Efficacy of antiplaque mouthwashes: a five-day clinical trial

The aim of this study was to evaluate and compare the efficacy of antiplaque mouthwashes. Plaque levels were determined by applying a plaque-disclosing solution using the Turesky et al modification of the Quigley Hein plaque index. The control group (n = 6) brushed twice per day with fluoride toothpaste for one minute and rinsed with water, while the study groups (n = 6) brushed once per day with fluoride toothpaste for one minute, followed by rinsing with 5.0 mL of mouthwash diluted with 10.0 mL of water for 30 seconds. The control group brushed and rinsed with water twice per day. The results indicated that cetylpyridinium chloride in combination with sodium fluoride offered maximum plaque inhibition, followed by chlorhexidine gluconate and sodium monofluorophosphate, while plaque levels increased in the control group and with the combination of chlorhexidine gluconate and sodium fluoride. The only antiplaque agents to demonstrate a statistically significant difference from the control were cetylpyridinium chloride in combination with sodium fluoride, and chlorhexidine gluconate. Increasing the fluoride concentration had no impact on antiplaque activity.     

A meta-analysis of six-month studies of antiplaque and antigingivitis agents

BACKGROUND AND METHODS: The author conducted a systematic review of the literature to evaluate the efficacy of antigingivitis and antiplaque products in six-month trials. He searched electronic databases for six-month randomized clinical studies that evaluated both antiplaque and antigingivitis properties of dentifrices or mouthrinses. In addition, the author solicited unpublished studies from manufacturers. RESULTS: Seventeen studies support the antiplaque, antigingivitis effects of dentifrices containing 0.30 percent triclosan, 2.0 percent Gantrez copolymer. There was no evidence of efficacy for triclosan products containing either soluble pyrophosphate or zinc citrate. Dentifrices with stannous fluoride had statistically significant, but marginally clinically significant, evidence of an antiplaque effect; however, there was both a statistically and clinically significant antigingivitis effect. The largest body of studies (21 studies) supported the efficacy of mouthrinses with essential oils. A smaller body of studies (seven) supported a strong antiplaque, antigingivitis effect of mouthrinses with 0.12 percent chlorhexidine. Results for mouthrinses with cetylpyridinium chloride varied and depended on the product's formula. CONCLUSIONS: The studies in this systematic review provide strong evidence of the antiplaque, antigingivitis effects of multiple agents. These results support the use of these agents as part of a typical oral hygiene regimen.     

Review of fluorosis risk of self-applied topical fluorides: dentifrices, mouthrinses and gels

Abstract – The literature on the risks of dental fluorosis and the benefits from the use of fluoride dentifrices, mouthrinses and self-applied gels has been briefly reviewed. While there are several studies that have investigated the impact of dentifrices on the development of dental fluorosis, results are mixed. Although there is far less research investigating the relationship between the use of mouthrinses and dental fluorosis, the available evidence generally fails to identify this technology as one of the major causes of dental fluorosis. Although there is little direct evidence to suggest that the use of self-applied fluoride gels contributes to the development of denial fluorosis, ingestion of fluoride from these systems is of genuine concern and their use by preschool age children is not recommended.     

The antibacterial and antiplaque effectiveness of mouthwashes containing cetylpyridinium chloride with and without alcohol in improving gingival health

This article briefly discusses the antibacterial action ofcetylpyridinium chloride (CPC) and its efficacy in the removal of bacterial plaque as an adjunct to the mechanical cleaning of tooth surfaces. It reviews new studies on the effectiveness of mouthwash formulations containing CPC against two common oral bacteria species and in disrupting plaque biofilms. Finally, this article reviews three clinical studies which support that the daily use of mouthwashes containing 0.075% CPC, with and without alcohol, represents a valuable complement to daily mechanical plaque control.     

A physiochemical approach to the study of amines as antiplaque agents.

Alkyl and aromatic amines were evaluated for inhibitory activity against S mutans 6715. Only the alkylamines were active and this may be due to their greater basicity. The agents that showed good activity were decylamine, dodecylamine, tetradecylamine, and hexadecylamine. In addition to the free bases, the hydrochloride and hydrofluoride salts were also tested for inhibitory activity and the same four agents were shown to be most active. These agents appear to hold good promise as antiplaque agents against S mutans 6715, therefore, further in vitro studies against other plaque-forming bacteria and toxicological and clinical evaluation seems to be warranted to determine the best clinical agent.     

Comparison of antiplaque agents using an in vitro assay reflecting oral conditions.

An in vitro assay is described using saliva-treated bovine enamel slabs for determining the potential of chemotherapeutic agents to adsorb to tooth surfaces and act against plaque-forming bacteria. Chlorhexidine was found to inhibit the formation of in vitro plaque by Actinomyces viscosus, A naeslundii, Streptococcus mutans and S sanguis. Actinobolin was found to have marked antibacterial properties but limited adsorptive qualities.     

Calcium release rates from tooth enamel treated with dentifrices containing whitening agents and abrasives

Tooth whitening agents containing hydrogen peroxide and carbamide peroxide are used frequently in esthetic dental procedures. However, lesions on the enamel surface have been attributed to the action of these products. Using conventional procedures for separating and isolating biological structures, powdered enamel was obtained and treated with hydrogen peroxide, carbamide peroxide, and sodium bicarbonate, ingredients typically found in dentifrices. The enamel was exposed to different pH levels, and atomic emission spectrometry was used to determine calcium release rates. As the pH level increased, the rate of calcium release from enamel treated with dentifrices containing whitening agents decreased. Carbamide peroxide produced the lowest amount of decalcification, while sodium bicarbonate produced the highest release rates at all pH levels.     

Influence of buffering effects of dentifrices and fluoride gels on abrasion on eroded dentine

OBJECTIVE: Evaluation of abrasion resistance of eroded and non-eroded dentine brushed with experimental dentifrices and gels of varying buffering capacities. DESIGN: One hundred and twenty human dentine specimens were distributed among six groups (A-F) according to the different buffering capacities of experimental toothpastes and gels. The dentifrices (pH: 4.5) and gels (pH: 4.5) differed in fluoride content, RDA-value and buffer capacity (given as mg KOH needed for neutralisation): (A) 0.125%F, RDA: 77, 6mg KOH; (B) 0.125%F, RDA: 125, 24mg KOH; (C) 0.125%F, RDA: 129, 12mg KOH; (D) 0%F, RDA: 81, 1.55mg KOH; (E) 1.25%F, RDA: 21, 8.5mg KOH; (F) 0.125%F, RDA: 7, 3.11mg KOH. Ten specimens were cycled through three alternating demineralisations (1% citric acid, 5min) and remineralisations (artificial saliva, 1min) including brushing abrasion in an automatic brushing machine (2 x 2000 strokes). Ten samples of each group were not eroded, but only brushed. RESULTS: After three cycles, loss of dentine was determined by profilometry (mean +/- S.D. [microm]). Eroded samples: (A) 37.12+/-4.95; (B) 48.67+/-4.77; (C) 39.88+/-3.76; (D) 32.92+/-2.67; (E) 3.65+/-1.35; (F) 6.47+/-1.31. Uneroded samples: (A) 30.78+/-6.47; (B) 37.84+/-7.75; (C) 30.07+/-3.05; (D) 26.93+/-2.30; (E) 1.76+/-0.94; (F) 0.51+/-0.18. Analysis of variance revealed significantly higher abrasion values for the eroded compared to the non-eroded samples (P相似文献