Function and morphology of macula before and after removal of idiopathic epiretinal membrane

PURPOSE: To study the function and morphology of the macula of the eye before and after the removal of unilateral idiopathic epiretinal membrane (ERM). METHODS: Focal macular electroretinograms (fmERGs) elicited by a 15 degrees stimulus were recorded in 37 eyes of 37 patients with a unilateral ERM. The amplitudes of the a- and b-waves and the oscillatory potentials (OPs) were compared with the corresponding waves in the normal fellow eyes before and after removal of the ERM. In 29 eyes followed up for more than 6 months after surgery, the fmERGs and foveal and parafoveal thicknesses, measured by optical coherence tomography (OCT), were evaluated. RESULTS: Before surgery, the mean amplitudes of all components of the fmERGs were significantly smaller than in the fellow eyes, with the decrease largest for the OPs, followed by the b-waves and then the a-waves. The eyes with less severely reduced a-wave amplitude (>70% of the fellow eyes) had significantly lower b-wave to a-wave (b/a) ratios. After surgery, the amplitudes of the b-wave and OPs were still significantly smaller in the affected eyes. The mean foveal and parafoveal thicknesses were significantly less after surgery; however, the thickness was still more in the affected eyes. The decrease of the OPs remained after surgery and correlated with increased parafoveal thickness (r = -0.460, P = 0.011). CONCLUSIONS: The decreased fmERGs indicate that macular function is impaired in eyes with ERM. The decrease of the b-wave and OPs in the 29 eyes examined after vitrectomy may be due to the still thickened macular retina.     

Local macular electroretinographic responses in idiopathic central serous chorioretinopathy

Using focal stimuli to human macular regions, we recorded electroretinograms in 24 patients with central serous chorioretinopathy of recent onset (mean visual acuity, 20/20). The stimulus spot was 10 degrees in diameter. Intact fellow eyes served as controls. The local macular electroretinograms of the affected eyes were significantly reduced and the implicit time in each component was significantly prolonged. The mean (+/- S.D.) amplitudes, expressed as percentages of mean amplitudes recorded in fellow eyes, were 64.6% +/- 22.7% (a-wave), 49.6% +/- 21.0% (b-wave), and 15.0% +/- 21.6% (oscillatory potentials). Two to five months after the macular detachment resolved, recordings in 18 patients showed remarkable recovery of a- and b-waves and shortened implicit times. However, the oscillatory potentials showed significantly small recovery in amplitude. Since oscillatory potentials and b-waves were significantly more deteriorated than a-waves in the presence of macular detachment, and oscillatory potentials showed selective delay of recovery in the convalescent stage, central serous chorioretinopathy may involve functional disturbances in the inner retinal layer as well as the photoreceptors.     

Electroretinographic changes in eyes with idiopathic macular hole treated by vitrectomy

We recorded full-field electroretinograms before and after vitrectomy in 18 eyes of 18 patients with idiopathic macular hole. The results were compared between affected and fellow eyes in the preoperative and early (within 10 days) and late (3 to 6 months) postoperative periods. No significant changes between affected and control eyes were found in the amplitude of the rod electroretinogram, mixed cone-rod electroretinogram, cone electroretinogram a-and b-waves or 30-Hz flicker electroretinogram in all stages of the study. The peak implicit times of the cone electroretinogram (a-and b-wave) and dark-and light-adapted oscillatory potential (O1-O4), however, were delayed. Also, the amplitude of the oscillatory potentials (O1+O2+O3+O4) was significantly reduced in the early postoperative period. By the late period, all of these changes had resolved. We concluded that electrophysiologic changes were derived from a transitory dysfunction of the inner retina. The possible causes of the electroretinographic changes would include mechanical trauma of the surgery, intravitreous air tamponade or the changes in vitreous electrolytes after surgery. Oscillatory potentials were more sensitive than a-and b-waves in eliciting dysfunction of the inner retina in operate on eyes.     

Oscillatory potentials as predictors to amplitude and peak time of the photopic b-wave of the human electroretinogram

The oscillatory potentials are viewed by many as small oscillations of a highfrequency domain that ride on the b-wave of the electroretinogram. A study of electroretinograms and oscillatory potentials performed in 25 normal subjects was undertaken to substantiate my claim that oscillatory potentials are fast retinal potentials that are integrated to form the b-wave. The prominence of the OPs on the ascending limb of the b-wave was found to be only weakly correlated (r = –0.37) to the amplitude of the oscillatory potentials (measured in the 100–1000 Hz recordings). There was, however, a high correlation (r = 0.78) between the prominence of the oscillatory potentials and their frequency domain as determined by the peak-to-peak timing. Furthermore, the peak-to-peak timing of the oscillatory potentials was highly correlated with the b-wave peak time (r = 0.86) as well as with the a-wave trough to b-wave peak time (r = 0.90), while the amplitude of the oscillatory potentials was correlated to the amplitude of the b-wave (r = 0.78). Interestingly, when combining the amplitude of the oscillatory potentials with the time interval between oscillatory potentials 2 and 3 and 3 and 4, a higher correlation (r = 0.88) was found with the b-wave amplitude. The latter finding would support my claim that the b-wave represents an integration (amplitude as a function of time) of the oscillatory potentials.     

Electroretinographic responses in patients with pulseless disease vary with head and body positions

We examined bright-flash electroretinograms obtained in two Japanese women with pulseless disease. One 48-year-old woman (case 1) who has had the disease for 17 years showed no oscillatory potentials. When she sat and tilted her head to the right, a- and b-wave amplitudes diminished in the left eye. A second 48-year-old woman (case 2) who has had the disease for 10 years also demonstrated absent oscillatory potentials. When she sat and raised her chin, a- and b-wave amplitudes diminished in both eyes. These amplitudes were normal when the patients were in a supine position. Offprint requests to: S. Hayasaka     

Predominant loss of the photopic negative response in central retinal artery occlusion

PURPOSE: To determine how the photopic negative response (PhNR) is affected in central retinal artery occlusion (CRAO). DESIGN: Observational case series. METHODS: Seven patients with unilateral CRAO were included. Full-field scotopic and photopic electroretinograms (ERGs) including the PhNR were recorded. Each ERG amplitude in the affected eye was expressed as a percentage of amplitude of the corresponding wave in the unaffected eye. RESULTS: Mean of the PhNR amplitude was reduced to 12.3 +/- 11.7% of that of unaffected eyes whereas the cone b-wave amplitude was attenuated to only 73.4 +/- 30.4%. This reduction of the PhNR amplitude was more significant than that of other waves including the rod b-wave, maximum a-wave and b-wave, cone a-wave and b-wave, and 30 Hz flicker ERG (P <.005). CONCLUSIONS: The PhNR was severely affected in CRAO despite relative preservation of the cone b-wave, implicating massive loss of ganglion cells and their axons.     

The effect of 2-amino-4-phosphonobutyric acid on the oscillatory potentials of the electroretinogram

Previous reports have shown that an intravitreal injection of 2-amino-4-phosphonobutyric acid, a glutamate analogue that selectively blocks the photoreceptors' input to the on-bipolar cells, produces a rapid decrease in the amplitude of the electroretinographic b-wave. To our knowledge, the effect of this glutamate analogue has not been examined on the oscillatory potentials. We therefore conducted such a study. A needle electrode was inserted into the anterior chamber of the eyes of seven anesthetized and paralyzed rabbits to record simultaneously the electroretinogram and the oscillatory potentials. These responses were evoked by flashes of white light delivered in mesopic conditions. As expected, an injection of 2-amino-4-phosphonobutyric acid, produced a rapid decrease in the amplitude of the b-wave, while the a-wave was relatively spared. The amplitude of the oscillatory potentials also decreased rapidly. At maximal effect, the electroretinogram essentially consisted of a normal a-wave followed by small oscillations and no evidence of a b-wave. The 100–1000 Hz recording confirmed that the oscillations seen on the postinjection electroretinograms were remnants of the original oscillatory potentials.     

单眼视网膜静脉阻塞患者对侧眼黄斑功能的多焦视网膜电图检测

目的 观察单眼视网膜静脉阻塞(RVO)患者对侧眼黄斑功能的变化.方法 对比分析24例经荧光素眼底血管造影(FFA)确诊为单眼RVO患者的24只对侧眼及18位正常受试者18只正常眼的多焦视网膜电图(mfERG)检测结果,比较两组受试者黄斑功能的差异.采用罗兰RETIsean电生理仪记录mfERG,将记录图形分别按照6个同心圆和4个象限对P1、N1波的振幅密度及潜伏期进行比较和分析.结果 RVO患者对侧眼在中心第1、2环处P1、N1波的振幅密度显著低于正常眼,差异有统计学意义(t=4.520,2.147;P＜0.05);其它各环、各象限振幅密度及潜伏期在两组间均未见明显差异(P＞0.05).结论 与正常眼相比,RVO患者对侧眼黄斑中心凹视功能受损.     

The Electroretinogram in Patients with Retinal Vascular Occlusion

Purpose: to measure and analyze the electroretinogram (ERG) in patients with retinal vascular occlusion.Method: fifty-eight cases (59 eyes) of retinal vascular occlusion and the fellow eyes of 47 cases were tested with Ganzfeld ERG. The scotopic and photopic ERG, and oscillatory potentials were tested according to the ERG standard of ISCEV. Results: The abnormal rates of OPs and b wave were higher in retinal vascular occlusion. The abnormal ERG appeared mostly in CRVO among four types of retinal vascular occlusion. The comparisons of some amplitudes and latencies between the fellow eyes and the affected eyes showed statistically significant difference. Conclusion: The oscillatory potentials and b waves have important roles in evaluating the retinal function of patients with retinal vascular occlusions. There are some clinical significance for comparing ERG between the affected eye and the fellow eye.     

角膜针刺伤外伤性白内障的视觉电生理改变

评价因注射针头等针刺所造成的角膜穿孔伤及外伤性白内障的视觉电生理检查结果。方法对１５例视觉电生理检查结果进行分析。包括受伤眼与对侧眼的ＥＲＧ，Ｆ－ＶＥＰ及ＯＰｓ波。结论眼前段的针刺伤可引起视觉电生理检查结果的明显异常，故应考虑其累及眼后段的问题。     

Changes in foveal thickness and macular function after transpupillary thermotherapy for age-related macular degeneration

PURPOSE: To evaluate the effect of transpupillary thermotherapy (TTT) on foveal thickness and macular function in eyes with choroidal neovascularization (CNV) associated with age-related macular degeneration. METHODS: Sixteen eyes with occult CNV and 6 eyes with classic CNV were treated with TTT. Optical coherence tomography and focal macular electroretinograms (FMERGs) elicited by a 15-degree stimulus were performed before, 3 months after TTT in 22 eyes and 6 months after TTT in 18 eyes. RESULTS: Before TTT, the fovea in 20 of the 22 eyes with CNV was significantly thicker than that of normal subjects. The foveal thickness was reduced after TTT in 11 of 14 eyes with occult CNV and remained unchanged in 2 eyes. One eye with occult CNV before TTT developed a classic CNV with significant macular edema and increased foveal thickness 3 months after TTT. The amplitudes of the FMERGs were reduced in all eyes before TTT. In eyes with occult CNV, the mean b-wave amplitude increased significantly after TTT (p = 0.0260 at 3 months, p = 0.0142 at 6 months). When the change of foveal thickness was less than 20% after TTT, all eyes with occult CNV had a 30% or more increase in the b-wave amplitude. In eyes with classic CNV, the mean amplitude of the a- and b-waves did not change significantly after TTT. CONCLUSIONS: TTT improves macular function in eyes with occult CNV associated with age-related macular degeneration more when the change of foveal thickness is slight.     

Analysis of focal macular ERG in idiopathic central serous chorioretinopathy

Focal macular electroretinogram (MERG), was analyzed in 33 patients with unilateral central serous chorioretinopathy (CSC) of recent onset. The stimulus spots were 5 degrees, 10 degrees and 15 degrees in diameter. Nonaffected fellow eyes served as controls. When macular detachment was present, the MERG showed significantly reduced amplitude and delayed peak latency in a-wave, b-wave and oscillatory potentials (OPs) in all stimulus spots. The reduction of amplitude in 5 degree and 10 degree spots was more significant in b-wave and OPs than in a-wave. In the convalescent stage, the a-wave and b-wave recovered to nearly normal levels, however OPs showed selective delay of recovery. These abnormalities shown by MERG strongly suggest that CSC may involve functional disturbances in the inner retinal layer as well as photoreceptors. It has been assumed that the pathogenic properties of CSC are receptor disorientation and a disturbance in the rate of photopigment regeneration. The present study showed that the abnormal pattern of MERG in CSC cannot be explained simply by the assumption of receptor disorientation or a disturbance of photopigment regeneration by analyzing similar conditions in normal eyes.     

Electroretinogram changes after scleral buckling surgery of retinal detachment

Objective To observe changes in visual function after a single scleral buckling surgery for rhegmatogenous retinal detachment (RD) by using ERG (electroretinogram). Methods One eye from 56 patients with rhegmatogenous RD was chosen. Forty-three corresponding normal fellow eyes from these patients were chosen as controls. Single scleral buckling surgery was carried out and a full-field ERG was performed before the surgery, and 1 and 6 months after surgery. Results The mean amplitude of ERG decreased and the latency (except for the a-wave) was delayed in the eye with a retinal detachment, and wavelets of the oscillatory potential decreased or were completely lacking. One month after surgery, the amplitudes of the a and b waves were noticeably improved (except for the 30 Hz flicker responses), but the latency (except for the a-wave) was still delayed. The ratio of b/a (mixed response) increased 1 month after surgery, with no further changes thereafter. The amplitude of the scotopic b wave was 58.1% of the control eyes, while the 30 Hz flicker responses was only 45.8% of controls; the difference between the two responses was significant (P < 0.001). The number of oscillatory potential wavelets increased, but the total amplitude of the oscillatory potentials did not exhibit any obvious changes during the follow-up period (P = 0.20). In the 41 patients whose detachment involved the macula preoperatively, the amplitude of the 30 Hz flicker responses improved significantly after surgery (P = 0.037). Six months after the operation, the wave amplitudes were not significantly different from 1 month after surgery, but there was a tendency toward a decrease in the latency. Conclusions After reattachment of the retina, visual function showed dramatic improvement 1 month after the surgery. The postreceptoral responses recovered more than the a-wave. The rod system recovered more quickly and completely than the cone system during the follow-up period. The incomplete recovery observed by using ERGs indicates that there is irreversible damage that likely occurs following retinal detachment and surgery.     

视网膜脱离眼的黄斑局部视网膜电图

目的：通过对视网膜脱离（retinal detachment,RD）眼的局部视网膜电图（local electroretinogram,LERG)记录分析,进一步了解RD眼黄斑部光感受器细胞与第二级神经元功能异常的情况,并对LERG与视功能预后的关系进行探讨。方法：120例RD患者128只眼的LERG被记录分析,应用手提眼底镜式局部刺激器通过放大的瞳孔直视眼底监控固视状况,记录a波、b波与OPs各项成分。结果：与对照组相比,LERG的a波、b波与OPs的异常率：在＜1周组分别为15%、15%与10%;在1-2周组为35%、45%与50%;在2-4周组为46.86%、56.25%与62.5%;在4-8周组为76%、84%与88%;在8周以上组则为86.96%、91.30%与95.56%。a波与b波在脱离时间＜1周组与对照组无明显差异;1-2周组a波与b波开始开始有明显降低（P＜0.05),随着发病时间的延迟,b波的下降较a波更为迅速,在2-4周则具有高度显著意义（P＜0.05)。b/a值在早期RP病变表现正常或轻度异常,伴随病程增加有降低趋势,在4-8周组即出现显著性降低（P＜0.05)。在眼底镜下黄斑部脱离的48只眼中,LERG各项成分的降低均有统计学意义;而在眼底镜下观测不到黄斑脱离的80只眼中,b波、OPs与OP2子波振幅也表现异常（P＜0.05)。结论：⑴在视网膜脱离眼,黄斑部光感受器与第二级神经元细胞的功能损害同时存在;⑵b波与a波的比值变化表明了内层与外层的相对损害程度,随着病情的发展,视网膜内层的损害有加重趋势;⑶RD伴黄斑脱离者的视网膜内外层功能受损程度明显增加,而镜下未脱离者也可存在功能的损害;⑷RD眼的OPs振幅可为视网膜内层循环功能的损害提供敏感性指标。研究认为：LERG对RD眼黄斑功能异常的客观定位诊断与视功能预后具有特定的临床意义。     

Optical coherence tomography and focal macular electroretinogram in eyes with epiretinal membrane and macular pseudohole

PURPOSE: To determine the morphology of macular pseudoholes (MPHs) and the relationship of morphology to macular function. DESIGN: Observational case series. METHODS: Optical coherence tomography (OCT) was performed on 42 eyes of 42 consecutive patients with an epiretinal membrane (ERM) and an MPH. The diameters of the MPH, and the thickness of the foveal and parafoveal retina were measured. Of these 42 eyes, focal macular electroretinograms (FMERGs) were recorded from 22 eyes of 22 patients with a 15 degree stimulus; FMERGs were also recorded with a 5 degree stimulus from 9 eyes of these 22 eyes. RESULTS: In 42 eyes, the mean +/- Standard deviation (SD) diameter (437.7 +/- 172.8 microm) and geometrical shape of the MPHs were not significantly correlated with the visual acuity. The MPHs were divided into 2 types from the OCT images at the base of MPHs; group A had normal thickness (100-199 microm; n = 29), and group B (n = 13) had thicknesses of >or= 200 microm, or thickness < 100 microm, or irregular base. The visual acuity in group A (logarithm of the minimum angle of resolution [log MAR] mean +/- SD:.083 +/-.144) was significantly better than group B (log MAR,.407 +/-.212, P <.0001). There was a significant reduction in the amplitude of all components of FMERGs elicited by the 15 degree stimulus in the affected eyes (mean +/- SE, A-wave: 1.26 +/-.12 microv, B-wave: 3.07 +/-.27 microv, oscillatory potentials: 1.23 +/-.25 microv) compared with the normal fellow eyes (A-wave: 1.58 +/-.13 microv, B-wave: 4.14 +/-.27 microv, oscillatory potentials: 2.35 +/-.29 microv). A significant correlation was found between the relative amplitudes of the B-wave elicited by the 5 degree stimulus and the visual acuity (r =.918, P =.0005). CONCLUSIONS: In eyes with an ERM and an MPH, the visual acuity is generally correlated with the OCT images. Macular function of eyes with an MPH resembles eyes with an ERM without an MPH. The effect of the ERM appears to be different on the base and parafovea of the MPHs.     

Reduced amplitude of oscillatory potentials in female carriers of X-linked recessive congenital stationary night blindness

We studied the electroretinograms of 12 female carriers in eight families with X-linked recessive congenital stationary night blindness. Forty-two normal eyes served as controls. The age and refractive error of the normal eyes were matched to those of the female carriers. We found the amplitude of the oscillatory potentials (01 + 02 + 03 + 04) in carriers was statistically smaller than in normal eyes. Seventeen of 22 eyes of carriers were more than +/- 2 S.D. away from normal, and the mean value was statistically lower than normal (P less than .001). The peak time of oscillatory potentials, and the amplitude of the a-, b-, scotopic b-, and photopic b-waves were all within the normal range. The selective abnormality of the amplitude of the oscillatory potentials is a new finding in female carriers in X-linked recessive congenital stationary night blindness.     

Focal macular electroretinograms before and after removal of choroidal neovascular lesions

PURPOSE: To evaluate the changes in focal macular electroretinograms (fmERGs) after surgical removal of choroidal neovascular (CNV) lesions. METHODS: Fourteen patients (14 eyes) with subfoveal or juxtafoveal CNV associated with age-related macular degeneration and 1 patient with idiopathic CNV underwent vitrectomy and removal of the lesions. fmERGs elicited by a 15 degree stimulus were recorded before and 3 months after surgery. Optical coherence tomography (OCT) was performed to measure the foveal and parafoveal thickness before and 3 months after surgery. RESULTS: Preoperative fmERGs were markedly reduced in all eyes. The mean amplitude of the b-wave in 15 eyes recorded 3 months after surgery increased significantly (P = 0.0022, Wilcoxon signed rank test). In all eyes except two with nearly nonrecordable a- and b- waves, the mean b-wave-to-a-wave ratio after surgery increased significantly in all eyes (P = 0.0330, Wilcoxon signed rank test). The percentage increase in the b-wave amplitude correlated significantly with the percentage decrease in the mean parafoveal retinal thickness (r = 0.688, P = 0.0076). CONCLUSIONS: The decreased macular ERGs were partially recoverable in the early postoperative period. The decreased retinal edema after surgery may have contributed to this recovery.     

糖尿病性黄斑水肿视网膜功能定量研究

目的:应用多焦视网膜电图评估糖尿病性黄斑水肿的视网膜功能.方法:选取2010-03/2014-03我院眼科经眼底血管造影检查确诊为糖尿病性黄斑水肿的患者30例48眼为观察组(其中局限性水肿18眼,弥漫性水肿24眼,囊样水肿6眼),选取视力0.8以上,经裂隙灯显微镜检查均未发现异常,全身情况无异常者15例30眼为对照组,两组研究对象均行多焦视网膜电图检查,并对其结果进行统计学分析.结果:糖尿病性黄斑水肿组多焦视网膜电图中心凹、黄斑区、黄斑外区a、b波的振幅密度与对照组相比均差异存在统计学意义(P＜0.01);中心凹处观察组和对照组a波的振幅密度分别为25.2±10.48、37.93±7.19nv/deg2,b波的振幅密度分别为77.16±27.97、113.42±11.79nv/deg2;黄斑区观察组和对照组a波的振幅密度分别为14.27±4.99、27.42 ±2.86nv/deg2,b波的振幅密度分别为43.14±14.77、69.99±10.07 nv/deg2;黄斑外区观察组和对照组a波的振幅密度分别为7.82±2.79、11.46±1.54nv/deg2,b波的振幅密度分别为19.85±6.5、31.56±6.0nv/deg2.中心凹处、黄斑区及黄斑外区多焦视网膜电图a、b波振幅密度在局限性黄斑水肿组与弥漫性黄斑水肿组和囊样黄斑水肿组间均存在统计学意义(P＜0.01).结论:糖尿病性黄斑水肿的多焦视网膜表现为a、b波振幅密度下降,潜伏期延长,振幅密度比潜伏期敏感.     

钕-钇铝石榴石激光玻璃体松解术治疗人工晶状体植入术后前部玻璃体混浊

目的 观察钕-钇铝石榴石(neodymium-yttrium aluminum garnet,Nd:YAG)激光玻璃体松解术对人工晶状体植入手术后前部玻璃体混浊的治疗效果。 方法 对裂隙灯显微镜联合光相干断层扫描（optical coherence tomography, OCT）和B型超声检查确诊的人工晶状体植入手术后前部玻璃体混浊患者47例49只眼，采用Nd:YAG激光行晶状体后囊切开的同时进行前部玻璃体切开及松解，观察激光治疗前后的视力变化、前部玻璃体混浊的改善情况以及治疗后的并发症。 结果 49只眼中，前部玻璃体混浊伴有晶状体后囊混浊46 只眼，晶状体后囊无明显混浊3只眼。Nd:YAG激光玻璃体松解术后视力均有改善,与术前比较差异有显著性的意义(t=3 2.50，P=0.007)。激光松解术后15 min前部混浊的玻璃体形成透明区者21只眼，占42.86% ；24 h内形成透明区者47只眼，占95.92%；2只眼在术后7 d透明区小于瞳孔接受了第2次激光治疗。全部患眼术中和术后无并发症发生。 结论 人工晶状体植入手术后视力缓慢下降的患者，除考虑有后发障外，还应注意是否有前部玻璃体混浊的存在。Nd:YAG激光晶状体后囊切开联合前部玻璃体松解是治疗人工晶状体植入手术后前部玻璃体混浊的有效方法。 （中华眼底病杂志，2003，19：99-101）     

影响视网膜脱离患者视网膜功能的因素

目的:评价视网膜脱离患者年龄、病程、视网膜脱离面积、黄斑脱离情况等因素对视网膜功能的影响。方法:将孔源性视网膜脱离(retinal detachment,RD)188例189眼的患者年龄、病程、视网膜脱离面积、黄斑脱离情况、视力与视网膜脱离眼的fERG和mfERG各指标进行相关分析。结果:影响RD眼fERG和mfERG的主要因素是脱离面积、黄斑脱离和视力。以|γ|>0.4,且P≤0.05判定为有相关性。脱离面积与明视和暗适应最大反应ERG a、b波幅值,30Hz闪烁光幅值,OPs波数和幅值负相关;与mfERG象限野P1波幅值密度、幅值负相关。相关系数最高者为fERG暗适应最大反应b波幅值(γ=-0.704)。黄斑脱离与明视和暗适应最大反应ERG b波幅值,30Hz闪烁光ERG幅值负相关;与mfERG环形野环1的P1波幅值密度、幅值负相关,与mfERG象限野P1波幅值密度负相关,相关系数最高者为mfERG环形野环1的P1波幅值(γ=-0.584)。视力与明视和暗适应最大反应a、b波幅值,30Hz闪烁光幅值,OPs子波数和幅值正相关;与mfERG环形野环1的P1波幅值密度、幅值正相关,相关系数最高者为30Hz闪烁光ERG幅值(γ=0.597)。RD眼的fERG异常率最高者为暗适应最大反应ERG b波幅值,异常率为71.3%,视网膜脱离象限野mfERG异常率最高者为P1波幅值,异常率为85.3%。结论:影响RD患者视网膜功能的重要因素是脱离面积和黄斑脱离情况。RD眼对视网膜功能异常反应的mfERG对视网膜功能异常反应的敏感性高于fERG。