除湿通淋颗粒治疗慢性非细菌性前列腺炎临床观察

目的观察除湿通淋颗粒治疗慢性非细菌性前列腺炎的临床疗效。方法采用随机分组、平行对照、单盲观测的临床试验研究方法,将84例慢性非细菌性前列腺炎患者分为除湿通淋颗粒治疗组(治疗组)及癃清片对照组(对照组),每组42例。治疗组患者口服除湿通淋颗粒治疗,对照组口服癃清片。两组用药4周后观察美国国立卫生院前列腺炎症状评分(NIH-CPSI)及中医证候积分。结果治疗组NIH-CPSI评分总有效率为85.71%,对照组为69.05%。治疗组中医证候积分总有效率为92.86%,对照组为71.43%。两组患者NIH-CPSI评分及中医证候积分总有效率比较差异有统计学意义(P0.05)。结论除湿通淋颗粒治疗慢性非细菌性前列腺炎临床疗效显著。     

慢性细菌性前列腺炎给予双石通淋胶囊+间断性左氧氟沙星治疗的效果评估

目的探讨双石通淋胶囊+间断性左氧氟沙星治疗慢性细菌性前列腺炎的临床效果。方法选取我院前些年经治的100例慢性细菌性前列腺炎进行前瞻性对照研究,按照随机数字表达法将其分为观察组与参考组,各为50例。参考组采用间断性左氧氟沙星治疗,观察组同时采用双石通淋胶囊+间断性左氧氟沙星治疗,观察两组治疗效果。结果观察组治疗总有效率明显大于参考组,患者美国国立卫生研究院慢性前列腺症状指数(NIHCPSI)评分明显优于参考组(P0.05);治疗后,观察组C反应蛋白(CRP)、白细胞计数(WBC)及白介素-2(IL-2)等水平明显优于参考组(P0.05)。结论双石通淋胶囊治疗+间断性左氧氟沙星治疗慢性细菌性前列腺炎效果确切,可作为有效治疗方案在临床推广。     

盐酸坦洛新联合阿米替林治疗慢性非细菌性前列腺炎

目的 回顾性分析盐酸坦洛新缓释胶囊联合阿米替林治疗慢性非细菌性前列腺炎的作用机制和临床疗效.方法 对94例慢性非细菌性前列腺炎患者随机分组,治疗组50例,口服盐酸坦洛新缓释胶囊(0.2 mg,每晚1次)和阿米替林(25 mg,每天2次);对照组44例,仅口服盐酸坦洛新缓释胶囊(0.2 mg,每晚1次).疗程均为6～8周.采用美国国立卫生研究院慢性前列腺炎症状指数评分(NIH-CPSI)对2组治疗前、后分别评分.结果 94例患者均获得随访,随访时间2～12个月.治疗后患者症状明显改善,NIH-CPSI总分治疗组及对照组均明显下降[(14.8 ±4.1)vs (29.2 ±3.5),(17.1±3.8)vs(28.5±4.7),P均＜0.05)],且治疗组低于对照组[(14.8±4.1) vs(17.1±3.8),P＜0.05)].治疗组总有效率92.0％,对照组总有效率68.2％.治疗组仅2例嗜睡,l例头晕,能继续用药,对照组无明显不良反应.结论 盐酸坦洛新缓释胶囊联合阿米替林治疗慢性非细菌性前列腺炎效果良好.     

复方玄驹胶囊联合体外短波热疗治疗慢性非细菌性前列腺炎疗效观察

目的 观察复方玄驹胶囊联合体外短波热疗治疗慢性非细菌性前列腺炎的疗效.方法 110例患者随机分为治疗组和对照组.对照组采用体外短波热疗,治疗组在此基础上加用复方玄驹胶囊.观察两组临床疗效和治疗前后国际慢性前列腺炎症状指数（NIH-CPSI）变化情况.结果 治疗组总有效率为92.73%,对照组总有效率为74.55%,治疗组疗效优于对照组（P 〈 0.05）;两组治疗后NIH-CPSI评分较治疗前明显改善（P 〈 0.05或P 〈 0.01）.结论复方玄驹胶囊联合体外短波热疗治疗慢性非细菌性前列腺炎疗效确切,值得临床推广应用.     

泌淋胶囊联合盐酸坦索罗辛治疗慢性非细菌性前列腺炎疗效观察

目的:观察泌淋胶囊联合盐酸坦索罗辛治疗慢性非细菌性前列腺炎(CAP)的有效性与安全性。方法:治疗组60例患者给予泌淋胶囊与盐酸坦索罗辛,对照组60例患者给予前列康片与盐酸坦索罗辛,均连续用药4周。治疗前后分别观察NIH-CPSI、EPS。采用美国国立卫生研究院(NIH)制定的前列腺炎症状评分(CPSI)标准判定疗效。结果:治疗组临床治愈率48.33%,总有效率93.33%,对照组临床治愈率和总有效率分别为41.67%,85.00%,两组比较有显著性差异(P<0.05)。两组治疗前后NIH-CPSI积分及EPS中WBC、pH值均有不同程度的改善,但治疗组的NIH-CPSI积分改善最显著(P<0.05)。结论:泌淋胶囊联合坦索罗辛治疗慢性非细菌性前列腺炎有效、安全。     

微波联合前列舒通胶囊治疗慢性前列腺炎

目的:观察微波联合前列舒通胶囊治疗慢性前列腺炎的疗效。方法:将100例慢性前列腺炎患者随机分为观察组和对照组各50例,观察组给予微波联合前列舒通胶囊治疗,对照组只给予前列舒通胶囊治疗。观察并比较两组临床疗效和慢性前列腺炎症状量表(NIH-CPSI)及临床症状评分。结果:两组治疗后NIH-CPSI、临床症状评分较治疗前均有明显改善(P0.05);组间治疗后比较,治疗组NIH-CPSI、临床症状评分优于对照组(P0.05);治疗组总有效率为90%,对照组总有效率为76%,观察组疗效优于对照组(P0.05)。结论:微波联合前列舒通胶囊治疗慢性前列腺炎疗效显著,值得临床推广应用。     

癃闭舒胶囊联合盐酸坦索罗辛治疗慢性非细菌性前列腺炎105例

目的 观察癃闭舒胶囊联合盐酸坦索罗辛治疗慢性非细菌性前列腺炎(CAP)的有效性与安全性.方法 治疗组60例患者给予癃闭舒胶囊与盐酸坦索罗辛,对照组45例患者给予前列康片与盐酸坦索罗辛,均连续用药4周.治疗前后分别观察NIH-CPSI、最大尿流率(MFR)、平均尿流率(AFR)、前列腺肛门指诊(DRE)、EPS.采用美国国立卫生研究院(NIH)制定的前列腺炎症状评分(CPSI)标准判定疗效.结果 治疗组临床治愈率48.33%,总有效率95.00%,对照组临床治愈率和总有效率分别为37.78%,86.67%,两组比较有显著性差异(P＜0.05).两组治疗前后NIH-CPSI积分及EPS中WBC,pH值与尿流率均有不同程度的改善,但治疗组的NIH-CPSI积分与尿流率改善最显著(P＜0.05).结论 癃闭舒胶囊联合坦索罗辛治疗慢性非细菌性前列腺炎有效、安全.     

中西医结合治疗慢性非细菌性前列腺炎58例临床观察

目的探索前列安通胶囊联合特拉唑嗪治疗慢性非细菌性前列腺炎的临床疗效,为中西医结合防治慢性非细菌性前列腺炎提供依据。方法 116例慢性非细菌性前列腺炎患者随机分为对照组和治疗组各58例,两组均采用盐酸特拉唑嗪片治疗,治疗组加前列安通胶囊,两组患者均药物治疗3个月后进行临床证候疗效评价,并分别在治疗前、治疗后1个月、治疗后2个月和治疗后3个月,进行中医证候积分、NIH-CPSI(疼痛、尿路症状和生活质量影响)积分评估。结果对照组总有效率为68.96%,治疗组总有效率为82.75%,治疗组总有效率明显优于对照组(P0.05)。与治疗前比较,两组患者治疗后中医证候积分、疼痛、尿路症状和生活质量影响评分均降低,其中治疗组治疗后1个月和两组治疗后2个月、3个月中医证候积分、疼痛、尿路症状和生活质量影响评分降低,差异均有统计学意义(P0.05)。与对照组比较,治疗组患者治疗2个月、3个月中医证候积分、疼痛、尿路症状和生活质量影响评分降低,差异有统计学意义(P0.05)。结论前列安通胶囊联合特拉唑嗪可明显改善慢性非细菌性前列腺炎患者中医证候积分、NIH-CPSI(疼痛、尿路症状和生活质量影响)积分,临床疗效确切。     

盐酸坦索罗辛胶囊在慢性非细菌性前列腺炎中的应用

目的观察盐酸坦索罗辛胶囊在慢性非细菌性前列腺炎中的应用效果。方法选择重庆市云阳县人民医院2012年10月~2014年1月收治的慢性非细菌性前列腺炎患者88例,随机分为两组,治疗组和对照组,每组各44例。治疗组给予盐酸坦索罗辛胶囊,每天1粒,口服;左氧氟沙星胶囊每次1粒,每天2次,口服。对照组仅给予左氧氟沙星胶囊治疗,服法同治疗组。4周为1个疗程。两组均治疗2个疗程。观察两组临床疗效,观察并记录两组患者治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)、前列腺液中白细胞计数(EPS-WBC)及最大尿流率、药物不良反应发生情况。结果治疗后,治疗组显效23例,有效19例,总有效率为95.45%;对照组显效20例,有效16例,总有效率为81.82%,两组总有效率比较差异有统计学意义(P<0.05)。两组治疗前NIH-CPSI各项指标(疼痛与不适、排尿症状、生活质量)评分、EPS-WBC及最大尿流率比较,差异均无统计学意义(P>0.05);两组治疗后NIH-CPSI各项指标评分、EPS-WBC均较治疗前显著降低,差异有统计学意义(P<0.05),且治疗组下降更明显(P<0.05)。与治疗前比较,两组治疗后最大尿流率均显著增高,差异有统计学意义(P<0.05),且治疗组增高更明显(P<0.05)。两组治疗过程中均未见明显不良反应发生。结论盐酸坦索罗辛胶囊治疗慢性非细菌性前列腺炎效果确切,能明显改善临床症状,提高患者生活质量,且无明显不良反应,值得临床推广应用。     

蒲芪通补方治疗慢性非细菌性前列腺炎的临床疗效观察

目的:观察蒲芪通补方治疗慢性非细菌性前列腺炎的临床疗效。方法:将60例湿热瘀阻型慢性非细菌性前列腺炎患者随机分为治疗组和对照组,每组30例。治疗组给予蒲芪通补方,对照组给予前列解毒胶囊治疗,疗程均为4周。评价两组的临床疗效,比较两组患者治疗前后的慢性前列腺炎症状评分(NIH-CPSI)及前列腺液(EPS)检查白细胞计数的改善情况。结果:治疗组和对照组的总有效率分别为93.33%和80.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的各项症状评分及EPS检查白细胞计数情况较治疗前均显著改善(P<0.05),且治疗组在改善疼痛不适、排尿异常等症状评分方面疗效优于对照组(P<0.05,P<0.01)。结论:蒲芪通补方治疗慢性非细菌性前列腺炎具有较好的疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.