六神丸＋华素片：同服易致“肠炎”

六神丸是常用药物,不少人家中备有此药。六神丸主要由牛黄、麝香、蟾酥、明雄黄、冰片、珍珠等6味中药以及朱砂组成,因功效”神速”．得名“六神丸“。六神丸有清热解毒、消肿止痛作用．对咽喉肿痛、喉痹失音、口舌糜烂、牙痛、流行性腮腺炎有效。因此,不少人出现喉咙疼痛时．常用六神丸治疗。     

六神丸巧治常见病

百年名药六神丸六神丸是饮誉国内外的著名中成药,已有二百多年的历史。它由牛黄、珍珠、蟾酥、雄黄、麝香和冰片六味名贵中药配制而成,因其功效神速而显著,故得名"六神丸"。它乌黑发亮、颗粒细小、形如芥子。六神丸有着强大的清热解毒、消肿止痛和     

有用又有害的六神丸

六神丸是一百多年前雷允上诵芬堂独有的一个验方。雷允上本人原是清初一名江湖郎中,传说是他创建了雷允上药店,并发明了六神丸药方。目前,雷允上药店在苏沪杭等地知名度很高,雷允上的子孙分享了雷允上药系的传承。独传秘方奇妙有如北方的同仁堂。但有确切记载,六神丸的创研者是雷允上的后裔清末雷子纯,并由他放在诵芬堂出售。解放前六神丸的秘方沿传至嫡裔雷善觉,1962年在清华大学求学的长女、中共党员雷璧芬,将六神丸的秘方捐献给国家,以造福更多的人。1995年,雷璧芬把香港和东南亚的六神丸市场全部献给国家,至此,六神丸的专利合二为一。现在已是广为人知并为家庭常备良药之一。     

六神丸对鼠S180生长的抑制作用与抑制血管生成的关系

目的探讨六神丸对肿瘤血管形成抑制作用.方法通过建立动物肿瘤模型,运用六神丸实验治疗,检测其抑瘤率和肿瘤内血管密度,以及瘤体VEGF表达的改变.结果六神丸具有明显的抑制S180肉瘤生长作用.实验组的S180瘤体内微血管密度均明显低于对照组,免疫组化显示六神丸大、中剂量组均可下调S180瘤体内VEGF的表达.结论六神丸对肿瘤血管形成均有明显抑制作用,降低VEGF的表达可能是其抑制肿瘤血管形成的主要机制之一.     

六神丸的新用途和禁忌

六神丸的新用途和禁忌文／陈世荣六神丸是我国著名的中成药，由蟾蜍、雄黄、牛黄、珍珠、冰片等各贵中药精制而成，具有清心透窍、解毒消肿、止痛功能，广泛用于咽喉肿痛、痈疽疮疗等病。近几年我们在临床实践中观察，发现六神丸还有许多新的用途和禁忌。ｌ六神丸的新用途...     

六神丸皮肤科新用途

治疗带状疱疹六神丸主药系蟾酥,有解毒、消肿、止痛、癖秽浊的功效。现代发现有很强的抗炎和抗病毒作用。据报道,有人用六神丸治疗带状疱疹患者18例,每次内服8- 110粒,每日3次;同时取六神丸40-60 粒温开水溶化后外涂患处,用药5-7 天即可痊愈。亦可将六神丸以米醋研化后,外涂搽患处皮肤,每日3次,     

服六神丸三牢记

六神丸沿用至今已有250余年历史。六神丸主要由牛黄、麝香、蟾酥、雄黄、冰片、珍珠6味药组成,方中还含有朱砂,具有强大的清热解毒、消肿止痛作用,特别对小儿咽喉肿痛、喉痹失音、口舌糜烂、牙痛、流行性腮腺炎有独到之功效。但服用六神丸有很多讲究,主要应注意以下几个方面：     

服用六神丸六大注意事项

正六神丸是传统中成药,来源于清代康熙年间的《雷允上诵芬堂方》,沿用至今已有250多年的历史。由于其具有易用、高效、速效等特点,深受人们的青睐。六神丸主要由牛黄、麝香、蟾酥、雄黄、冰片、珍珠六味名贵药材配制而成,因其功效神速而显著,故名为"六神丸"。六神丸具有清热解毒、消肿止痛、敛疮生肌等功效,常用于咽喉肿痛、扁桃体炎、口舌糜烂、     

服“六神丸”引起的……

‘六神丸’是许多家庭药箱中的常备药品。大人孩子嗓子疼了,便服几粒‘六神丸’。这种做法到底对不对? 3岁的冬冬嗓子疼,妈妈便给她服了1瓶‘六神丸’(按说明幼儿应服5粒以内),半小时后冬冬大汗淋漓,面色苍白,急送医院抢救才脱险。医生说,这是‘六神丸’中毒。 六神丸具有清热解毒、消肿止痛的作用,临床上主要用来治疗急性咽喉炎或急性扁桃体炎时的咽喉肿痛或疖肿疖疮、乳痈阴疽等。其主要成分有牛黄、珍珠、麝香、雄黄、蟾蜍等成分,其中引起中毒的是蟾酥。     

服用六神丸要小心

六神丸具有清热解毒、消肿止痛的作用,国内外享有盛誉。服用六神丸的人很多,但剂量如掌握不好可造成中毒。所以要引起重视。 六神丸的主要戊分之一是蟾酥。中医用蟾酥来治疗疔疮发背、咽喉肿痛、小儿疳积,疤骨流痰及各种无名肿毒。医学研究人员发现,对骨关节结核     

六君子丸联合四联疗法提高脾胃虚弱型Hp感染者根除率的研究

目的探究六君子丸联合四联疗法治疗脾胃虚弱型幽门螺旋杆菌（Hp）感染者的临床效果。方法选取2010年8月—2013年5月在我院就诊的600例因Hp感染引发消化性溃疡的患者,其中脾胃虚弱型Hp感染者72例,将其随机分为对照组和观察组,每组36例。对照组采用四联疗法,观察组在此基础上加用六君子丸,观察比较两组患者的治疗效果及Hp根除率。结果对照组总有效率为88.9%,观察组总有效率为91.7%,两组的总有效率差异无统计学意义（P〉0.05）;对照组患者Hp根除率为66.7%,观察组患者Hp根除率为83.3%。观察组Hp根除率明显高于对照组,具有统计学意义（P〈0.05）。结论采用六君子丸联合四联疗法能够显著提高脾胃虚弱型Hp感染者的根除率,值得临床借鉴使用。     

The impact of the October 1995 'pill scare' on oral contraceptive use in the United Kingdom: analysis of a general practice automated database

OBJECTIVES: We aimed to measure the change in prescribing of oral contraceptives after the October 1995 UK 'pill-scare'. DESIGN: Analysis was undertaken of an automated database of 100 general practices (372 doctors) in England, Scotland and Wales which use the AAH Meditel computer system. Analysis involved two stages. First, we reviewed prescribing of oral contraceptives at three time periods: before the scare (18.10.95); the following three months (19.10.95-18.1.96); and 3- 6 months post-scare (19.1.96-18.4.96). Second, we examined the cohort of women on the pill at the time of the scare to assess discontinuation rates and pill switches after 6 months. RESULTS: Six months after the scare the proportion of women between 16 and 50 years of age prescribed any contraceptive pill decreased by only 3.5% (95% confidence limits: 2.2%-4.8%). The proportion of pill-users prescribed third generation pills decreased from 53.4% to 18.1%, while prescribing of second generation pills increased from 20.1% to 48.4%. The proportion of women currently on third or second generation pills at the time of the scare, who were no longer prescribed any pill after 6 months, was the same as for the equivalent period in the previous year. CONCLUSIONS: The number of women prescribed the pill did not alter markedly after the pill- scare. The main change was a switch from third to second generation pill types. In any future pill-scare women should be warned about the risk of pill-failure if the correct procedure for switching pills is not followed.      

Impact of pill organizers and blister packs on adherence to pill taking in two vitamin supplementation trials

The impact of pill organizers on pill taking was determined in the Trial of Antioxidant Vitamins C and E (TRACE) Study, a factorial trial of vitamin C and vitamin E supplementation in 184 individuals. Participants were recruited in 1996-1997 and randomized to one of two groups (pill organizer or no organizer) and to one of four supplement groups for 2 months. The pill count (observed/expected X 100%) distribution was similar in the organizer and no organizer group for both vitamins. Mean differences in changes in serum vitamin levels between active and placebo groups did not differ by pill organizer use. The impact of pill organizers and blister packs was compared in another trial, the Vitamins, Teachers, and Longevity (VITAL) Study, in 297 individuals randomized in 1993-1994 to receive study pills either in blister packs or in pill organizers and to take one of two supplements. Among those with lower adherence, the pill count distribution in the blister-pack group exceeded that in the organizer group. Mean differences in serum vitamin E levels between active and placebo groups did not differ by types of pill packaging. In summary, use of blister packs, but not pill organizers, improved adherence as measured by pill counts among those with lower adherence. Neither pill delivery system improved adherence as measured by serum vitamin levels.     

Prospects for increased contraceptive pill use in Japan.

Although oral contraceptives are not commercially available in Japan, a low-dose contraceptive pill is expected to become available soon. The current rate of pill use is less than 1 percent, but recent survey data indicate that about 10 percent of currently married women of reproductive age intend to use the pill when it comes on the market. Those who favor the pill do so because it is highly effective in preventing unwanted pregnancies, and because it reduces the need for abortions. Many other women report uncertainty about the pill because of concern about side effects. Given that Japan has a contraceptive failure rate of about 25 percent, with 29 percent of women having had at least one abortion, many women who do not yet favor the pill may shift to it once the low-dose pill comes on the market and they are reassured about its safety. Thus, the rate of pill use is likely to rise well above 10 percent.     

内障丸对多囊卵巢大鼠卵巢颗粒细胞凋亡的影响

目的:探讨内障丸对多囊卵巢大鼠卵巢颗粒细胞凋亡的影响。方法:将60只24日龄雌性SD大鼠随机分为6组,分别为内障丸低剂量组、内障丸中剂量组、内障丸高剂量组、36日模型组、67日模型组和正常对照组。从36日造模成功后开始给药,连续30天。采用TUNEL法检测各组大鼠卵巢颗粒细胞的凋亡情况。结果:内障丸高剂量组大鼠与67日模型组相比卵巢颗粒细胞凋亡明显减少。结论:内障丸可抑制多囊卵巢大鼠卵巢颗粒细胞凋亡,改善卵巢功能。     

The effects of three different regimens of oral contraceptives and three different intrauterine devices on the levels of hemoglobin, serum iron and iron binding capacity in anemic women

The effects on hemoglobin, iron and iron binding capacity (IBC) in 150 moderately anemic women of 1) a 21-day low-dose combined pill, 2) the same low-dose combined pill for 21 days, followed by 7 days of an iron-containing pill, 3) the same low-dose combined pill administered for 63 consecutive days, followed by 7 days of no pill intake, 4) Lippes IUD, 5) TCu 220C and 6) Progestasert were studied. The three pill regimens were associated with an increase in hemoglobin and serum iron after 12 months. However, the iron pill and 63-day schedule groups produced an increase in hemoglobin and iron at the 6th month ans a diminution of IBC at 12 months. The Lippes and TCu 220C groups did not show any change in hemoglobin, iron or iron binding capacity after 12 months. The Progestasert group showed an increase in hemoglobin and iron levels at 6 and 12 months, and a diminution of IBC at 12 months. The pill and Progestasert have advantages as contraceptives in anemic women.     

Estimating airborne benzene exposures from air monitoring data for mineral spirits

"Low aromatics" vs. "regular" mineral spirits differ substantially in their aromatic hydrocarbon content. Mineral spirits contain benzene and other compounds that boil at temperatures below the cited boiling point range of 300 ° to 415 °F. Available published information shows that until at least 2000, the benzene content of regular mineral spirits was typically 0.1% wt/wt and at times could have been 1.0% wt/wt. The present analysis accounts for benzene's higher volatility compared to mineral spirits as a whole and applies thermodynamic principles to estimate benzene vapor exposure as a subset of measured exposure to total hydrocarbons generated by the evaporation of mineral spirits. For a scenario in which the bulk mineral spirits only partially evaporate, this analysis explains the error in assuming that the mole fraction of benzene to "everything else" is the same in the vapor and liquid phases. It is shown that for a given concentration of total hydrocarbon vapor, the benzene vapor concentration can be more than 65-fold greater during mineral spirits evaporation compared to after all the mineral spirits has evaporated. In turn, it is reasonable to expect that during the use of regular mineral spirits, containing benzene typically at 0.1% wt/wt (as applies to usage prior to 2000), benzene vapor exposures could have exceeded 1 ppm even though the mineral spirits vapor exposure did not exceed 100 ppm, the ACGIH? TLV? time-weighted average (TWA) value for mineral spirits. The same analysis can be applied to current petrochemical products, such as toluene, that contain benzene and for which the required physico-chemical information is available. The analysis provides evidence that the material safety data sheet (MSDS) for a petrochemical product containing benzene at less than 0.1% wt/wt should, pursuant to Hazard Communication Standard requirements, identify the benzene as a hazardous ingredient.     

Partner influence on early discontinuation of the pill in a predominantly Hispanic population

CONTEXT Although studies have examined U.S. pill users' patterns of discontinuation, little is known about pill discontinuation, and the effects of partner influence, among Hispanics. METHODS Follow‐up data on pill use were collected from 213 predominantly Hispanic women who requested the pill in a urban family planning clinic in 2000. Logistic regression analyses were conducted to assess the association between a range of factors, including partner and relationship variables, and the odds that women discontinued use before starting their second pack of pills. RESULTS The overall rate of early discontinuation was 23%. Women who reported that their partner was unaware of their planned pill use had significantly elevated odds of discontinuing use (odds ratio, 3.4). Other variables that were independently associated with increased odds of early pill discontinuation were not taking the first pill during the clinic visit (3.0), feling happy about the prospect of a pregnancy in the next six months (2.4) and intending to use the pill for one year or less (2.3). Age, which was assessed as a continuous variable, was negatively associated with the odds of early discontinuation (0.9). CONCLUSIONS Male partners' awareness of planned pill use may be a maker for the level of communication and commitment in the relationship. Women may choose to disclose their planned pill use to supportive partners, and this may be beneficial to the relationship and the couble's contraceptive use. However, clinicians should take women's circumstances and needs into account before counseling them the tell a partner that they intend to use the pill.     

The abortion pill: a solution for unsafe abortions in developing countries?

The abortion pill is a new abortion technique which does not require technically skilled health personnel. Several clinical researchers have stated that the ease of administration of the abortion pill gives it the potential to save lives in countries where thousands of women die annually from complications of failed abortions due to poor health services. This article discusses medical and users' aspects of the abortion pill, with particular emphasis on its use in developing countries, and questions the usefulness of the abortion pill in areas where health care facilities are in short supply. It stresses the need to consider the social, cultural and health care context in which the abortion pill will be used before it is sold on the world market. The safety and efficacy of the abortion pill could be adversely affected by the way women perceive its effectiveness, women's beliefs about conception and pregnancy, and their health status. In the present two-phase administration form the abortion pill is not likely to be appropriate for use in developing countries with a shortage of health care facilities.     

Trends in use of oral contraceptives--data from the 1987 National Health Interview Survey

Despite fluctuations in current use rates for oral contraceptives, ever-use of the pill has remained remarkably stable for all cohorts of U.S. women born since 1945. Approximately 80 percent of these women report having used the pill at some time. Average duration of use is about five years among cohorts who had access to the pill from their earliest reproductive years. Among women born before 1940, whites are more likely than blacks to have ever used the pill, but no racial difference is evident among women in later cohorts. Age at first use of the pill has declined with each succeeding five-year birth cohort. Black women are more likely than white women to have used oral contraceptives before age 18, but by age 25, about three-fourths of blacks and whites have used the pill. Among ever-users born before 1945, the majority began taking the pill after their first full-term pregnancy; this pattern is reversed among more recent cohorts.