Bone mineral density in diabetes mellitus patients with and without a Charcot foot

Objective:  To measure bone mineral density in patients with diabetes mellitus and the complication Charcot osteoarthropathy (CA). Research design and methods:  A total of 49 patients with diabetes were investigated. The population consisted of patients with an acute CA (n = 17) or chronic CA (n = 7). Control groups consisted of diabetes patients with (n = 9) and without neuropathy (n = 11) and who had an amputation of the first toe (n = 5). Values measured were bone mineral density (BMD) in lumbar spine, hip and calcaneus, using lunar DEXA scanner. The bone turnover markers CTX‐1 and N‐MID were measured. Results:  There were no differences in BMD measured in the spine and hip. There was an increase in the markers of bone turnover in the patients with acute CA. The BMD of the calcaneus was statistically lower in the affected foot in patients with chronic Charcot (P < 0·01), than in the unaffected foot, but there were no statistically significant differences between the BMD of the calcaneus in the feet in the other groups. Conclusions:  From this study, we can conclude that there were no differences in BMD values in the spine and hip between groups. There were no differences between BMD of the calcaneus between groups, except that patients with chronic Charcot had a significantly lower calcaneal BMD in the affected foot than in the healthy foot. Furthermore, there was an increased bone turnover in the group with acute CA, which was not found in the other patients groups. This suggests that the Charcot foot is a rather local phenomenon, with little effect on the skeleton in general.     

运动对绝经后女性骨密度的影响

目的：观察运动对绝经后女性骨密度的影响。方法：绝经后女性106名分为运动组37例和对照组69例。运动组进行广场舞、爬山、慢跑等运动干预,对照组未进行任何干预。采用双能X线吸收仪测试其全身及各部位骨矿含量（BMC）和骨密度（BMD）,并进行比较。结果：运动干预8个月后,运动组全身BMD和BMC值均较干预前及对照组明显增加（P＜0．05）,而对照组全身BMD和BMC值均较8个月前下降,但差异无统计学意义。运动组胸椎的BMD、BMC和盆骨的BMC均较干预前及对照组明显增加（P＜0．05）,而腰椎的BMD、BMC和盆骨的BMD干预后差异无统计学意义;对照组干预后腰椎、盆骨的BMD、BMC均较8个月前明显下降（P＜0．05）,而胸椎的BMD、BMC 8个月前后差异无统计学意义。运动组上肢优势侧BMD、BMC和下肢双侧BMD、BMC均较干预前及对照组明显增加（ P＜0．05）,而上肢非优势侧BMD、BMC干预前后差异无统计学意义;对照组上肢非优势侧BMD、BMC均较8个月前及上肢优势侧BMD明显下降（P＜0．05）,而上肢优势侧BMC和下肢双侧BMD、BMC 8个月前后差异无统计学意义。结论：常规运动可显著提高绝经后女性胸椎 BM D和BM C ,而只能维持其腰椎和盆骨的BM D、BM C;上下肢、优势侧与非优势侧活动不均衡可影响相关部位 BM D和BM C的变化。     

卵巢切除大鼠皮质骨骨密度与生物力学特性分析(英文)

目的观察去势后不同时间大鼠皮质骨骨密度与生物力学特性的变化,以探讨雌激素减少对皮质骨骨密度及生物力学特性的影响。方法40只雌性大鼠随机分为去势组和对照组,各组分别于术后6及12周各处死其中10只。取血、尿标本分别测血清Ca,P,碱性磷酸酶(ALP)和尿Ca,P,羟脯氨酸(HOP)。用骨密度仪测定大鼠胫骨骨密度,用三点挤压实验测定股骨最大载荷、弯曲刚度、最大应力以及弹性模量的变化。结果去势6及12周组血Ca,ALP,尿Ca/Cr,尿HOP/Cr均明显高于对照组(P<0.01),而血P、尿P/Cr与对照组相比无显著差异(P>0.5)。去势6周骨密度与最大载荷、弯曲刚度、最大应力以及弹性模量与对照组相比无显著差异(P>0.05),而去势12周组骨密度明显低于对照组(P<0.01),而最大载荷、弯曲刚度、最大应力以及弹性模量均低于对照组(P<0.05)。结论骨密度和生物力学参数的测量对于骨质疏松症动物模型的建立及治疗骨质疏松症药物疗效的判断有重要的意义。     

女性腰椎侧位与后前位骨密度的相关性研究

目的分析女性腰椎侧位与后前位骨密度(BMD)的相关性,探索女性腰椎骨密度的变化规律。方法观察166名45~70岁的女性无骨质疏松症状健康体检者,使用GE Lunar Prodigy型双能骨密度仪测量观察对象的腰椎后前位BMD(L2-4BMD)、侧位BMD(B2-4BMD),根据是否绝经及L2-4BMD是否正常,将观察对象分为4组,即未绝经L2-4BMD正常组、未绝经L2-4BMD异常组、绝经后L2-4BMD正常组、绝经后L2-4BMD异常组,分析L2-4BMD、B2-4BMD及其与年龄、体质量指数等的相关关系,并建立回归方程。结果在L2-4BMD正常组,绝经者BMD与未绝经者比较有显著差异,绝经后BMD明显降低;在L2-4BMD异常组,绝经者BMD与未绝经者比较,L2-4BMD明显降低,B2-4BMD无显著差异。各组B2-4BMD与L2-4BMD均具有显著相关关系。绝经后L2-4BMD正常组B2-4BMD与绝经年数的相关有显著统计学意义。多元回归分析显示,因变量B2-4BMD(y)主要由L2-4BMD(X1)、绝经年数(X2)、体质量指数(X3)决定,各组具有相应的回归模型:绝经后L2-4BMD正常组、绝经后L2-4BMD异常组、未绝经L2-4BMD正常组、未绝经L2-4BMD异常组,其B2-4BMD的回归方程分别为:r=0.147+0.501X1-0.007X2,y=-0.437+0.457X1+0.024X3,y=0.102+0.559X1,y=-0.350+0.947X1。结论女性B2-4BMD与L2-4BMD有显著相关关系;女性B2-4BMD与是否绝经、L2-4BMD是否正常有关,绝经后女性更应当早期检查骨密度。     

老年知识分子骨密度影响因素286例研究

目的：探讨影响老年知识分子骨密度的因素及防治老年骨质疏松的措施。方法：采用整群抽样方法对两所高等院校２８６例（男１０３例，女１８３例）５０岁以上老人进行骨密度及相关因素调查。结果：随着年龄增长，骨密度呈现明显下降趋势。老年女性较男性骨密度下降显著。适度运动及经常饮用牛奶可促使骨密度增高。结论：运动及合理膳食有预防老年骨密度下降的作用     

兰州市区汉族、回族正常人群骨密度研究

目的 通过测量兰州市区1865例次汉族、回族健康人群的骨密度(bone mineral density,BMD),确定本地区汉族、回族BMD的正常参考值范围,并比较研究汉族、回族BMD随年龄变化的规律.方法 使用X线骨密度仪(prodigy DPX-NT型美国GE-Luner公司)测定兰州市区20～75岁以上的汉族、回族健康人群的腰椎和股骨BMD,按不同性别每5岁分为一年龄组,得出BMD均值、标准差.结果 汉族、回族男性及女性各部位出现骨峰值的年龄段略有不同,腰2～4椎体汉族、回族男性及女性基本在30～35岁左右达到骨峰值,汉族、回族男性及女性的股骨颈骨峰值在25～30岁年龄组,汉族、回族男性及女性的大转子骨峰值在20～25岁年龄组,汉族、回族男性及女性的Ward三角区骨峰值在25～30岁年龄组,但多数均在40岁前随骨量逐渐增加而达到骨峰值.其后随年龄的增长BMD降低,女性BMD在50岁后加速下降.男性无加速下降的趋势.结论 本研究建立了兰州市区汉族、回族各年龄段BMD的正常值参考范围,为今后骨质疏松的预防、诊断、研究提供了客观数据和比较的依据.     

脑卒中偏瘫患者骨密度变化及继发骨质疏松症的特点

目的：探讨脑卒中患者肢体瘫痪对其骨密度（BMD）和骨质疏松（OP）患病率的影响。方法：102例广东省佛山地区常住的脑卒中患者（脑卒中组），男46例，女56例，年龄55—85岁（平均72.8±9.2岁），使用美国 Hologic公司双能X线骨密度仪对正位腰椎（L1-L4）、双侧前臂远端和股骨近端进行BMD测定，并与352例本地区健康人（对照组）进行BMD及OP患病率的比较。结果：脑卒中组的偏瘫侧前臂、股骨颈、Ward′s区的BMD值明显低于健侧（0.444±0.11 vs 0.478±0.09，0.716±0.16 vs 0.757±0.16, 0.373±0.15 vs 0.407±0.15, P<0.05），偏瘫侧股骨颈、Ward′s区和腰椎BMD明显低于对照组（0.716±0.16 vs 0.844±0.12, 0.373±0.15 vs 0.495±0.13, 0.768±0.18 vs 0.831±0.13, P<0.05）。病程≥3个月的患者的偏瘫侧前臂、股骨颈和腰椎BMD明显低于病程<3个月的患者（0.415±0.10 vs 0.474±0.11，0.672±0.16 vs 0.751±0.16，0.722±0.14 vs 0.802±0.19，P<0.05），且病程≥3个月的患者的健侧BMD也低于病程<3个月的患者，但差异没有显著性（P>0.05）。女性脑卒中患者各部位的BMD明显低于男性（P<0.05）。脑卒中组偏瘫侧股骨的OP患病率高于健侧（P<0.05），男性腰椎和股骨、女性股骨的OP患病率高于对照组（P<0.05）。结论：脑卒中后偏瘫患者患侧前臂、股骨近端和腰椎BMD度低于健康人和健侧；女性患者BMD低于男性患者，病程越长，BMD越低。患侧肢体OP患病率高于健侧，脑卒中患者股骨的OP患病率高于健康人。     

黔江区正常人群骨密度调查研究

目的：了解黔江区健康成年人骨密度变化规律及骨质疏松患病情况,指导骨质疏松症的防治。方法应用美国 LUNAR Prodigy 双能 X 线骨密度仪（DXA）,测量1110例（男483例,女627例）20岁以上黔江区居民腰椎正位（L1～4）骨密度（BMD）。结果（1）黔江区健康男性腰椎骨密度峰值出现在30～34岁年龄组;女性骨密度峰值出现在35～39岁年龄组。女性45岁以后骨密度明显下降（P ＜0．01）,男性60岁以后骨密度明显下降（P ＜0．05）。（2）黔江区50岁以上健康男性腰椎骨质疏松患病率为13．2％,女性腰椎骨质疏松患病率为42％;男性腰椎骨量减少患病率为34．9％。女性腰椎骨量减少患病率为38．5％。（3）与其他年龄组比较,50～54岁组、55～59岁组女性的骨质疏松患病率增高（P ＜0．01）,但60岁以后无明显差异,男性相邻年龄组患病率无明显差异;50～54岁、55～59岁组同龄男女患病率差异无统计学意义,60岁以后女性患病率高于男性（P ＜0．01）。结论（1）黔江区骨质疏松症防治形势严峻;（2）减少女性 OP 患病率,围绝经期干预极为关键。     

Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women

Osteopontin (OPN) is an extracellular matrix protein that is expressed in bone cells such as osteoblast and osteocytes and associated with bone turnover and bone mineral density (BMD) in postmenopausal women. Here, we aimed to investigate the relationship between circulating OPN levels and BMD in postmenopausal women in Southern China. A total of 362 postmenopausal women were consecutively recruited into this study from 2011–2013. Serum levels of OPN, receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL), and bone turnover markers were analyzed. BMD was measured by dual energy X-ray absorptiometry. Osteoporosis and osteopenia were diagnosed according to the World Health Organization criteria. Serum OPN levels were remarkably higher in the osteoporotic group than those in the osteopenic and normal groups (all p?r?=??0.25, p?=?0.004; r?=??0.66, p?r?=??0.28, p?=?0.001; respectively) and positively associated with type I procollagen amino-terminal propeptide (PINP), carboxy-terminal cross-linking telopeptide of type I collagen (CTX), and RANKL (r?=?0.20, p?=?0.020; r?=?0.17, p?=?0.036; r?=?0.19, p?=?0.028, respectively) in the osteoporotic group. In multiple regression analyses, lumbar spine BMD, PTH and RANKL were the predictors for serum OPN levels. In conclusion, OPN serum levels are negatively related to BMD and positively correlated with bone turnover levels in this group of Chinese postmenopausal women.     

青年女性肌力、身体成分与骨密度的关联性研究

目的:通过对青年女性不同部位肌力、身体成分、BMD的同步综合性实验,探讨它们之间的确切关联,为骨质疏松早期干预和女性体质改善提供依据。方法:25—44岁女性(5岁分组),进行仰卧推举、负重蹲起、负重屈肘的1RM和仰卧推举15RM、仰卧举腿等肌力与耐力测试;同步使用GE双能X线骨密度仪进行全身、正位脊椎(L2—L4)、双侧股骨颈BMD及体脂百分比、肌肉含量等身体成分测定。结果:青年女性30岁以后,体重和体脂百分比有明显上升,BMD水平在30岁左右最高。仰卧推举与全身BMD值的相关系数为0.344—0.728。40—44岁年龄组仰卧举腿次数与正位脊柱BMD相关系数为0.726(P<0.05),提示随着年龄的增大,腰腹肌肉耐力可在一定程度上影响正位脊柱BMD水平。结论:青年女性的上肢和胸背部最大肌力、胸背部、腰腹部肌肉耐力与骨密度关系密切,提示加强这部分肌力练习的针对性,对于提高全身BMD有更为积极的作用;青年女性从40岁左右开始全身BMD水平下降明显,其中股骨颈的BMD下降更早;增加肌肉含量对提高骨密度水平有直接作用。     

Comprehensive osteoporosis management with easy access to bone mineral density measurements

Background The majority of people with osteoporosis are never evaluated even though effective treatments are available. The County Council of Värmland in Sweden has implemented an osteoporosis management model that has been shown to be effective in promoting awareness and providing care for osteoporosis patients. Discussions among a prevention group on osteoporosis in the county council were opened in 1997. The county of Värmland covers a large area, and the distances from the peripheral parts to the main city are approximately 300 km and cumbersome for the inhabitants. The importance of having an osteoporosis service that could reach the county inhabitants in a convenient way was therefore recognized. Methods Three thousand four hundred patients were evaluated between March 2001 and December 2003. Guidelines for patient selection for bone density testing and treatment guidelines were formulated. Promoting awareness was an important prerequisite for the model to function. This was accomplished by having the measurement devices where the patients showed up and by regular education of the primary care doctors. Results and conclusions A multidisciplinary team was established and consisted of primary care doctors, orthopaedic surgeons, internists, physiotherapists, a patient organization member, a county health care representative and nurses. Team members met every third month and agreed upon clinical guidelines for implementing the system. The presented osteoporosis management system is not a screening approach as all patients had risk factors for osteoporosis before they were suggested for bone density testing. This study shows that providing a comprehensive package of measures makes it possible to establish an effective osteoporosis management system with limited economical resources.     

2型糖尿病性骨质疏松症病人的护理

目的了解2型糖尿病性骨质疏松症病人骨质疏松的情况并制订护理对策。方法对65例2型糖尿病性骨质疏松症病人使用双能X线骨密度仪测定病人骨质情况,给予饮食控制、适当运动和(或)口服降糖药物治疗以控制血糖,口服钙尔奇、福善美等药物治疗骨质疏松,以及心理护理,运动、饮食的指导。结果65例病人骨密度均有不同程度的改变,其中12例发生股骨颈骨折,17例发生腰椎压缩性骨折,6例骨折后发生压疮。结论糖尿病病人骨质疏松的治疗除了控制血糖外,可通过X线片及骨密度仪测定判断病人骨质疏松情况,并实施健康教育,让病人掌握糖尿病骨质疏松症基本知识、保健知识,达到减少并发症发生,提高病人生活质量的目的。     

Effects of alendronate and risedronate on bone mineral density and bone turnover markers in late postmenopausal women with osteoporosis

This study was undertaken to compare the effects of alendronate and risedronate on bone mineral density (BMD) and bone turnover markers (BTMs) in late postmenopausal women with osteoporosis. Thirty women older than 60 y of age were randomly assigned to receive alendronate 10 mg (n=16) or risedronate 5 mg (n=14) on a daily basis. The patients were followed every 3 mo for 12 mo. BMD measurements were taken at baseline and at the end of the study, and BTMs were measured at 3-mo intervals. By the end of the study, there were statistically significant increases in BMD in both groups at all sites at which they were measured (P < .001). However, these differences were not statistically significant between groups. By the end of the study, all BTMs had decreased significantly and to a similar extent in both groups. The most significant change was observed in the third month of the study. A negative correlation was noted between percentage change in bonespecific alkaline phosphatase and femoral neck BMD (r=-0.467). This study reported no difference between the 2 drugs in their effects on BMD and BTMs.     

成都地区城乡人群骨密度调查分析

目的调查成都地区城乡人群腰椎、髋部骨密度（BMD）和原发性骨质疏松症（OP）的患病率及影响因素。方法用整群随机抽样≥20岁人群共1460人,采用DEXA测量L     

早期干预对脊髓损伤大鼠骨密度的影响

目的：建立脊髓损伤(SCI)动物模型，探讨在SCI后早期应用阿仑膦酸钠(ALN)和，或脉冲电磁场(PEMFs)对SCI大鼠骨密度(BMD)的影响。方法：将62只3月龄健康雌性SD大鼠随机分为假手术(Sham)组、SCI组、SCI ALN组、SCI PEMFs组、SCI PEMFs ALN组，Sham组仅行椎板切除术，其余4组行T10椎体水平脊髓完全横向切断术。脊髓横断大鼠于术后1周开始应用ALN和，或PEMFs，ALN每次0．25mg/kg腹腔注射，每周3次，共7周；PEMFs 30min／d，共7周。所有动物于术后8周时取材，检测股骨BMD值。结果：3月龄健康雌性SD大鼠脊髓完全横断术后8周时股骨BMD显减低；PEMFs早期应用可使股骨整体、股骨中段及下端BMD显增高：ALN早期应用可使股骨整体、股骨中段及股骨上下端BMD显增高；在本实验条件下ALN作用比PEMFs更强、更全面：ALN及：PEMFs早期联合应用比二单独应用时在BMD方面表现出更好的改善趋势，但析因分析表明二早期联合应用的协同效应不显。结论：3月龄雌性健康SD大鼠脊髓完全横断术后8周时股骨已发生显的骨量丢失：ALN及PEMFs早期应用可抑制SCI后骨量丢失，其中ALN的作用比PEMFs更强。     

河北地区2型糖尿病患者骨密度变化与影响因素的初步探讨

目的测定河北地区2型糖尿病患者骨密度,并对其影响因素进行相关分析,以探讨2型糖尿病患者骨密度的改变及骨质疏松的发病机制,为其防治提供理论依据。方法双能X线吸收法测定57例2型糖尿病患者和61例年龄、体质量指数(BMI)匹配的对照组的腰椎及双侧股骨骨密度。结果2型糖尿病男性患者骨密度在第1腰椎,女性右侧股骨大转子、粗隆间及右侧股骨平均值较正常对照组显著下降,分别为(0.875±0.192)g/cm2vs(1.038±0.288)g/cm2,(0.579±0.979)g/cm2vs(0.637±0.109)g/cm2,(0.880±0.115)g/cm2vs(0.949±0.165)g/cm2,(0.767±0.100)g/cm2vs(0.823±0.137)g/cm2,均P<0.05;女性糖尿病骨质疏松患者与非糖尿病骨质疏松患者的临床资料比较,糖尿病组的空腹血糖(FBG)、餐后血糖(PBG)、糖化血红蛋白(HbA1c)显著升高,分别为(8.38±2.50)mmol/L vs(5.20±0.27)mmol/L,(13.17±3.86)mmol/L vs(6.70±0.40)mmol/L,(7.29±1.12)%vs(5.94±0.16)%,均P<0.05;糖尿病患者的骨密度与病程(男性r=-0.603,P=0.043;女性r=-0.461,P=0.016)、HbA1c(男性r=-0.690,P=0.041;女性r=-0.436,P=0.021)呈负相关,与BMI(男性r=0.654,P=0.043;女性r=0.413,P=0.028)呈正相关,女性糖尿病患者的骨密度还与年龄(r=-0.457,P=0.016)、绝经年限(r=-0.561,P=0.003)呈负相关,与雌激素(r=0.384,P=0.039)呈正相关。结论2型糖尿病患者较正常人易发生骨质疏松;血糖控制不良、低BMI和病程长为2型糖尿病合并骨质疏松的高危因素。     

Effects of lumbar disc surgery on bone mineral density in women with lumbar disc disease

This prospective study evaluated 60 reproductive-age and postmenopausal women with lumbar disc disease to demonstrate the short-term effects of lumbar disc surgery on bone mineral density (BMD). Lumbar BMD was measured preoperatively and 3 months postoperatively by dual-energy X-ray absorptiometry (DEXA). Surgery was performed at only one level (L3-L4) and consisted of partial hemilaminectomy, discectomy, and, if necessary, partial facetectomy. Before surgery, 50% of the patients had osteopenia, and 31.7% had osteoporosis. After surgery, BMD decreased 5.5% in L3 vertebrae (P=.07), 14% in L4 vertebrae (P=.003), and 4.6% in L1-L4 (P=.039). Six of 11 patients with normal BMD before surgery became osteopenic postoperatively; 9 of 30 women with osteopenia fulfilled criteria for osteoporosis after surgery. Reproductive-age and postmenopausal women undergoing surgery for lumbar disc disease are at risk of bone loss and should be spared an extensive procedure, which can further increase the amount of bone lost. All women for whom a surgical intervention is planned should be evaluated by DEXA preoperatively and postoperatively.     

Pamidronate increases bone mineral density in women with postmenopausal or steroid-induced osteoporosis

INTRODUCTION: We aimed to determine the efficacy and safety of a cyclic intravenous therapy with pamidronate in patients with postmenopausal or glucocorticoid-induced osteoporosis. METHODS: We enrolled 86 Austrian female patients with postmenopausal (n = 69, mean age 68.13 +/- 1.14) or glucocorticoid-induced (n = 17, mean age 66.89 +/- 2.03) osteoporosis defined as a T-score of < -2.5 for bone mineral density (BMD) of the lumbar spine L1-L4. Patients received a single intravenous dose of 30 mg pamidronate at 3 months intervals. The per cent change in BMD was primary, whereas the safety and the biological response were secondary endpoints. RESULTS: Seventy-six female patients (88%) completed study. Sixty patients received pamidronate therapy for the treatment of late postmenopausal osteoporosis and 16 patients received the same treatment for glucocorticoid-induced osteoporosis. At the end of the trial, lumbar spine (L1-L4) BMD increased significantly in patients with postmenopausal osteoporosis (P = 0.000067), whereas in patients with glucocorticoid-induced osteoporosis no significant change was observed (P = 0.724). The increase in the Ward's triangle BMD did not reach significance level in postmenopausal women receiving pamidronate (P = 0.0740). However, pamidronate treatment for glucocorticoid-induced osteoporosis resulted in a significant increase in Ward's triangle BMD (P = 0.0029). The efficacy of pamidronate treatment for postmenopausal osteoporosis was also reflected in a decrease in circulating biochemical markers for bone formation, including alkaline phosphatase and osteocalcin. In addition, pamidronate was well tolerated with no incidence of severe gastrointestinal events. CONCLUSION: Cyclic intravenous administration of pamidronate is well-tolerated therapy in postmenopausal osteoporosis, and increases spinal BMD. Randomized controlled studies with adequate number of patients are needed to test the efficacy of the compound in the treatment of glucocorticoid-induced osteoporosis.     

住院老年男性26例骨密度与雄性激素关系分析

目的:观察老年骨质疏松症与雄激素水平是否有关。方法:住院>60岁的老年男性病人26例,用酶联免疫方法测定性激素,包括睾酮(T)、促性腺激素(FSH、LH)泌乳素(PLT),雌激素(E2)。应用NOLAND双能X线骨密度仪测定骨密度,并进行相关分析。结果:显示睾酮(T)与Ward三角区骨密度(BMD)密切相关,r=0.4075,P<0.025;促黄体生成素(LH)与L2～4BMD密切相关,r=0.4649,P<0.01。结论:雄激素减低是造成老年男性骨质疏松的重要因素之一。     

中药骨康对去势大鼠血清骨钙素及离体骨密度的影响

目的探讨中药骨康对绝经后骨质疏松大鼠模型血清骨钙素的影响。方法采用雌性SD大鼠,运用随机对照分组的原则,分别分为正常对照组、模型组、中药骨康组及尼尔雌醇组,去双侧卵巢后造绝经后骨质疏松大鼠模型,造模3个月后,分别采用生理盐水、中药骨康及尼尔雌醇对其进行灌胃,灌胃3个月后采用摘眼球取血,离心分离血清,放免分析法测定其血清骨钙素含量,并行离体右胫骨双能X线扫描。结果中药骨康组大鼠血清骨钙素水平明显高于模型组及尼尔雌醇组,两者相比有显著性差异,P<0.05;骨康治疗组大鼠离体骨密度显著高于模型组,两者相比P<0.05。结论中药骨康能显著提高模型大鼠血清骨钙素水平,并能显著提高其离体骨骨密度,表明其具有促进去势模型大鼠骨形成的作用。