共查询到20条相似文献，搜索用时 31 毫秒
1.
Tamara Gedankien Peter J. Fried Alvaro Pascual-Leone Mouhsin M. Shafi 《Clinical neurophysiology》2017,128(12):2419-2427
Objective
We studied the correlation between motor evoked potentials (MEPs) and early TMS-evoked EEG potentials (TEPs) from single-pulse TMS before and after intermittent Theta Burst Stimulation (iTBS) to the left primary motor cortex (M1) in 17 healthy older participants.Methods
TMS was targeted to the hand region of M1 using a MRI-guided navigated brain stimulation system and a figure-of-eight biphasic coil. MEPs were recorded from the right first dorsal interosseous muscle using surface EMG. TEPs were extracted from a 61-channel EEG recording. Participants received 90 single TMS pulses at 120% of resting motor threshold before and after iTBS.Results
Across all participants, the change in N15-P30 TEP and MEP amplitudes were significantly correlated (r = 0.69; p < 0.01). Average TEP responses did not change significantly after iTBS, whereas MEP amplitudes showed a significant increase.Conclusions
Changes in corticospinal reactivity and cortical reactivity induced by iTBS are related. However, the effect of iTBS on TEPs, unlike MEPs, is not straightforward.Significance
Our findings help elucidate the relationship between changes in cortical and corticospinal excitability in healthy older individuals. Going forward, TEPs may be used to evaluate the effects of theta-burst stimulation in non-motor brain regions. 相似文献2.
Lecio F. Pinto Emily J. Gilmore Ognen A. Petroff Adithya Sivaraju Nishi Rampal Lawrence J. Hirsch Nicolas Gaspard 《Clinical neurophysiology》2017,128(6):1083-1090
Objective
To describe EEG and clinical correlates, DC recordings and prognostic significance of cyclic seizures (CS).Methods
We reviewed our prospective continuous EEG database to identify patients with CS, controls with non-cyclic status epilepticus (SE) and controls without seizure matched for age and etiology. EEG was reviewed with DC settings.Results
39/260 (15%) patients with electrographic seizures presented with CS. These patients were older (62 vs. 54 years; p = 0.04) and more often had acute or progressive brain injury (77% vs. 52%; p = 0.03) than patients with non-cyclic SE and had a lower level of consciousness, were more severely ill, than matched controls. CS almost always had focal onset, often from posterior regions. Patients with CS trended towards worse prognosis. When available (12 patients), DC recordings showed an infraslow cyclic oscillation of EEG baseline synchronized to the seizures in all cases.Conclusions
CS occur mostly in older patients with acute or progressive brain injury, are more likely to be associated with poor outcome than patients with other forms of nonconvulsive SE, and are accompanied by synchronous oscillations of the EEG baseline on DC recordings.Significance
CS are a common form of non-convulsive status epilepticus in critically ill patients and provide further insights into the relationship between infraslow activity and seizures; further study on this relationship may shed light on the mechanisms of seizure initiation and termination. 相似文献3.
Roland Renzel Christian R. Baumann Ian Mothersill Rositsa Poryazova 《Clinical neurophysiology》2017,128(1):147-152
Objectives
Electroencephalography (EEG) is one of the methods used in predicting the outcome after cerebral hypoxia. In this study we aim to evaluate the significance of generalized periodic discharges (GPD) as a prognostic marker.Methods
We retrospectively analyzed the medical histories of patients, who underwent an EEG after cardiac arrest during the time period from 2005 to 2013 at the University Hospital Zurich. All EEGs were re-interpreted using the 2012 American Clinical Neurophysiology Society (ACNS) classification for intensive care unit (ICU) EEGs.Results
Out of 131 patients, in which an EEG was recorded after cardiopulmonary resuscitation, 119 were included in our study. The average interval between cardiac arrest and EEG-recording was 3.8 ± 3.0 days (range: 0–14 days). Persistent GPDs (i.e. GPDs more than 24 h after the event) were found in thirty-two (26.9%) of the patients initial EEGs. The appearance of persistent GPDs preceded fatal outcome in 100% of all cases (vs. 69.0% in the non-GPD-group, p < 0.0001).Conclusion
Among other encephalopathic markers in EEG persistent GPDs are a highly specific prognostic marker of fatal outcome in patients with hypoxic encephalopathy.Significance
Using standardized EEG interpretation, this study identified persistent GPDs as a specific prognostic marker in post cardiac arrest syndrome. 相似文献4.
5.
Joanna L. Evans Jacob W. Nadler Xavier A. Preud&#x;homme Eric Fang Rommie L. Daughtry Joseph B. Chapman David Attarian Samuel Wellman Andrew D. Krystal 《Clinical neurophysiology》2017,128(8):1421-1425
Objective
Delirium is a common post-operative complication associated with significant costs, morbidity, and mortality. We sought sleep/EEG predictors of delirium present prior to delirium symptoms to facilitate developing and targeting therapies.Methods
Continuous EEG data were obtained in 12 patients post-orthopedic surgery from the day of surgery until delirium assessment on post-operative day 2 (POD2).Results
Diminished total sleep time (r = ?0.68; p < 0.05) and longer latency to sleep onset (r = 0.67; p < 0.05) on the first night in the hospital were associated with greater POD2 delirium severity. Patients experiencing delirium slept 2.4 h less and took 2 h longer to fall asleep. Greater waking EEG delta power (r = 0.84; p < 0.05) on POD1 and less non-REM sleep EEG delta power (r = ?0.72; p < 0.05) on night 2 also predicted POD2 delirium severity.Conclusions
Loss of sleep on night1 post-surgery is an early predictor of subsequent delirium. EEG Delta Power alterations in waking and sleep appear to be later indicators of impending delirium. Further work is needed to evaluate reproducibility/generalizability and assess whether sleep loss contributes to causing delirium.Significance
This first study to prospectively collect continuous EEG data for an extended period prior to delirium onset identified EEG-derived indices that predict subsequent delirium that could aid in developing and targeting therapies. 相似文献6.
Jung-Won Shin Byeongsoo Yim Seung Hun Oh Nam Keun Kim Sang kun Lee Ok-Joon Kim 《Clinical neurophysiology》2017,128(5):756-762
Objective
We aimed to redefine various periodic patterns (PPs) observed on electroencephalography (EEG) in patients with sporadic Creutzfeldt–Jakob disease (sCJD) using the American Clinical Neurophysiology Society’s (ACNS) Criteria.Methods
We analyzed EEG data of 23 patients with sCJD were admitted to two university hospitals between August 2005 and September 2015.Results
We classified PPs on EEG data into three types: irregular periodic discharges (PDs) with superimposed rhythmic activities, appearing at a median of 8 weeks after onset (w.a.o.); rhythmic sharp-and-wave, at a median of 11 w.a.o.; and PDs with biphasic or triphasic morphology, at a median of 17 w.a.o. Of 16 patients presenting with PPs, 14 had widespread lesions in both cortical and subcortical areas with clinical stage III at admission, and shorter time intervals for admission to hospital from disease onset than patients without PPs (Patients with PP, 11.6 ± 12.2 weeks; without PP, 18.2 ± 8.3 weeks; p = 0.033).Conclusions
PPs largely presented as three types at different stages of disease progression, and patients who had PPs had more wide spread lesions and rapid disease progression.Significance
Our redefinition of PPs demonstrated on EEG using the ACNS criteria may contribute to further understanding of the pathological mechanisms of sCJD, and PPs might be a predictive factor of a rapid sCJD progression. 相似文献7.
F. Fürbass S. Kampusch E. Kaniusas J. Koren S. Pirker R. Hopfengärtner H. Stefan T. Kluge C. Baumgartner 《Clinical neurophysiology》2017,128(8):1466-1472
Objective
This study investigated sensitivity and false detection rate of a multimodal automatic seizure detection algorithm and the applicability to reduced electrode montages for long-term seizure documentation in epilepsy patients.Methods
An automatic seizure detection algorithm based on EEG, EMG, and ECG signals was developed. EEG/ECG recordings of 92 patients from two epilepsy monitoring units including 494 seizures were used to assess detection performance. EMG data were extracted by bandpass filtering of EEG signals. Sensitivity and false detection rate were evaluated for each signal modality and for reduced electrode montages.Results
All focal seizures evolving to bilateral tonic-clonic (BTCS, n = 50) and 89% of focal seizures (FS, n = 139) were detected. Average sensitivity in temporal lobe epilepsy (TLE) patients was 94% and 74% in extratemporal lobe epilepsy (XTLE) patients. Overall detection sensitivity was 86%. Average false detection rate was 12.8 false detections in 24 h (FD/24 h) for TLE and 22 FD/24 h in XTLE patients. Utilization of 8 frontal and temporal electrodes reduced average sensitivity from 86% to 81%.Conclusion
Our automatic multimodal seizure detection algorithm shows high sensitivity with full and reduced electrode montages.Significance
Evaluation of different signal modalities and electrode montages paces the way for semi-automatic seizure documentation systems. 相似文献8.
Nicolás M. Phielipp Utpal Saha Tejas Sankar Akihiro Yugeta Robert Chen 《Clinical neurophysiology》2017,128(6):1109-1115
Objective
To evaluate the safety of repetitive transcranial magnetic stimulation (rTMS) in patients with implanted subdural cortical electrodes.Methods
We performed ex-vivo experiments to test the temperature, displacement and current induced in the electrodes with single pulse transcranial magnetic stimulation (TMS) from 10 to 100% of stimulator output and tested a typical rTMS protocol used in a clinical setting. We then used rTMS to the motor cortex to treat a patient with refractory post-herpetic neuralgia who had previously been implanted with a subdural motor cortical electrode for pain management. The rTMS protocol consisted of ten sessions of 2000 stimuli at 20 Hz and 90% of resting motor threshold.Results
The ex-vivo study showed an increase in the coil temperature of 2 °C, a maximum induced charge density of 30.4 μC/cm2/phase, and no electrode displacement with TMS. There was no serious adverse effect associated with rTMS treatment of the patient. Cortical tremor was observed in the intervals between trains of stimuli during one treatment session.Conclusions
TMS was safe in a patient with implanted Medtronic Resume II electrode (model 3587A) subdural cortical electrode.Significance
TMS may be used as a therapeutic, diagnostic or research tool in patients this type of with implanted cortical electrodes. 相似文献9.
Milica G. Kramberger Katarina Giske Lena Cavallin Ingemar Kåreholt Thomas Andersson Bengt Winblad Vesna Jelic 《Clinical neurophysiology》2017,128(9):1575-1582
Objective
The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population.Methods
Patients with Alzheimer’s disease (AD, n = 58), mild cognitive impairment (MCI, n = 141), subjective cognitive impairment (SCI, n = 194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording. Background activity (BA) and episodic and continuous abnormalities were assessed visually in EEG.Results
WML (p = 0.006) and atrophy in medial temporal regions (MTA) (p = <0.001) were associated with slower BA in all diagnoses. WML were associated in SCI with total episodic EEG abnormalities (p = 0.03).Conclusions
EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.Significance
Even the standard visually assessed EEG can complement a memory clinic diagnostic workup. 相似文献10.
Michelle A. O&#x;Reilly Joe Bathelt Elena Sakkalou Hanna Sakki Alison Salt Naomi J. Dale Michelle de Haan 《Clinical neurophysiology》2017,128(11):2191-2199
Objective
Young children with congenital visual impairment (VI) are at increased risk of behavioral vulnerabilities. Studies on ‘at risk’ populations suggest that frontal EEG asymmetry may be associated with behavioral risk. We investigated frontal asymmetry at 1 year (Time 1), behavior at 2 years (Time 2) and their longitudinal associations within a sample of infants with VI. Frontal asymmetry in the VI sample at 1 year was also compared cross-sectionally to an age-matched typically sighted (TS) group.Methods
At Time 1, 22 infants with VI and 10 TS infants underwent 128-channel EEG recording. Frontal asymmetry ratios were calculated from power spectral density values in the alpha frequency band. At Time 2, Achenbach Child Behavior Checklist data was obtained for the VI sample.Results
63.6% of the VI sample and 50% of the TS sample showed left frontal asymmetry; no significant difference in frontal asymmetry was found between the two groups. 22.7% of the VI sample had subclinical to clinical range ‘internalizing’ behavior difficulties. Greater left frontal asymmetry at one year was significantly associated with greater emotionally reactive scores at two years within the VI sample (r = 0.50, p = 0.02).Conclusions
Left frontal asymmetry correlates with later behavior risk within this vulnerable population.Significance
These findings make an important first contribution regarding the utility of frontal EEG asymmetry as a method to investigate risk in infants with VI. 相似文献11.
Sung Wook Chung Benjamin P. Lewis Nigel C. Rogasch Takashi Saeki Richard H. Thomson Kate E. Hoy Neil W. Bailey Paul B. Fitzgerald 《Clinical neurophysiology》2017,128(7):1117-1126
Objectives
To examine the effects of intermittent TBS (iTBS) and continuous TBS (cTBS) on cortical reactivity in the dorsolateral prefrontal cortex.Methods
10 healthy participants were stimulated with either iTBS, cTBS or sham at F3 electrode. Single- and paired-pulse TMS and concurrent electroencephalography (EEG) were used to assess change in cortical reactivity and long-interval intracortical inhibition (LICI) via TMS-evoked potentials (TEPs) and TMS-evoked oscillations.Results
Significant increases in N120 amplitudes (p < 0.01) were observed following iTBS over prefrontal cortex. Changes in TMS-evoked theta oscillations and LICI of theta oscillations were also observed following iTBS (increase) and cTBS (decrease). Change in LICI of theta oscillations correlated with change in N120 amplitude following TBS (r = ?0.670, p = 0.001).Conclusions
This study provides preliminary evidence that TBS produces direct changes in cortical reactivity in the prefrontal cortex. Combining TBS with TMS-EEG may be a useful approach to optimise stimulation paradigms prior to the conduct of clinical trials.Significance
TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex. 相似文献12.
Ninah Koolen Lisa Oberdorfer Zsofia Rona Vito Giordano Tobias Werther Katrin Klebermass-Schrehof Nathan Stevenson Sampsa Vanhatalo 《Clinical neurophysiology》2017,128(6):1100-1108
Objective
To develop a method for automated neonatal sleep state classification based on EEG that can be applied over a wide range of age.Methods
We collected 231 EEG recordings from 67 infants between 24 and 45 weeks of postmenstrual age. Ten minute epochs of 8 channel polysomnography (N = 323) from active and quiet sleep were used as a training dataset. We extracted a set of 57 EEG features from the time, frequency, and spatial domains. A greedy algorithm was used to define a reduced feature set to be used in a support vector machine classifier.Results
Performance tests showed that our algorithm was able to classify quiet and active sleep epochs with 85% accuracy, 83% sensitivity, and 87% specificity. The performance was not substantially lowered by reducing the epoch length or EEG channel number. The classifier output was used to construct a novel trend, the sleep state probability index, that improves the visualisation of brain state fluctuations.Conclusions
A robust EEG-based sleep state classifier was developed. It performs consistently well across a large span of postmenstrual ages.Significance
This method enables the visualisation of sleep state in preterm infants which can assist clinical management in the neonatal intensive care unit. 相似文献13.
Lauren C. Weeke Inge M. van Ooijen Floris Groenendaal Alexander C. van Huffelen Ingrid C. van Haastert Carolien van Stam Manon J. Benders Mona C. Toet Lena Hellström-Westas Linda S. de Vries 《Clinical neurophysiology》2017,128(12):2428-2435
Objective
Classify rhythmic EEG patterns in extremely preterm infants and relate these to brain injury and outcome.Methods
Retrospective analysis of 77 infants born <28 weeks gestational age (GA) who had a 2-channel EEG during the first 72?h after birth. Patterns detected by the BrainZ seizure detection algorithm were categorized: ictal discharges, periodic epileptiform discharges (PEDs) and other waveforms. Brain injury was assessed with sequential cranial ultrasound (cUS) and MRI at term-equivalent age. Neurodevelopmental outcome was assessed with the BSITD-III (2 years) and WPPSI-III-NL (5 years).Results
Rhythmic patterns were observed in 62.3% (ictal 1.3%, PEDs 44%, other waveforms 86.3%) with multiple patterns in 36.4%. Ictal discharges were only observed in one and excluded from further analyses. The EEG location of the other waveforms (p < 0.05), but not PEDs (p = 0.238), was significantly associated with head position. No relation was found between the median total duration of each pattern and injury on cUS and MRI or cognition at 2 and 5 years.Conclusions
Clear ictal discharges are rare in extremely preterm infants. PEDs are common but their significance is unclear. Rhythmic waveforms related to head position are likely artefacts.Significance
Rhythmic EEG patterns may have a different significance in extremely preterm infants. 相似文献14.
Frédéric Zubler Andreas Steimer Rebekka Kurmann Mojtaba Bandarabadi Jan Novy Heidemarie Gast Mauro Oddo Kaspar Schindler Andrea O. Rossetti 《Clinical neurophysiology》2017,128(4):635-642
Objective
Outcome prognostication in comatose patients after cardiac arrest (CA) remains a major challenge. Here we investigated the prognostic value of combinations of linear and non-linear bivariate EEG synchronization measures.Methods
94 comatose patients with EEG within 24 h after CA were included. Clinical outcome was assessed at 3 months using the Cerebral Performance Categories (CPC). EEG synchronization between the left and right parasagittal, and between the frontal and parietal brain regions was assessed with 4 different quantitative measures (delta power asymmetry, cross-correlation, mutual information, and transfer entropy). 2/3 of patients were used to assess the predictive power of all possible combinations of these eight features (4 measures × 2 directions) using cross-validation. The predictive power of the best combination was tested on the remaining 1/3 of patients.Results
The best combination for prognostication consisted of 4 of the 8 features, and contained linear and non-linear measures. Predictive power for poor outcome (CPC 3–5), measured with the area under the ROC curve, was 0.84 during cross-validation, and 0.81 on the test set. At specificity of 1.0 the sensitivity was 0.54, and the accuracy 0.81.Conclusion
Combinations of EEG synchronization measures can contribute to early prognostication after CA. In particular, combining linear and non-linear measures is important for good predictive power.Significance
Quantitative methods might increase the prognostic yield of currently used multi-modal approaches. 相似文献15.
Tommaso Fedele Claudio Schönenberger Gabriel Curio Carlo Serra Niklaus Krayenbühl Johannes Sarnthein 《Clinical neurophysiology》2017,128(10):1851-1857
Objective
The detectability of high frequency oscillations (HFO, >200 Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA).Methods
In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7 Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia.Results
In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p < 0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p < 0.001) for recordings with low impedance (<5 kΩ). Average amplitudes were indistinguishable between anesthesia compounds.Conclusion
Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance.Significance
Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings. 相似文献16.
Anneleen Dereymaeker Amir H. Ansari Katrien Jansen Perumpillichira J. Cherian Jan Vervisch Paul Govaert Leen De Wispelaere Charlotte Dielman Vladimir Matic Alexander Caicedo Dorado Maarten De Vos Sabine Van Huffel Gunnar Naulaers 《Clinical neurophysiology》2017,128(9):1737-1745
Objective
To assess interrater agreement based on majority voting in visual scoring of neonatal seizures.Methods
An online platform was designed based on a multicentre seizure EEG-database. Consensus decision based on ‘majority voting’ and interrater agreement was estimated using Fleiss’ Kappa. The influences of different factors on agreement were determined.Results
1919 Events extracted from 280 h EEG of 71 neonates were reviewed by 4 raters. Majority voting was applied to assign a seizure/non-seizure classification. 44% of events were classified with high, 36% with moderate, and 20% with poor agreement, resulting in a Kappa value of 0.39. 68% of events were labelled as seizures, and in 46%, all raters were convinced about electrographic seizures. The most common seizure duration was <30 s. Raters agreed best for seizures lasting 60–120 s. There was a significant difference in electrographic characteristics of seizures versus dubious events, with seizures having longer duration, higher power and amplitude.Conclusions
There is a wide variability in identifying rhythmic ictal and non-ictal EEG events, and only the most robust ictal patterns are consistently agreed upon. Database composition and electrographic characteristics are important factors that influence interrater agreement.Significance
The use of well-described databases and input of different experts will improve neonatal EEG interpretation and help to develop uniform seizure definitions, useful for evidence-based studies of seizure recognition and management. 相似文献17.
Korhan Buyukturkoglu Camillo Porcaro Carlo Cottone Andrea Cancelli Matilde Inglese Franca Tecchio 《Clinical neurophysiology》2017,128(5):807-813
Objective
To investigate the EEG-derived functional connectivity at rest (FCR) patterns of fatigued Multiple Sclerosis (MS) patients in order to find good parameters for a future EEG-Neurofeedback intervention to reduce their fatigue symptoms.Methods
We evaluated FCR between hemispheric homologous areas, via spectral coherence between pairs of corresponding left and right bipolar derivations, in the Theta, Alpha and Beta bands. We estimated FCR in 18 MS patients with different levels of fatigue and minimal clinical severity and in 11 age and gender matched healthy controls. We used correlation analysis to assess the relationship between the fatigue scores and the FCR values differing between fatigued MS patients and controls.Results
Among FCR values differing between fatigued MS patients and controls, fatigue symptoms increased with higher Beta temporo-parietal FCR (p = 0.00004). Also, positive correlations were found between the fatigue levels and the fronto-frontal FCR in Beta and Theta bands (p = 0.0002 and p = 0.001 respectively).Conclusion
We propose that a future EEG-Neurofeedback system against MS fatigue would train patients to decrease voluntarily the beta coherence between the homologous temporo-parietal areas.Significance
We extracted a feature for building an EEG-Neurofeedback system against fatigue in MS. 相似文献18.
Alice D. Lam Douglas Maus Sahar F. Zafar Andrew J. Cole Sydney S. Cash 《Clinical neurophysiology》2017,128(9):1647-1655
Objective
In mesial temporal lobe (mTL) epilepsy, seizure onset can precede the appearance of a scalp EEG ictal pattern by many seconds. The ability to identify this early, occult mTL seizure activity could improve lateralization and localization of mTL seizures on scalp EEG.Methods
Using scalp EEG spectral features and machine learning approaches on a dataset of combined scalp EEG and foramen ovale electrode recordings in patients with mTL epilepsy, we developed an algorithm, SCOPE-mTL, to detect and lateralize early, occult mTL seizure activity, prior to the appearance of a scalp EEG ictal pattern.Results
Using SCOPE-mTL, 73% of seizures with occult mTL onset were identified as such, and no seizures that lacked an occult mTL onset were identified as having one. Predicted mTL seizure onset times were highly correlated with actual mTL seizure onset times (r = 0.69). 50% of seizures with early mTL onset were lateralizable prior to scalp ictal onset, with 94% accuracy.Conclusions
SCOPE-mTL can identify and lateralize mTL seizures prior to scalp EEG ictal onset, with high sensitivity, specificity, and accuracy.Significance
Quantitative analysis of scalp EEG can provide important information about mTL seizures, even in the absence of a visible scalp EEG ictal correlate. 相似文献19.
Anne Weissbach Tobias Bäumer Peter P. Pramstaller Norbert Brüggemann Vera Tadic Robert Chen Christine Klein Alexander Münchau 《Clinical neurophysiology》2017,128(1):275-280
Objectives
Mutations in the Parkin and PINK1 gene account for the majority of autosomal recessive early-onset Parkinson cases. There is increasing evidence that clinically asymptomatic subjects with single heterozygous mutations have a latent nigrostriatal dopaminergic deficit and could be taken as in vivo model of pre-symptomatic phase of Parkinsonism.Methods
We charted premotor–motor excitability changes as compensatory mechanisms for subcortical dopamine depletions using transcranial magnetic stimulation by applying magnetic resonance-navigated premotor–motor cortex conditioning in 15 asymptomatic, heterozygous Parkin and PINK1 mutation carriers (2 female; mean age 53 ± 8 years) and 16 age- and sex-matched controls (5 female; mean age 57 ± 9 years). Participants were examined at baseline and after acute l-dopa challenge.Results
There were l-dopa and group specific effects during premotor–motor conditioning at an interstimulus interval of 6 ms indicating a normalisation of premotor–motor interactions in heterozygous Parkin and PINK1 mutation carriers after l-dopa intake. Non-physiologically high conditioned MEP amplitudes at this interval in mutation carriers decreased after l-dopa intake but increased in controls.Conclusion
Premotor–motor excitability changes are part of the cortical reorganization in asymptomatic heterozygous Parkin- and PINK1 mutation carriers.Significance
These subjects offer opportunities to delineate motor network adaptation in pre-symptomatic Parkinsonism. 相似文献20.
Päivi Nevalainen Viviana Marchi Marjo Metsäranta Tuula Lönnqvist Sanna Toiviainen-Salo Sampsa Vanhatalo Leena Lauronen 《Clinical neurophysiology》2017,128(7):1337-1343