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灰苞蒿中物碱和黄酮成分研究 总被引:3,自引:1,他引:2
从灰苞蒿Artemisia raxbughiana地上部分的混合溶剂(石油醚-乙醚-甲醇)提取物和乙醇提取物中首次分离并鉴定了1个生物碱和4个黄酮成分:N-苯基-2-萘胺,5,4'-二羟基-3,6,7-三甲氧基黄酮(喷杜素),5,7-二羟基-3,3',4'-三甲氧基黄酮(quercetin 3,3',4'-三甲基醚)5,7-二羟基-6,3',4'-三甲氧基黄酮(异泽兰黄素),5,7,4'-三羟基- 相似文献
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香蕉中5—羟色胺的荧光测定和薄层鉴定 总被引:2,自引:0,他引:2
通过用丙酮浸渍,对香蕉中的5-羟色胺进行荧光测定和薄层鉴定。其平均回收率为90.6%。蕉肉的5-羟色胺含量为4-30ppm,蕉皮的5-羟色胺含量为0.4-1.8ppm。 相似文献
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从何首乌Polygonum multiflorum块根中分离得到二苯乙烯甙,经理化性质和波谱数据分析为2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖甙(2,3,5,4'-terahydroxystilbene-2-O-β-D-glucoside),是首乌有效成分。又以此化合物为对照品,测定首乌制剂中二苯乙烯甙的含量。 相似文献
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白蔹多酚类化学成分的研究(II) 总被引:4,自引:0,他引:4
对百蔹多酚类化学成分的进一步研究分离得到了7个多酚类化合物,经波谱分析及化学方法鉴定它们为二聚没食子酸,1,4,6-三氧-没食子酰基-β-D-吡喃葡萄糖,2,4,6-三氧-没食子酰基-D-吡喃葡萄糖,2,3,4,6-四氧-没食子酰基-D-吡喃葡萄糖,6-氧-二聚没食子酰基-1,2,3-三氧-没食子酰基-β-D-吡喃葡萄糖,槲皮素-3-O-α-L-吡喃鼠李糖,槲皮素-3-O-(2-O-没食子酰基)- 相似文献
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HPLC法测定丹参粉针剂中丹参素及原儿茶醛的含量 总被引:14,自引:1,他引:14
建立了反相HPLC法测定抗心肌缺血新药丹参粉针的含量测定方法。采用YWGC18柱,以对羟基苯甲酸为内标,水-甲醇-二甲基甲酰胺-冰醋酸(90:4:4:2)为流动相,检测波长281nm,测得的线性范围:丹参素1-4μg(r=0.9997),原儿茶醛1-6μg(r=0.9995);平均回收率:丹参素99.1%,RSD为1.2%;原儿茶醛98.7%,RSD为1.5%。 相似文献
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从臭灵丹[Laggeraplerodonta(DC.)Benth]地上部分的水煎浓缩液的氯仿、醋酸乙酯、正丁醇提取液中,通过反复硅胶柱层析及重结晶,分得4个化合物。经理化性质及光谱测定,分别鉴定为:臭灵丹二醇(pterodondiol)、臭灵丹三醇乙(pterodontriolB)、3’,4’,5-三轻基-3,6,7.三甲氧基黄酮(3’,4’,5-trihydroxy-3,6,7-trimethoxyflavone)和橙皮甙(hesperidin)。其中,后2个为首次从该植物中分离得到的化合物。 相似文献
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目的:研究4种斑蝥素衍生物与铂铬合物(斑铂,Dpt)对实验动物的抗癌作用,力图开发一种新型的铂族金属抗癌药。方法:以S180肉瘤、H22肝癌料体瘤及其腹水瘤小鼠为实验动物,通过腹腔或静脉给予不同剂量的4种化合物Dptl-15、Dpt5-10、Dpt12-3、Dpt6-2,分别观察药物对小鼠瘤重及存活天数的影响,以顺后为阳性对照,生理盐水为阴性对照。所有数据进行t检验。结果:4种斑铂(Dpt1-15 相似文献
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Haroon Ahmad Nasar Ali Bashir Ahmad Ibrar Khan 《Journal of traditional Chinese medicine》2012,32(4):616-620
Objective
Plants produce a variety of useful bioactive materials that have been used to cure different ailments of human beings. With the same idea in mind, the crude methanolic extract and various fractions of Solanum surrattense were screened for antibacterial, antifungal, phytotoxic and heamagglutination activities.Methods
Standardized assays were followed for the determination of antibacterial, antifungal phytotoxic and heamagglutination activity.Results
The results of the antibacterial showed that crude methanolic extract was significantly active against Staphylococcus aureus (86%) The n-hexane fraction showed good activity against Pseudomonas aerogenosa (66.6%) and Bacillus subtilus (66.6%). The crude methanolic extract and various fractions were inactive against all test fungi. The crude methanolic extract, n-hexane, CHCI3 and aqueous fractions showed moderate phytotoxic activities of 46.67%, 40.00%, 33.34% and 33.34% respectively at 1000 μg/mL. The crude methanolic extract and various fractions S. surrattense were unable to agglutinate RBCs of the human blood indicating that this species lack phytolectins.Conclusion
The test sample showed significant antibacterial activity, no antifungal and heamagglutination activity while moderate phytotoxic was observed against Lemna minor L. 相似文献12.
Rhuan Amorim Ritter Maria Vivina Barros Monteiro Frederico Ozanan Barros Monteiro Silvane Tavares Rodrigues Marina Lira Soares Jean Carlos Ramos Silva Maria das Dores Correia Palha Germano Francisco Biondi Sheila Canevese Rahal Manoel Malheiros Tourinho 《Journal of ethnopharmacology》2012
Ethnopharmacological relevance
The lack of ethnoveterinary surveys in Brazil, especially in the Amazon region, results in losses in the veterinary phytopharmacology field and in scientific documentation of the cultural traditions of plant use in the treatment of animal diseases.Aim of the study
To catalog, analyze and disseminate the ethnoveterinary knowledge of the inhabitants of Colares Island, Pará state, eastern Amazon, Brazil.Materials and methods
A total of 72 interviews were conducted, and semi-structured questionnaires were answered by 18 men and 54 women. The data obtained were quantitatively analyzed using the informant consensus factor (ICF) and use value (UV). The plants with a reported medicinal use for domestic animals were harvested, herbalized and botanically identified.Results
Fifty-six plants, distributed in 49 genera and 35 families, were indicated to have 23 different medicinal uses, divided into six categories of use. The highest ICF (0.80) was obtained for the antiparasitic class. The Euphorbiaceae family exhibited the highest number of citations, and the species with the highest UVs were Caladium cf. bicolor, Bixa orellana, Carapa guianensis, Jatropha curcas and Cymbopogon citratus. The parts of the 56 plants that were most frequently used to prepare ethnoveterinary medications were the leaves (46%), bark (15%), roots and fruit (10%). The use of the macerated leaves was the most common method of application, used by 43% of the interviewees, and the majority of the preparations (87.3%) used a single plant. In addition to medicinal plants, the interviewees reported the use of products of animal and mineral origin.Conclusion
The present study contributed to the establishment of an inventory of plants used in ethnoveterinary practices in this region of the Brazilian eastern Amazon. Future phytochemical and pharmacological studies are needed to confirm the efficacy and safety of the identified plants, enabling communities to use them in a more economic, effective and safe manner. 相似文献13.
Yan Lin Xiao-yun Wang Ren Ye Wan-hua Hu Shu-chen Sun Hong-juan Jiao Xiu-hua Song Zheng-zhong Yuan Yuan-yuan Zheng Guo-qing Zheng Jin-Cai He 《Journal of ethnopharmacology》2013
Ethnopharmacological relevance
Wuling Capsule is a single herbal formula from mycelia of precious Xylaria nigripes (Kl.) Sacc and its pharmacological function have a tranquilizing effect on the central nervous system. The aim of the study to evaluate the efficacy and safety of Wuling capsule in treatment of insomnia.Materials and methods
We performed a multicenter, randomized, double-blind, placebo-controlled study. The participants received either placebo (n=92) or Wuling capsule (n=94) for 4 weeks and a follow-up period for 2 weeks.Results
Compared between pre-treatment and post-treatment, the global Pittsburgh sleep quality index (PSQI) scores in both Wuling capsule group and placebo group improved significantly (P<0.01). However, there was no significant difference between Wuling capsule group and placebo group (P>0.05). Scores of clinical global impressions scale (CGI-I) at each week in Wuling capsule group was similar to those in placebo group (P>0.05). Compared between pre-treatment and post-treatment, scores of the four components of world health organization on quality of life brief scale (WHOQOL-BREF) in both Wuling capsule group and placebo group improved significantly (P<0.01). However, there were no difference between the two groups (P>0.05). The rate of adverse events was 10.10% in Wuling group, and 6.73% in placebo group (P>0.05).Conclusions
Wuling capsule can improve insomnia when compared with pre-treatment for 4 weeks and be a well tolerated by all the patients at the 6 weeks of study period. However, there are no significant in the results of the variables tested when compared with placebo control. Further additional rigorous randomized clinical trials are still required. 相似文献14.
Bolivar P Cruz-Paredes C Hernández LR Juárez ZN Sánchez-Arreola E Av-Gay Y Bach H 《Journal of ethnopharmacology》2011,137(1):141-147
Ethnopharmacological relevance
To study the potential benefit of the traditional Mexican medicinal plant Galium mexicanum Kunth (Rubiaceae). Hexane, chloroform, and methanol extracts as well as various fractions from these extracts were tested to determine antibacterial, antifungal, antiparasitic or anti-inflammatory activities in vitro.Materials and methods
Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Their antibacterial and antifungal activities were assessed on nine bacterial and four fungal strains. Leishmania donovani was used as a protozoan strain for antiparasitic activity. The anti-inflammatory activity of the compounds was investigated by measuring the secretion of interleukin-6 when macrophages were exposed to lipopolysaccharide.Results
Various extracts and fractions obtained from this plant exhibit antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. Of special interest was the hexane fraction HE 14b, which show antibacterial (ranging between 67 and 666 μg/ml) and antifungal (at concentrations of 333 μg/ml) activities. Also the hexane fraction HE 5 exhibited antiparasitic activity (at concentrations of 260 μg/ml), whereas the methanol fraction ME 13-15 showed a potent anti-inflammatory activity when compared to dexamethasone. Chemical analyses of the chloroform extract show the presence of triterpenes, saponins, flavonoids, sesquiterpene lactones, and glucosides, but no tannins were detected in the assayed extract.Conclusions
The benefit of Galium mexicanum as a traditional medicinal plant was confirmed using antibacterial and antifungal assays in vitro. We also report for the first time, and to the best of our knowledge, antiparasitic and anti-inflammatory activities of this plant. 相似文献15.
Lima ZP dos Santos Rde C Torres TU Sannomiya M Rodrigues CM dos Santos LC Pellizzon CH Rocha LR Vilegas W Souza Brito AR Cardoso CR Varanda EA de Moraes HP Bauab TM Carli C Carlos IZ Hiruma-Lima CA 《Journal of ethnopharmacology》2008,120(2):149-160
Ethnopharmacological relevance
Ethnopharmacological survey indicated leaves of Byrsonima fagifolia Nied. (Malpighiaceae) against gastrointestinal disorders.Aim of the study
The methanolic extract from the leaves of Byrsonima fagifolia (denominated BF) was evaluated for toxic, mutagenic, gastroprotective, antidiarrheal, antibacterial and immunomodulatory activities.Materials and methods
The preventive and healing action of BF against gastric ulcer was evaluated in experimental models in rodents. We evaluated immunomodulatory (by murine peritoneal macrophages), antidiarrheal (by induced diarrhea with castor oil and intestinal motility) and antibacterial action of BF against standard strain of Escherichia coli, Staphylococcus aureus and Helicobacter pylori. The safety of use of BF was also evaluated by mutagenic (Ames assay) and by analyses of toxicity parameters.Results
Phytochemical BF profile indicated the presence of phenolic compounds with antioxidant and radical-scavenging properties. BF significantly inhibited gastric lesions induced by ethanol and HCl/ethanol and endogenous mucosal sulphydryl groups (SHs) participated efficaciously in BF gastroprotection. BF blocked development of inflammation process and also has antidiarrheal actions. This extract accelerated the healing of the gastric ulcerated mucosa by stimulating proliferative factors and by increasing production of gastric mucus with no toxic action. The substances responsible for the protective action are concentrated in the ethyl acetate fraction that demonstrated no mutagenic action in vitro.Conclusions
Byrsonima fagifolia presents gastroprotective, healing and antidiarrheal activities supporting previous claims that its traditional use by Brazilians can treat these gastrointestinal ailments. 相似文献16.
New N-hydroxypyridones, militarinones E (1) and F (2), phenylhydrazones, farylhydrazones A (3) and B (4), a quinazolinone, 2-(4-hydroxybenzyl)quinazolin-4(3H)-one (5), and the known militarinones A (6) and B (7) were isolated from cultures of the Cordyceps-colonizing fungus Isaria farinosa. The structures of 1-5 were elucidated by spectroscopic methods, and 3 was confirmed by X-ray crystallography. The absolute configuration of the C-4' secondary alcohol in 1 was deduced via the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complex. Compounds 1 and 6 showed significant cytotoxicity against A549 cells, whereas 7 was active against Staphylococcus aureus, Streptococcus pneumoniae, and Candida albicans. 相似文献
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Riccardo Di Novella Nicola Di NovellaLaura De Martino Emilia ManciniVincenzo De Feo 《Journal of ethnopharmacology》2013
Aim of study
This paper reports an ethobotanical survey of the traditional uses of medicinal and useful plants in an area of the National Park of Cilento and Vallo di Diano, Campania, Southern Italy.Materials and methods
This study conducted between 2009 and 2011, gathered information on the medicinal plants traditionally used in Southern Italy (Campania Region). In all, we interviewed 70 key informants, whose age ranged between 50 and 85 years. This people belonged to families which had strong links with traditional activities of the area.Results
The research resulted to the identification of 192 plants belonging to 64 families. Among the species reported, 86 are used in human medicine, 15 in veterinary medicine, 69 as human foods, 18 as animal feed, 61 for domestic and 8 for agricultural uses.Conclusion
A survey of the available literature on Southern Italy ethnobotany reveals that some species have been never reported and about 10% of cited uses are new. Data obtained show that in the studied area the folk use of plants is alive and still derives from daily practice. 相似文献19.
Williams DE Patrick BO Behrisch HW Van Soest R Roberge M Andersen RJ 《Journal of natural products》2005,68(3):327-330
Dominicin, a new cyclic peptide, and the new bromopyrrole alkaloid laughine (4) have been isolated from the marine sponge Eurypon laughlini collected in Dominica. The structures of 1 and 4 were determined by a combination of spectroscopic analysis and chemical degradation. Single-crystal X-ray diffraction analysis confirmed the structure of dominicin (1). 相似文献
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Abida Bano Mushtaq AhmadMuhammad Zafar Shazia SultanaSofia Rashid Mir Ajab Khan 《Journal of ethnopharmacology》2014