Some aspects of structural disturbances in the DNP complex when damaged by N-nitroso-N-methylurea

The effect of solubilization of deoxyribonucleoproteins (DNP) in a medium of near-physiological ionic strength after treatment with the mutagen N-nitroso-N-methylurea (NMU) is highly dependent on the NMU concentration. To convert DNP into a soluble state, the critical number of groups in the DNA and protein must evidently be modified. On the basis of data obtained by the circular dichroism method and by viscosimetry it is concluded that after treatment with NMU the DNP complex becomes soluble in solvents with near-physiological ionic strength largely as a result of labilization and dissociation of the DNA-protein bonds.Laboratory of Biophysics, Institute of Medical Genetics, Academy of Medical Sciences of the USSR. Sector of Kinetics of Chemical and Biological Processes, Institute of Chemical Physics, Academy of Sciences of the USSR. Laboratory of Physical Methods of Investigation, D. I. Ivanovskii Institute of Virology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S Debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 6, pp. 674–677, June, 1976.     

Mineralization of ground substance of new bone tissue in mouse marrow organ cultures

Laboratory of Immunomorphology, N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. Laboratory of Medical Biophysics, Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. V. Prozorovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 106, No. 11, pp. 614–616, November, 1988.     

Prevention of arrhythmias in conscious animals during acute ischemia with the aid of a serotonin analog

Laboratory of Pathophysiology of the Heart, Research Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR. Department of Organic Chemistry, D. I. Mendeleev Moscow Chemical Engineering Institute. S. Ordzhonikidze All-Union Pharmaceutical Chemical Research Institute, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR I. K. Shkhvatsabaya.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 106, No. 10, pp. 410–412, October, 1988.     

Adaptation to stress increases the resistance of heart cell nuclei to the damaging action of single-stranded exogenous DNA

Research Institute of General Pathology and Pathophysiology, Academy of Medical Sciences of the USSR, Moscow. Leningrad Institute of Nuclear Physics, Academy of Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S. Debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 5, pp. 460–462, May, 1991.     

Absence of a radiation-induced adaptive response of lymphocytes in Down's syndrome

N. I. Pirogov Second Moscow Medical Institute. Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. P. Bochkov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 9, pp. 290–292, September, 1991.     

Induction of tumoricidal activity of human and murine peritoneal macrophages by antitumor chemotherapy

Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. M. Navashin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 108, No. 9, pp. 330–332, September, 1989.     

Multiple forms of DNA-methylases from hepatic nuclei of animals in health and disease

Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR, Moscow. Institute of Biochemistry, Academy of Sciences of the Uzbek SSR, Tashkent. State Institute of Hygiene, Hungarian Ministry of Health, Budapest. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S. Debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 1, pp. 36–39, January, 1991.     

Is xanthine oxidase a universal source of superoxide radicals in liver damage induced by ischemia and reperfusion?

Department of Kinetics of Chemical and Biological Processes, Institute of Chemical Physics, Academy of Sciences of the USSR. Drug Research Institute, Ministry of the Medical and Biological Industry of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR Yu. A. Vladimirov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 6, pp. 548–550, June, 1990.     

Study of soluble lens proteins of normal mice and mice with cataract

Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR M. E. Vartanyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 6, pp. 609–610, June, 1991.     

Effect of cycloheximide on protein,RNA, and DNA synthesis in CHO and diploid human fibroblast cell cultures

All-Union Medical Genetics Research Center, Academy of Medical Sciences of the USSR, Moscow. Chernogolovka Branch, N. N. Semenov Institute of Chemical Physics, Moscow Region. (Presented by Academician of the Academy of Medical Sciences of the USSR N. P. Bochkov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 8, pp. 139–141, August, 1991.     

α-glycerophosphate dehydrogenase activity biorhythms in peripheral lymphocytes of rats with Walker carcinosarcoma

Chernogolovka Branch, Institute of Chemical Physics, Academy of Sciences of the USSR. N. N. Burdenko Principal Military Hospital. Institute of Pediatrics, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR, F. I. Komarov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 107, No. 6, pp. 731–735, June, 1989.     

Effect of the gaba antagonist 4-ethylbicyclophosphate on global and synaptic neuronal evoked responses in hippocampal slices

Laboratory of Organic Synthesis, Reception of Physiologically Active Substances Group, Institute of Physiologically Active Substances, Academy of Sciences of the USSR, Chernogolovka, Moscow Region. Laboratory of Functional Synaptology, Brain Institute, All-Union Mental Health Research Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR O. S. Adrianov. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 4, pp. 339–341, April, 1991.     

Antibody levels to different determinants of group A streptococcal polysaccharide and autoantibodies to the basal layer of the skin epithelium in rheumatic fever

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR. Institute of Immunology, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. V. Prozorovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No 12, pp. 624–627, December, 1991.     

Mechanism of the antioxidative action of carnosine

I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. All-Union Mental Health Research Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. E. Severin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 5, pp. 477–478, May, 1991.     

Some kinetic features of membrane-bound monoamine oxidase

Initial reaction-velocity versus substrate-concentration curves for serotonin oxidation catalyzed by monoamine oxidase (MAO) from fragments of rat liver or bovine brain mitochondrial membranes have a complex, nonhyperbolic shape; this is regarded as a kinetic manifestation of substrate cooperativeness for membrane-bound MAO. The possibility of interaction between different types of MAO based on conformational changes in the membrane itself is discussed.Scientific-Research Institute for Biological Trials of Chemical Compounds, Ministry of the Medical Industry of the USSR. Institute of Biological Medical Chemistry, Academy of Medical Sciences of the USSR. All-Union Vitamin Scientific-Research Institute, Ministry of the Medical Industry of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. N. Orekhovich.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 3, pp. 288–289, March, 1977.     

Correlation between doubling time of volume of human lung tumors and labeling index

The labeling index (incubation with thymidine-H³) and the volume doubling time (repeated roentgenography) were compared for three human lung tumors: two squamous-cell carcinomas with different levels of differentiation, and one hamartoma. The minimal doubling time (178 days) was found for the squamous-cell carcinoma with a lower level of differentiation and with the highest labeling index (19.0%). The hamartoma (a benign lung tumor) had the longest doubling time (1250 days) and the smallest labeling index (3.8%).Sector of Kinetics of Chemical and Biological Processes, Institute of Chemical Physics, Academy of Sciences of the USSR. Thoracic Department, Institute of Experimental and Clinical Oncology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 1, pp. 59–61, January, 1976.     

Correlation between intracellular and cellular regeneration of the renal tubular epithelium of the kidney in necrotizing nephrosis

Department of Biology, Grodno Medical Institute. Laboratory of Autoradiography and Histochemistry, A. V. Vishnevskii Institute of Surgery, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR D. S. Sarkisov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 2, pp. 203–205, February, 1990.     

Cytochemical manifestations of short- and long-term activation of the rat brain dopaminergic system

Laboratory of Cytochemistry, Brain Research Institute, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR O. S. Adrianov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 7, pp. 41–42, July, 1991.     

Changes in organization of the intermediate filament system in human fibroblasts in lysosomal storage diseases and their experimental models

Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR. Institute of Carcinogenesis, All-Union Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. I. Archakov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 3, pp. 263–268, March, 1992.     

Dynamics of transcription activity of cerebellar Purkinje cell chromatin after systemic circulatory arrest

Institute of General Resuscitation, Academy of Medical Sciences of the USSR. N. I. Pirogov Second Moscow Medical Institute N. K. Kol'tsov Institute of Developmental Biology, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR. V. A. Negovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 3, pp. 232–235, March, 1991.