Socioeconomic inequalities in risk of congenital anomaly.

AIMS: To investigate socioeconomic inequalities in the risk of congenital anomalies, focusing on risk of specific anomaly subgroups. METHODS: A total of 858 cases of congenital anomaly and 1764 non-malformed control births were collected between 1986 and 1993 from four UK congenital malformation registers, for the purposes of a European multicentre case control study on congenital anomaly risk near hazardous waste landfill sites. As a measure of socioeconomic status, cases and controls were given a value for the area level Carstairs deprivation index, by linking the postcode of residence at birth to census enumeration districts (areas of approximately 150 households). RESULTS: Risk of non-chromosomal anomalies increased with increasing socioeconomic deprivation. The risk in the most deprived quintile of the deprivation index was 40% higher than in the most affluent quintile. Some malformation subgroups also showed increasing risk with increasing deprivation: all cardiac defects, malformations of the cardiac septa, malformations of the digestive system, and multiple malformations. No evidence for socioeconomic variation was found for other non-chromosomal malformation groups, including neural tube defects and oral clefts. A decreasing risk with increasing deprivation found for all chromosomal malformations and Down's syndrome in unadjusted analyses, occurred mainly as a result of differences in the maternal age distribution between social classes. CONCLUSION: Our data, although based on limited numbers of cases and geographical coverage, suggest that more deprived populations have a higher risk of congenital anomalies of non-chromosomal origin and some specific anomalies. Larger studies are needed to confirm these findings and to explore their aetiological implications.     

Socioeconomic inequalities in very preterm birth rates

AIMS: To investigate the extent of socioeconomic inequalities in the incidence of very preterm birth over the past decade. METHODS: Ecological study of all 549 618 births in the former Trent health region, UK, from 1 January 1994 to 31 December 2003. All singleton births of 22(+0) to 32(+6) weeks gestation (7 185 births) were identified from population surveys of neonatal services and stillbirths. Poisson regression was used to calculate incidence of very preterm birth (22-32 weeks) and extremely preterm birth (22-28 weeks) by year of birth and decile of deprivation (child poverty section of the Index of Multiple Deprivation). RESULTS: Incidence of very preterm singleton birth rose from 11.9 per 1000 births in 1994 to 13.7 per 1000 births in 2003. Those from the most deprived decile were at nearly twice the risk of very preterm birth compared with those from the least deprived decile, with 16.4 per 1000 births in the most deprived decile compared with 8.5 per 1000 births in the least deprived decile (incidence rate ratio 1.94; 95% CI (1.73 to 2.17)). This deprivation gap remained unchanged throughout the 10-year period. The magnitude of socio-economic inequalities was the same for extremely preterm births (22-28 weeks incidence rate ratio 1.94; 95% CI (1.62 to 2.32)). CONCLUSIONS: This large, unique dataset of very preterm births shows wide socio-economic inequalities that persist over time. These findings are likely to have consequences on the burden of long-term morbidity. Our research can assist future healthcare planning, the monitoring of socio-economic inequalities and the targeting of interventions in order to reduce this persistent deprivation gap.     

Socioeconomic status and injury risk in children

Research has consistently shown that low socioeconomic status (SES) is associated with an increased risk of poor health and death in adults and children. Studies from around the world have shown an inverse relationship between SES and childhood injury morbidity and mortality. For example, compared with children with high SES, children with low SES are at an increased risk of death from pedestrian collisions, fires, falls and drownings, and at an increased risk of hospitalization from recreation or play injuries. Research from England and Wales shows that these disparities in mortality between high and low SES children may be widening over time. This paper provides an overview of the literature on the relationship between SES and childhood injury morbidity and mortality, outlines the postulated mechanisms for this relationship, and highlights some intervention studies targeted to low SES children.     

Socioeconomic inequalities in abdominal obesity in Brazilian female adolescents: a national-based study

The aim of the present study was to identify the prevalence of abdominal obesity and verify the socioeconomic inequities in abdominal obesity among female adolescents from all regions of Brazil. A cross sectional nationwide study was carried out on abdominal obesity with 2,488 women aged 15 to 19 years in the National Survey on Demography and Health of Women and Children (PNDS), 2006. Abdominal obesity was identified based on waist circumference (WC). Demographic and socioeconomic data (age, skin color, schooling level, socioeconomic status, area of residence, geographic region, marital status, and private health insurance) were collected. Poisson regression was used for multivariate analysis. The prevalence of abdominal obesity was 24.7 % (95 % confidence intervals; 20.9, 28.3). The mean WC value was 74.1 cm (SD?=?9.3). Adolescents who studied fewer years, those living in a socially and economically more developed region and those who had a partner, showed higher prevalence of abdominal obesity. Effective actions to reduce abdominal obesity include equitable early childhood development programs and education and interventions within the health systems should be complemented with population-based policies specifically designed to reduce socioeconomic inequalities.     

Cystic adenomatoid malformation: late diagnosis of a congenital anomaly

Cystic adenomatoid malformation (CAM) is a congenital lung malformation characterized by adenomatoid proliferation of alveoli and terminal bronchioli. It is usually diagnosed perinatally, but some silent cases are discovered during childhood or adulthood. We present the case of a 9-year-old girl who presented with chest pain. Chest X-ray showed a cystic image in the upper lobe of the left lung, which was confirmed by computed tomography and magnetic resonance angiography. Lobectomy of the affected segment was performed and histological examination confirmed the diagnosis of CAM type I.     

Female hypospadias with vaginal stones: A rare congenital anomaly

ObjectiveTo highlight the unusual and late presentation of the rare congenital urethral anomaly of female hypospadias and its management.Patients and methodsWe report on four cases (aged 18–65 years; mean 34 years and 3 months) of female hypospadias; two presented with urinary incontinence, recurrent UTI since birth and dyspareunia, and two were diagnosed during catheterization following retention of urine. One of the younger patients had vaginal stones. We reached the diagnosis by catheterization, voiding cysto-urethrogram and panendoscopy. A periurethral vaginal flap urethroplasty was performed in three layers with excellent results in three cases, and one patient was managed conservatively.ResultsResults were excellent in the three cases treated surgically. Patients were continent after urethroplasty and were happy to pass urine in a stream with complete emptying of the bladder for the first time in their life. Two of them had fertility problems due to urogenital septal defects and are undergoing appropriate treatment.ConclusionsVaginal voiding leads to urinary stagnation in the vagina causing urinary pseudo-incontinence and vaginal stones. Early diagnosis requires a high index of suspicion.     

Coronary ischemia secondary to congenital anomaly of the left coronary artery

Coronary artery anomalies constitute 2.2 % of congenital malformations of the heart. The most common abnormality is anomalous origin of the left coronary artery from the pulmonary trunk, also known as Bland-White-Garland syndrome. Clinical manifestations are due to myocardial ischemia caused by the creation of an arteriovenous shunt. The childhood type of this anomaly presents high mortality from heart failure. The adult type develops myocardial infarction, arrhythmias, sudden cardiac death or signs of congestive heart failure. Surgical repair is essential. Various surgical approaches are available and the treatment of choice is direct left coronary artery reimplantation in the aorta. An alternative technique is to create an aortopulmonary tunnel (Takeuchi technique). Marked improvement is usually observed after surgical repair. We report two cases of myocardial ischemia due to coronary anomalies.     

Early use of probiotics is important therapy in infants with severe congenital anomaly

Background: Infants with severe congenital anomaly often need to undergo operation followed by antibiotic therapy. As a result they inevitably acquire abnormal intestinal microbiota, which cause severe infections such as necrotizing enterocolitis. Also, intestinal function deteriorates and their nutritional state is very poor. In order to prevent these situations probiotic therapy is proposed as an effective supporting treatment. Probiotic therapy were therefore applied to infants with severe congenital anomaly as early as possible to ascertain its efficacy. Methods: As probiotics, two bacteria were used: Bifidobacterium breve Yakult and Lactobacillus casei Shirota. Probiotic therapy was used in four infants with severe congenital anomaly as early as possible after surgery. Their intestinal microbiota and physical growth were followed through the treatment course. Results: Two patients suffered from meconium peritonitis with ileal atresia. One patient was born with complex anomalies (omphalocele, bladder exstrophy, myelomeningocele). The fourth patient suffered from complete urorectal septum malformation. The intestinal microbiota of these four patients was first induced to be probiotic dominant and finally changed to commensal anaerobe dominant that was similar to normal intestinal microbiota. Pathogenic bacteria were seldom detected. The patients' physical growth was excellent despite short bowel and pulmonary hypoplasia. Conclusion: Probiotic therapy was effective in inducing probiotic dominant intestinal microbiota and normal intestinal microbiota in infants with severe congenital anomalies. As a result their intestinal absorptive functions were activated and severe infections were completely prevented. All of the infants grew well despite their physical disadvantages.     

Renal transplantation and congenital anomaly of the kidney and urinary tract

Paediatric renal transplantation in children differs from adult series because of the high incidence of abnormalities of the lower urinary tract. We report our experience concerning five children with end-stage renal disease and associated bladder dysfunction due to posterior urethral valves, and lower urinary tract abnormalities (‘valve bladder’), who underwent renal transplantation without prior correction of the uropathy. Of 151 paediatric patients (aged 34 months to 23 years) who underwent renal transplantation, 58 had lower urinary tract abnormalities, and 42 underwent surgical correction of the uropathy prior to renal transplantation. In 15 patients, the uropathy was fibrotic bladder secondary to posterior urethral valves (‘valve bladder’). After clinical and urodynamic evaluation, all 15 patients were considered as candidates for bladder augmentation. In 10 patients, the bladder augmentation was performed prior to renal transplantation. The remaining five patients presented with oligoanuria at the time of the evaluation, and the decision to consider bladder augmentation was postponed until the post-transplant period. At the time of renal transplantation, 2 of the 5 patients underwent ureterostomy, and three had a ureteral reimplant associated with a suprapubic catheter for 2 months. Periodic assessment of renal function and bladder capacity/compliance was performed, as was renal ultrasound. After 4 months, the five patients were re-evaluated for the need for bladder augmentation. At 1, 2, 3 and 4 months follow-up, the five patients had normal renal function with improvement of bladder capacity and absence of hydronephrosis. In 3 of the 5 children, bladder augmentation was judged to be no longer necessary due to the complete restoration of clinical and urodynamic parameters. Therefore, renal transplantation can be safely performed without pre-emptive reconstruction of the lower urinary tract. When possible, ureteral reimplantation is recommended, even in a very small valve bladder, since the initial indication for bladder augmentation may be modified once normal diuresis has been restored.     

Developmental deep venous system anomaly associated with congenital malformation of the brain

We report a rare case of developmental deep venous system anomaly. The great vein of Galen and the straight sinus were absent. Both internal cerebral veins and the basal veins of Rosenthal drained into a large frontal interhemispheric falcine vein, which eventually drained into the superior sagittal sinus. The patient also had an associated neuronal migration anomaly.     

Fetal,perinatal, and infant death with congenital renal anomaly

Aims: To ascertain why 19.6% of pregnancies in which a fetal renal anomaly has been detected fail to produce a surviving child, and whether antenatal diagnostic accuracy has altered since specialised fetal medicine units were established in 1995. Methods: An analysis of deaths was conducted among fetuses and babies with a congenital abnormality in the urinary tract notified to the Northern Region Congenital Abnormality Survey (NorCAS). There were 560 deaths among 2857 cases with an anomaly in the urinary tract delivered between 19 February 1984 and 21 March 2000. Results: Renal anomaly was the cause of death in 323 (57.7%) cases. Excluding 10 which were not screened, 126 (60%) of 210 pre-1995 had been suspected antenatally and 81 (78.6%) of 103 post-1995. No abnormality had been suspected in 39 (18.6%) cases pre-1995 and four (3.9%) post-1995. Postnatal death occurred in 89 (41.4%) pre-1995 and in 13 (12%) post-1995. There were 209 cases of death caused by anomalies in other systems but with a renal anomaly present, of which 66 (31.6 %) were chromosomal and 36 (54.5%) had a horseshoe kidney. Of the cases with a horseshoe kidney, 56.3% had a chromosomal anomaly. Conclusions: The antenatal diagnosis of renal anomalies which cause death did not improve significantly in the second period of this study. However, the number of false positive antenatal diagnoses and the number of postnatal deaths were significantly lower and the number of pregnancy terminations were significantly higher. This reduced the risk of delivering a live baby with an unexpected fatal renal anomaly.     

Socioeconomic differences in risk factors for obesity in adolescents in Northern Ireland.

OBJECTIVES. To test for socioeconomic differences in some biological and behavioral risk factors for obesity in a representative and contemporary sample of adolescents. METHODS: Cohort study of 2 016 randomly selected 12- and 15-year-olds representative of Northern Ireland, studied in 2000. We tested for differences in obesity risk factors based on a priori hypotheses between adolescents from affluent (n=487) versus deprived (n=237) families. Potential risk factors were dietary energy and macronutrient intake, habitual physical activity, TV viewing and computer use, and physical fitness. RESULTS: Adolescents of higher socioeconomic status reported significantly lower habitual energy intake (210 kJ/kg/d SD 80 vs. 229 kJ/kg/d SD 91, p < 0.01); significantly higher levels of habitual physical activity (physical activity score 25.9 SD 16.6 vs. 20.9 SD 16.4, p < 0.001), and had significantly higher cardiorespiratory fitness (estimated VO2 max 46.2 ml/kg/min SD 8.4 vs. 43.4 ml/kg/min SD 8.3, p < 0.001). Prevalence of overweight and obesity (BMI >85th percentile) in the cohort was 29.1% and was slightly but not significantly higher in the low (33.8%) versus the high (28.5%) socioeconomic groups. CONCLUSIONS: Differences in some of the biological and behavioral risk factors for obesity exist between adolescents of different socioeconomic status in Northern Ireland. These may help explain the basis of established socioeconomic differences in obesity risk.     

Fetal, perinatal, and infant death with congenital renal anomaly.

AIMS: To ascertain why 19.6% of pregnancies in which a fetal renal anomaly has been detected fail to produce a surviving child, and whether antenatal diagnostic accuracy has altered since specialised fetal medicine units were established in 1995. METHODS: An analysis of deaths was conducted among fetuses and babies with a congenital abnormality in the urinary tract notified to the Northern Region Congenital Abnormality Survey (NorCAS). There were 560 deaths among 2857 cases with an anomaly in the urinary tract delivered between 19 February 1984 and 21 March 2000. RESULTS: Renal anomaly was the cause of death in 323 (57.7%) cases. Excluding 10 which were not screened, 126 (60%) of 210 pre-1995 had been suspected antenatally and 81 (78.6%) of 103 post-1995. No abnormality had been suspected in 39 (18.6%) cases pre-1995 and four (3.9%) post-1995. Postnatal death occurred in 89 (41.4%) pre-1995 and in 13 (12%) post-1995. There were 209 cases of death caused by anomalies in other systems but with a renal anomaly present, of which 66 (31.6 %) were chromosomal and 36 (54.5%) had a horseshoe kidney. Of the cases with a horseshoe kidney, 56.3% had a chromosomal anomaly. CONCLUSIONS: The antenatal diagnosis of renal anomalies which cause death did not improve significantly in the second period of this study. However, the number of false positive antenatal diagnoses and the number of postnatal deaths were significantly lower and the number of pregnancy terminations were significantly higher. This reduced the risk of delivering a live baby with an unexpected fatal renal anomaly.     

Environmental risk factors in congenital malformations of the eye

Developmental eye defects such as coloboma are a significant cause of visual morbidity in children, and are more common in India than elsewhere. The possible role of environmental factors in the aetiology of these conditions was investigated by studying birth order, symptoms of vitamin A deficiency (night blindness), drug use and maternal illness in pregnancy, rubella antibodies and exposure to agricultural chemicals. Through hospital records and community-based rehabilitation programmes in Andhra Pradesh, children with colobomata were recruited from schools for the blind. Eighty-three mothers of affected children were interviewed. The results showed that 43% of parents were consanguineous, that 19% had a positive family history and that the frequency of coloboma was highest in second-born children. Eleven (16%) mothers had a history of night blindness while pregnant with the affected child; seven (8%) took medication during the 1st trimester, abortifacients in two cases; three reported fever in the 1st trimester; and 11 (13%) reported exposure to agricultural chemicals.     

Ascertainment and accuracy of Down syndrome cases reported in congenital anomaly registers in England and Wales

OBJECTIVE: Congenital anomaly registers allow the rates of anomalies to be monitored and are essential for understanding their epidemiology. We estimate the ascertainment and accuracy of records of Down syndrome (DS) on national and regional registers in England and Wales. METHODS: Probabilistic record linkage was used to match records of DS from three sources: the National Down Syndrome Cytogenetic Register (NDSCR), seven regional members of the British Isles Network of Congenital Anomaly Registers (BINOCAR) and the National Congenital Anomaly System (NCAS). Capture-recapture methods were then used to estimate the ascertainment of each register. RESULTS: The NDSCR and BINOCAR registers ascertain around 95% of both pre-natally and post-natally diagnosed cases of DS. NCAS collects data only on births and ascertains 55% of cases of DS births, which is currently around 25% of all DS diagnoses. NCAS ascertainment varies according to whether a BINOCAR register covering the same area contributes information to NCAS, varying from 80% in areas where regional registers contribute to 50% where regional registers do not. CONCLUSIONS: Active case finding through regional registers is essential for monitoring congenital anomalies. The ascertainment of the NDSCR and BINOCAR is sufficient to provide reliable epidemiology and surveillance of congenital anomalies, whereas that of NCAS is not.