532nm连续激光照射下鸡冠组织热效应的动物实验研究

目的:观察532nm连续激光照射下鸡冠组织的温度和血流变化特点,为光动力疗法(Photodynamic Therapy,PDT)治疗鲜红斑痣(Port-winestain,PWS)中激光光剂量的安全性提供实验依据。方法:将雄性3月龄公鸡15只,按功率密度100、150、200、250和300mW/cm2随机分为5组,每组3只。采用波长532nm半导体泵浦倍频KTP连续激光器照射2cm×2cm     

532nm KTP激光治疗鲜红斑痣的疗效及安全性的探讨

目的:探索新型532 nm KTP激光对黄种人不同类型鲜红斑痣的疗效及不良反应并与595 nm脉冲染料激光比较。方法:将入组鲜红斑痣患者的自身皮损随机分成KTP激光治疗区及PDL治疗区,分别予以532 nm KTP激光和595nm PDL治疗,每2个月治疗一次,共2～3次。每次治疗前、治疗后即刻以及治疗后2个月对患者激光治疗后的皮损进行疗效及安全性评价。结果:532 nm KTP激光治疗组和595 nm PDL治疗组每个疗程治疗后疗效均无显著差异。在既往曾接受PDL治疗出现治疗抵抗的患者,经532 nm KTP激光治疗后,皮损取得了一定改善。532 nm KTP激光治疗组在治疗时疼痛程度及治疗后紫癜的程度均显著低于595 nm PDL治疗组。结论:新型532 nm KTP激光治疗鲜红斑痣的疗效与595nm PDL相近,不良反应少,安全性好,可以作为鲜红斑痣治疗的另一选择方案。     

血管靶向光动力治疗儿童面部鲜红斑痣的临床护理

目的：观察血管靶向光动力治疗鲜红斑痣的疗效与护理特点。 方法：鲜红斑痣患儿30例,男性12例,女性18例;年龄1～3岁。病变部位均为面部。采用血管靶向光动力治疗,激光器为全固态激光治疗仪（北京心润心公司产）,波长532nm,     

四种光疗疗法治疗浅表性皮肤血管性疾病的临床分析

目的 比较不同的光疗疗法治疗皮肤血管性疾病的特点及临床疗效.方法 回顾性总结分析可变脉宽532 nm激光,脉冲染料585 nm激光,IPL强光治疗系统和铜蒸气激光光动力学疗法(PDT)治疗鲜红斑痣、草莓状血管瘤、葡型性血管瘤、血管角皮瘤、毛细血管扩张、血管痣、充血性增生性瘢痕的疗效.结果 可变脉宽532 nm激光:治疗鲜红斑痣治愈及基本治愈率为21.7%,草莓状血管瘤为68.5%;脉冲染料585 nm激光:治疗鲜红斑痣治愈及基本治愈率为19.4%,葡型性血管瘤为77.8%,血管角皮瘤100.0%,充血性增生性瘢痕100.0%;IPL强光系统治疗3型以下鲜红斑痣治愈及基本治愈率为0%;PDT治疗各型鲜红斑痣治愈及基本治愈率为45.6%.结论 对于浅表性皮肤血管性疾病各种光疗疗法各有其特点,对于鲜红斑痣的治疗,激光光动力学疗法(PDT)是一种疗效可靠,安全,疗程短的最佳疗法.     

五种波长激光用于鲜红斑痣光动力治疗的动物实验研究

<正>目的:观察连续457nm激光、脉冲510.6nm激光、连续532nm激光、脉冲532nm激光、脉冲510.6nm和578.2nm混合激光对鲜红斑痣动物模型的光动力效应及副作用差异。     

铜蒸汽激光用于光动力疗法治疗鲜红斑痣50例疗效分析

氩离子激光和ＫＴＰ／５３２激光用于光动力疗法治疗鲜红斑痣已取得了良好的临床效果。本文在此基础上，以铜蒸汽激光为光源，对５０例鲜红斑痣患者的５７个病灶进行了光动力学治疗，经２至１４个月随访观察，治疗全部有效。本文还分析了与疗效有关的问题。     

不同波长激光治疗浅表性皮肤血管性疾病临床分析

目的：观察分析比较各种不同的激光疗法治疗皮肤血管性疾病的特点及临床疗效。方法：对应用可变脉宽532nm激光，脉冲染料585nm激光，IPL强光治疗系统及铜蒸气激光光动力学疗法，治疗鲜红斑痣、草莓状血管瘤、葡型性血管瘤、血管角皮瘤、毛细血管扩张、血管痣、充血性增生性瘢痕进行回顾性总结分析。     

血管靶向光动力治疗婴幼儿鲜红斑痣的护理配合

目的:探讨血管靶向光动力治疗婴幼儿鲜红斑痣的护理方法。方法:2016年1月至2017年1月,回顾性分析血管靶向光动力治疗鲜红斑痣婴幼儿30例的临床资料,年龄1～3岁,经静脉注射光敏剂,给药剂量2 mg/kg,激光波长532 nm,功率密度80～100 m W/cm2,时间10～15 min。治疗前做好患儿和家属的健康教育、心理护理,避光物品的准备,光敏剂的准确配制及注射,医护密切配合。治疗中指导患儿和家属正确配合。治疗后不良反应的观察及护理。结果:30例患儿平稳度过治疗期,配合良好。整个治疗过程未见明显的全身和局部不良反应,治疗后疗效明显高于治疗前。结论:血管靶向光动力治疗婴幼儿鲜红斑痣安全、有效。激光治疗前后周全的护理配合是治疗成功的关键一环。     

基于数据库的光动力治疗鲜红斑痣专家系统

正目的:建立光动力治疗鲜红斑痣数据库,为医疗数据存储和统计学分析提供方便;通立专家库系统为光动力疗法提供信息化支持。方法:(1)以MySQL为基础搭建平台,从中国人民解放军总医院激光科800例光动力疗法治疗鲜红斑痣的病例中抽取年龄、体重、给药剂量、功率密度、光照时间、治疗结果等特征建立电子病例数据库。利用K-Means算法对数据库内     

两种激光联合光动力疗法治疗鲜红斑痣的临床研究

<正>目的:总结两种激光联合光动力疗法治疗鲜红斑痣的临床疗效。方法:A组:激光治疗无明显效果改作光动力治疗的Ⅲ型鲜红斑痣患者23例,男性9例,女性14例;平均年龄34岁,红斑面积平均20.35cm2,脉冲染料激光治疗3次后行光动力治疗3次。B组:为光动力治疗后的分散病灶用脉冲染料激光治疗的Ⅲ型鲜红斑痣患者56例,男性26例,女性30例;平均年龄27岁,红斑面积平均34.73cm2,光动力治     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）