口腔颌面部结外型非霍奇金淋巴瘤临床研究

目的:探讨原发于口腔颌面部结外型非霍奇金淋巴瘤的多样性及其鉴别诊断。方法:回顾性分析1999.3-2006.10收住我科的15例颌面部结外型非霍奇金淋巴瘤的临床资料。结果:15例颌面部结外型非霍奇金淋巴瘤临床表现多样性,首诊易发生误诊。结论:原发于颌面部的非霍奇金淋巴瘤临床表现多样性需与其他疾病相鉴别,以减少误诊;确诊需依靠病理学诊断。治疗上以CHOP及改良CHOP方案化疗为主。     

口腔颌面-颈部淋巴瘤临床误诊原因分析

目的：分析口腔颌面（颈）部淋巴瘤误诊原因,并提出相应对策。方法：呼伦贝尔市医院口腔颌面外科1992-2006年共收治口腔颌面部恶性淋巴瘤45例,对其中7例初次临床诊断与病理诊断均未诊断为恶性淋巴瘤,再次病检后最终确诊为恶性淋巴瘤进行回顾性分析。结果：本组首诊误诊率17.8％。其中误诊为炎症者占75％。结论：口腔颌面（颈）部淋巴瘤因其临床表现多样性及无特异性症状体征,易误诊。故临床专科医师应提高对本病的认识,减少淋巴瘤的误诊。     

口腔颌面部非霍奇金淋巴瘤临床病理分析

目的:探讨与口腔颌面部非霍奇金淋巴瘤确诊相关的临床病理特点。方法:对2000-02—2012-03郑州大学附属洛阳市中心医院口腔颌面外科收治的17例非霍奇金淋巴瘤,进行回顾性临床病理分析。结果:口腔颌面部非霍奇金淋巴瘤可发生于任何年龄,男女之比为2.4∶1,可发生于颈部及颌下区、牙龈、腭部、腮腺、颊部及舌根部等。病理类型以B细胞淋巴瘤多见。临床及病理首诊确诊率均偏低。结论:口腔颌面部非霍奇金淋巴瘤临床表现多样,确诊依靠病理学诊断,但对取检标本及病理诊断均有较高要求,有些不典型病例需进行分子生物学检测及严密随访。     

口腔颌面部非霍奇金淋巴瘤多样性表现及诊治

目的探讨口腔领面部非霍奇金淋巴瘤的多样性表现及诊断、治疗。方法回顾分析了58例口腔领面部非霍奇金淋巴瘤患者的临床资料。结果58例领面部非霍奇金淋巴瘤缺乏统一的临床表现,治疗方案采用综合治疗或单独应用化疗。结论口腔领面部非霍奇金淋巴瘤恶性度较高,表现多样,确诊需依靠病理检查。综合治疗和化疗都是有效的治疗方法。     

口腔颌面部非霍奇金淋巴瘤门诊误诊23例临床分析

目的 分析门诊误诊口腔颌面部非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)患者的临床特点,避免误诊.方法 对23例门诊误诊口腔颌面部NHL患者的临床资料及病理报告进行回顾性研究.结果 23例患者中,男∶女＝1.88∶1.00,平均年龄42岁.发病部位依次为颈部、腮腺、腭部及牙龈,患者均经病理检查证实为非霍奇金淋巴瘤.结论 NHL恶性程度较高,表现多样,首诊时易被误诊,确诊需依靠病理检查.     

结外型口腔恶性淋巴瘤临床病理分析

目的:研究结外型口腔恶性淋巴瘤的发病情况和临床病理特点。方法:对青岛大学医学院附属医院口腔颌面外科1988-07—2008-12收治的24例结外型口腔恶性淋巴瘤患者进行回顾性临床病理分析,研究其发病年龄、发病部位、病理分型及临床表现。结果:结外型口腔恶性淋巴瘤发病率低,分布于各个年龄段,男性发病多于女性,可发生于舌根、腭、颊、唇、牙龈等部位,临床表现多样,多为非霍奇金淋巴瘤,以B细胞恶性淋巴瘤多见。结论:结外型口腔恶性淋巴瘤临床表现多样,应注意鉴别诊断。肿块切取活检,辅以全身系统性检查,是诊断结外型口腔恶性淋巴瘤的有效手段。     

腮腺舍格伦综合征与非霍奇金淋巴瘤相关性分析

目的:了解腮腺非霍奇金淋巴瘤与舍格伦综合征的临床及发病机制的相关性，正确诊断和治疗舍格伦综合征，尽早明确有无恶性变。方法：对142例口腔颌面部的非霍奇金淋巴瘤中21例发生在腮腺的非霍奇金淋巴瘤，及3例从合格伦综合征演变成淋巴瘤的病例进行分析。结果：21例腮腺区非霍奇金淋巴瘤的局部表现主要为肿块、反复肿胀，与类肿瘤型舍格伦综合征的一般特征和腮腺表现有相关性，其中3例腮腺淋巴瘤患者有明确的舍格伦综合征病史。结论：舍格伦综合征与腮腺非霍奇金淋巴瘤的发生发展，以及临床表现有相关性，部分类肿瘤型舍格伦综合征可演变为淋巴瘤，临床表现和免疫学改变可早期判断舍格伦综合征有无恶性变。     

口腔颌面部非何杰金氏淋巴瘤(附4例报告)

<正> 恶性淋巴瘤(简称ML)是原发于淋巴结或其他淋巴组织的恶性肿瘤,国内资料统计占全部恶性肿瘤的3～6％,死亡率居恶性肿瘤的第10位。但该病大都就诊于内科,所以口腔颌面部ML专题报道较少。ML临床表现复杂,病理表现又不完全一致,因此临床很容易误诊。现将临床初诊误诊或待诊,最后经病理检验确诊4例非何杰金氏淋巴瘤在口腔颌面部临     

口腔颌面部结核12例临床分析

目的：总结口腔颌面部结核的临床特征和误诊原因。方法：对2005．2—2010．12桂林市第三人民医院和广西壮族自治区南溪山医院收治的经病理确诊的12例口腔颌面部结核病例进行全面分析。结果：本组12例口腔颌面部结核表现为单个淋巴结结核（8例），单个口腔黏膜溃疡（3例），结节增生并溃疡（1例）。其中2例合并活动性肺结核。对5例淋巴结结核仅行手术完整切除，另7例采用手术切除及规范抗结核治疗。结论：口腔颌面部结核的临床表现不典型，全身症状少见，误诊率高，依靠病理学诊断，以手术及规范的抗结核药物治疗为首选。     

口腔颌面部结核误诊原因临床分析

目的：分析口腔颌面部结核的误诊原因。方法：对13例口腔结核病误诊病例的误诊原因进行分析。结果：口腔颌面部结核病发病部位、临床表现多样化,容易导致误诊。结论：口腔颌面部结核病确诊主要靠病理检查,复杂病例需多种方法综合分析,必要时应进行抗结核诊断性治疗。     

口腔颌面颈部恶性淋巴瘤56例临床分析

目的：探讨头颈部恶性淋巴瘤的发病特点、临床表现以及预后的相关性分析。方法：搜集56例头颈部恶性淋巴瘤病例,采用HE染色法进行观察,分析临床特点及预后情况。结果：56例头颈部恶性淋巴瘤患者中非霍奇金恶性淋巴瘤和霍奇金恶性淋巴瘤患者分别为47例（83.93%）和9例（16.07%）,常见临床体征是包块（痛性及无痛性）,感染溃疡。49例回访,7例失访。在回访中,22例（44.90%）复发,经分析表明复发率与患者的年龄及累计部位的差异具有统计学意义（P〈0.05）。发病部位依次为颈部、颌下、颏下。仅有头颈部症状者48例（85.71%）。初次诊断不明确者46例（82.14%）。1次病理诊断的确诊率为84.8%。治疗主要为手术＋化疗。患者5年生存率58%。结论：结外型恶性淋巴瘤的临床表现及组织学形态多样化,容易与临床上其他疾病相混淆。应通过病理检查及免疫组织化学检查以明确诊断。累犯≥2个部位和年龄〉50岁头颈部恶性淋巴瘤患者的复发率较高。     

2013—2017年武汉市1953例口腔颌面部肿瘤、囊肿与瘤样病变构成比分析

目的　分析2013—2017年武汉市口腔颌面部肿瘤、囊肿与瘤样病变发病情况,从而为临床诊断与治疗提供重要参考依据。方法　研究资料来源于2013—2017年武汉市2所医院收治的住院病例,经病理检查诊断为口腔颌面部肿瘤、囊肿或瘤样病变1953例,分别按性别、年龄、发病部位进行划分并分析结果。结果       1953例患者中口腔颌面部良性肿瘤占51.87%、恶性肿瘤占19.05%、囊肿占23.30%、瘤样病变占5.78%。口腔颌面部肿瘤患者的男女构成比（分别为49.02%和50.98%）基本无差异,其中以涎腺肿瘤居高（41.44%）,且肿瘤多为良性（73.14%）。口腔颌面部囊肿男性构成比（54.73%）高于女性（45.27%）,其中以颌骨囊肿居高（41.54%）。口腔颌面部瘤样病变女性构成比（57.53%）高于男性（42.47%）,其中以牙龈瘤居高（69.91%）。年龄分布上总体在20 ~ <30岁年龄段构成比居高（18.64%）,≥70岁构成比较低（3.02%）。病变部位以口腔部位（26.83%）为主,其中口腔颌面部肿瘤、瘤样病变均多发于口腔,而囊肿多发于涎腺。结论    武汉市口腔颌面部肿瘤、囊肿与瘤样病变以肿瘤最为常见,且以良性为主,不同性别间囊肿与瘤样病变存在差异性,口腔作为好发部位,临床应密切关注,及时采取防治措施以控制疾病发生。     

Comparison of apoptosis and apoptosis-related gene products between extranodal oral B-cell lymphoma and maxillofacial nodal B - cell lymphoma

Twenty-seven cases of primary extranodal oral B-cell lymphoma and 22 cases of primary maxillofacial nodal B-cell lymphoma were investigated for the presence of apoptotic cells and the expression of apoptosis-related gene products by terminal deoxynucleotidyl-mediated dUTP nick end labeling (TUNEL) and immunohistochemistry. The majority of extranodal oral diffuse large B-cell lymphomas (17/25, 68%) and maxillofacial nodal diffuse large B-cell lymphomas (14/16, 88%) contained no or less than 10% apoptotic cells. Whereas the majority of extranodal oral diffuse large B-cell lymphomas (18/25, 72%) and maxillofacial nodal diffuse large B-cell lymphomas (13/16, 81%) contained more than 10% of Ki-67-positive cells. Bcl-2-, Bax-, p53- and Ki-67-positive rates were higher in maxillofacial nodal diffuse large B-cell lymphomas than in extranodal oral diffuse large B-cell lymphomas, but only Bax (chi2 test, 0.01相似文献   

Localized B-cell non-Hodgkin's lymphoma of oral cavity and maxillofacial region: a clinical study

OBJECTIVE: Non-Hodgkin's lymphomas (NHL) are the third most common group of malignant lesions in the oral cavity and maxillofacial region. Most such lymphomas have been shown to be predominantly of B-lineage. The purpose of the present study is to analyze the clinical signs and symptoms and the clinical staging of B-cell NHL of this region. STUDY DESIGN: Eighteen adults, with B-cell NHL manifestations of the oral cavity and maxillofacial region, were available for this study. The clinical stage according to the Ann Arbor system was assessed by history, physical, and laboratory examination. Hematoxylin and eosin--stained slides and paraffin blocks were available for all cases. Histologic diagnosis was based on the WHO classification of tumors. RESULTS: The mean age of patients at the time of biopsy was 64 years. At the time of the disease presentation, according to the Ann Arbor system, 11 patients were in stage IE, 2 patients in stage IIE, 2 patients in stage IIIE, 1 patient in stage IVE, and 2 patients in stage IV. The typical clinical appearance was a painless local mass lateral or bilateral. Often there is a superficial ulceration of the tumor mass. Tonsillar NHL was the most frequent site occurring in 8 patients followed by NHL of the oral cavity, of the salivary glands, and of the mandible. Grading revealed that most cases were high grade (11 cases), followed by the cases of low grade (5 cases) and intermediate grade (2 cases). All the different histologic types may be observed, but the most frequently encountered is the diffuse large type. CONCLUSIONS: The B-cell NHL may involve both osseous and soft tissues of the oral cavity and maxillofacial region. The favored sites are tonsils, palatal mucosa and parotid glands. The typical clinical appearance is a painless local mass lateral or bilateral. Often there is a superficial ulceration of the tumor mass. According to the Ann Arbor system, the majority of the cases at the time of diagnosis are in stage I or II. Most patients have high grade disease. All the different histologic types may be observed, but the most frequently encountered is the diffuse large type.     

Non-Hodgkin lymphoma of the mandible--a case report with differential diagnostic considerations

Approximately 5% of all malignant lesions are diagnosed as malignant lymphomas, of which 2-3% are localized in the head and neck region. After the squamous cell carcinoma and neoplasms of the salivary glands, malignant lymphomas represent the third most frequent malignant lesion in that region. Malignant lymphomas can be grouped into Hodgkin- and non- Hodgkin lymphomas (NHL) and subdivided into nodal (lymph nodes) and extranodal lymphomas. We present the case of an extranodal non-Hodgkin lymphoma in the left mandible of a 47-year-old woman, who was referred to our department with an unclear swelling, which was supposed to be infectious. After clinical and radiological examination, a biopsy was taken and a CD20 and BCL-6 protein positive non-Hodgkin lymphoma of the large B-cell type (DLBCL) was diagnosed. The patient was treated primarily with immunochemotherapy (R-CHOP protocol) and refused to undergo a subsequent radiotherapy. The 18 months follow-up showed a complete remission of the lymphoma. In this paper, the NHL in the oral and maxillofacial region is presented as a cause of unclear swelling. Important differential diagnostic conditions are discussed.     

口腔颌面部金属异物取出61例临床总结

目的:探讨口腔颌面部金属异物最佳手术取出途径。方法:将我科1999—2008年口腔颌面部金属异物61例诊治情况进行分析总结。结果:61例中的65个口腔颌面部金属异物都顺利取出,没有发生伤口感染,创口均愈合良好。结论:口腔颌面部异物应用平板探测器X线数字成影(DDR)线片,必要时可行三维CT重建准确定位,在明确诊断后,尽量沿着原创口选择手术途径,如明视下手术取出困难可在X线透视下取出。     

Orofacial non-Hodgkins lymphoma in Nigerians.

PURPOSE: In this study, we sought to determine the occurrence of primary non-Hodgkins lymphoma (NHL) in the oral and maxillofacial region among Nigerians. PATIENTS AND METHODS: We retrospectively studied hospital records that included radiographs of all patients with a histopathologically confirmed diagnosis of NHL in the Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria, between January 1992 and December 1997. Data were expressed as mean +/- SD or number (%). RESULTS: During the study period, 66 cases of NHL were recorded. Seventeen patients had concomitant extranodal lymphomas involving the gastrointestinal tract, nasopharynx, skin, lungs, kidney, and thyroid, in descending order. Three patients (4.5%) presented primarily with extranodal oral and maxillofacial disease. The ages of these patients ranged from 18 to 50 years (mean +/- SD, 32.3 +/- 16.3 years; median, 29 years). Within the same period, there were 121 cases of Burkitts lymphoma. The onset of lesions varied from 6 to 20 weeks. Two patients had intermediate-grade lesions; the remainder had low-grade lesions. Two presented with stage II disease, and the remainder were stage I. All of the patients had chemotherapy with remission of their lesions but were followed up to 6 months. Most of them did not complete the treatment cycles due to financial and social constraints. CONCLUSIONS: The rarity of primary NHL of oral and maxillofacial region has been aptly shown in this study. The need for the establishment of an effective oncology policy with the active collaboration of voluntary agencies is emphasized. This would ensure ready availability of the required chemotherapeutic agents and hospital care at affordable costs.     

颌面部黏膜相关淋巴组织淋巴瘤12例的临床分析

目的 加深对黏膜相关淋巴组织淋巴瘤的临床及病理特征认识。方法 对10年来本院收治的12例(口腔颌面外科9例、眼科3例)颌面部黏膜相关淋巴组织淋巴瘤的临床、病理资料及治疗预后情况进行回顾性分析。结果 12例患者中单纯切除肿瘤原发灶8例、切除原发灶并术后联合化疗(CHOP方案)3例及单纯联合化疗1例。所有病例病情均得到完全缓解。结论 颌面部黏膜相关淋巴组织淋巴瘤多为无痛性过程,发展缓慢,长期局限。多种治疗均可完全缓解病情,达到无瘤生存状态,预后较好。