共查询到20条相似文献，搜索用时 31 毫秒
1.
Anne Weissbach Tobias Bäumer Peter P. Pramstaller Norbert Brüggemann Vera Tadic Robert Chen Christine Klein Alexander Münchau 《Clinical neurophysiology》2017,128(1):275-280
Objectives
Mutations in the Parkin and PINK1 gene account for the majority of autosomal recessive early-onset Parkinson cases. There is increasing evidence that clinically asymptomatic subjects with single heterozygous mutations have a latent nigrostriatal dopaminergic deficit and could be taken as in vivo model of pre-symptomatic phase of Parkinsonism.Methods
We charted premotor–motor excitability changes as compensatory mechanisms for subcortical dopamine depletions using transcranial magnetic stimulation by applying magnetic resonance-navigated premotor–motor cortex conditioning in 15 asymptomatic, heterozygous Parkin and PINK1 mutation carriers (2 female; mean age 53 ± 8 years) and 16 age- and sex-matched controls (5 female; mean age 57 ± 9 years). Participants were examined at baseline and after acute l-dopa challenge.Results
There were l-dopa and group specific effects during premotor–motor conditioning at an interstimulus interval of 6 ms indicating a normalisation of premotor–motor interactions in heterozygous Parkin and PINK1 mutation carriers after l-dopa intake. Non-physiologically high conditioned MEP amplitudes at this interval in mutation carriers decreased after l-dopa intake but increased in controls.Conclusion
Premotor–motor excitability changes are part of the cortical reorganization in asymptomatic heterozygous Parkin- and PINK1 mutation carriers.Significance
These subjects offer opportunities to delineate motor network adaptation in pre-symptomatic Parkinsonism. 相似文献2.
J.P. Neverdahl P.M. Omland M. Uglem M. Engstrøm T. Sand 《Clinical neurophysiology》2017,128(12):2411-2418
Objective
To investigate motor cortical excitability, inhibition, and facilitation with navigated transcranial magnetic stimulation (TMS) in migraine in a blinded cross-sectional study.Methods
Resting motor threshold (RMT), cortical silent period (CSP), short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were compared in 27 interictal migraineurs and 33 controls. 24 female interictal migraineurs and 27 female controls were compared in subgroup analyses. Seven preictal migraineurs were also compared to the interictal group in a hypothesis-generating analysis. Investigators were blinded for diagnosis during recording and analysis of data.Results
SICI was decreased in interictal migraineurs when compared to healthy controls (p = 0.013), CSP was shortened in female interictal migraineurs (p = 0.041). ICF was decreased in preictal compared to interictal migraineurs (p = 0.023). RMT and ICF were not different between interictal migraineurs and controls.Conclusion
Cortical inhibition was decreased in migraineurs between attacks, primarily in a female subgroup, indicating an importance of altered cortical inhibition in migraine.Significance
Previous studies on motor cortical excitability in migraineurs have yielded varying results. This relatively large and blinded study provides support for altered cortical inhibition in migraine. Measuring intracortical facilitation in the period preceding migraine attacks may be of interest for future studies. 相似文献3.
Luis Velázquez-Pérez Johannes Tünnerhoff Roberto Rodríguez-Labrada Reidenis Torres-Vega Yusely Ruiz-Gonzalez Paolo Belardinelli Jacqueline Medrano-Montero Nalia Canales-Ochoa Yanetza González-Zaldivar Yaimeé Vazquez-Mojena Georg Auburger Ulf Ziemann 《Clinical neurophysiology》2017,128(12):2493-2502
Objective
Clinical data suggest early involvement of the corticospinal tract (CST) in spinocerebellar ataxia type 2 (SCA2). Here we tested if early CST degeneration can be detected in prodromal SCA2 mutation carriers by electrophysiological markers of CST integrity.Methods
CST integrity was tested in 15 prodromal SCA2 mutation carriers, 19 SCA2 patients and 25 age-matched healthy controls, using corticomuscular (EEG-EMG) and intermuscular (EMG-EMG) coherence measures in upper and lower limb muscles.Results
Significant reductions of EEG-EMG and EMG-EMG coherences were observed in the SCA2 patients, and to a similar extent in the prodromal SCA2 mutation carriers. In prodromal SCA2, EEG-EMG and EMG-EMG coherences correlated with the predicted time to ataxia onset.Conclusions
Findings indicate early CST neurodegeneration in SCA2. EEG-EMG and EMG-EMG coherence may serve as biomarkers of early CST neurodegeneration in prodromal SCA2 mutation carriers.Significance
Findings are important for developing preclinical disease markers in the context of currently emerging disease-modifying therapies of neurodegenerative disorders. 相似文献4.
Antoine Gueguen Claude Jardel Marc Polivka S. Veronica Tan Françoise Gray Catherine Vignal Anne Lombès Olivier Gout Hugh Bostock 《Clinical neurophysiology》2017,128(7):1258-1263
Objective
To explore potential spreading to peripheral nerves of the mitochondrial dysfunction in chronic progressive external ophthalmoplegia (CPEO) by assessing axonal excitability.Methods
CPEO patients (n = 13) with large size deletion of mitochondrial DNA and matching healthy controls (n = 22) were included in a case-control study. Muscle strength was quantified using MRC sum-score and used to define two groups of patients: CPEO-weak and CPEO-normal (normal strength). Nerve excitability properties of median motor axons were assessed with the TROND protocol and changes interpreted with the aid of a model.Results
Alterations of nerve excitability strongly correlated with scores of muscle strength. CPEO-weak displayed abnormal nerve excitability compared to CPEO-normal and healthy controls, with increased superexcitability and responses to hyperpolarizing current. Modeling indicated that the CPEO-weak recordings were best explained by an increase in the ‘Barrett-Barrett’ conductance across the myelin sheath.Conclusion
CPEO patients with skeletal weakness presented sub-clinical nerve excitability changes, which were not consistent with axonal membrane depolarization, but suggested Schwann cell involvement.Significance
This study provides new insights into the spreading of large size deletion of mitochondrial DNA to Schwann cells in CPEO patients. 相似文献5.
Matteo Bologna Kelly Bertram Giulia Paparella Claudia Papi Daniele Belvisi Antonella Conte Antonio Suppa David R. Williams Alfredo Berardelli 《Clinical neurophysiology》2017,128(9):1547-1552
Objective
Abnormal primary motor cortex plasticity might be involved in the pathophysiology of progressive supranuclear palsy. In the present study we aimed to investigate possible abnormalities of depotentiation, a mechanism involved in plasticity regulation, in this condition.Methods
Primary motor cortex excitability, investigated with single and paired-pulse transcranial magnetic stimulation, as well as long-term potentiation-like plasticity and its reversibility, were studied using theta burst stimulation in 15 patients with progressive supranuclear palsy and 11 healthy controls. Participants underwent two sessions using (1) the intermittent theta-burst stimulation (potentiation protocol) and (2) intermittent theta-burst stimulation combined with a depotentiation protocol (a short continuous theta-burst stimulation).Results
Patients with PSP had higher corticospinal excitability and lower intracortical inhibition than healthy controls. Intermittent theta-burst stimulation elicited an abnormally increased long term potentiation-like effect in patients in comparison to healthy subjects. However, the depotentiation protocol was able to reverse the effects intermittent theta-burst stimulation on motor cortex excitability both in patients and in healthy controls.Conclusions
Altered primary motor cortex plasticity in patients with PSP does not reflect an abnormality of depotentiation.Significance
This study provides information for a deeper understanding of the possible pathophysiological mechanisms underlying the altered M1 plasticity in PSP. 相似文献6.
Hatice Kumru Sergiu Albu John Rothwell Daniel Leon Cecilia Flores Eloy Opisso Josep Maria Tormos Josep Valls-Sole 《Clinical neurophysiology》2017,128(10):2043-2047
Objective
Repetitive application of peripheral electrical stimuli paired with transcranial magnetic stimulation (rTMS) of M1 cortex at low frequency, known as paired associative stimulation (PAS), is an effective method to induce motor cortex plasticity in humans. Here we investigated the effects of repetitive peripheral magnetic stimulation (rPMS) combined with low frequency rTMS (‘magnetic-PAS’) on intracortical and corticospinal excitability and whether those changes were widespread or circumscribed to the cortical area controlling the stimulated muscle.Methods
Eleven healthy subjects underwent three 10 min stimulation sessions: 10 Hz rPMS alone, applied in trains of 5 stimuli every 10 s (60 trains) on the extensor carpi radialis (ECR) muscle; rTMS alone at an intensity 120% of ECR threshold, applied over motor cortex of ECR and at a frequency of 0.1 Hz (60 stimuli) and magnetic PAS, i.e., paired rPMS and rTMS. We recorded motor evoked potentials (MEPs) from ECR and first dorsal interosseous (FDI) muscles. We measured resting motor threshold, motor evoked potentials (MEP) amplitude at 120% of RMT, short intracortical inhibition (SICI) at interstimulus interval (ISI) of 2 ms and intracortical facilitation (ICF) at an ISI of 15 ms before and immediately after each intervention.Results
Magnetic-PAS, but not rTMS or rPMS applied separately, increased MEP amplitude and reduced short intracortical inhibition in ECR but not in FDI muscle.Conclusion
Magnetic-PAS can increase corticospinal excitability and reduce intracortical inhibition. The effects may be specific for the area of cortical representation of the stimulated muscle.Significance
Application of magnetic-PAS might be relevant for motor rehabilitation. 相似文献7.
Simon Podnar Stayko Sarafov Ivailo Tournev Gregor Omejec Janez Zidar 《Clinical neurophysiology》2017,128(4):505-511
Objective
To systematically study peripheral nerve morphology in patients with transthyretin (TTR) amyloidosis and TTR gene mutation carriers using high-resolution ultrasonography (US).Methods
In this prospective cross-sectional study we took a structured history, performed neurological examination, and measured peripheral nerve cross-sectional areas (CSAs) bilaterally at 28 standard locations using US. Demographic and US findings were compared to controls.Results
Peripheral nerve CSAs were significantly larger in 33 patients with familial amyloid polyneuropathy (FAP) compared to 50 controls, most dramatically at the common entrapment sites (median nerve at the wrist, ulnar nerve at the elbow), and in the proximal nerve segments (median nerve in the upper arm, sciatic nerve in the thigh). Findings in 21 asymptomatic TTR gene mutation carriers were less marked compared to controls, with CSAs being larger only in the median nerve in the upper arm. Nerve CSAs correlated with abnormalities on nerve conduction studies.Conclusion
Using US, we confirmed previous pathohistological and imaging reports in FAP of the most pronounced peripheral nerve thickening in the proximal limb segments.Significance
Similar to US findings in diabetic and vasculitic neuropathies these predominantly proximal locations of nerve thickening may be attributed to ischaemic nerve damage caused by poor perfusion in the watershed zones along proximal limb segments. 相似文献8.
Mamede de Carvalho Artiom Poliakov Cristiano Tavares Michael Swash 《Clinical neurophysiology》2017,128(11):2200-2204
Objective
We studied motor unit recruitment to test a new method to identify motor unit firing rate (FR) variability.Methods
We studied 68 ALS patients, with and without upper neuron signs (UMN) in lower limbs, 24 patients with primary lateral sclerosis (PLS), 13 patients with spinal cord lesion and 39 normal subjects. All recordings were made from tibialis anterior muscles of normal strength. Subjects performed a very slight contraction in order to activate 2 motor units in each recording. 5–7 motor unit pairs were recorded in each subject. Mean consecutive differences (MCD) were calculated for each pair of potentials. The mean MCD for each muscle was estimated as the mean from the total number of pairs recorded. A p value < 0.01 was accepted as significant.Results
MCD of FR frequency was less in the subjects with spinal cord lesion and PLS. In addition, the FR frequency of the 1st motor unit in a pair of units was markedly reduced in PLS, and in subjects with spinal cord lesions.Conclusion
These results support a lower threshold and reduced FR fluctuation in spinal motor neurons of spastic patients.Significance
This method can be developed for detection of UMN lesions. 相似文献9.
Michele Ribolsi Giulia Lisi Viviana Ponzo Alberto Siracusano Carlo Caltagirone Cinzia Niolu Giacomo Koch 《Clinical neurophysiology》2017,128(10):2037-2042
Objective
Altered cortical connectivity and plasticity seems to be asymmetrical between the hemispheres in patients with schizophrenia (SCZ). We evaluated long-term potentiation (LTP) in parietal-frontal circuits of both hemispheres using a cortico-cortical Paired Associative Stimulation (cc-PAS) protocol testing the rules of Hebbian-like spike timing dependent plasticity (SPTD).Methods
12 SCZ and 12 healthy subjects (HS) underwent a cc-PAS protocol to activate, by means of paired pulses of transcranial magnetic stimulation (TMS), the short-latency connection between posterior parietal cortex (PPC) and primary motor cortex (M1) of both hemispheres. Motor-evoked potentials (MEPs) were collected to assess the time course of the after effects of cc-PAS protocol measuring MEP amplitude as index of cortico-cortical associative plasticity.Results
While HS showed a similar time course of LTP-like plasticity in the two hemispheres, SCZ revealed a weaker late-LTP-like plasticity in the left compared to the right hemisphere after cc-PAS protocol.Conclusions
SCZ failed to show the typical long-lasting increase of M1 excitability observed after cc-PAS protocol in both hemispheres, with a greater reduction in the left one.Significance
Our findings provide novel neurophysiological evidence for an asymmetric impairment of the left parietal-frontal network in SCZ patients. 相似文献10.
Alana B. McCambridge James W. Stinear Sarah Peek Winston D. Byblow 《Clinical neurophysiology》2017,128(9):1608-1616
Objective
Cervical propriospinal premotoneurons (PN) relay descending motor commands and integrate peripheral afferent feedback. Effects of anodal transcranial direct current stimulation (a-tDCS) on propriospinal excitability in the upper limbs are unknown.Methods
Healthy right-handed adults received a-tDCS or sham tDCS over primary motor cortex (M1) at 1 mA (Experiment 1, n = 18) or 2 mA current intensity (Experiment 2, n = 15). Propriospinal excitability was assessed by suppression of background electromyography (EMG) in extensor carpi radialis (ECR) from electrical stimulation of the superficial radial nerve during bilateral (Experiment 1 and 2) or unilateral (Experiment 2 only) activation of the left and/or right ECR. EMG suppression could be attributed to an early propriospinal component and late cortical component. Motor evoked potentials (MEP) were obtained as a manipulation check.Results
Before tDCS, propriospinal-mediated cutaneous-induced suppression was present in each arm for early and late components. ECR MEP amplitude increased after 1 mA, but not 2 mA, a-tDCS. Neither 1 mA nor 2 mA a-tDCS modulated either component of ipsilateral or contralateral propriospinal excitability during bilateral or unilateral tasks.Conclusions
Propriospinal-mediated cutaneous-induced suppression was not modulated by a-tDCS in healthy adults.Significance
Reporting non-significant findings is paramount for the development of clinically-relevant tDCS protocols. 相似文献11.
Raffaele Nardone Viviana Versace Luca Sebastianelli Francesco Brigo Stefan Golaszewski Monica Christova Eugen Gallasch Leopold Saltuari Eugen Trinka 《Clinical neurophysiology》2017,128(10):1971-1977
Objective
There is increasing evidence that an involvement of central nervous system (CNS) can occur in several myopathies. Transcranial magnetic stimulation (TMS) may represent a valuable tool for investigating important neurophysiological and pathophysiological aspects of cortical involvement in neuromuscular disorders. In this review paper we aimed to perform a systematic search of the studies employing TMS techniques in subjects suffering from myopathies.Methods
A literature search was conducted using PubMed and Embase. We identified and reviewed 9 articles matching the inclusion criteria. One hundred twenty patients were included in these studies, which have applied TMS in patients with muscle disorders.Results
To date, a few studies using TMS have been performed in myopathic patients and detected subclinical abnormalities in cortical reactivity and plasticity. The most consistent finding was a decrease in intracortical inhibition, which likely represents a non-specific compensatory mechanism of the CNS in an attempt to overcome the muscle deficit through an increase of the motor cortex output to deficient muscles.Conclusions
Application of TMS to characterize the pathophysiology of the CNS in these subjects appears to be safe and may lead to the development of valuable biomarkers. Well-defined motor cortical excitability patterns can be identified in the different muscle diseases, even if preliminary findings should be confirmed in future studies in larger cohorts of patients.Significance
TMS studies may shed new light on the physiological and pathophysiological mechanisms underlying the cortical involvement in muscle disorders. 相似文献12.
Zhongwei Guo Xiaozheng Liu Jiapeng Li Fuquan Wei Hongtao Hou Xingli Chen Xinwei Li Wei Chen 《Clinical neurophysiology》2017,128(7):1344-1349
Objective
To explore brain activity in AD with depression (D-AD) based on fractional amplitude of low-frequency fluctuation (fALFF).Methods
Twenty-two D-AD and 21 AD without depression patients (nD-AD) were examined by magnetic resonance imaging during resting state. Neuropsychiatric Inventory and Hamilton Depression Rating Scale were employed to assess the severity of depression. We analysed the characteristics of fALFF in D-AD differing from nD-AD. We also examined the correlation between fALFF and the depression severity.Results
D-AD patients had higher fALFF in right fusiform gyrus, left caudate nucleus, and right middle temporal gyrus (MTG), meanwhile lower fALFF in supplementary motor area (SMA) than nD-AD patients.Conclusions
Abnormal fALFF changes in fusiform gyrus, caudate nucleus, MTG and SMA may be important neuropathophysiologic characteristics of depression in AD.Significance
We have clarified the potential neuropathological changes of depression in AD based on fALFF method, which is crucial for effective intervention. 相似文献13.
Tamara Gedankien Peter J. Fried Alvaro Pascual-Leone Mouhsin M. Shafi 《Clinical neurophysiology》2017,128(12):2419-2427
Objective
We studied the correlation between motor evoked potentials (MEPs) and early TMS-evoked EEG potentials (TEPs) from single-pulse TMS before and after intermittent Theta Burst Stimulation (iTBS) to the left primary motor cortex (M1) in 17 healthy older participants.Methods
TMS was targeted to the hand region of M1 using a MRI-guided navigated brain stimulation system and a figure-of-eight biphasic coil. MEPs were recorded from the right first dorsal interosseous muscle using surface EMG. TEPs were extracted from a 61-channel EEG recording. Participants received 90 single TMS pulses at 120% of resting motor threshold before and after iTBS.Results
Across all participants, the change in N15-P30 TEP and MEP amplitudes were significantly correlated (r = 0.69; p < 0.01). Average TEP responses did not change significantly after iTBS, whereas MEP amplitudes showed a significant increase.Conclusions
Changes in corticospinal reactivity and cortical reactivity induced by iTBS are related. However, the effect of iTBS on TEPs, unlike MEPs, is not straightforward.Significance
Our findings help elucidate the relationship between changes in cortical and corticospinal excitability in healthy older individuals. Going forward, TEPs may be used to evaluate the effects of theta-burst stimulation in non-motor brain regions. 相似文献14.
Hugo Massé-Alarie Louis-David Beaulieu Richard Preuss Cyril Schneider 《Clinical neurophysiology》2017,128(3):442-453
Objective
The study tested whether combining repetitive peripheral magnetic stimulation (RPMS) and motor training of the superficial multifidus muscle (MF) better improved the corticomotor control of spine than training alone in chronic low back pain (CLBP).Methods
Twenty-one participants with CLBP were randomly allocated to [RPMS + training] and [Sham + training] groups for three sessions (S1–S3) over a week where MF was stimulated before training (volitional contraction). Training was also home-practiced twice a day. Changes were tested at S1 and S3 for anticipatory postural adjustments (APAs) of MF and semi-tendinosus (ST), MF EMG activation, cortical motor plasticity (transcranial magnetic stimulation) and pain/disability.Results
The RPMS group showed immediate decrease of pain at S1, then improvement of MF activation, ST APA, M1 facilitation, and pain/disability at S3. Changes were larger when brain excitability was lower at baseline. Disability index remained improved one month later.Conclusions
Combining RPMS with training of MF in CLBP impacted motor planning, MF and lumbopelvic spine motor control and pain/disability one week after the onset of protocol. Brain plasticity might have favoured motor learning and improved daily lumbopelvic spine control without pain generation.Significance
Clinically, RPMS impacted the function by improving the gains beyond those reached by training alone in CLBP. 相似文献15.
Hannah Pickering Jenna Murray Cindy S.-Y. Lin Christine Cormack Andrew Martin Matthew C. Kiernan Arun V. Krishnan 《Clinical neurophysiology》2017,128(1):93-99
Objective
To explore the benefits of modified-release fampridine on walking distance in MS.Methods
This was a randomised double-blind, placebo-controlled crossover trial of fampridine in 25 MS patients. The primary outcome measure was the six minute walk test (6MWT). A p-value < 10% led to rejection of the null hypothesis.Results
The pre-specified criterion for statistical significance was met, with a 17 m improvement in 6MWT in the treatment arm. In addition, baseline S2 accommodation, a nerve excitability parameter that reflects slow K+ channel activity, modified the effect of fampridine. For patients who had abnormally high S2 accommodation values, there was a 28 m improvement in the 6MWT (p = 0.04). In contrast, for patients with low S2 values, a 0 m improvement was noted (p = 1.0).Conclusion
The study provides evidence that fampridine may improve walking distance. Nerve excitability assessment may be useful in selecting those patients who are most likely to gain benefit from fampridine.Significance
Fampridine may improve walking distance in MS. Nerve excitability assessment may assist in identifying those patients most likely to respond to fampridine. 相似文献16.
Alonso Zea Vera Gewalin Aungaroon Paul S. Horn Anna W. Byars Hansel M. Greiner Jeffrey R. Tenney Todd M. Arthur Nathan E. Crone Katherine D. Holland Francesco T. Mangano Ravindra Arya 《Clinical neurophysiology》2017,128(10):2087-2093
Objective
To examine current thresholds and their determinants for language and motor mapping with extra-operative electrical cortical stimulation (ECS).Methods
ECS electrocorticograph recordings were reviewed to determine functional thresholds. Predictors of functional thresholds were found with multivariable analyses.Results
In 122 patients (age 11.9 ± 5.4 years), average minimum, frontal, and temporal language thresholds were 7.4 (± 3.0), 7.8 (± 3.0), and 7.4 (± 3.1) mA respectively. Average minimum, face, upper and lower extremity motor thresholds were 5.4 (± 2.8), 6.1 (± 2.8), 4.9 (± 2.3), and 5.3 (± 3.3) mA respectively.Functional and after-discharge (AD)/seizure thresholds were significantly related. Minimum, frontal, and temporal language thresholds were higher than AD thresholds at all ages. Minimum motor threshold was higher than minimum AD threshold up to 8.0 years of age, face motor threshold was higher than frontal AD threshold up to 11.8 years age, and lower subsequently. UE motor thresholds remained below frontal AD thresholds throughout the age range.Conclusions
Functional thresholds are frequently above AD thresholds in younger children.Significance
These findings raise concerns about safety and neurophysiologic validity of ECS mapping. Functional and AD/seizure thresholds relationships suggest individual differences in cortical excitability which cannot be explained by clinical variables. 相似文献17.
Christoph Neuwirth Paul E. Barkhaus Christian Burkhardt José Castro David Czell Mamede de Carvalho Sanjeev Nandedkar Erik Stålberg Markus Weber 《Clinical neurophysiology》2017,128(3):495-500
Objective
Motor Unit Number Index (MUNIX) is a quantitative neurophysiological measure that provides an index of the number of lower motor neurons supplying a muscle. It reflects the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS). However, it is unclear whether MUNIX also detects motor unit loss in strong, non-wasted muscles.Methods
Three centres measured MUNIX in 49 ALS patients every three months in six different muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis, abductor hallucis) on the less affected side. The decline of MUNIX in initially non-wasted, clinically strong muscles (manual muscle testing, MMT grade 5) was analysed before and after onset of weakness.Results
In 49 subjects, 151 clinically strong muscles developed weakness and were included for analysis. The average monthly relative loss of MUNIX was 5.0% before and 5.6% after onset of weakness. This rate of change was significantly higher compared to ALS functional rating scale (ALSFRS-R) and compound muscle action potential (CMAP) change over 12 months prior to the onset of muscle weakness (p = 0.024).Conclusion
MUNIX is an electrophysiological marker that detects lower motor neuron loss in ALS, before clinical weakness becomes apparent by manual muscle testing.Significance
This makes MUNIX a good biomarker candidate for disease progression and possibly pharmacodynamics responds. 相似文献18.
Belinda M. Brown Hamid R. Sohrabi Kevin Taddei Samantha L. Gardener Stephanie R. Rainey-Smith Jeremiah J. Peiffer Chengjie Xiong Anne M. Fagan Tammie Benzinger Virginia Buckles Kirk I. Erickson Roger Clarnette Tejal Shah Colin L. Masters Michael Weiner Nigel Cairns Martin Rossor Neill R. Graff-Radford Ralph N. Martins 《Alzheimer's & dementia》2017,13(11):1197-1206
Introduction
The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers.Methods
In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression.Results
No differences in brain amyloid load, CSF Aβ42, or CSF tau were observed between low and high exercise groups. Nevertheless, when examining only those already accumulating AD pathology (i.e., amyloid positive), low exercisers had higher mean levels of brain amyloid than high exercisers. Furthermore, the interaction between exercise and estimated years from expected symptom onset was a significant predictor of brain amyloid levels.Discussion
Our findings indicate a relationship exists between self-reported exercise levels and brain amyloid in autosomal dominant AD mutation carriers. 相似文献19.
Louis-David Beaulieu Hugo Massé-Alarie Edith Ribot-Ciscar Cyril Schneider 《Clinical neurophysiology》2017,128(7):1290-1298
Objective
To investigate the ability of transcranial magnetic stimulation (TMS) outcomes in the chronic stroke population to (i) track individual plastic changes and (ii) detect differences between individuals. To this end, intrarater “test-retest” reliability (relative and absolute) was tested for the ipsilesional and contralesional hemispheres.Methods
Thirteen participants with a unilateral stroke (≥6 months ago) and sensorimotor impairments were enrolled. Single and paired-pulse TMS outcomes were obtained from the primary motor cortex (M1) representation of the tibialis anterior muscle in both hemispheres and at two sessions separated by one week. The standard error of the measurement (SEMeas), minimal detectable change (MDC) and intraclass correlation coefficient (ICC) were studied.Results
Active motor threshold and latency of motor evoked potentials provided the lowest SEMeas and highest ICCs for both ipsi- and contralesional hemispheres. However, MDC were generally large, thus questioning the use of TMS outcomes to track individual plastic changes of M1.Conclusions
Our study provided supporting evidence of good to excellent intrarater reliability for a few TMS outcomes and proposed recommendations on the interpretation and the use of that knowledge in future work.Significance
Psychometric properties of TMS measures should be further addressed in order to better understand how to refine their use in clinical settings. 相似文献20.
Lisbeth Hoejkjaer Larsen Ivan Chrilles Zibrandtsen Troels Wienecke Troels Wesenberg Kjaer Mark Schram Christensen Jens Bo Nielsen Henning Langberg 《Clinical neurophysiology》2017,128(11):2217-2226