66例痤疮患者血清睾酮及雌二醇水平研究

对６６例痤疮患者和２０名正常人的血清睾酮及雌二醇水平进行检测。结果显示：伴有多毛现象女性患者的血清睾酮水平和男性患者的雌二醇水平明显高于正常对照组（Ｐ〈０．０５），提示痤疮发生与性激素水平改变有关。     

座疮患者血清睾酮及雌二醇水平研究

我们测定了45例痊疮患者及38例正常人血清睾酮及雌二醇水平男性患者组血清雌二醇水平(230.2pmol/L)高于正常对照组(163.9 mol/L).女性患者组血清睾酮水平(5.45nmo1/L)高于正常对照组(3.71nmol/L).我们观察到18例女性患者中16例((88.9%)伴有程度不同的月经周期紊乱,故建议这种情况的痤疮患者可采用人工周期疗法.     

The effect of nizoral on hypophyseal gonadotropic function and the production of sex steroid hormones by the testes and ovaries in human subjects and experimental animals

Experiments with mature male and female rats and female mice have shown that nizoral, a nonsteroid estrogenic drug, in a dose of 10 mg/kg stimulates estradiol production in male and female rats, suppresses basal and stimulates LH production, promotes a relative predominance of FSH in female animals, and suppresses FSH in male rats. In humans of a reproductive age, orally taking 200 mg of nizoral during 1-26 weeks, the drug stimulates FSH and LH production, suppressing estradiol production in men. The blood levels of prolactin, testosterone and progesterone are unchanged (the hypophyseal gonadotropic and the peripheral steroid hormones have been radioimmunoassayed). The detected shifts in the hormonal regulation of the reproductive system during nizoral therapy is evidence that nizoral should be very cautiously administered to patients with dyshormonal diseases, with the hormonal profile monitored over the course of treatment.     

女性更年期痤疮患者的临床特征及睾酮和雌二醇水平的检测

目的 探讨女性更年期痤疮患者血清性激素水平的变化,临床特征及治疗方法。方法 对66例患者的临床特征及治疗进行了观察;测定其中35例患者的血清睾酮和雌二醇水平。结果 患者睾酮、雌二醇与正常人对照组相比较差异无显著性,但睾酮/雌二醇显著高于正常人对照组(P<0.05)。63.6%的患者在更年期发病。皮损以上唇及颏部最多,其次为颊部、额部,多呈散在分布,以粉刺及炎性丘疹或丘脓疱疹为主,少数有炎性结节。多为轻至中度痤疮。78.8%的患者一般治疗即可治愈,其余患者用性激素治愈。结论 更年期因卵巢功能衰退,雌激素分泌减少,雌雄激素比例失衡,肾上腺源性雄激素相对过甚而导致痤疮。更年期痤疮多为轻至中度,皮损以粉刺、炎性丘疹或丘脓疱疹为主,以上唇及颏部最多。绝大多数患者一般治疗即可治愈。     

Serum levels of gonadotrophins, testosterone and estradiol in acne vulgaris]

In 69 male acne patients, 15--24 years old and 17 young men of the same age plasma FSH, prolactin, testosterone and estradiol are determined. Only the mean testosterone levels are significantly elevated in acne patients against the controls.     

男性酒渣鼻患者血清睾酮及雌二醇的检测

目的探讨血清睾酮及雌二醇的水平在男性酒渣鼻发病中的作用。方法采用放射免疫法对47例男性酒渣鼻患者血清睾酮、雌二醇进行了测定,并以25例正常男性作为对照。结果患者组睾酮、雌二醇与正常对照组比较差异无显著性,但21例伴皮脂溢出症者,睾酮明显高于正常对照组(P<0.05),血清睾酮浓度的升高幅度与酒渣鼻病程及分期无明显的相关性。结论血清睾酮浓度的升高是伴皮脂溢出症的男性酒渣鼻患者的重要原因。     

老年脑梗死患者血清性激素变化的临床研究

目的:分析老年脑梗死与血清性激素变化之问的关系,并探讨性激素引起脑梗死可能的机制.方法:选取2008午6月-2011年10月笔者所在医院收治的68例老年急性脑梗死患者作为研究对象,选择同期的58例健康体检者作为对照组.采用放射免疫法测定两组患者血清雌二醇、睾酮、催乳素和血清孕酮的水平,并将两组测定结果进行比较.结果:男性脑梗死组急性和恢复期患者E2、E2/Te水平均明显高于男性对照组(P>0.05),女性脑梗死组急性期和恢复期患者E2、Te均明显低于女性对照组(P>0.05),而E2/Te与对照组比较差异无统计学意义(P<0.05).男女脑梗死患者急性期和恢复期的Pr、PRL与对照组比较差异均无统计学意义(P>0.05).结论:男性E2、E2/Te水平升高,而女性E2水平降低,可能是引起脑梗死的危险因素之一.对患者血清性激素的研究有助于了解脑梗死的发病情况.     

痤疮患者血清性激素水平的研究

采用放射免疫法测定了33例痤疮患者血清黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）、睾酮（T）、孕酮（P）水平。发现女性患者LH、FSH、E2皆低于正常组（P＜0．001），T与正常组差异不显著（P＞0．05），P高于正常组（P＜0．01）。男性患者LH、FSH低于正常组（P＜0．001），E2和T较正常组差异不显著（P＞0．05）。提示血清LH、FSH水平的异常可能在痤疮发病中起一定作用。     

Sex hormones in male psoriasis patients and their correlation with the Psoriasis Area and Severity Index

Modulation of psoriasis severity by estradiol during pregnancy, menstruation and menopause has been investigated previously. The correlation between sex hormones and Psoriasis Area Severity Index (PASI) has not been studied in male psoriasis patients. We investigated serum sex hormones in male psoriasis patients compared with healthy controls and correlated these findings with PASI. Estradiol, testosterone, follicle‐stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured in 47 male patients with psoriasis and 20 healthy controls. Patients with psoriasis showed higher body mass index and higher serum levels of FSH and LH relative to healthy controls, although this difference was not statistically significant. However, serum levels of testosterone and estradiol were significantly different between patients with psoriasis and healthy controls. Testosterone was significantly increased in control patients and estradiol was significantly increased among psoriatic patients. A significant inverse correlation was found between estradiol and PASI. Although the role of sex hormones in the pathogenesis of psoriasis has not been demonstrated, this is the first report of an inverse correlation between estradiol and PASI in male patients.     

Percutaneous resorption of testosterone, androstenedione and estradiol and their effect on serum steroid levels

2.5 mg/m2 body surface of testosterone, 0.5 mg/m2 estradiol and 1.25 mg/m2 androstenedione were applied to the skin of healthy young men. The steroids were dissolved in a mixture of ethanol, water, and propylenglycol and applied to 10% of the body surface. Thus the amount given was equivalent to about one fifth of the amount in mg/m2. Serum levels of testosterone, androstenedione, and estradiol were measured by means of radioimmunology, both before the application as well as 2, 4, 8, and 24 h afterwards. Pregneolone and androstenedione did not alter the serum levels of the hormones determined. Testosterone and estradiol lead to a short peak of their serum concentration. Our results indicate that precursor steroids, pregnenolone and androstenedione, are rapidly metabolized to other compounds before they reach the blood in measurable amounts.     

Serum hormone levels in men with severe acne.

In order to evaluate the hormonal milieu in young men with severe acne, we measured serum estradiol (E2), total testosterone (T), free testosterone (FT), dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), and sex hormone binding globulin (SHBG) levels in sixteen male patients aged 20-30 years with severe acne, including twelve cases of nodular-cystic acne, and in seventeen age-matched normal controls. There were no significant differences in the serum levels of T, FT, DHT, DHEA-S, or SHBG between the patients and the controls, but serum E2 was significantly higher in the patient population. Thus, the hemodynamics of serum androgens in male patients with acne do not seem to differ significantly from that of normal controls. Elevated E2 levels might affect the inflammatory response of acne vulgaris through the release of thymic hormones, as reported in the literature.     

羊肠线穴位埋藏法治疗寻常痤疮临床观察与试验研究

目的观察羊肠线穴位埋藏法治疗痤疮临床疗效并探讨其作用机制。方法将107例病人随机分成痤疮治疗组与痤疮对照组,进行临床对比观察,治疗组取血清检测睾酮和雌二醇,与正常对照组比较,并做治疗前后比较。结果治疗组临床疗效优于对照组,差异显著(P<0.05),羊肠线穴位埋藏法可降低女性血清中升高的睾酮水平(P<0.05)。结论羊肠线穴位埋藏法治疗痤疮疗效显著,其作用机制可能与调节患者性激素水平有关。     

Male sex hormone status in dermatitis herpetiformis

In twenty-eight men with dermatitis herpetiformis (DH) the mean serum testosterone levels were within normal limits, but high levels were found in three patients with partial villous atrophy and two who had normal jejunal biopsies. The introduction of a gluten-free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle-stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. Thus, raised levels of testosterone and gonadotrophin were found in only a minority of men with DH, in contrast to the more marked changes previously reported in males with coeliac disease.     

迟发性或持久性女性痤疮患者血清性激素水平的研究

目的 探讨迟发性或持久性女性痤疮患者体内性激素的改变。方法 采用放射免疫分析法,对２５岁以后发病或病程超过５年的３２例女性痤疮患者黄体期血清中８种性激素进行了测定,并以３０例正常女性徐为对照。结果 患者组睾酮、雌烯二酮、硫酸脱氢表雄酮均显著高于对照组（Ｐ〈０．００１）;雌二醇、孕酮、泌乳素、卵泡刺激素和黄体生成素无明显变化（Ｐ〉０．０５）。结论 生激素升高可能是女性疮疮迟发和持久不愈的主要原因。     

Elevated free testosterone concentration in men and women with acne vulgaris

Plasma total and free testosterone, total and free dihydrotestosterone, androstenedione and sex-hormone binding globulin concentrations were measured in 42 women and 17 men with acne vulgaris and compared with controls. Free testosterone concentrations were significantly elevated in both male and female acne sufferers, whilst free dihydrotestosterone levels were significantly raised in both sexes with severe acne but not in women with mild acne. The other plasma total androgens were not significantly elevated apart from total testosterone levels in those women with acne who also had irregular menstrual cycles, and who comprised about one third of the female group with acne as the main complaint. Sex-hormone binding globulin concentrations were significantly reduced in women with severe and moderate but not mild acne. No inherited expression was detected in levels of this carrier-protein on the maternal side or in siblings with acne, although the familial nature of acne was confirmed in our study.     

女性痤疮与多囊卵巢综合征的相关性研究

目的 检测成年女性痤疮患者体内性激素水平的变化,探讨其与多囊卵巢综合征（PCOS）的相关性。方法 采用放射免疫分析法,对50例痤疮患者进行血清性激素水平测定和妇科经阴道超声检查。以30例正常成年女性为对照。结果 痤疮组睾酮、二氢睾酮、脱氢表雄酮及黄体生成素水平增高,与正常对照组比较差异有高度显著性（P＜0．001或P＜0．01）;雌二醇、卵泡刺激素、孕酮水平变化不明显（P均＞0．05）。50例中有28例患PCOS。对其中10例应用达英－35治疗,可降低血清雄激素水平。结论 高雄激素血症和PCOS与成年女性痤疮有关,且是其长期不愈的重要原因。达英－35对此类痤疮有较好疗效。     

寻常型痤疮患者性激素水平与发病的相关性研究

目的探讨痤疮患者外周血雄激素(T)及雌二醇(E2)含量对寻常型痤疮发生发展的影响。方法双盲随机抽取2009年8月-2011年6月本科门诊病例131例痤疮患者和131名正常对照组,采用放射免疫法检测血清雄激素(T)和雌二醇(E2)水平。结果痤疮患者性激素(雄激素、雌二醇)水平与对照组相比无明显相关性(P>0.05)。结论痤疮患者性激素(雄激素、雌二醇)水平与痤疮发病无明显相关     

The sex hormone content of the peripheral blood in women with gonorrhea and gonorrhea-trichomoniasis infections

Peripheral blood estradiol, progesterone, testosterone were measured in 100 women with gonorrhea and Gonococcus-Trichomonas infection. Estradiol levels were found reduced in both phases, progesterone level elevated in the follicular and lowered in the lutein phases of the menstrual cycle as against the norm. Elevated testosterone levels were revealed in the peripheral blood of women with gonorrhea, particularly so in chronic gonorrhea and mixed Gonococcus-Trichomonas infection. Therapy did not result in normalization of blood hormone concentrations, this pointing to advisability of including the drugs correcting hormonal disorders into a complex of treatment of such patients.     

The hormonal profile of patients with pemphigus and bullous pemphigoid

Radioimmunoassays of some hypophyseal, adrenal, thyroid, pancreatic, and sexual gland hormones, carried out in patients with pemphigus and bullous pemphigoid, have revealed increased levels of ACTH and hydrocortisone in their blood sera, vs. the reference values. Glucocorticoid therapy has normalized the ACTH level, and hydrocortisone content has proved to be below the norm. The blood plasma triiodothyronine level has been elevated, whereas insulin and glucagon lowered in the patients with pemphigus vs. those with bullous pemphigoid. In females of a menopausal age, suffering from pemphigus, increased levels of estradiol and reduced ones of testosterone have been detected, as compared to those suffering from bullous pemphigoid. These data evidence a varying functional activity of the endocrine glands in these dermatitides.     

Serum Sex Hormone Levels in Adult Patients with Atopic Dermatitis

Serum levels of sex hormones were measured in adult patients with atopic dermatitis (AD) and compared with those in sex- and age-matched healthy controls. In 40 male patients with AD, serum levels of testosterone (T) (447 ± 96 vs 593 ± 149 ng/dl, P<0.001), free testosterone (FT) (14.6 ± 3.2 vs 20.0 ± 5.1 pg/ml, P<0.001) and estradiol (E₂) (27.2 ± 7.2 vs 33.2 ± 7.9 pg/ml, P<0.05) were significantly lower and serum levels of luteinizing hormone (LH) (4.57 ± 1.6 vs 3.11 ± 1.2 mIU/ml, P<0.001) were significantly higher than those in healthy controls. There were no significant differences in serum levels of dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone (DHEA), or follicle stimulating hormone (FSH) between the two groups. In 25 female patients with atopic dermatitis, T, FT, DHT and DHEA-S levels did not differ from controls. In conclusion, serum T levels were lower in male patients with AD. However, similar changes were not seen in female patients.