个旧市50—80年代志贺氏菌监测的统计分析

应用交叉积差的矩阵表示法同组中构成比的统计检验方法,对云南省个旧市50～80年代间志贺氏菌菌型分布差异情况进行显著性检验。结果表明,该市四个不同年代贺氏菌菌型分布的构成有显著差异。通过统计检验使菌型分布变化的比较更为客观、科学和清晰。     

磺胺脒制造过程中“硫化”阶段杂质的分离

在了解生产磺胺脒的过程中,我们发现有许多问题可以作进一步的研究。这些问题的解决可能会对生产上有一定的帮助。其中问题之一就是"硫化"工段产品中杂质的分离。目前生产磺胺脒的步骤如下:     

单因素方差分析在药物稳定性影响因素筛选中的应用

介绍用单因素方差分析法筛选药物稳定性影响因素的一般程序。该法得到的结果不仅能反映主要影响因素，而且还能定量描述其影响程度。     

抗癌素的抗炎实验

采用大白鼠腹股沟植入棉球法产生与临床某些炎症后期病理变化相似的肉芽增生模型，证实抗癌素１５ｍｇ／ｋｇ，３０ｍｇ／ｋｇ具有抑制炎症作用，并具量效关系，与阴性对照组蒸馏水比较有显著差异，与阳性对照组吲哚美辛比较作用较弱。     

麻黄碱的作用受体研究——家兔主动脉条肾上腺素能受体

麻黄碱对离体家兔主动脉条具兴奋作用,此种兴奋可被苯苄胺所阻断。高浓度的麻黄碱对苯苄胺的阻断具“自我保护”(self-protection)作用,对腎上腺素或去甲腎上腺素具“交叉保护”(cross-protection),而后二者对麻黄碱則无“交叉保护”作用。这些实驗指出,麻黄碱除作用于腎上腺素能受体外,对主动脉平滑肌尚可能有其它作用受体。     

无菌检查直接接种法不易判断结果品种的方法改进

目的：解决无菌检查直接接种法中，有些无抗菌作用的药品因培养管浑浊不易进行结果判断的问题，方法：采用薄膜过滤法操作。结果：培养管澄清。结论：缩短了培养时间，消除了判断误差。提高了阳性检出率。     

楝属川楝素含量与生物活性的关系

本文报道用高速液相色谱测定了川楝素含量的各地楝树样品水提物及几种川楝素产品对菜青虫的生物活性,讨论了川楝素含量与生物活性的关系。叶、果样品中虽不含或仅含少量川楝素,但对试虫仍表现出一定的活性。皮中含有较丰富的川楝素,其含量与拒食活性呈正相关,但与毒效作用不相关。四川样品川楝素含量及生物活性均很高而值得重视。川楝素粗产品相对于纯川楝素而言对试虫具更高的生物活性。这种川楝素含量与活性的非线性关系说明样品中其它成份也具活性或与川楝素有着协同作用。通过测定、分析和讨论,指出用川楝素粗产品防治菜青虫是一经济、有效,可行的措施。文中应用了评判援效型杀虫剂的新方法,供讨论和参考。     

地塞米松促进骨形成作用的观察

将培养的原代成骨细胞调制成不同密度,在培养生长的不同时间点上和给予已知对骨形成有不同作用的药物刺激后,测其骨结节量,通过与不添加药物的空白组比较,结果在该成骨细胞培养的１～２５ｄ中,地塞米松组在各种条件下都显示出很强的促进骨形成作用。     

氟哌啶醇对人体淋巴细胞SCE频率的影响

本文研究抗精神病药物氟哌啶醇对离体培养的人体淋巴细胞的SCE频率影响的效应。并与对照组进行比较,差异“不显著”。     

THE PRESENT STATUS OF THE AUTOREGULATION THEORY OF THE PATHOGENESIS OF HYPERTENSION

1. The autoregulation theory of hypertension has been attractive because it postulates a mechanism whereby an early rise in cardiac output becomes ‘transformed’ through normal autoregulatory processes into an elevated total peripheral resistance. 2. ‘Normal’ autoregulation involved in control of blood flow of regional beds is a rapid process compared with the slow changes postulated by the autoregulation theory. 3. Evidence is presented that under appropriate experimental conditions ‘volume’ factors (cardiac output) and ‘constrictor’ factors exert independent long-term effects in developing and in established hypertension. There is little evidence to support the autoregulation theory of hypertension.     

THE RESPONSE OF THE COSTO-UTERINE MUSCLE OF THE RAT TO ADRENORECEPTOR AGONISTS DURING THE OESTROUS CYCLE: A COMPARISON WITH THE UTERINE HORN

• 1 Adrenoreceptors in the rat costo-uterine muscle were compared with those in the uterine horn. The responses of electrically-stimulated preparations of both tissues to isoprenaline and phenylephrine were investigated in the absence and presence of phentolamine and propranolol to block α- and β-adrenoreceptors respectively. Preparations were taken from rats at known stages of the four-day oestrous cycle.
• 2 Both adrenoreceptor agonists consistently inhibited contractions in both tissues; threshold sensitivity to isoprenaline was similar for both tissues and at all cycle stages. The same held true for phenylephrine, which was only approximately 1/400 as potent as isoprenaline. A generally similar pattern was observed when concentrations producing maximum inhibition were compared; however during proestrus, phenylephrine was more potent in producing maximal responses in uterine horns than in costo-uterine muscles.
• 3 Phentolamine had no effect on inhibitory responses to isoprenaline in either tissue, nor to phenylephrine in costo-uterine muscles, but slightly enhanced the inhibitory action of phenylephrine in uterine horns from proestrous rats. Propranolol blocked the inhibitory effects of both drugs, revealing an excitatory effect of phenylephrine in the uterine horns at proestrus.
• 4 These observations, and estimates of pA₂ values for propranolol against both agonists, indicate that β-adrenoreceptors insensitive to cyclical fluctuations in ovarian hormone levels, are predominant in the uterine horn and may be the exclusive adrenoreceptor present in the costo-uterine muscle. In the uterine horn a small sub-population of excitatory α-adrenoreceptors, the presence of which is masked by β-adrenoreceptors, can be demonstrated during proestrus. These receptors may be dependent upon the presence of the endometrium and/or the circular smooth muscle layer. The costo-uterine muscle, which lacks excitatory α-adrenoreceptors, could serve as a useful model of the longitudinal layer of the myometrium in investigations of drug actions at β-adrenoreceptors.

     

角质层在胡椒属生药中的鉴定意义

本文用扫描电镜对9种胡椒属生药进行了叶表面角质层研究,发现角质层对生药的鉴别很有价值,并根据其特征制定出检索表。     

THE SOLUTION CONFORMATION OF THE FERRICHROMES.

Ferrichrome, ferricrocin and ferrichrysin are ferric cyclohexapeptides whose general primary composition is represented by Res³-Res²-Gly¹-Orn³-Orn²-Orn¹, where the Res^2,3 sites are occupied by glycyl or l -seryl residues and Orn^1,2,3 stands for δ-N-acetyl-δ-N-hydroxy-l -ornithyl. The 220 MHz proton magnetic resonance spectra of deferriferricrocin and deferriferrichrysin in aqueous and in deuterodimethyl sulfoxide solutions are reported and discussed in terms of the molecular conformations. In (CD₃)₂SO the chemical shift temperature dependences of the amide proton resonances suggest two-fold symmetric structures containing two intramolecular hydrogen bonds. Such hydrogen-bonding, and other features of the data, are consistent with antiparallel β-pleated sheet structures, as in the Schwyzer model for cyclohexapeptides. In terms of sites paired by the hydrogen bonds, however, the β-fold differs. In water a random conformation is suggested for these peptides.     

蜂毒磷脂酶A_2的降压作用

iv蜂毒磷脂酶A_2(PLA_2)可使麻醉大鼠和猫的血压产生快速而明显的下降,降压作用主要与释放组胺有关,合用组胺H_1、H_2受体拮抗剂,可以显著减弱蜂毒PLA_2的降压作用。     

关于白颜树属的分类问题

将白颜树属Gironniera分成Gironniera亚属和Galumpita亚属是不合理的,应取消Galumpita亚属,将该亚属中枝条无托叶环痕的种类移到糙叶树属Aphananthe中去,白颜树属只包含枝条有托叶环痕的种类。     

香荚兰素对抗大鼠杏仁核点燃效应

用大鼠杏仁核点燃模型研究了香荚兰素的抗癫痫作用。每日一次低电流刺激杏仁基底外侧核可在第15天使大鼠产生典型的五期反应,刺激后放电显著延长。香荚兰素在不产生中枢抑制作用的剂量即可抑制点燃效应的五期反应,ED₅₀为286 mg/kg(ip),同时使刺激后放电时程比对照组下降28.6%。苯妥英钠抑制五期反应的ED₅₀为56mg/kg,也能明显缩短刺激后放电时程。本文提供了一种新型慢性实验性癲痫模型。     

滨海沙土微量元素与木麻黄生长的关系

本文探讨了广东滨海沙土中微量元素B、Mo、Mn、Cu、Zn与木麻黄生长的关系,结果表明:B、Mo有利于促进生长与抗病,Cu含量高对生长有抑制作用,其余的作用不明显。