤完全栓塞36个,近全栓塞4个,部分栓塞1个。患者出院时行改良Rankin量表(mRS)评分,0分35例,1分3例,2分1例,1例死亡为6分;出院后3~6个月随访mRS评分0分38例,1分1例,无动脉瘤复发及新发神经功能障碍病例。结论颅内后循环动脉瘤具有特殊的临床与影像学表现,且复杂动脉瘤较为常见,对于颅内后循环动脉瘤,血管内介入治疗是一种安全有效的治疗方法。  相似文献   

15.
Among 121 intracerebral aneurysms presenting at one institution between 1984 and 1989, 16 were treated by endovascular means. All 16 lesions were intradural and intracranial, and had failed either surgical or endovascular attempts at selective exclusion with parent vessel preservation. The lesions included four giant middle cerebral artery (MCA) aneurysms, one giant anterior communicating artery aneurysm, six giant posterior cerebral artery aneurysms, one posterior inferior cerebellar artery aneurysm, one giant mid-basilar artery aneurysm, two giant fusiform basilar artery aneurysms, and one dissecting vertebral artery aneurysm. One of the 16 patients failed an MCA test occlusion and was approached surgically after attempted endovascular selective occlusion. Treatment involved pretreatment evaluation of cerebral blood flow followed by a preliminary parent vessel test occlusion under neuroleptic analgesia with vigilant neurological monitoring. If the test occlusion was tolerated, it was immediately followed by permanent occlusion of the parent vessel with either detachable or nondetachable balloon or coils. The follow-up period ranged from 1 to 8 years. Excellent outcomes were obtained in 12 cases with complete angiographic obliteration of the aneurysm and no new neurological deficits and/or improvement of the preembolization symptoms. Four patients died: two related to the procedure, one secondary to rupture of another untreated aneurysm, and the fourth from a postoperative MCA thrombosis after having failed endovascular test occlusion. The angiographic, clinical, and cerebral blood flow criteria for occlusion tolerance are discussed.  相似文献   

16.
Endovascular treatment of paraclinoid aneurysms   总被引:3,自引:0,他引:3  
BACKGROUND: Paraclinoid aneurysms include those that are distal to the cavernous segment of the internal carotid artery and proximal to the posterior communicating artery. The purpose of this study was to review our experience with the endovascular treatment of this group of aneurysms, which are difficult to treat surgically. METHODS: Between June 1994 and April 1999, 66 patients (56 female, 10 male) with a mean age of 50.1 years (range 13-75, median 51) underwent endovascular treatment for 71 paraclinoid aneurysms. The mean size of the dome was 8.9 mm (range 3-25 mm, median 7) and the of neck was 3.8 mm (range 1.4-8 mm, median 4). Thirteen patients presented with acute subarachnoid hemorrhage, and 4 with previous subarachnoid hemorrhage. Six aneurysms produced mass effect with visual symptoms, 4 presented with transient ischemic attacks, and 44 were incidental. Nine patients had had previous unsuccessful surgery. All procedures were performed under general anesthesia and with systemic heparinization. RESULTS: Ninety endovascular procedures were performed on 71 aneurysms: GDC coiling in 78 (including 45 with the remodeling technique), permanent balloon occlusion in 9, and 3 had both GDC coiling and permanent balloon occlusion. In ten aneurysms it was not possible to place coils in the lumen of the aneurysm with the available technology and balloon occlusion was not indicated. Five of these were treated surgically and 5 remain untreated. All patients had immediate post procedure angiography. Of the 61 aneurysms that were treated, 46 (75%) have angiographic follow-up of 6 months or more. Morphological outcome following endovascular therapy for 61 aneurysms at last available follow-up showed > 95% occlusion in 52/61 (85.2%) and <95% in 9/61 (14.8%). Eight patients required surgery, 2 for partial coiling, 2 for refilling of a neck remnant, 2 for persistent mass effect and 2 for coil protrusion. In the 90 procedures performed, 2 (2.2%) patients had major permanent deficits (1 monocular blindness, 1 hemiparesis), 1 (1.1%) had a minor visual field cut, and 2 (2.2%) patients died from major embolic events. CONCLUSION: Properly selected paraclinoid aneurysms can be successfully treated by endovascular technology. The morbidity and mortality rate of the endovascular approach in our experience is equal to or better than the published surgical series of similar aneurysms. We recommend that the endovascular approach be given primary consideration in the treatment of paraclinoid aneurysms.  相似文献   

17.
Ogilvy CS  Hoh BL  Singer RJ  Putman CM 《Neurosurgery》2002,51(1):14-21; discussion 21-2
OBJECTIVE: Posterior circulation aneurysms can be difficult lesions to treat surgically, and they have potential for high morbidity and mortality, particularly in elderly patients or those in poor neurological condition. In an effort to improve outcomes, our combined neurosurgical and neuroendovascular unit has used both surgical clipping and endovascular coiling techniques to treat posterior circulation aneurysms. Patients considered at high risk for surgery were managed with endovascular treatment. METHODS: From 1990 to 1998, 197 posterior circulation aneurysms in 189 patients were treated in our combined neurovascular unit. Of these aneurysms, 128 were ruptured, 63 were unruptured, and 6 had a distant history of rupture in patients who came to our center for delayed or repeat treatment. A total of 132 aneurysms were treated with surgical clipping (85 ruptured, 46 unruptured, and 1 with distant history of rupture) and 65 aneurysms were treated with endovascular coiling (43 ruptured, 17 unruptured, and 5 with distant history of rupture). Dissecting aneurysms of the vertebral or posteroinferior cerebellar arteries or aneurysms treated with proximal (Hunterian) occlusion were excluded from this analysis. Surgical risk was assessed using a previously described system (Massachusetts General Hospital [MGH] grade), which incorporates age, Hunt and Hess grade, size of lesion, and Fisher grade. RESULTS: Overall clinical outcomes at 1 year of follow-up were 77.2% excellent or good, 10.2% fair, 4.1% poor, and 8.6% dead. Surgical treatment resulted in 95.6% complete aneurysm occlusion and 4.4% with residual aneurysm after surgical treatment, whereas endovascular treatment resulted in 32.3% complete occlusion, 26.2% with residual aneurysm, and 41.5% with partial occlusion. In most cases, however, treatment with Guglielmi detachable coils (Boston Scientific/Target, Fremont, CA) was performed for palliation rather than complete radiographic occlusion. Outcome was closely associated with MGH grade with either treatment modality. Excellent/good outcomes were achieved in 96, 92.3, 82.9, 46.2, and 0% of surgically treated patients with MGH Grades of 0, 1, 2, 3, and 4, respectively. In comparison, excellent/good outcomes were achieved in 100, 84.2, 61.9, 0, and 50% of endovascularly treated patients with MGH Grades of 0, 1, 2, 3, and 4, respectively. CONCLUSION: A combined surgical and endovascular approach to posterior circulation aneurysms can achieve good outcomes in high-risk surgical patients treated by use of coiling techniques.  相似文献   

18.
Peripherally located aneurysms of the posterior circulation are extremely rare. The outcome of patients with peripherally located aneurysms has been poor, and the treatment of such aneurysms has been surgically challenging. We report a consecutive series of peripherally located ruptured aneurysms in the posterior circulation, and discuss in this article the optimal treatment strategy for such lesions. Clinical presentation, neuroradiological findings, treatment method, and the outcome were reviewed retrospectively. Two cases with distal posterior cerebral artery aneurysm, two with distal posterior inferior cerebellar artery aneurysm, two with anterior inferior cerebellar aneurysm, and one with superior cerebellar artery aneurysm were included in this study (mean age, 59.3 +/- 16.0, M:F = 1:6). Three patients with good neurological status on admission who underwent clipping of the aneurysmal neck via craniotomy showed a favorable outcome. In contrast, four patients with poor neurological status on admission who underwent endovascular proximal occlusion of the parent artery showed an unfavorable outcome. Although the outcome of patients who underwent endovascular surgery was poor, endovascular proximal occlusion was effective in preventing re-rupture of the aneurysms. Proximal occlusion of the parent artery has several shortcomings such as cerebral infarction, but proximal occlusion at the very distal area of the parent arteries would not be critical because of good collateral circulation. Thus, endovascular proximal occlusion may provide us another option in the treatment of peripherally located aneurysms especially in patients with poor neurological status. Further data is needed to discover the optimal treatment for patients with peripherally located cerebral aneurysms.  相似文献   

19.
Endovascular treatment of distally located giant aneurysms   总被引:3,自引:0,他引:3  
Ross IB  Weill A  Piotin M  Moret J 《Neurosurgery》2000,47(5):1147-52; discussion 1152-3
OBJECTIVE: Because giant aneurysms (GAs) can be technically difficult to clip, the endovascular approach is becoming increasingly popular. Endovascular treatment of distally located GAs, which often requires parent vessel occlusion, is particularly challenging because limited pathways are available for collateral flow. We aimed to determine the outcomes of endovascular attempts to treat GAs downstream from the circle of Willis. METHODS: Between 1991 and 1998, 27 patients with 27 distally located very large aneurysms or GAs were evaluated for possible endovascular treatment. Ten underwent selective embolization and 9 were treated with primary parent vessel occlusion, with or without distal bypass. Eight patients could not be treated endovascularly. RESULTS: Selective embolization resulted in only one cure. Two patients died as a result of subarachnoid hemorrhage during the follow-up period. One coil-treated patient, who underwent subsequent spontaneous parent vessel occlusion, and all nine patients treated primarily with parent vessel occlusion were considered cured after their treatments. Only two patients treated with parent vessel occlusion experienced periprocedural ischemia, which did not result in a major deficit in either case. Of the eight patients who could not be treated endovascularly, one succumbed to surgery, four died while being treated conservatively, and three were lost to follow-up monitoring. CONCLUSION: Selective aneurysm embolization is usually not curative in these situations. For selected patients, however, endovascular parent vessel occlusion is usually safe and effective in preventing the progression of symptoms and bleeding.  相似文献   

20.
Summary  Object. We wish to report our experience in the management of residual or recurrent intracranial aneurysm after previous endovascular or surgical treatment.  Methods. We performed a retrospective review of the clinical notes, operation records and cerebral angiograms of eighteen patients who were known to have undergone treatment for residual or recurrent aneurysms.  Results. During the period of April 1994 to May 1999, 210 patients were treated for an intracranial aneurysm either surgically or by endovascular methods. Eighteen of these patients (8.6%) were subsequently treated for residual or recurrent aneurysm. Thirteen achieved a complete occlusion. Complete occlusion was achieved in five of the eight patients who underwent endovascular treatment as a second procedure. Seven out of ten surgical cases achieved complete occlusion. Fifteen patients made a good recovery according to the Glasgow Outcome Score. Two patients who presented in a poor grade subarachnoid haemorrhage (SAH) were left severely disabled. One patient died after retreatment.  Conclusions. The treatment of cerebral aneurysm remnants can be performed effectively using a variety of modalities. The original purpose of the treatment, which is total occlusion of the lesion, can thus be achieved.  相似文献   

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