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Gibbons BJ Brignole EJ Azubel M Murakami K Voss NR Bushnell DA Asturias FJ Kornberg RD 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(6):1949-1954
Structures of complete 10-subunit yeast TFIIH and of a nested set of subcomplexes, containing 5, 6, and 7 subunits, have been determined by electron microscopy (EM) and 3D reconstruction. Consistency among all the structures establishes the location of the "minimal core" subunits (Ssl1, Tfb1, Tfb2, Tfb4, and Tfb5), and additional densities can be specifically attributed to Rad3, Ssl2, and the TFIIK trimer. These results can be further interpreted by placement of previous X-ray structures into the additional densities to give a preliminary picture of the RNA polymerase II preinitiation complex. In this picture, the key catalytic components of TFIIH, the Ssl2 ATPase/helicase and the Kin28 protein kinase are in proximity to their targets, downstream promoter DNA and the RNA polymerase C-terminal domain. 相似文献
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Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF) 总被引:1,自引:0,他引:1
Mas C Lussier-Price M Soni S Morse T Arseneault G Di Lello P Lafrance-Vanasse J Bieker JJ Omichinski JG 《Proceedings of the National Academy of Sciences of the United States of America》2011,108(26):10484-10489
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Sophie Mourgues Violette Gautier Anna Lagarou Christine Bordier Amandine Mourcet Joris Slingerland Lara Kaddoum Frédéric Coin Wim Vermeulen Anne Gonzales de Peredo Bernard Monsarrat Pierre-Olivier Mari Giuseppina Giglia-Mari 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(44):17927-17932
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