52例骨转移癌放射治疗止痛效果分析

目的探讨骨转移癌姑息性放射治疗的止痛疗效。方法52例骨转移癌89处转移灶均有影像学相关检查明确诊断,予姑息性放射治疗止痛,针对不同病情选用适当的放射治疗方案,共分为5个不同剂量分割组:1组:2Gy/次,5次/周,20次完成,共14例;2组:3Gy/次,5次/周,15次完成,共10例;3组:5Gy/次,3次/周,7次完成,共11例;4组:7Gy/次,2次/周,5次完成,共8例;5组:10Gy/次,1次/周,3次完成,共9例。结果各组有效率分别为92.8%、90.0%、90.9%、100%、87.5%,总有效率为92.3%。结论骨转移癌放射治疗止痛效果好,并且不同剂量分割疗效无明显差异。     

骨转移癌80例的放射治疗合并化疗止痛效果分析

本研究自1996年3月至2004年5月对80例骨转移癌148处病灶进行放射治疗合并化疗,现将疗效报告如下。1资料与方法1·1一般资料:男性45例,女性35例,年龄38~77岁,中位年龄56·5岁。原发癌均有病理证实,其中肺癌25例,乳腺癌30例,鼻咽癌10例,宫颈癌3例,大肠癌5例,其他癌7例。骨转移病灶均经X线摄片、ECT、CT、磁共振成像(MRI)等明确诊断。骨转移灶分布情况:多发性39例,单发性41例。其中脊柱转移占39·2%,骨盆转移占24·3%,肋骨转移占17·6%,四肢骨转移16·9%,颅骨转移占2%。全组病例均有顽固性骨痛,疼痛重度25例,中度疼痛48例,轻度疼痛7例。1·…     

骨转移癌放射治疗的止痛效果

1资料与方法1.1病例资料本组128例,男77例,女51例。年龄37～83岁,平均58.5岁。其中肺癌37例,乳腺癌33例,肝癌26例,前列腺癌15例,肾癌8例,直肠癌4例,甲状腺癌2例,原位不明癌3。转移灶:单发73例,占57.03%;多发55例,占42.97%。转移部位:以胸腰椎居多共62例,占48.44%;骨盆25例,占19.53%;髋关节16例,占12.50%;股骨和肋骨各10例,共占15.63%;颅骨等共5例,占3.90%。所有骨转移瘤均经X线或CT、MRI明确诊断。1.2治疗方法根据患者情况,针对转移灶的多少和症状轻重缓急,选取1个或3个骨转移灶,利用直线加速器4MVX线外照射治疗,40～60Gy/4～6周,或4～6…     

骨转移癌放射治疗46例疗效观察

目的:分析放射治疗对恶性肿瘤骨转移的治疗效果.方法:46例骨转移癌患者均采用6MV-X线直线加速器.其中34例采用常规照射,DT 2 Gy/次,5次/周,总DT 40 Gy;另12例采用快速照射,DT 3 Gy/次,4-5次/周,总DT 30Gy.结果:46例骨转移癌患者放疗后止痛总有效率为95.7%(44/46).结论:放射治疗是治疗骨转移癌的一种好方法,可较持久的获得止痛效果,相对延长生存期.     

骨转移癌不同剂量分割放疗止痛疗效分析

目的探讨不同分割剂量放疗对骨转移癌止痛的疗效。方法62例骨转移癌病人共82个病灶采用两种不同分割剂量放疗。常规分割放疗组33例,每次2Gy,每周5次,总剂量30～40Gy/3～4周;非常规分割放疗组29例,每次3Gy,每周5次,总剂量30Gy/2周。结果常规分割放疗组完全缓解(CR)率70.5%,部分缓解(PR)率20.5%,总有效率90.9%;非常规分割放疗组完全缓解(CR)率62.2%,部分缓解(PR)率21.6%,总有效率83.8%。组间比较差异无显著性(P>0.05)。结论不同分割剂量放疗对骨转移癌疼痛的缓解程度无影响,采用何种分割方式应根据病情及生存期长短来决定。     

放射治疗骨转移癌42例临床分析

目的分析42例骨转移癌放射治疗止痛效果。方法采用6MV-X线照射骨转移癌42例共72处病灶,常规分割组：28处病灶,200cGy／次,5次／周,总剂量3000～5000cGy;低分割组：44处病灶,400cGy／次,隔日1次,3次／周,总剂量2400—3600cGy。结果放疗止痛总有效率为90．28％,常规分割组与低分割组有效率差异无统计学意义（P〉0．05）;低分割组止痛起效快于常规分割组。结论放射治疗是骨转移癌止痛的一种非常有效的手段。     

放射治疗骨转移癌42例临床分析

Objective To analyze the effect of pain control with radiotherapy in bone metastases from malig-nancies. Methods A total of 72 lesions in forty-two cases with bone mestastases were received 6my X ray. The con-ventional radiotherapy was performed in 28 lesions in the way of 200cGy/fraction,5 fracties/week,total dose of 3000 ～5000cGy. The hypofractionation radiotherapy was.performed in 44 lesions in the way of 400cGy/fracfion,3 frac-tions/week,total dose of 2400～3600cGy. Results Overal pain relief rate was 90.28%, there were no significant differences between the two groups(P 0.05). The pain relief of hypofractionation radiotherapy was faster than anoth-er. Conclusion Radiotherapy is a very effective way to relieve pain in bone metastases from malignacies.     

放射治疗骨转移癌42例临床分析

Objective To analyze the effect of pain control with radiotherapy in bone metastases from malig-nancies. Methods A total of 72 lesions in forty-two cases with bone mestastases were received 6my X ray. The con-ventional radiotherapy was performed in 28 lesions in the way of 200cGy/fraction,5 fracties/week,total dose of 3000 ～5000cGy. The hypofractionation radiotherapy was.performed in 44 lesions in the way of 400cGy/fracfion,3 frac-tions/week,total dose of 2400～3600cGy. Results Overal pain relief rate was 90.28%, there were no significant differences between the two groups(P 0.05). The pain relief of hypofractionation radiotherapy was faster than anoth-er. Conclusion Radiotherapy is a very effective way to relieve pain in bone metastases from malignacies.     

放射治疗骨转移癌42例临床分析

Objective To analyze the effect of pain control with radiotherapy in bone metastases from malig-nancies. Methods A total of 72 lesions in forty-two cases with bone mestastases were received 6my X ray. The con-ventional radiotherapy was performed in 28 lesions in the way of 200cGy/fraction,5 fracties/week,total dose of 3000 ～5000cGy. The hypofractionation radiotherapy was.performed in 44 lesions in the way of 400cGy/fracfion,3 frac-tions/week,total dose of 2400～3600cGy. Results Overal pain relief rate was 90.28%, there were no significant differences between the two groups(P 0.05). The pain relief of hypofractionation radiotherapy was faster than anoth-er. Conclusion Radiotherapy is a very effective way to relieve pain in bone metastases from malignacies.     

放射治疗骨转移癌42例临床分析

Objective To analyze the effect of pain control with radiotherapy in bone metastases from malig-nancies. Methods A total of 72 lesions in forty-two cases with bone mestastases were received 6my X ray. The con-ventional radiotherapy was performed in 28 lesions in the way of 200cGy/fraction,5 fracties/week,total dose of 3000 ～5000cGy. The hypofractionation radiotherapy was.performed in 44 lesions in the way of 400cGy/fracfion,3 frac-tions/week,total dose of 2400～3600cGy. Results Overal pain relief rate was 90.28%, there were no significant differences between the two groups(P 0.05). The pain relief of hypofractionation radiotherapy was faster than anoth-er. Conclusion Radiotherapy is a very effective way to relieve pain in bone metastases from malignacies.     

局部放疗联合唑来膦酸治疗骨转移癌痛

目的探讨局部放疗联合唑来膦酸对骨转移癌患者的镇痛效果。方法 32例骨转移癌患者,局部放疗,DT总量3000 cGy/10f/2W,给予唑来膦酸4mg加入生理盐水100ml中,静脉滴注时间不<15min,d1,每4周为1周期;用药2周期后评价疗效。结果 32例患者中,疼痛完全缓解(CR)23例,部分缓解(PR)5例,无缓解(NR)4例,总有效率87.5%(28/32);毒副反应主要是发热、肌肉疼痛、恶心、呕吐等,经对症处理后恢复。结论局部放疗联合唑来膦酸对骨转移癌患者镇痛效果较好,且毒副反应可耐受。     

唑来膦酸与放疗联合治疗对恶性肿瘤骨转移的效果观察

目的观察唑来膦酸与放疗联合对恶性肿瘤骨转移的治疗效果。方法选取我院患者从2010年2月至2012年1月所收治的恶性肿瘤骨转移患者55例作为临床研究对象,将所有患者随机分为治疗组和对照组两组,所有患者均使用西门子直线加速器6MV对骨转移的疼痛处进行姑息性放疗,治疗组在对照组的基础上加用唑来膦酸进行治疗。观察两组患者的镇痛效果、止痛起效时间和不良反应,以及治疗组治疗前后的血钙、血磷和血镁值。结果治疗组总有效率为96．4％,平均起效时间为（3．2±1．1）d;对照组总有效率为78．2％,止痛起效时间为（7_3±1．9）d。差异有显著性（P〈0．05）。治疗组患者主要出现发热、胃肠道不适、低血钙、蛋白尿和血清肌酐轻度升高。对照组患者则未发现明显不良反应。治疗组用药前后的血钙、血磷和血镁值差异无显著性（P〉0．05）。结论放疗联合唑来膦酸可以有效控制疼痛,同时保护并修复被破坏的骨质功能,改善患者生活质量,因此我们推荐这种联合治疗方式在临床当中使用。     

Predictors of skeletal-related events among cancer patients with bone metastases treated with zoledronic acid: a secondary analysis of a randomized study

Background: The purpose of the current study is to assess the predictors of skeletal-related events (SREs) among advanced cancer patients with bone metastases treated with zoledronic acid within a randomized study.

Research design and methods: This is a secondary analysis of patient-level data of advanced cancer patients with bone metastases who were treated with monthly zoledronic acid in the NCT00330759 clinical trial.

Results: A total of 702 patients were included in the current analysis. In univariate logistic regression analysis, higher body mass index (P = 0.034) and lytic nature of bone metastasis (P = 0.008) were found to be predictive of a higher probability of SREs. When the two factors were included in a multivariate logistic regression model, both of them were predictive of the later development of SREs (P value for higher body mass index = 0.015; P value for lytic bone lesions = 0.005).

Conclusion: Among advanced cancer patients with bone metastases, lytic nature of metastases, as well as higher body mass index, are associated with a higher probability of SREs.

Trial registration number: this clinical trial was registered at clinicaltrials.gov with the number: nct0033     

因卡膦酸二钠治疗骨转移癌的临床研究

目的:评价因卡膦酸二钠治疗恶性肿瘤骨转移痛及改善活动能力的效果。方法:60例骨转移癌疼痛患者随机分为治疗组和对照组,治疗组单次静脉滴注因卡膦酸二钠10 mg,对照组单次静脉滴注帕米膦酸二钠60～90 mg,观察2周内患者骨痛及活动能力改善效果。结果:总有效率治疗组为86.7%,对照组为83.3%,2组止痛效果差异无统计学意义(P>0.05);治疗组和对照组改善患者活动能力的总有效率分别为76.7%和73.3%,2组差异无统计学意义(P>0.05);对照组的发热率为13.3%,治疗组无发热病例。结论:因卡膦酸二钠对于恶性肿瘤骨转移所引起的骨痛具有较好的治疗作用,可提高患者的活动能力。因卡膦酸二钠与帕米膦酸二钠骨痛缓解率、活动能力的改善基本相似,而因卡膦酸二钠的不良反应较轻。     

48例脑转移瘤放射治疗疗效分析

目的 探讨放射治疗对脑转移瘤的疗效及应用价值。方法 将48例脑转移瘤患者采用直线加速器6MVX线全脑照射DT30～40Gy／15～20次／3～4周，大部分病人缩野局部追加10～20Gy／5～10次／1～2周。结果 36例显效，11例好转，总有效率97．9％，平均生存期6．3月。结论 脑转移瘤放射治疗能明显缓解症状，提高生存质量，延长生存期。     

化瘀止痛联合外温法治疗转移性骨肿瘤疼痛临床观察

目的 探讨化瘀止痛联合外温法治疗转移性骨肿瘤疼痛的近期疗效.方法 将120例转移性骨肿瘤疼痛患者按照随机数字表法随机分为观察组(60例)和对照组(60例).在原有止痛基础上,观察组给予定痛膏(均匀涂覆疼痛部位,涂覆面积以超过疼痛面积2 cm为宜,厚度0.1 ～0.3 cm)联合肿瘤高频热疗治疗,对照组单用盐酸羟考酮缓释片治疗.结果 观察组部分缓解33例,轻度缓解18例,总有效率为86.4％;对照组部分缓解18例,轻度缓解26例,总有效率为73.3％;2组总有效率比较,差异有统计学意义(P＜0.05).观察组治疗后生活质量评分为(79.0±3.9)分,对照组治疗后生活质量评分为(66.0±2.0)分,2组生活质量评分比较,差异有统计学意义(P＜0.05).结论 化瘀止痛联合外温法治疗转移性骨肿瘤疼痛止痛效果明显优于单用盐酸羟考酮缓释片,并可提高生存质量.     

152例骨转移癌的放射治疗技术

目的研究骨转移癌姑息性放射治疗的定位、摆位方法及注意事项,使放射治疗达到预期目的。方法实施并分析152例骨转移癌姑息性放射治疗过程的注意事项及照射技术。结果使用模拟定位机、直线加速器等设备能顺利完成放射治疗并使96.7%患者疼痛减轻。结论规范放疗技术操作,有效治疗骨转移疼痛。     

肿瘤骨转移行放射治疗的临床护理探析

目的：分析肿瘤骨转移行放射治疗的临床护理。方法患者100例随机分为观察组和对照组各50例,观察组行优质护理,对照组行常规护理,对比分析两组的护理满意度。满意度=（满意＋一般）/总例数×100%。结果观察组满意率96%,对照组满意率76%,两组比较差异有统计学意义（P＜0.05）。结论对患者采取优质护理,能有效提升患者生活质量。