共查询到6条相似文献,搜索用时 0 毫秒
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Michael Alifrangis Sidsel Nag Mette L. Schousboe Deus Ishengoma John Lusingu Hirva Pota Reginald A. Kavishe Richard Pearce Rosalynn Ord Caroline Lynch Seyoum Dejene Jonathan Cox John Rwakimari Daniel T.R. Minja Martha M. Lemnge Cally Roper 《Emerging infectious diseases》2014,20(8):1280-1286
Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine–pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004–2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages. 相似文献
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Sa?d C. Boubidi Ibrahim Gassen Yacine Khechache Karima Lamali Boualem Tchicha Cécile Brengues Michela Menegon Carlo Severini Didier Fontenille Zoubir Harrat 《Emerging infectious diseases》2010,16(2):301-303
An outbreak of Plasmodium falciparum malaria occurred in Tinzaouatine in southern Algeria in 2007. The likely vector, Anopheles gambiae mosquitoes, had not been detected in Algeria. Genes for resistance to chloroquine were detected in the parasite. The outbreak shows the potential for an increase in malaria vectors in Algeria. 相似文献
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Yang Z Li C Miao M Zhang Z Sun X Meng H Li J Fan Q Cui L 《Emerging infectious diseases》2011,17(3):498-501
We performed a molecular epidemiologic survey of mutations associated with drug-resistance genes in Plasmodium falciparum in northeastern Myanmar. In this region, 3 highly mutated drug-resistance haplotypes and 1 associated with decreased quinine susceptibility were prevalent, which suggests that parasites may be resistant to multiple commonly used antimalarial drugs. 相似文献
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Independent Lineages of Highly Sulfadoxine-Resistant Plasmodium falciparum Haplotypes,Eastern Africa
Steve M. Taylor Alejandro L. Antonia Whitney E. Harrington Morgan M. Goheen Victor Mwapasa Ebbie Chaluluka Michal Fried Edward Kabyemela Mwayi Madanitsa Carole Khairallah Linda Kalilani-Phiri Antoinette K. Tshefu Stephen J. Rogerson Feiko O. ter Kuile Patrick E. Duffy Steven R. Meshnick 《Emerging infectious diseases》2014,20(7):1140-1148
Sulfadoxine-resistant Plasmodium falciparum undermines malaria prevention with sulfadoxine/pyrimethamine. Parasites with a highly resistant mutant dihydropteroate synthase (dhps) haplotype have recently emerged in eastern Africa; they negated preventive benefits of sulfadoxine/pyrimethamine, and might exacerbate placental malaria. We explored emerging lineages of dhps mutant haplotypes in Malawi, the Democratic Republic of the Congo, and Tanzania by using analyses of genetic microsatellites flanking the dhps locus. In Malawi, a triple-mutant dhps SGEG (mutant amino acids are underlined) haplotype emerged in 2010 that was closely related to pre-existing double-mutant SGEA haplotypes, suggesting local origination in Malawi. When we compared mutant strains with parasites from the Democratic Republic of the Congo and Tanzania by multiple independent analyses, we found that SGEG parasites were partitioned into separate lineages by country. These findings support a model of local origination of SGEG
dhps haplotypes, rather than geographic diffusion, and have implications for investigations of emergence and effects of parasite drug resistance. 相似文献