共查询到20条相似文献,搜索用时 15 毫秒
1.
V. V. Malyshev L. S. Vasil'eva S. B. Belogorov T. V. Nefedova 《Bulletin of experimental biology and medicine》1995,119(6):567-570
Preadaptation of rats to altitude hypoxia results in reduced activation of lipid peroxidation during subsequent stress, inflammation,
or both, as compared to hypoxiaunadapted animals, with the result that secondary changes in organs and tissues of adapted
rats are much less pronounced and conditions are created for alleviating the acute inflammation and the stress reaction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 590–593, June, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
2.
V. I. Urbanovich T. A. Vylegzhanina O. A. Maneeva T. E. Kuznetsova E. L. Ryzhkovskaya 《Bulletin of experimental biology and medicine》1999,127(5):511-514
In experiments on guinea pigs, the nerve-tissue relationships in gingival papillae were studied under conditions of experimental
inflammation induced by local (turpentine injection) and general (whole-body γ-irradiation). It is found that structural and
metabolic changes in the lamina propria and epithelium of the gingival mucosa correlate with disturbances in trophic influences
from the sympathetic nervous system.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 564–568, May, 1999 相似文献
3.
Using the model of acute infectious peritonitis in rats, it is shown that inflammation induced in the absence of mast cells
is characterized by marked inhibition of reparative processes. The most significant accumulation of functionally active fibroblasts
and the development of granulations and young connective tissue in the mesentery occur 5–10 days after flogogen injection
in the natural development of inflammation and after 10–20 days in the absence of mast cells. The data suggest that under
natural conditions mast cells directly or indirectly stimulate reparative processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
3, pp. 262–265, March, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
4.
Yamazaki K Takazoe M Tanaka T Ichimori T Saito S Iida A Onouchi Y Hata A Nakamura Y 《Journal of human genetics》2004,49(12):664-668
Crohn disease (CD) is an inflammatory bowel disease characterized by chronic transmural, segmental, and typically granulomatous inflammation of the gut. Recently, two novel candidate gene loci associated with CD, SLC22A4 and SLC22A5 on chromosome 5 known as IBD5 and DLG5 on chromosome 10, were identified through association analysis of Caucasian CD patients. We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023). However, the reported genetic variants that were indicated to be causative in the Caucasian population were completely absent in or were not associated with Japanese CD patients. These findings imply significant differences in genetic background with CD susceptibility among different ethnic groups and further indicate some difficulty of population-based studies. 相似文献
5.
Thein vitro neutrophil-stimulating activities of twoS. aureus strains are compared with theirin vivo cytotoxic activities, including the use of intact heterologous neutrophils. After opsonization with normal autologous serum,
clinical isolates ofS. aureus differ in the ability to induce luminol-dependent chemiluminescence of guinea pig peritoneal neutrophils. After opsonization,
the opsonin-dependent strain markedly stimulates chemiluminescence in comparison with the opsonin-independent strain. The
local inflammation induced in guinea pig by intracutaneous administration of the opsonized opsonin-dependent strain is more
intense than that induced by the opsonin-independent strain. Intramuscular administration of opsonin-dependentS. aureus strain increases mortality in mice from 10 to 46% while the addition of normal guinea pig neutrophils to the inoculate has
no effect on this process. Opsonization of opsonin-independent strain decreased mortality from 78 to 40%, the effect being
potentiated by the addition of neutrophils to inoculate (mortality 14%). Presumably, the opsonin dependence ofS. aureus manifestedin vitro is associated with its pathogenicityin vivo, which may be caused by intense stimulation of the respiratory burst in neutrophils.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 298–300, September, 1996 相似文献
6.
A. M. Avanesov G. A. Drozdova G. M. Drogova A. V. Pasechnik V. A. Frolov 《Bulletin of experimental biology and medicine》1997,124(2):760-763
Changes in the hemostasis system are experimentally shown in rabbits with modeled allergic inflammation (Arthus phenomenon)
of the maxilla. Suppression of immune processes has an adverse effect on this system, while immunostimulation improves hemostatic
parameters. Immunosuppression impairs lysosomal mechanisms of inflammation, while stimulation of the immune system normalizes
these mechanisms.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 157–160, August, 1997 相似文献
7.
The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential
influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree
of inflammation induced in the air pouch model across four commonly utilized inbred strains in both male and female mice.
We then applied an in silico mapping method to identify loci potentially associated with determining inflammation severity for each gender. Air pouches
were induced by subcutaneous injection 3 (3 cc) and 5 (1.5 cc) days prior to the experiment. 4h after carrageenan injection,
exudates were retrieved and leukocyte concentration quantified using a hemocytometer. The in silico mapping method was applied as described below. The strain order for mean leukocyte count/mL in inflamed exudates differed
between genders. In males, the order was C57BL/6J > BALB/cByJ > DBA/2J > DBA/1J, while in females the order was BALB/cByJ
> DBA/2J > C57BL/6J > DBA/1J. The difference in inflammation severity between genders reached significance only in C57BL/6J
mice. Independent in silico analysis based on phenotypic data from male versus female mice identified distinct sets of loci as potentially associated
with the exudate count reached. We conclude that the degree of inflammation induced in the mouse air pouch model of inflammation
is strain-specific and, therefore, genetically based, and the pattern of interstrain differences is altered in male relative
to female mice. The loci identified by in silico mapping likely contain genes with differential roles in determining this phenotype between genders. 相似文献
8.
Clinically nonphlogogenetic phagocyte reaction under conditions of bacterial challenge was studiedin vivo. The “mission” of phagocytes under such conditions is completed by evacuation of phagocytized bacteria from the site of capture
into the blood and then into the intestine. The purulent process induced by massive doses ofStaphylococcus aureus (25×106 and 25×108 bacteria), without any concomitant injury to the peritoneum does not lead to the development of inflammation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 356–360, September, 1997 相似文献
9.
Mitsushige Sugimoto Yoshio Yamaoka 《Archivum immunologiae et therapiae experimentalis》2009,57(1):45-56
The cure rates of Helicobacter pylori infection by using a combination of a proton pump inhibitor (PPI) and antimicrobial agents are mainly influenced by bacterial
susceptibility to antimicrobial agents and the magnitude of acid inhibition during the treatment. Currently used empirical
triple therapies do not reliably produce a ≥80% cure rate on an intention-to-treat basis. Therefore, tailored regimens based
on relevant microbiological findings and pharmacogenomics are recommended for attaining an acceptable ≥95% cure rate. Recently,
virulence factors of H. pylori, such as cagA and vacA, are reported to be major factors determining the cure rates. Individuals infected with strains with cagA-negative and vacA s2 genotypes have significantly increased risk of eradication failure of H. pylori infection. These virulence factors enhance gastric mucosal inflammation and are associated with the development of peptic
ulcer and gastric cancer. H. pylori virulence factors induce proinflammatory cytokines, such as interleukin (IL)-1, IL-8, and tumor necrosis factor (TNF)- which
influence mucosal inflammation and/or gastric acid secretion. When physicians select an H. pylori eradication regimen with an acceptable cure rate, they might need to consider H. pylori virulence factors, especially cagA and vacA. 相似文献
10.
Actinobacillus actinomycetemcomitans 《Microbial pathogenesis》2001,30(6):359
Actinobacillus actinomycetemcomitans has been specifically implicated in the aetiology of one or more of the periodontal diseases, conditions in which inflammation of the gums is associated with destruction of the alveolar bone supporting the teeth. In these diseases there is loss of attachment of the gums (gingivae) to the teeth forming a periodontal pocket. The microenvironment of this pocket is extremely complex and it is likely that there will be substantial variation in the environmental conditions operating in this habitat. The aim of the current investigation was to study the effect of disease-relevant environmental factors on the production and release of secreted surface- associated proteins of A. actinomycetemcomitans. These secreted proteins contain many of the virulence determinants of this organism. A range of environmental conditions were investigated: growth in a CO2-enriched aerobic atmosphere vs anaerobic growth, presence of serum or blood, biofilm vs planktonic mode of growth and iron depletion. Differential expression of a number of the secreted surface-associated proteins was observed under different growth conditions and these included the glycolytic enzyme triose phosphate isomerase. An ability to adapt to prevailing environmental conditions may facilitate the survival of the organism in the changing microÍenvironment of the periodontal pocket. 相似文献
11.
O. K. Khmel'nitskii V. M. Kotovich 《Bulletin of experimental biology and medicine》1995,120(5):1128-1132
Foci of candidal pneumonia in the presence of iatrogenic immunodeficiency and dysbacteriosis caused by preinjection of cyclophosphamide
and ampiox were examined by histoautoradiography and light and electron microscopy. Not only did the pathomorphogenesis ofCandida infection, type of manifestation of tissue defense reactions, and degree of manifestation of the pathogenic characteristics
of the agent change under such conditions, but the mediation of the inflammation as well.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
11, pp. 506–510, November, 1995 相似文献
12.
G. V. Poryadin A. N. Kazimirskii F. N. Paleev A. I. Makarkov Zh. M. Salmasi N. P. Sanina 《Bulletin of experimental biology and medicine》1999,127(1):77-79
Negative correlation between the severity of infective allergic myocarditis and the content of CD8+ lymphocytes has been established. The counts of CD25+ and CD71+ lymphocytes increased during the early period of the disease. Attenuation of inflammation in the myocardium was associated
with a tendency to normalization of these parameters.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 86–88, January, 1999 相似文献
13.
Antibacterial activity of neutrophils and peritoneal macrophages toward massive doses ofStaphylococcus aureus is studiedin vivo. Two types of antibacterial response are revealed: nonphlogogenic (physiological) and phlogogenic (inflammatory). Nonphlogogenic
reaction is characterized by pronounced antibacterial effect of phagocytes on cocci. Transition to phlogogenic response is
accompanied by impaired function of phagocytes involving their self-destruction and disintegration, which decreases their
antibacterial activity and promotes inflammation. 相似文献
14.
E. V. Eliseeva V. A. Nevzorova M. Yu. Protopopova 《Bulletin of experimental biology and medicine》1997,124(6):1243-1245
Distribution and activity of NADPH-diaphorase colocalized with NO-synthetase are studied in bronchial epithelium, pneumocytes,
and alveolar macorphages of rats with experimental bronchial asthma. Increased activity of NO-synthetase in these structures
indicates that nitric oxide is involved in allergic inflammation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 697–700, December, 1997 相似文献
15.
A. V. Shurlygina G. I. Litvinenko T. I. Dergacheva V. A. Trufakin 《Bulletin of experimental biology and medicine》2000,130(3):895-897
Plasma content of thymosin-α1 and its circadian variations in patients with inflammatory gynecologic diseases differ from those in healthy donors and depend
on the type of inflammation and efficacy of treatment. It is concluded that not only the absolute content of thymic hormones,
but also their biorhythmic variations are important for immune regulation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 327–329, September, 2000 相似文献
16.
E. D. Gol'dberg A. M. Dygai N. A. Klimenko B. Yu. Gumilevskii E. V. Simanina E. Yu. Sherstobaev 《Bulletin of experimental biology and medicine》1995,120(4):1016-1018
Using the mouse model of acute infectious peritonitis caused byEscherichia coli, it is shown that the development of inflammation is accompanied by increases in the number of erythrokaryocytes, erythroid
colony-forming units, and erythroid hematopoietic islets in the bone marrow and by rises in the activities of supernatants
of cultured stimulated adherent and nonadherent myelokaryocytes and of peripheral blood. The results of this study indicate
that a characteristic, feature of acute inflammation is strong activation of erythropoiesis with the development of hyperplasia
of the erythroid marrow.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
10, pp. 382–384, October, 1995 相似文献
17.
D. D. Tsyrendorzhiev A. A. Zubakhin D. N. Mayanskii 《Bulletin of experimental biology and medicine》1995,120(4):999-1002
(CBA×C57B1/6) F1 mice injected with zymosan intravenously developed granulomas in the liver; the number of granulomas in mice pretreated with
gadolinium chloride, a selective blocker of Kupffer cells, was half that in the untreated animals. Kupffer cells isolated
from the liver 5 days after zymosan injection, i.e., during the period when granuloma generation was at its height, displayed
a high capacity for stimulating both the luminol-dependent chemiluminescence of blood leukocytes (which is associated with
the generation of reactive oxygen species) and the colony-forming activity of bone marrow cells; this capacity was much lower
in mice pretreated with gadolinium chloride. It is shown that granulomatous inflammation of the liver is directly dependent
on the activity of Kupffer cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
10, pp. 366–369, October, 1995
Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences 相似文献
18.
Correlation of antiinflammatory and hormonal activity of derivatives of the 8,16-diazasteroid series
B. B. Kuz'mitskii B. A. Volynets N. A. Mizulo V. M. Nasek O. F. Lakhvich 《Bulletin of experimental biology and medicine》1995,119(2):159-162
Antiinflammatory activity and mechanism of action are studied for seven compounds of the 8,16-diazasteroid series. It is established
that the antiinflammatory activity of the compounds is increased on the whole due to the reduced ketofunction in the 12 position
of 8,16-diazasteroid as well as for the introduction of methoxy groups in the 2 and 3 position or phenol substitute in the
16 position. The activity of compounds VI and VII also depends on the inflammation model or on the pain reaction and differs
significantly from the effectiveness of diclofenac sodium and prednisolone. Unlike the latter, the compounds under study are
virtually devoid of hormonal activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
2, pp. 168–171, February, 1995
Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences 相似文献
19.
V. V. Omigov D. L. Nepomnyashchikh G. A. Lapii 《Bulletin of experimental biology and medicine》1996,122(1):742-747
Biopsy specimens of gastric mucosa from patients with chronic gastritis are examined. The dynamics of structural changes occurring
during the development of chronic inflammation is demonstrated and the ultrastructural changes in the mucosa cell populations
are described, which together with the radioautographic analysis of biosynthetic reactions and morphometric data characterizes
the complex structural and functional rearrangements in the gastric mucosa.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 103–108, July, 1996 相似文献
20.
Early kinetics of the transcriptional response of human leukocytes to staphylococcal superantigenic enterotoxins A and G 总被引:1,自引:0,他引:1
Olivier Dauwalder Alexandre Pachot Marie Anglique Cazalis Malick Paye Caroline Faudot Cdric Badiou Bruno Mougin Franois Vandenesch Jerome Etienne Gerard Lina Guillaume Monneret 《Microbial pathogenesis》2009,47(3):171-176