Etude d'infections à virus ECHO 9

At Ste. Justine Hospital, Montreal, during the period 1957-61, ECHO 9 virus was isolated in 27 cases, in 20 of these during the summer of 1961. All had evidence of meningeal irritation, accompanied by fever and headache. Four of the 20 patients diagnosed during the summer of 1961 had convulsions; 12 presented with a rash; and two simulated meningococcemia. Of the 27 patients, two were paralyzed and one case was diagnosed as transverse myelitis. ECHO 9 virus was isolated from stools and from throat specimens in equal proportion; it was isolated from cerebrospinal fluid in only two instances. Pathogenicity for suckling mice was observed in two of 22 inoculated directly with the specimen material and in 10 of 11 inoculated with the cultured material.     

Epidemic acute haemorrhagic conjunctivitis due to Coxsackie virus A24 variant in Ghana

An outbreak of acute haemorrhagic conjunctivitis (AHC) occurred in Accra, Ghana, reaching a peak in July 1987. Individuals ranging from infants to adults over 50 years were infected, with those between 20 and 30 years being the most affected group. There was a female preponderance. Clinical features included conjunctivitis, subconjunctival haemorrhage and ocular pain. Some patients reported of blurred vision due to mild keratitis. Isolation of virus from clinical specimens of AHC patients was successful only in cells of human origin such as HeLa and FL. Coxsackie virus A24 variant (CA 24v) was identified as the aetiologic agent. This is the first report to associate CA 24v with an epidemic of AHC in Africa, south of the Sahara, which is outside the endemic area of Southeast Asia and the Caribbeans. This finding suggests that earlier outbreaks of AHC in Ghana and Africa may have been due to CA 24v but went undetected. The results of various tests performed during this study suggest that, at least, two antigenically different viruses of CA 24v circulated during the course of this epidemic.     

An epidemic of ECHO 6 virus infection

Fourteen cases of infection with ECHO 6 virus in the Chelmsford area from August to December 1968 are described. A comparative account of the seasonal, geographical and age incidence is given, and its relationship to certain epidemiological aspects is discussed.     

Fatal neonatal meningitis due to Group B streptococci

A case of fatal neonatal meningitis due to Group B β-haemolytic Streptococcus is described. Early diagnosis and institution of vigorous antibiotic therapy were of no avail. Although the mortality rate is very high in comparison to many other neonatal bacterial infections reported so far, it is difficult to explain the fact that there are so few references to it as a pathogen in the British literature.     

一起由埃可病毒30型引起的病毒性脑炎疫情调查

摘要：目的探讨2012年夏季广东省罗定市病毒性脑炎的流行病学特征、临床表现和病原学因素,为今后地区性病毒性脑炎的预防控制提供科学依据。方法回顾性调查分析288例病毒性脑炎患儿的流行病学资料和临床资料。结果288例病例分布于罗定市21个乡镇,罹患率为23.37／10万,各乡镇罹患率差异有统计学意义（218.46,x2=0.00）;首发病例发生在2012年4月19日,发病高峰期为5月份,至7月上旬疫情平息;发病人群中男性187例,女性101例,男女比例为1.85：1,发病年龄从4月龄至31岁,以3-8岁为主。288例病毒性脑炎病例的主要临床症状为发热、头痛、呕吐,病情普遍较轻,预后良好。45份患者脑脊液、血清和粪便等肠道病毒阳性标本检出埃可30型病毒核酸阳性18份,埃可9型病毒核酸阳性1份。结论2012年夏季广东省罗定市病毒性脑炎的流行主要由肠道病毒埃可30型引起,今后应加强对病毒性脑炎的监测和防控工作。     

Hypersecretion of anti-diuretic hormone due to tuberculous meningitis.

Three patients with tuberculous meningitis complicated by hypersecretion of anti-diuretic hormone are described. The recognition of this complication is important in the treatment and prognosis of tuberculous meningitis.