Pancreatic endocrinomas: A statistical analysis of 1,857 cases

A total of 1857 cases of pancreatic endocrinomas and related pathological disorders producing gut-pancreatic hormones were collected from the world literature and were statistically analyzed and evaluated. The entire series in the present study consisted primarily of histologically confirmed islet cell tumors, but included 30 cases of vasoactive intestinal peptide (VIP)-producing neurogenic tumors and 54 cases of islet hyperplasia, the former being excluded from the systematic evaluation. The series consisted of seven groups: (1) gastrinomas/Zollinger-Ellison syndrome (ZES), (2) somatostatinomas, (3) glucagonomas/diabetes-dermatitis syndrome (DDS), (4) insulinomas/hypoglycemic syndrome (HGS), (5) vipomas/watery diarrhea hypokalemia achlorhydria (WDHA) syndrome, (6) pancreatic polypeptide (PP)-producing tumors (PPomas), and (7) miscellaneous endocrinomas. The statistical analysis dealt mainly with the location, male/female ratio, age distribution, clinical and pathological features, multiplicity, and malignant nature of pancreatic endocrinomas. The delineating of 52 PPomas in this series, and confirmation of the tumor entity by radioimmunoassay and immunocytochemical procedures, were matters of special emphasis in this study.     

Injuries of the stomach. An analysis of 95 cases

In this series the stomach was involved in 8% of patients undergoing surgical exploration for abdominal injuries (most commonly by penetrating trauma). The stomach has strong walls and these are not torn by blunt trauma unless it is severe. Such trauma commonly involves adjacent vascular organs such as the liver, spleen and pancreas, resulting in dangerous haemorrhage. Careful search of both walls of the stomach and the diaphragm, especially after penetrating blunt trauma, is mandatory if complications are to be avoided. The mortality in this series was mostly caused by associated injuries.     

Therapeutic status of stomach cancer in East Germany in 1976 from the surgical viewpoint. A statistical analysis of national and clinical results

Treatment results are reported about 6 220 cases, registered in the National Cancer Registry of the GDR in 1976. 43.7% had only a symptomatic treatment. 56.0% were operated and only 21.0% were resected. Overall postoperative mortality was 20.6%. Out of these patients resected radically only 24.7% had a 5-year-survival. The overall 5-year-survival rate was 5.1%. Regarding site, stage and surgical methods these results are not satisfying and have to be improved. Therefore, the necessity of regional concentration of gastric cancer treatment is emphasized.     

Ameloblastic carcinoma: an analysis of 14 cases.

OBJECTIVES: To present the classifications of malignant ameloblastomas, provide histopathologic guidelines for the diagnosis of ameloblastic carcinoma, and discuss treatment and long-term follow-up. STUDY DESIGN: Fourteen archival specimens of ameloblastic carcinoma with detailed treatment and follow-up documentation were identified by the authors. RESULTS: Traditional methods of microscopic observation form the basis for diagnosis. Histopathologic features of ameloblastic carcinoma include lack of differentiation, hypercellularity, high mitotic index, vascular invasion, and neural invasion. CONCLUSION: The long-term follow-up findings in this study support the concept that aggressive surgical intervention provides the best chance for survival. Patients treated otherwise had recurrence. The patients with the highest number of recurrences did not survive the disease.     

中晚期胃癌术前新辅助化疗92例分析

目的评价中晚期胃癌术前新辅助化疗的作用。方法总结2003年至2008年间92例入院后经CT、B超、胃镜等检查后诊断为中晚期胃癌并通过新辅助化疗后再行手术治疗的病例,并与2000年至2002年间收治的未经新辅助化疗的中晚期胃癌49例对照分析。结果化疗组肿瘤缩小或明显缩小者66例（71.7%）,行根治性手术切除者69例（75%）,行局部切除者17例（18.5%）,姑息性手术者6例（6.5%）。对照组行根治性手术切除者24例（48.9%）,行局部切除者15例（30.6%）,姑息性手术者10例（20.4%）。所有病例均术后经病理证实,化疗组Ⅲa期46例,Ⅲb期33例,Ⅳ期13例,对照组Ⅲa期25例,Ⅲb期16例,Ⅳ期8例。结论对于以往手术切除较为困难或根治率低的中晚期胃癌,术前配合新辅助化疗,可提高手术切除率及根治率。     

Arguments for regional centralized treatment of stomach cancer. A statistical study of national results

An analysis was made of therapeutic results obtained from 6,220 cases of primary gastric carcinoma and from 1,308 cases of radical surgery, as listed in the 1976 National Cancer Record of the GDR. Results were examined relative to the number of radical operations per annum. Involved in the above treatment of gastric carcinoma were 237 surgical wards throughout the GDR. Numbers of radical operations were between one and four per annum in 56.1 per cent of all wards (Group I), between 5 and 19 in 40.5 per cent (Group II), and 20 or more in only 3.4 per cent (Group III). Radical removability accounted for 13.2 per cent of all cases in Group I, 28.2 per cent in Group II, and 38.5 per cent in Group III. Better therapeutic results relative to the number of radical operations per annum were reflected in the following absolute five-year survival rates: 3.4 per cent in Group I, 6.8 per cent in Group II, and 10.6 per cent in Group III. These findings are likely to support the advisability of regional centralisation of treatment for stomach carcinoma.