共查询到20条相似文献,搜索用时 31 毫秒
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Maria Mota Simona Georgiana Popa Eugen Mota Adina Mitrea Doina Catrinoiu Dan Mircea Cheta Cristian Guja Nicolae Hancu Constantin Ionescu‐Tirgoviste Radu Lichiardopol Bogdan Mircea Mihai Amorin Remus Popa Cornelia Zetu Cornelia Gabriela Bala Gabriela Roman Cristian Serafinceanu Viorel Serban Romulus Timar Ioan Andrei Veresiu Adrian Radu Vlad 《Journal of Diabetes》2016,8(3):336-344
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Lutz Heinemann John M. Beals James Malone James Anderson Jennie G. Jacobson Vikram Sinha Sheila M. Corrigan 《Journal of Diabetes》2019,11(4):292-300
The earliest marketed insulins were crude acidic formulations with concentrations of ≤10 units/mL. Since the early 1920s, insulins have improved continually, via bioengineering, process, and chemical modifications. Today, most insulin formulations have a concentration of 100 units/mL (U100). However, more concentrated insulin formulations (200, 300, and 500 units/mL; U200, U300, and U500, respectively) are also available. There is a tendency to assume that concentrated insulins are similar, both to each other and to their U100 counterparts, but this is not always the case: two concentrated insulins, namely insulin degludec U200 and insulin lispro U200, are bioequivalent to their U100 counterparts, whereas regular human insulin U500 and insulin glargine U300 are not. The advent of these concentrated insulins offers greater opportunities to provide tailored therapy for patients; it also introduces potential confusion, and highlights the need for prescriber and patient education. Precise and accurate dedicated insulin delivery devices are also necessary for the safe use of these concentrated insulins. Although some clinicians only use concentrated insulin with obese and severely insulin‐resistant patients, other patients would also benefit from the reduced injection volume associated with concentrated insulins, or the modified time‐action profile of some concentrated insulins. The aim of this review is to enhance understanding of the historic development and the safe and effective use of concentrated insulins in clinical practice. 相似文献
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Louise J. Maple‐Brown Greta Lindenmayer Federica Barzi Cherie Whitbread Christine Connors Elizabeth Moore Jacqueline Boyle Marie Kirkwood I‐Lynn Lee Danielle Longmore Paula van Dokkum Mary Wicks Michelle Dowden Chrissie Inglis Margaret Cotter Renae Kirkham Sumaria Corpus Sridhar Chitturi Sujatha Thomas Kerin O'Dea Paul Zimmet Jeremy Oats Harold D. McIntyre Alex Brown Jonathan E. Shaw 《Journal of Diabetes》2019,11(9):761-770
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Fish are good for your health in more ways than you may expect. For one, eating fish is a common dietary recommendation for a healthy diet. However, fish have much more to provide than omega‐3 fatty acids to your circulatory system. Some fish species now serve as important and innovative model systems for diabetes research, providing novel and unique advantages compared with classical research models. Not surprisingly, the largest share of diabetes research in fish occurs in the laboratory workhorse among fish, the zebrafish (Danio rerio). Established as a genetic model system to study development, these small cyprinid fish have eventually conquered almost every scientific discipline and, over the past decade, have emerged as an important model system for metabolic diseases, including diabetes mellitus. In this review we highlight the practicability of using zebrafish to study diabetes and hyperglycemia, and summarize some of the recent research and breakthroughs made using this model. Equally exciting is the appearance of another emerging discipline, one that is taking advantage of evolution by studying cases of naturally occurring insulin resistance in fish species. We briefly discuss two such models in this review, namely the rainbow trout (Oncorhynchus mykiss) and the cavefish (Astyanax mexicanus). 相似文献
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Prevalence of and risk factors for diabetic ketosis in Chinese diabetic patients with random blood glucose levels >13.9 mmol/L: Results from the CHina study in prEvalence of diabetiC Ketosis (CHECK) study 下载免费PDF全文
Leili Gao Yufeng Li Dadong Fei Li Ma Shuchun Chen Bo Feng Qing Su Linong Ji 《Journal of Diabetes》2018,10(3):249-255
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Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study 下载免费PDF全文
Wei Bao Yiqing Song Kimberly A. Bertrand Deirdre K. Tobias Sjurdur F. Olsen Jorge E. Chavarro James L. Mills Frank B. Hu Cuilin Zhang 《Journal of Diabetes》2018,10(5):373-379
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Sarah H. Koning Klaas Hoogenberg Helen L. Lutgers Paul P. van den Berg Bruce H.R. Wolffenbuttel 《Journal of Diabetes》2016,8(6):770-781
Gestational diabetes mellitus (GDM) is a global health concern, not only because its prevalence is high and on the increase, but also because of the potential implications for the health of mothers and their offspring. Unfortunately, there is considerable controversy in the literature surrounding the diagnosis and treatment of GDM, as well as the possible long‐term consequences for the offspring. As a result, worldwide there is a lack of uniformly accepted diagnostic criteria and the advice regarding the treatment of GDM, including diet, insulin therapy, and the use of oral blood glucose‐lowering agents, is highly variable. In this review we provide an overview of the important issues in the field of GDM, including diagnostic criteria, different treatment regimens available, and the long‐term consequences of GDM in the offspring. 相似文献