针刺与手法治疗颈椎病对比分析

INTRODUCTION During the course of the rehabilitation of cervical disease, it wasfound that symptoms of the patient is not always occurred simulan-iously. So the combination of acupuncture and the manuvor methodaccording to the situation or with assistance of cervical tractionshould be used, physical therapy or traditional Chinese herb. Inaddition, it is important to establish self health care, correct positionand appropriate cervical muscle exercise.     

Analysis of amelioration of neurological function on cervical degeneration disease after treatment with cervical spine locking plate

Objective To discuss the clinical effect of treatment with anterior decompression,bone graft and cervical locking plate fixation for cervical degeneration disease.Method 23 patients with cervical spondylotic myelopathy and cervical ossification of the posterior longitudinal ligament have undergone the treatment of anterior cervical spine locking plate fusion,Neurological signs and symptoms were evaluated before and after surgery,and mean follow-up time was 11,3 months.Result In all cases,radiography demonstrated a solid bony fusion,Additional general complications include a large wound hematoma in one and hoarseness in one ,All patients‘ neurological function were improved.Conclusion The clinical effect of treatment with anterior decompression,bone graft and cervical locking plate fixation for cervical degeneration disease is satisfactory.     

颈椎间盘突出症合并腰椎间盘突出症的非手术治疗效果分析

Background: There are many reports about the operative or non- operative treatments of herniation of cervical disc or prolapse of lumbar intervertebral disc, but few about the non- operative treatments curative effect and attentive affairs of their combination. Objective: To study the non- operative treatments' curative effect of herniation of cervical disc combined with prolapse of lumbar intervertebral disc. Design: To make retrospective survey and study of non- operative treatments' curative effect of herniation of cervical disc combined with prolapse of lumbar intervertebral disc. Unit: First Affiliated Hospital of Anhui Medical University. Subject: From February 1990 to February 1998, 55 patients were with the complication, occupied 15. 41% of the simple cervical disc, and 9. 34% of the simple lumbar intervertebral disc.     

Anterior cervical corpectomy decompression and fusion for cervical kyphosis in a girl with Ehlers-Danlos syndrome:A case report

BACKGROUND Spinal deformities in Ehlers-Danlos syndrome(EDS; type VI) are generally progressive and severe. Surgical treatment has been described for kyphoscoliosis in the thoracolumbar spine. However, there are few studies describing the consequences of an anterior approach in cervical kyphosis. An anterior approach may not be able to fully decompress the spinal canal and restore the normal curvature of the cervical spine. Therefore, the anterior approach for cervical kyphosis in young children is hard. We describe the first case in an EDS girl with cervical kyphosis who received satisfactory anterior cervical corpectomy decompression and fusion.CASE SUMMARY The chief complaints of a 16-year-old girl with EDS were double upper limb weakness for 7 years and double lower limb walking instability for 2 years.Moreover, the imaging results revealed that the degree of kyphosis from cervical vertebra 2 to 4 accompanying with spinal cord compression was 30°. An anterior cervical corpectomy involving cervical vertebra 3 and a titanium mesh implant were performed with internal fixation. The results at 3 mo after surgery demonstrated that the anterior fusion was solid, and the kyphosis of the cervical spine was corrected. Additionally, the power of all four extremities was significantly improved.CONCLUSION The incidence rate of cervical kyphosis in EDS is rare. The surgical treatment for these patients, especially an anterior approach, is challenging. Therefore, to develop safer and more effective strategies to treat cervical kyphosis in EDS,there is still much work to do.     

Oncogenic role of Tc17 cells in cervical cancer development

BACKGROUND As one of the subsets of CD8+T cells,Tc17 cells have recently been identified and are characterized by the secretion of interleukin(IL)-17,which is related to inflammatory diseases.AIM To assess the status of Tc17 cells in cervical cancer and investigate the biological function of Tc17 cells in cervical cancer development.METHODS Flow cytometry assay,immunohistochemistry,and immunofluorescence were performed to detect the levels and phenotype of Tc17 cells in blood and tumor samples from patients with cervical cancer.Prior to cell suspension culture,ELISA was carried out to measure the production of IL-6,IL-1β,IL-23,CXCL12,and IL-17 in tumor tissue supernatant and co-cultured supernatant of patients with cervical cancer.In addition,multivariate analysis was performed to identify factors associated with overall survival using the Cox proportional hazards model.RESULTS Compared with normal tissues,Tc17 cells specifically accumulated in tumor tissues of cervical cancer patients.Cancer cells produced a greater amount of IL-6,IL-1β,and IL-23,which in turn promoted Tc17 cell polarization.Unlike the traditional cytotoxic CD8^+T cells,Tc17 cells secreted IL-17,which subsequently promoted CXCL12 expression in tumor cells,eventually enhancing the proliferation and migration of tumor cells.Thus,the ratio of tumor-infiltrating Tc17 cells was highly correlated with poor clinical outcome in patients with cervical cancer.CONCLUSION Our data identified the oncogenic role of Tc17 cells in the development of cervical cancer.We propose that the ratio of Tc17 cells may be a useful index in the prognosis of patients with cervical cancer.     

阴道镜对宫颈病变的诊断价值研究

Objective To research the value of colposcopy examination for all kinds of cervical lesions. Methods Analyze the results of 3,258 cases of patients, who have taken the colposcopy examination in our hospital from Jan, 2005 to Jun, 2008. Results Among the 3,258 cases colposcopy examination, there were 458 cases with the abnormal colposcope and having the needle biopsy through the colposcopy,including 137 cases of low degree lesion by the pathological diagnosis, 84 cases of high degree lesion(CIN2～ CIN3) , 18 cases of cervical invasive carcinoma, 79 cases of chronic inflammation, and 150 cases of cervical benign tumor. Conclusion The colposcope picture has higher coincidence rate in the colposcope xgc and the histopathology diagnosis, and is important in finding the cervical cancer, cervical precancerous lesion, human papillomavirus infection and complicated precancerous lesion in the early stage.     

Effect of AXIS lateral mass screw—plate internal fixation system on functional recovery of spinal cord in fracture of lower cervical vertebrae

AIM:To evaluate the methods and results of the AXIS lateral maas screw-plate system in the treating of lower cervical apine injury.METHODS:29 caaes of lower cervical vertebrae injury were fixed with AXIS system,All of them were followed-up for more than 1 year,RESULTS:All cases had a good bone union without malformation.We found no complication of the injury to the vertebral arteries or nerves,There was no loosening of the plate and screw.CONCLUSION:AXIS lateral mass screwplate system has the characteristic of stable.simple and safe and is suitable for the treatmont of lower cervical spine injury.     

牵引和体疗治疗神经根型颈椎病800例

Background:The mechanism of cervical spondylopathy is very complex.During the retrograde degeneration of the cervical vertebrae hyperosteogeny occurs at the anterior and posterior edges of the vertebrae and the small joints and hyperemia,swelling,fibrosis,calcification or ossification might occur in the around articular ligaments and stimulate or pressure spinal nerve root,the spinal cord,cervical sympathetic nerves and the vertebral artery and cause different clinical manifestations.     

辨证疗法对颈椎关节功能障碍的康复观察

Background:Cervical spondylopathy belonging to chronic and multiple diseases is common among elders,which seriously affects work and life of patients.Cervical spondylopathy is considered as arthragia- syndrome,dizzy,flaccidity- syndrome,stiffness of nape in traditional chinese medicine.Differentiating treatment was effective in treatmenting the condition. Objective:To study effect of differntiating treatment on joint dysfunction following cervical spondylopathy. Unit:Shenzhen Chinese Medicine Hospital Subjects:128 outpatients,76 male,52 femlae,aged 24～ 68 years.Duration of condition lasted for 3 months to 18 years.Teachers,band staffs are susceptible for the condition.Of all patients,47 suffered from cervical spondylopathy of nerve root form,42 from cervical spondylopathy of cervical form,23 from cervical spondylopathy of vertebral artery form,8 from cervical spondylopathy of myeloid form.According to differntiating type in traditional chinese medicine,89 patients suffered from arthralgia form,31 from dizzy form,and 8 from flaccidity form. Intervention:Huangqi Guizhi Tang Jiajian consisting of Astragalus root(30 g),Cinnamom twig(10 g),White peony root(15 g),Pueravia root(20 g),Licorice root(6 g),Fresh ginger(10 g),Chiness- date(10 g),Notoptery gium root(10 g),Ledebouriella root(10 g)Spatholobus stem(30 g) was administrated for patients suffered from cervical spondylopathy of arthrlgia form.For patients     

交感神经型颈椎病及相关疾病的系统康复

INTRODUCTION There are many symptoms of sympathetic nerve type of cervical spondylopathy, most of which are subjective symptoms and one of the most common symptom is flustered, chest distress. Disease condition is often prolonged, main symptoms of disturbance of posterior thoracic vertebrae joints are back pain and chest distress. Diagnosis of both diseases are mainly according to clinical manifestation, but some symptoms aren't typical and often missed or misdiagnosed. Some patients with disturbance of posterior thoracic vertebrae don' t present with obvious back pain but chest distress, If complicated with cervical spondylopathy, all symptoms are explained with cervical spondylopathy and disturbance of posterior thoracic vertebrae joints is neglected that will lead to prolongation.     

颈椎后路侧块钢板螺钉置入治疗多节段颈椎病伴颈椎失稳

背景：侧块钢板螺钉内固定技术已广泛用于创伤及各种原因引起的颈椎不稳、滑脱和颈椎重建。目的：探讨后路椎板减压侧块固定辅助小关节撑开植骨融合治疗多节段颈椎病的效果。方法：作者以＂颈椎,侧块,内固定,植骨＂为检索词,在中国期刊全文数据库中,采用电子检索的方式进行文献检索。排除Meta分析及重复性研究,共检索到22篇文献,从颈椎侧块临床解剖、侧块螺钉固定技术,侧块螺钉固定疗效等方面进行探讨。结果与结论：颈椎侧块螺钉为后路短节段固定,最大限度地保留了颈椎的活动度,能实现对颈脊髓的充分减压,恢复椎间高度,维持颈椎生理曲度,稳定颈椎的失稳节段,并能预防颈椎后凸畸形以及神经根麻痹的发生及颈椎失稳的加重,是治疗多节段颈椎病伴颈椎失稳的有效方法。     

电子阴道镜在宫颈病变中的应用体会

目的：探讨电子阴道镜（简称阴道镜）在宫颈病变中的应用价值。方法对150例宫颈病变患者行阴道镜检查,并与病理学检查进行对照,评估阴道镜对宫颈病变的诊断价值。结果150例患者阴道镜检查结果与病理检验结果符合率为95.33%,其中宫颈息肉、宫颈湿疣及宫颈浸润癌符合率为100.00%,宫颈上皮内瘤的符合率为81.82%。结论阴道镜对宫颈癌的早期诊断的具有较强的敏感性和特异性,是临床早期发现宫颈疾病的重要手段之一。     

大麻素2型受体在宫颈上皮内瘤变和宫颈癌中的表达

目的研究大麻素受体2(CB2受体)在正常宫颈组织、宫颈上皮内瘤变(CIN)和宫颈癌中的表达,探讨其在宫颈癌的发生发展中的作用和意义。方法采用免疫组织化学方法分别检测正常宫颈组织、各级宫颈上皮内瘤变组织和宫颈癌中CB2受体的表达情况。结果 CB2受体在正常宫颈组织、宫颈上皮内瘤变组织和宫颈癌中均有表达;宫颈上皮内瘤变组织和宫颈癌中CB2受体表达水平明显高于正常组;CB2受体表达水平随组织恶性程度的增加而升高(P均<0.01)。结论 CB2受体在宫颈上皮内瘤变组织和宫颈癌中表达明显升高,且其升高水平随病变组织恶性程度的增加而增加,提示CB2受体可能在正常宫颈组织向宫颈上皮内瘤变和宫颈癌的逐级演变过程中起着重要作用。     

53893例宫颈癌筛查结果及分析

目的 探讨宫颈癌筛查现状.方法 对53893例宫颈癌筛查的结果进行分析,讨论可能的影响因素及解决办法.结果 宫颈癌高危人群集中在40～65岁,与国内大数据统计的宫颈癌高发年龄基本符合,常规进行宫颈癌筛查可降低宫颈癌的发生率.结论 定期进行宫颈癌筛查可预防宫颈癌的发生、个性化群体筛查是宫颈癌筛查改进的方向.     

宫颈癌中fascin和galectin-3表达的临床意义

目的 探讨fascin和galectin-3在宫颈癌中的表达,了解其在宫颈癌淋巴道转移及临床判断预后方面的作用.方法 应用免疫组化法检测fascin和galectin-3在10例正常宫颈组织、32例宫颈上皮内瘤变及108例宫颈癌组织中的表达情况,并分析fascin和galectin-3表达与相关病理参数的关系.结果 宫颈癌组织中fascin蛋白的表达显著高于宫颈上皮内瘤变及正常宫颈组织,宫颈上皮内瘤变中fascin蛋白的表达显著高于正常宫颈组织;fascin 表达与肿瘤大小、淋巴结转移密切相关;其在宫颈腺鳞癌的表达高于宫颈腺癌(P＜0.05).galectin-3蛋白在宫颈癌、宫颈上皮内瘤变及正常宫颈组织的表达差异不显著(P＞0.05),在宫颈非鳞癌的表达显著高于正常宫颈组织、宫颈上皮内瘤变及宫颈鳞癌;galectin-3表达与深肌层浸润和淋巴结转移密切相关;其在宫颈腺鳞癌中的表达高于宫颈腺癌以及宫颈鳞癌中的表达.fascin与galectin-3在宫颈癌中的表达成正相关.结论 fascin和galectin-3参与了宫颈癌的发生发展、浸润和淋巴道转移,两者在宫颈癌的淋巴转移过程中可能有协同作用;fascin在鉴别宫颈腺鳞癌与腺癌时可能有一定的参考价值,galectin-3今后可能成为诊断宫颈腺鳞癌的重要检测指标之一.     

宫颈癌中表皮生长因子受体的表达与临床预后的相关性研究

目的 研究表皮生长因子受体(EGFR)在宫颈癌及宫颈上皮内瘤样病变(CIN)中的表达,并探讨其与宫颈癌发生、浸润转移及预后的相互关系.方法 应用免疫组化法对100例宫颈癌、60例CIN及40例正常宫颈上皮组织中的EGFR进行检测.结果 正常上皮、CIN、宫颈癌组织的EGFR过表达率分别为O%(0/40)、51.67%(31/60)、78.00%(78/100).宫颈癌组的EGFR过表达率显著高于CIN组(P<0.05,OR=3.32,95%CI∶1.67～6.63),2组的EGFR过表达率均显著高于对照组(P均<0.01).EGFR过表达与宫颈癌临床分期、肿瘤体积、病理类型、组织分化、宫颈浸润深度、颈管侵犯及淋巴结转移均无显著相关(P均>0.05),与宫颈癌预后也无显著相关(P>0.05).结论在宫颈癌变过程中,EGFR过度表达水平随着宫颈病变程度的加重而上升,提示EGFR过度表达与宫颈肿瘤的发生相关,EGFR可能成为有价值的宫颈癌生物学指标.EGFR过度表达与宫颈癌临床病理特征及预后无关.     

宫颈腺癌的超声声像图特征研究

目的：探讨经阴道超声检查在宫颈腺癌诊断中的应用价值。方法：回顾性分析首都医科大学附属北京妇产医院 2012年2月—2017 年4月经病理证实宫颈腺癌的病例60例,结合病理结果及分期,对其术前超声声像图特点进行分析。结果：60例宫颈腺癌超声图像中,29例呈现正常宫颈声像图或仅宫颈前后径增大,31例呈现异常宫颈声像图,以宫颈实性低回声肿块、宫颈内膜线回声中断为主要表现。结论：中晚期宫颈腺癌经经阴道超声检查具有宫颈实性低回声肿块,宫颈内膜线回声中断等声像特点。经阴道超声对中、晚期宫颈腺癌有较高的诊断价值, 但对于早期宫颈腺癌有一定的局限性。     

颈椎病合并颈椎损伤的MRI诊断

目的：分析颈椎病合并颈椎损伤的磁共振（ＭＲＩ）表现。方法：回顾性分析６２例颈椎病患者与３５例非颈椎病患者颈椎损伤的ＭＲＩ扫描资料与临床资料。结果：颈椎病合并颈椎损伤的ＭＲＩ表现包括椎体骨折与脱位、韧带撕裂,颈髓损伤、椎间盘损伤脱出、推动脉受压扭曲与狭窄、椎前血肿等损伤性表现及椎间盘变性脱出。黄韧带肥厚、椎管狭窄、后纵韧带钙化等颈椎退变表现。颈椎病组颈椎损伤易合并颈髓损伤,且多为无骨折脱位型颈髓损伤,颈髓损伤的位置与范围与颈椎原有病变的位置与范围一致。结论：ＭＲＩ能充分反映颈椎病合并颈椎损伤的表现特征,对治疗和预后有重要意义。     

KAI1在宫颈鳞癌中的表达及临床意义

目的探讨研究KAI1在正常宫颈、宫颈上皮内瘤变（cervical intraepithelial neoplasia,CIN）及宫颈鳞癌中的表达及其与宫颈鳞癌临床病理特征之间的关系,探讨其在宫颈鳞癌发生、发展和转移等方面的作用和意义。方法随机选取大庆龙南医院2009年1月-2010年10月间妇科门诊及住院手术切除的组织标本：10例正常宫颈组织、40例宫颈上皮内瘤变组织、36例宫颈鳞癌组织,应用免疫组织化学法对组织进行染色,以检测KAI1的表达情况。结果 KAI1主要在细胞膜和（或）细胞浆内表达,其在正常宫颈组织、CINⅠ、Ⅱ、Ⅲ、宫颈鳞癌组织中阳性表达呈递减趋势,依次为100%、87.5%、73.3%、63.1%、19.4%。KAI1在宫颈鳞癌表达与细胞分化程度及淋巴结转移相关,与组织浸润深度、临床分期、年龄、癌灶大小无关。提示KAI1可以抑制宫颈鳞癌的浸润和转移。结论 KAI1的高表达抑制宫颈鳞癌的发生发展,低表达可能预示着该肿瘤更具有侵袭性,预后差。     

宫颈细胞DNA倍体定量分析联合液基细胞学在宫颈癌早期筛查中的应用价值

目的探讨宫颈细胞DNA倍体检测联合液基细胞学在宫颈癌早期筛查中的应用价值。方法对12 630例患者采用宫颈细胞DNA倍体定量检测与液基细胞学联合进行宫颈病变的早期筛查,对其中1 146例宫颈细胞DNA倍体定量检测阳性和(或)宫颈液基细胞学阳性者行阴道镜检查并取活检,以病理诊断为金标准,评价两种方法在宫颈癌早期筛查中的作用与意义。结果 (1)宫颈DNA异倍体细胞的检出率和宫颈液基细胞学的阳性率分别为13.68%和8.97%,有统计学差异(P<0.01);(2)随着DNA异倍体细胞数量的增加,液基细胞学的阳性率也相应增加,且宫颈病变的严重程度也增加,两种方法检测结果均阳性者与活检病理诊断有较高的符合率;(3)以1²个倍体异常细胞为宫颈活检标准,发现宫颈病变的敏感性为98.10%,特异性为18.20%,符合率较差;若以3个以上DNA倍体异常或液基细胞学LSIL作为阴道镜检查并取活检,发现宫颈上皮内瘤变Ⅰ级以上的敏感性分别为89.14%和73.28%,特异性分别为75.80%和76.50%,均有较好的符合率。结论宫颈细胞DNA倍体定量检测与液基细胞学筛查均可作为宫颈癌及癌前病变的早期筛查的有效方法,且两者联合应用可明显提高对宫颈癌及癌前病变诊断的敏感性与特异性,达到早期诊治的目的。