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1.
Derlin T Weber C Habermann CR Herrmann J Wisotzki C Ayuk F Wolschke C Klutmann S Kröger N 《European journal of nuclear medicine and molecular imaging》2012,39(3):493-500
Purpose
The aim of the study was to determine the diagnostic performance of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the detection and localization of residual or recurrent disease in patients with multiple myeloma (MM) after stem cell transplantation. 相似文献2.
Lin FI Rao JE Mittra ES Nallapareddy K Chengapa A Dick DW Gambhir SS Iagaru A 《European journal of nuclear medicine and molecular imaging》2012,39(2):262-270
Purpose
Typically, 18F-FDG PET/CT and 18F-NaF PET/CT scans are done as two separate studies on different days to allow sufficient time for the radiopharmaceutical from the first study to decay. This is inconvenient for the patients and exposes them to two doses of radiation from the CT component of the examinations. In the current study, we compared the clinical usefulness of a combined 18F-FDG/18F-NaF PET/CT scan with that of a separate 18F-FDG-only PET/CT scan. 相似文献3.
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Joan Duch David Fuster Montserrat Muñoz Pedro Luís Fernández Pilar Paredes Montserrat Fontanillas Flavia Guzmán Sebastià Rubí Francisco Juan Lomeña Francesca Pons 《European journal of nuclear medicine and molecular imaging》2009,36(10):1551-1557
Purpose
The aim of this study was to prospectively evaluate 18F-FDG PET/CT in predicting response to neoadjuvant chemotherapy in large primary breast cancer. 相似文献5.
Domenico Albano Giovanni Bosio Raffaele Giubbini Francesco Bertagna 《Japanese journal of radiology》2017,35(10):574-583
Purpose
Langerhans cell histiocytosis (LCH) is a rare hematological disorder for which the utility of18F-FDG PET/CT is unclear. Our aim was to explore the metabolic features of LCH and the possible role of18F-FDG PET/CT in LCH evaluation.Materials and methods
We found 17 patients with histologically proven LCH who underwent 1718F-FDG PET/CT scans for staging and 42 scans for restaging/follow-up purposes. PET/CT results were compared with those obtained from other conventional imaging modalities (bone scintigraphy, plain radiogram, computed tomography, magnetic resonance).Results
18F-FDG PET/CT was positive in 15/17 patients, and it detected 36/37 lesions; all bone and extraskeletal lesions, except for a cecal lesion, were18F-FDG-avid. Only 1/4 of the patients with lung LCH had hypermetabolic lesions. The average SUVmax of the FDG-avid lesions was 7.3 ± 6.7, the average lesion-to-liver SUVmax ratio was 3.4 ± 2.5, and the average lesion-to-blood pool SUVmax ratio was 4 ± 3.2. In comparison to other imaging methods,18F-FDG PET/CT detected additional lesions or was able to evaluate treatment response earlier in 33/74 cases; it was confirmatory in 38/74 and detected fewer lesions in 3/74 (all three with lung LCH).Conclusions
18F-FDG PET/CT seems to be useful for evaluating LCH when compared to conventional imaging, except in pulmonary cases. It can be used both for staging and restaging purposes.6.
Erik Mittra Tarek El-Maghraby Cesar A. Rodriguez Andrew Quon I. Ross McDougall Sanjiv S. Gambhir Andrei Iagaru 《European journal of nuclear medicine and molecular imaging》2009,36(12):1952-1959
Purpose
Only a limited number of studies have evaluated the efficacy of 18F-FDG PET/CT for recurrent cervical carcinoma, which this study seeks to expand upon. 相似文献7.
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The impact of <Superscript>18</Superscript>F-FDG PET/CT in patients with liver metastases 总被引:1,自引:1,他引:0
Chua SC Groves AM Kayani I Menezes L Gacinovic S Du Y Bomanji JB Ell PJ 《European journal of nuclear medicine and molecular imaging》2007,34(12):1906-1914
Purpose The aim of this study was to assess the performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) versus dedicated contrast-enhanced CT (CECT) in the detection of metastatic liver disease.
Methods All patients that presented to our Institution with suspected metastatic liver disease who underwent 18F-FDG PET/CT and CECT within 6 weeks of each other, were retrospectively analyzed, covering a 5-year period. One hundred and
thirty-one patients (67 men, 64 women; mean age 62) were identified. Seventy-five had colorectal carcinoma and 56 had other
malignancies. The performance of CECT and that of 18F-FDG-PET/CT in detecting liver metastases were compared. The ability of each to detect local recurrence, extrahepatic metastases
and to alter patient management was recorded. The final diagnosis was based on histology, clinical and radiological follow-up
(mean 23 months).
Results In detecting hepatic metastases, 18F-FDG-PET/CT yielded 96% sensitivity and 75% specificity, whilst CECT showed 88% sensitivity and 25% specificity. 18F-FDG-PET/CT and CECT were concordant in 102 out of 131 patients (78%). In the colorectal group 18F-FDG-PET/CT showed 94% sensitivity and 75% specificity, whilst CECT had 91% sensitivity and 25% specificity. In the noncolorectal
group 18F-FDG-PET/CT showed 98% sensitivity and 75% specificity whilst CECT had 85% sensitivity and 25% specificity. Overall, 18F-FDG-PET/CT altered patient management over CECT in 25% of patients. CECT did not alter patient management over 18F-FDG-PET/CT alone in any patients.
Conclusion
18F-FDG-PET/CT performed better in detecting metastatic liver disease than CECT in both colorectal and noncolorectal malignancies,
and frequently altered patient management. The future role of CECT in these patients may need to be re-evaluated to avoid
potentially unnecessary duplication of investigation where 18F-PET/CT is readily available.
Authors stated no financial relationship to disclose 相似文献
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Hartmann A Eid K Dora C Trentz O von Schulthess GK Stumpe KD 《European journal of nuclear medicine and molecular imaging》2007,34(5):704-714
Purpose To retrospectively evaluate the diagnostic value of 18F-FDG PET/CT in trauma patients with suspected chronic osteomyelitis.
Methods Thirty-three partial body 18F-FDG PET/CT scans were performed in 33 patients with trauma suspected of having chronic osteomyelitis. In 10 and 23 patients,
infection was suspected in the axial and appendicular skeleton, respectively. In 18 patients, PET/CT was performed in the
presence of metallic implants. Histopathology or bacteriological culture was used as the standard of reference. For statistical
analysis, sensitivity, specificity and accuracy were calculated in relation to findings of the reference standard.
Results Of 33 PET/CT scans, 17 were true positive, 13 true negative, two false positive and one false negative. Eighteen patients
had chronic osteomyelitis and 15 had no osseous infection according to the reference standard. Sensitivity, specificity and
accuracy for 18F-FDG PET/CT was 94%, 87% and 91% for the whole group, 88%, 100% and 90% for the axial skeleton and 100%, 85% and 91% for
the appendicular skeleton, respectively.
Conclusion
18F-FDG PET/CT is a highly sensitive and specific method for the evaluation of chronic infection in the axial and appendicular
skeleton in patients with trauma. PET/CT allows precise anatomical localisation and characterisation of the infectious focus
and demonstrates the extent of chronic osteomyelitis with a high degree of accuracy. 相似文献
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Kimiteru Ito Yoshitaka Shida Kazuo Kubota Miyako Morooka Takashi Aruga Jun Itami Hiroshi Matsuda 《Annals of nuclear medicine》2010,24(9):649-654
Objective
Pyothorax-associated lymphoma (PAL) is a rare form of lymphoma and its management on 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined computed tomography (CT) has not been well reported. The purpose of this study was to evaluate the usefulness of FDG PET/CT in patients with PAL. 相似文献14.
Kevin London Siobhan Cross Ella Onikul Luciano Dalla-Pozza Robert Howman-Giles 《European journal of nuclear medicine and molecular imaging》2011,38(2):274-284
Purpose
In children with Hodgkin’s disease and non-Hodgkin’s lymphoma, the ability of 18F-fluoro-2-deoxy-D-glucose PET/CT and conventional imaging (CI) to detect malignant lesions and predict poor lesion response to therapy was assessed and compared. 相似文献15.
Jahae Kim Kang-Ho Choi Ho-Chun Song Joon-Tae Kim Man-Seok Park Ki-Hyun Cho 《European journal of nuclear medicine and molecular imaging》2016,43(12):2228-2235
Purpose
18F-FDG PET/CT can acquire both anatomical and functional images in a single session. We investigated which factors of 18F-FDG PET/CT imaging have potential as biomarkers for an increased risk of ischaemic stroke in cancer patients.Methods
From among cancer patients presenting with various neurological symptoms and hemiparesis, 134 were selected as eligible for this retrospective analysis. A new infarct lesion on brain MRI within 1 year of FDG PET/CT defined future ischaemic stroke. The target-to-background ratio (TBR) of each arterial segment was used to define arterial inflammation on PET imaging. Abdominal obesity was defined in terms of the area and proportion of visceral adipose tissue (VAT), subcutaneous adipose tissue and total adipose tissue (TAT) on a single CT slice at the umbilical level.Results
Ischaemic stroke confirmed by MRI occurred in 30 patients. Patients with stroke had higher TBRs in the carotid arteries and abdominal aorta (P?<?0.001) and a higher VAT proportion (P?=?0.021) and TAT proportion (P?=?0.041) than patients without stroke. Multiple logistic regression analysis showed that TBRs of the carotid arteries and abdominal aorta, VAT and TAT proportions, and the presence of a metabolically active tumour were significantly associated with future ischaemic stroke. Combining PET and CT variables improved the power for predicting future ischaemic stroke.Conclusion
Our findings suggest that arterial FDG uptake and hypermetabolic malignancy on PET and the VAT proportion on CT could be independent predictors of future ischaemic stroke in patients with cancer and could identify those patients who would benefit from medical treatment.16.
目的:多发性骨髓瘤是一种浆细胞恶性增殖性疾病,大约有80%的患者存在骨骼侵犯.本文探讨多发性骨髓瘤的18F-fluorodexoxyglucose(18F-FDG)PET/CT表现特点,提高对多发性骨髓瘤的认识.方法:26例按2001年WHO诊断标准确诊为多发性骨髓瘤的患者,均在治疗前行18F-FDG PET/CT显像.所有患者均依赖骨髓穿刺或活检取得明确病理学诊断.结果:26名患者均出现不同程度的骨质疏松.25例患者出现多发性骨质破坏,占总数的96.2%;其中11例患者出现颅骨破坏,占42.3%;25例出现脊柱骨质破坏,占96.2%;15例出现胸骨骨质破坏,占57.7%;21例出现肋骨骨质破坏,占80.8%;21例出现骨盆骨质破坏,占80.8%.部分骨破坏病灶呈18F-FDG高代谢灶.结论:多发性骨髓瘤的18F-FDG PET/CT表现具有一定特征,结合临床、影像、实验室和病理学检查能提高本病的诊断率. 相似文献
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Objective
Ewing sarcoma (ES) and osteosarcoma (OS) have different biological characteristics and respond differently to chemotherapy. We reviewed 18F-FDG PET imaging characteristics of ES and OS patients at baseline and following treatment to determine whether this biological variation is reflected in their imaging phenotype. 相似文献19.
Sampanna Jung Rayamajhi Bhagwant Rai Mittal Venkata Nagarjuna Maturu Ritesh Agarwal Amanjit Bal Pranab Dey Jaya Shukla Dheeraj Gupta 《Annals of nuclear medicine》2016,30(3):207-216
Purpose
There is currently no single modality for accurate characterization of enlarged mediastinal lymph nodes into benign or malignant. Recently 18F-fluorothymidine (FLT) has been used as a proliferation marker. In this prospective study, we examined the role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and 18F-FLT PET/CT in categorizing mediastinal lymph nodes as benign or malignant.Materials and methods
A total of 70 consecutive patients with mediastinal lymphadenopathy detected on computed tomography (CT) or chest radiograph underwent whole body 18F-FLT PET/CT and 18F-FDG PET/CT (within 1 week of each other). Lymph nodal tracer uptake was determined by calculation of standardized uptake value (SUV) with both the tracers. Results of PET/CT were compared with histopathology of the lymph nodes.Results
Histopathology results showed thirty-seven patients with sarcoidosis, seven patients with tuberculosis, nine patients with non-small cell lung cancer, five patients with Hodgkin’s lymphoma and twelve patients with non-Hodgkin’s lymphoma. The mean FDG SUVmax of sarcoidosis, tuberculosis, Hodgkin’s and non-Hodgkin’s lymphoma was 12.7, 13.4, 8.2, and 8.8, respectively, and the mean FLT SUVmax was 6.0, 5.4, 4.4, and 3.8, respectively. It was not possible to characterize mediastinal lymphadenopathy as benign or malignant solely based on FDG SUVmax values (p > 0.05) or FLT SUVmax values (p > 0.05). There was no significant difference in FDG uptake (p > 0.9) or FLT uptake (p > 0.9) between sarcoidosis and tuberculosis. In lung cancer patients, the FDG SUVmax and FLT SUVmax of those lymph nodes with tumor infiltration on biopsy was 6.7 and 3.9, respectively, and those without nodal infiltration was 6.4 and 3.7, respectively, and both the tracers were not able to characterize the nodal status as malignant or benign (p > 0.05).Conclusion
Though 18F-FLT PET/CT and 18F-FDG PET/CT reflect different aspects of biology, i.e., proliferation and metabolism, respectively, neither tracer could provide satisfactory categorization of benign and malignant lymph nodes. The results of this study clearly suggest that differentiation of mediastinal nodes into benign and malignant solely based on SUVmax values cannot be relied upon, especially in settings where tuberculosis and sarcoidosis are common.20.
Thomas Bird Sally Barrington Selvam Thavaraj Jean-Pierre Jeannon Andrew Lyons Richard Oakley Ricard Simo Mary Lei Teresa Guerrero Urbano 《European journal of nuclear medicine and molecular imaging》2016,43(7):1239-1247