中药穴位贴敷治疗美施康定所致便秘的临床观察及护理体会

目的:探讨中药穴位贴敷对服用阿片类药物(美施康定)所致便秘的疗效.方法:60例美施康定所致便秘患者,随机分入治疗组(中药穴位贴敷)30例、对照组(麻仁润肠丸)30例,观察两组疗效、便秘评分、副反应.结果:中药穴位贴敷治疗美施康定所致便秘总有效率为75%,优于麻仁润肠丸(总有效率53.3%),P<0.05.结论:中药穴位贴敷对服美施康定致便秘患者具有明显的缓泻通便作用,不良反应轻微,简便易行.     

中药穴位贴敷治疗老年便秘临床观察

目的:探讨中药穴位贴敷治疗老年便秘的效果。方法:将42例患者随机分为观察组(22例)、对照组(20例)。观察组除给予饮食指导外,采用穴位贴敷,对照组给予饮食指导。结果:观察组总有效率81.8%,对照组总有效率50.0%,治疗组优于对照组(P<0.05);治疗组首次排便时间(5.1±2.8)h,对照组为(10.1±7.3)h,两组比较差异有显著性意义(P<0.05)。结论:中药穴位贴敷对老年便秘具有预防作用。     

穴位贴敷治疗骨科卧床患者便秘效果观察

目的探讨中药贴敷穴位治疗骨科长期卧床患者便秘的疗效。方法对我院收治的100例骨科长期卧床出现便秘患者随机分为对照组和观察组，2组各50例，对照组采用腹部按摩，饮食调护，口服果导片等综合治疗；观察组在饮食调护的基础上腹部按摩后用中药贴敷穴位进行治疗。结果观察组疗效和总有效率均显著高于对照组（P〈0.01或P〈0.05）。结论中药贴敷穴位治疗可有效治疗骨科长期卧床患者出现的便秘。     

中药口服配合穴位贴敷治疗药物性便秘60例疗效观察

目的 观察中药口服配合穴位贴敷治疗阿片类药物所致便秘的临床疗效.方法 将120例符合纳入标准的患者随机分为治疗组和对照组各60例,治疗组予中药口服配合穴位贴敷治疗,对照组予口服麻仁软胶囊治疗,2组均以2周为1个疗程.结果 治疗组总有效率90%,对照组总有效率66.7%,差异具有统计学意义(P<0.05).结论 中药口服配合穴位贴敷治疗药物性便秘有较好的疗效.     

中药贴敷神阙穴治疗小儿腹泻疗效观察及护理

目的探讨中药贴敷神阙穴联合西医治疗小儿腹泻的临床效果。方法将86例小儿腹泻患儿随机分为治疗组和对照组,每组43例。对照组用常规西药进行治疗(补液、抗感染,口服肠道调节剂等),治疗组在对照组的基础上给予中药贴敷神阙穴,对两组治疗后的综合疗效进行比较。结果治疗效果治疗组明显优于对照组,差异有统计学意义(P0.05),结论中药穴位贴敷治疗能提高小儿腹泻的治疗效果。     

雾化吸入与中药穴位贴敷治疗小儿肺炎疗效观察

目的:观察雾化吸入同时加用中药穴位贴敷对小儿支气管肺炎的疗效。方法:将小儿支气管肺炎患者82例分为治疗组42例,对照组40例。对照组采用常规治疗,治疗组在常规治疗的基础上加用雾化吸入及中药穴位贴敷,比较疗效。结果:治疗组患儿临床恢复时间明显短于对照组(P<0.05),治愈率及总有效率明显高于对照组(P<0.05)。结论:在常规治疗的基础上加用雾化吸入、中药穴位贴敷治疗小儿支气管肺炎有明确疗效。     

中医综合护理技术治疗小儿便秘疗效观察

目的：观察中医综合护理技术治疗小儿便秘的临床效果。方法以随机数表法将2012年1~12月在我院儿科住院的110例小儿便秘患儿分为两组各55例,观察组患儿采用中医综合护理技术治疗(耳穴埋豆、中药穴位贴敷、中药灌肠、推拿按摩),10 d为1个疗程;对照组患儿采用传统的推拿疗法治疗,每天推拿治疗1次,10 d为1个疗程。10 d后观察两组患儿的症状量化评分和临床疗效。结果治疗后观察组患儿便秘的程度、腹胀或腹痛的状况、小便变黄的程度、胃纳减少状况和舌脉象等症状积分,以及面赤身热症状的积分分别与对照组比较差异均有统计学意义(P<0.05);治疗后观察组患儿的中医证候总分与对照组比较差异亦有统计学意义(P<0.05);观察组患儿的临床疗效明显优于对照组,差异有统计学意义(P<0.05)。结论中医综合护理技术治疗小儿便秘临床效果好,值得临床推广应用。     

中药煮散剂配合穴位贴敷治疗小儿急性咳嗽临床观察

目的:观察中药煮散剂配合穴位贴敷治疗小儿急性咳嗽的临床疗效.方法:选取2018年3月—2019年5月在安阳市中医院门诊就诊的120例诊断为急性咳嗽的患儿,分为对照组和治疗组,每组各60例.对照组常规西医治疗.治疗组口服中药煮散剂加穴位贴敷治疗.疗程为6d.比较两组临床疗效、中医症候积分、不良反应等.结果:治疗组疗效有效率、症候总积分减少和不良反应率均明显优于对照组,差异有统计学意义(P<0.05).结论:中药煮散剂配合穴位贴敷可明显提高小儿急性咳嗽的临床疗效,值得临床推广.     

推拿疗法配合中药配方颗粒敷脐治疗小儿湿热泻的临床研究

目的观察推拿疗法配合中药配方颗粒敷脐治疗小儿湿热泻的临床疗效。方法将62例小儿腹泻病患儿随机分为治疗组30例、对照组32例。治疗组给予推拿治疗,并应用中药配方颗粒敷脐治疗;对照组给予口服苍苓止泻口服液,并予蒙脱石散及培菲康口服辅助治疗。观察2组临床总疗效及大便次数、大便性状、呕吐、腹痛、腹胀、厌食、发热、脱水、肛门红、小便黄等症状体征的疗效。结果治疗组临床总疗效优于对照组(P<0.05)。在改善大便次数、大便性状、腹痛、腹胀、肛门红方面治疗组优于对照组(P<0.05)。在改善呕吐、厌食、发热、脱水、小便黄方面2组比较无显著性差异(P>0.05)。结论推拿配合中药敷脐治疗小儿湿热泻具有较好疗效。     

中药敷掌心疗法对糖尿病便秘的影响

目的 观察中药敷掌心疗法对糖尿病便秘的影响。 方法 将178例糖尿病合并便秘患者随机分成治疗组和对照组,治疗组病人于夜晚临睡前将制作好的握药丸置于双手掌心(劳宫穴),包扎固定,次晨取下;对照组口服麻仁丸,共治疗20天。观察两组患者治疗期间便秘症状积分、首次排便时间、排便间隔时间,并判定疗效。 结果 两组患者治疗后便秘总体疗效均佳,差异无统计学意义(P＞0.05);治疗后两组患者便秘积分均较前显著改善,治疗组(P＜0.01),对照组(P＜0.05),且治疗组优于对照组(P＜0.05);治疗组首次排便时间较对照组有缩短(P＜0.05);两组排便间隔时间均较治疗前明显缩短(P＜0.01,P＜0.05)。结论 中药敷掌心疗法可有效改善糖尿病患者的便秘症状。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.