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Hypoglycemia is a frequent occurrence in patients with diabetes who are treated with insulin and insulin secretagogues. Hypoglycemia is the limiting factor that prevents patients from achieving the glycemic control known to reduce the microvascular complications of diabetes. Recurrent episodes of hypoglycemia can lead to impaired awareness of hypoglycemia where the first symptom of a low blood sugar is unconsciousness. The fear of hypoglycemia has a significant effect on the quality of life of patients and their families. In the acute setting, hypoglycemia can kill, and clinical trials have demonstrated that a single episode of severe hypoglycemia increases the risk of subsequent mortality and cardiovascular events. Clinicians must make efforts to recognize and prevent hypoglycemia in order to prevent the adverse events associated with this event. Patient education is central to these efforts. Recent developments in glucose monitoring and drug development have provided more approaches that can be used to reduce the risk of hypoglycemia in patients with diabetes. 相似文献
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Louise J. Maple‐Brown Greta Lindenmayer Federica Barzi Cherie Whitbread Christine Connors Elizabeth Moore Jacqueline Boyle Marie Kirkwood I‐Lynn Lee Danielle Longmore Paula van Dokkum Mary Wicks Michelle Dowden Chrissie Inglis Margaret Cotter Renae Kirkham Sumaria Corpus Sridhar Chitturi Sujatha Thomas Kerin O'Dea Paul Zimmet Jeremy Oats Harold D. McIntyre Alex Brown Jonathan E. Shaw 《Journal of Diabetes》2019,11(9):761-770
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Epidemiology of diabetes mellitus,pre‐diabetes,undiagnosed and uncontrolled diabetes and its predictors in general population aged 15 to 75 years: A community‐based study (KERCADRS) in southeastern Iran;
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Hamid Najafipour Mojgan Sanjari Mostafa Shokoohi Ali‐Akbar Haghdoost Mehdi Afshari Mitra Shadkam Koorosh Etemad Ali Mirzazade 《Journal of Diabetes》2015,7(5):613-621
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Diabetes mellitus prevalence is increasing in South Asians but is stable in Chinese living in Singapore and Mauritius
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Kristin H.X. Tan Elizabeth L.M. Barr Vira Koshkina Stefan Ma Sudhir Kowlessur Dianna J. Magliano Stefan Söderberg Kee Seng Chia Paul Zimmet Wei‐Yen Lim 《Journal of Diabetes》2017,9(9):855-864
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Vishal Patel Amit Joharapurkar Tejal Gandhi Kirti Patel Nirav Dhanesha Samadhan Kshirsagar Vipin Dhote Jaysukh Detroja Rajesh Bahekar Mukul Jain 《Journal of Diabetes》2013,5(2):163-171
Background: In addition to its glucoregulatory actions, exendin‐4, a stable glucagon‐like peptide‐1 receptor agonist, exhibits protective effects in the pancreas and anti‐obesity effects. Suitable combination treatment with other anti‐obesity or pancreas protective agents would be an effective approach to optimize these additional effects. In the present study, we investigated the effects of the addition of omeprazole, a proton pump inhibitor, to exendin‐4 in db/db mice, an experimental model of obesity and type 2 diabetes. Methods: The effects repeated dose treatment for 14 days with exendin‐4 (8 μg/kg, s.c.) and omeprazole (30 mg/kg, s.c.) on glycemic control, food intake, and body weight were determined in obese and hyperglycemic db/db mice. The effects of these treatments on plasma gastrin, ghrelin, and leptin levels were determined, along with effects on nausea‐like symptoms. The pancreatic effects of the repeated dose treatment were assessed by measuring %HbA1c in the circulation as well as pancreatic insulin and glucagon content and glucokinase activity. Results: Combination treatment resulted in significant decreases in plasma leptin and ghrelin levels after repeated dosing. Omeprazole improved the anorectic and body weight‐lowering effects and reversed the inhibitory effect of exendin‐4 on gastrin levels after repeated dose treatment. The 14‐day combination treatment significantly reduced glucose excursion and improved insulin levels, with a concomitant decrease in %HbA1c levels. It also improved glucokinase activity and pancreatic insulin content, with a significant decrease in glucagon content. Conclusions: Combined treatment with omeprazole with exendin‐4 reduces food intake and body weight gain, most likely through changes in plasma ghrelin and leptin levels, and improves pancreatic insulin and glucagon content by improving glucokinase activity. 相似文献
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Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case‐control study in a sub‐Saharan African population with diabetes
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Eric Lontchi‐Yimagou Jérôme Legoff Jean‐Louis Nguewa Philippe Boudou Eric V. Balti Jean J. Noubiap Vicky Kamwa Barbara Atogho‐Tiedeu Marcel Azabji‐Kenfack Eric N. Djahmeni Martine Etoa Gaelle Lemdjo Vanessa Balla Mesmin Y. Dehayem Fabienne Foufelle Jean‐Claude Mbanya Jean‐Francois Gautier Eugene Sobngwi 《Journal of Diabetes》2018,10(11):866-873
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