高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

高原病与相关基因表达关系的研究进展

高原病作为一种由于进入高原引起的疾病,已经有相当多的研究,但其发病机制目前仍然不清楚,高原病遗传学方面的研究结果表明:基因多态性可能是高原病的发病机制之一.本文简要综述与缺氧调控的相关基因在高原缺氧人群的研究进展.     

氨茶碱对急进高原者抗缺氧效应的研究

目的:探讨氨茶碱对急进高原者抗缺氧的效应。方法:总共100名青年男性入选本试验。随机分为2组:氨茶碱组50名(A组),对照组50名(C组)。所有参试者均为从四川省(海拔400米)招募的新兵。在乘飞机从四川进入拉萨(海拔3658米)前7 d,A组和C组分别开始口服氨茶碱和安慰剂。在3个时间点(服药前、服药后7d、进入高原后3 d)抽血测定血浆一氧化氮(NO)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、过氧化氢(H2O2)、乳酸(LA)和动脉血氧饱和度(SaO2)。结果:在平原地区服药前、后两组的缺氧和氧化指标比较无统计学差异。进入高原后3 d,所有参试者的血浆SOD,CAT(仅对照组),H2O2,LA水平增加(P<0.01),NO,SaO2下降(P<0.05,<0.01)。A组的SOD,CAT,H2O2,LA水平较C组低(P<0.01),而NO和SaO2水平高于C组(P<0.05,P<0.001)。结论:氨茶碱具有抗高原缺氧和抗氧化作用。     

Association between metabolically unhealthy overweight/obesity and chronic kidney disease: The role of inflammation

AimOur study explored the association between subtypes of increased fat mass (with or without associated metabolic alterations) and the presence of chronic kidney disease (CKD).MethodsIn this cross-sectional survey in China, body mass index (BMI) was used to assess fat mass. Metabolically healthy was defined as no insulin resistance or any metabolic syndrome components except abdominal obesity. We also used two previous definitions of metabolically healthy. Multiple logistic regression models were used. Normal weight with metabolic health was designated the reference group. Three other subgroups included normal weight with metabolic unhealthiness, overweight/obesity with metabolic health and overweight/obesity with metabolic unhealthiness.ResultsOf the 2324 subjects, 11.77% overweight/obese subjects were metabolically healthy. Compared with normal-weight subjects who were metabolically healthy, overweight/obese subjects who were metabolically healthy did not have an increased risk of CKD (OR: 0.79, 95% CI: 0.29–2.14; P = 0.64), whereas overweight/obese subjects who were metabolically unhealthy had a significantly higher risk of CKD (OR: 2.47, 95% CI: 1.5–3.95; P < 0.001). Normal-weight subjects who were metabolically unhealthy also had a higher risk of CKD, but the P value was of borderline significance. On further adjusting for C-reactive protein (CRP) levels, ORs were much attenuated, but did not alter the associations observed. Using two other definitions of metabolically healthy resulted in similar results.ConclusionMetabolically unhealthy overweight/obesity, but not metabolically healthy overweight/obesity, is associated with an increased risk of CKD. Inflammation might mediate at least part of the association between metabolic changes and CKD prevalence.     

肥胖与心血管疾病的关系

肥胖患者的数量正以飞快的速度在世界范围内增长,肥胖与心血管疾病特别是高血压病,冠心病及胰岛素抵抗之间的关系密切,近年来的研究不断揭示肥胖在导致及加重心血管疾病中的作用越来越重要,但治疗方法仍旧缺乏,现就将近年来国内外对肥胖与心血管疾病之间的关系的研究作一简要综述。     

肥胖、高脂血症与急性胰腺炎相关性研究

目的　探讨肥胖、高脂血症在急性胰腺炎发病中的影响与作用。　方法　选择重症急性胰腺炎 (SAP)患者 98例 ,轻症急性胰腺炎 (MAP)患者 10 7例 ,测定体重指数 (BMI)、血脂水平以及急性胰腺炎相关的实验室检查指标。　结果　肥胖组 (BMI≥ 2 8kg/ m2 )共有 6 4例 ,超重组 (2 4 ≤ BMI<2 8kg/m2 )和体重正常组 (BMI<2 4 kg/ m2 )分别有 6 6例和 75例。肥胖组 SAP比例高于超重组和体重正常组 ;SAP患者 BMI和血三酰甘油高于超重组和体重正常组 ;对于肥胖的急性胰腺炎患者 ,血脂升高伴随着更为严重的胰腺和肝肾功能损害 ,在超重组和体重正常组未观察到同样的效应。　结论　肥胖影响急性胰腺炎的严重程度 ,并且肥胖者发生急性胰腺炎后 ,血脂水平可作为急性胰腺炎严重程度的预测指标。     

超重/肥胖与动态血压变化的关系

目的:探讨超重/肥胖和动态血压(ABP)变化的相互关系。方法:根据体重指数(BMI)共选择121例肥胖(n=62)、超重(n=39)和正常对照组(n=20)做24h动态血压检测(ABPM),比较3组ABP值的变化。结果:24h、日间和夜间平均收缩压和舒张压水平、日间和夜间血压负荷值在肥胖组>超重组>正常对照组(P<0.01),以夜间收缩压升高更明显;30%超重和56.8%肥胖者血压昼夜节律消失(P<0.01),夜间血压下降率<10%,呈非杓型曲线;BMI、腰围(WC)和ABP各值、负荷值、夜间血压下降率均呈正相关(r=0.32～0.467,P<0.05～<0.01),相关程度夜间高于日间,WC优于BMI。结论:超重、肥胖或腹型肥胖不仅加重血压负荷,还影响昼夜血压节律,这种改变WC高于BMI,且多出现在夜间。     

Association between nonalcoholic fatty liver disease and acute ischemic stroke severity and outcome

AIM: To evaluate the association of nonalcoholic fatty liver disease (NAFLD) with acute ischemic stroke severity and in-hospital outcome.METHODS: We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012 (n = 415; 39.5% males, mean age 78.8 ± 6.6 years). The severity of stroke was assessed with the National Institutes of Health Stroke Scale (NIHSS) score at admission. NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels [chronic hepatitis B or C, drug toxicity, increased alcohol consumption (> 21 and > 14 drinks per week in men and women, respectively), cholestatic diseases or rhabdomyolysis]. The outcome was assessed with the modified Rankin scale (mRS) score at discharge and in-hospital mortality. Adverse outcome was defined as mRS score at discharge ≥ 2. Dependency at discharge was defined as mRS score between 2 to 5.RESULTS: NAFLD was present in 7.7% of the study population. Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD (P < 0.05 for both comparisons). Demographic data, the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups. At admission, the NIHSS score did not differ between patients with and without NAFLD (6.3 ± 6.4 and 8.8 ± 9.6, respectively; P = NS). At discharge, the mRS score did not differ between the two groups (1.9 ± 2.2 and 2.6 ± 2.2 in patients with and without NAFLD, respectively; P = NS). Rates of dependency at discharge were also similar in patients with and without NAFLD (36.8% and 55.0%, respectively; P = NS) as were the rates of adverse outcome (42.9% and 58.6%, respectively; P = NS). In-hospital mortality rates also did not differ between the 2 groups (8.0% and 7.0% in patients with and without NAFLD, respectively; P = NS).CONCLUSION: The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome.     

超重和肥胖与动脉僵硬度的相关性研究

目的 分析超重和肥胖与动脉僵硬度的关系.方法 选取2007至2009年江苏省社区自然人群4585名为研究对象进行回顾性研究.以体质指数(BMI)评价超重和肥胖,肱踝脉搏波传导速度(baPWV)评价动脉僵硬度.将BMI分别作为连续变量(以l kg/m2递增)和等级变量(体重正常、体重过轻、超重和肥胖)进行logistic多因素逐步回归分析,评价高动脉僵硬度风险和人群归因危险度百分比,并通过受试者工作(ROC)曲线分析BMI对高动脉僵硬度的预测价值.结果 (1)控制年龄后,男性和女性的BMI与baPWV均呈正相关(r值分别为0.213和0.186,P均＜0.01).超重、肥胖人群baPWV和高动脉僵硬度发生率均高于正常组(P均＜0.01).(2)logistic回归模型校正年龄、性别、高血压因素后,连续变量BMI致高动脉僵硬度的OR值为1.146(95％CI:1.117～1.175,P＜0.01);当BMI为等级变量时,体重过轻OR值为0.369(95％ CI:0.141～0.962,P＜0.05),超重和肥胖OR值分别为1.576(95％CI:1.333～1.863,P＜0.01)和2.087(95％CI:1.615 ～2.698,P＜0.01).超重和肥胖者高动脉僵硬度的人群归因危险度百分比分别为19.1％和11.6％.(3) BMI评估高动脉僵硬度的ROC曲线下面积为0.661(95％ CI:0.645 ～0.678,P＜0.01),BMI预测高动脉僵硬度的最佳分割值为24.25 kg/m2.结论 超重和肥胖人群的动脉僵硬度高于体重正常人群.超重和肥胖是独立于年龄、性别、高血压之外的高动脉僵硬度危险因素.     

非酒精性脂肪肝血浆抵抗素与肥胖和胰岛素抵抗关系的研究

目的探讨非酒精性脂肪肝(NAFLD)血浆抵抗素与肥胖和胰岛素抵抗的关系。方法对兰州大学第一医院2005年10月至2006年2月60例NAFLD患者和28名年龄、性别相匹配的正常对照者,采用ELISA方法测定空腹血浆抵抗素,同时检测其身高、体重、腰围、臀围、血压、血糖、血脂、肝功能及胰岛素水平,并计算体重指数、脂肪百分比、腰臀比和胰岛素抵抗指数。结果NAFLD组与正常对照组相比,其血浆抵抗素明显升高[(8.56±2.5)ng/mL对(6.39±2.81)ng/mL,P<0.01]。相关分析显示血浆抵抗素与空腹胰岛素、胰岛素抵抗指数呈显著正相关(分别为r=0.271,P=0.036;r=0.30,P=0.020);而与腰臀比、体重指数、脂肪百分比、收缩压、舒张压、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血糖无相关性(P>0.05)。结论NAFLD患者血浆抵抗素明显升高,与胰岛素抵抗程度呈显著正相关,与肥胖无相关性。因而抵抗素可能主要与肝源性胰岛素抵抗有关,而与肥胖相关的胰岛素抵抗无关。     

Association between acute pancreatitis and peptic ulcer disease

AIM:To evaluate the relationship between peptic ulcer disease(PUD) and acute pancreatitis.METHODS:A cohort of 78 patients with acute pancreatitis were included in this study.The presence of PUD and the Helicobacter pylori(H.pylori) status were assessed by an endoscopic method.The severity of acute pancreatitis was assessed using Ranson's score,the Acute Physiology and Chronic Health Evaluation(APACHE) □ score,computed tomography severity indexand the clinical data during hospitalization,all of which were co...