上消化道疾病是否合并糖尿病胃镜检查结果的临床比较

目的比较上消化道疾病是否合并糖尿病患者胃镜检查结果的差异性。方法随机选择该院近年来治疗的60例糖尿病合并上消化道疾病患者(研究组)和具有可比性的60例单纯性上消化道疾病患者(对照组)为研究对象,两组患者均采用日本富士公司生产的201型电子胃镜进行检查,观察两组患者行胃镜检查时食管和胃组织损伤和食管胃十二指肠病变情况,比较相应检查结果构成比之间的差异是否具有统计学意义。结果研究组患者中,食管粘膜光滑和破损的例数分别为33例和27例,贲门口松弛、正常和紧张的例数分别为38例、9例和13例,有无胃底红斑的例数分别为24例和36例,有无胃底胃窦红斑的例数分别为49例和11例;对照组患者中,食管粘膜光滑和破损的例数分别为35例和25例,贲门口松弛、正常和紧张的例数分别为22例、20例和18例,有无胃底红斑的例数分别为22例和38例,有无胃底胃窦红斑的例数分别为51例和9例,两组患者除贲门口损伤构成比之间的差异有统计学意义外(P0.01),其他项目构成比之间的差异无统计学意义(P0.05)。研究组患者胃十二指肠溃疡、胃粘膜肠腺化生、胃十二指肠息肉和食管癌的检出率分别为21.67%、15.00%、6.67%和0.00%,对照组患者检出率分别为18.33%、0.00%、6.67%和3.33%,两组患者除胃粘膜肠腺化生检出率之间的差异有统计学意义外(P0.01),其他项目检出率之间的差异无统计学意义(P0.05)。结论与单纯上消化道疾病比较,合并糖尿病患者的贲门口松弛度和胃粘膜肠腺化生检出率较高,为疾病的诊断、鉴别诊断和治疗提供可靠的依据。     

超细电子胃镜在小儿上消化道疾病中的诊断价值

目的阐释超细电子胃镜检查在小儿上消化道疾病中的诊断价值。方法 206例小儿均行超细电子胃镜检查,其中25例于胃窦部及十二指肠病变部位取黏膜组织行病理检查,40例胃镜证实为食管、胃或十二指肠溃疡的病例,在胃窦部取黏膜进行了幽门螺杆菌检测。结果 16例十二指肠球部溃疡,溃疡深浅不等,底部被覆白苔、黄白苔或血痂。18例腹型过敏性紫癜,胃、十二指肠黏膜多发的出血、糜烂、溃疡,以十二指肠降部病变为著。5例非甾体抗炎药相关性溃疡,均见于胃窦部,溃疡较表浅,其中1例引起胃腔狭窄。1例食管溃疡并非萎缩性胃炎,食管近贲门附近可见两处浅溃疡,被覆少量白苔。门诊病人以胃、十二指肠慢性炎症为多,在胃镜下取异物2例,15例未见异常发现。40例上消化道溃疡幽门螺杆菌检测结果,18例呈阳性反应,主要见于十二指肠球部溃疡。结论超细电子胃镜检查对儿童是安全可行的,对于小儿上消化道疾病的诊断具有重要价值。     

2型糖尿病合并幽门螺旋杆菌感染96例胃镜检查临床分析

目的探讨2型糖尿病患合并幽门螺旋杆菌感染患者胃镜下的胃肠的病变临床特点。方法回顾性分析2013年1月—2017年12月行胃镜检查的2型糖尿病患者213例,根据是否合并幽门螺旋杆菌感染,分为2型糖尿病合并幽门螺旋杆菌组(DM+Hp,96例)及单纯2型糖尿病组(DM,117例)。分析两组患者的胃镜下消化性溃疡、反流性食管炎、十二指肠球炎、慢性胃炎及胃肠息肉检出率情况,并比较两组不同消化性溃疡构成比、溃疡大小、糖化血红蛋白水平及糖尿病病程差别。结果 DM+Hp组消化性溃疡、反流性食管炎、十二指肠球炎、糜烂性胃炎及胃肠息肉检出率高于DM组,差异有统计学意义(P0.05)。两组慢性胃炎总体检出率均为100.00%,慢性浅表性胃炎及慢性萎缩性胃炎检出率两组间差异无统计学意义(P0.05)。DM组胃溃疡检出比例高于DM+Hp组,差异有统计学意义(P0.05),十二指肠溃疡及复合型溃疡两组差异无统计学意义(P0.05);直径1.0 cm消化性溃疡比例DM+Hp组高于DM组(P0.05)。DM+HP组HbA1c高于DM组,但两组在糖尿病病程及合并疾病、口服阿司匹林比例上无差别(P0.05)。结论 2型糖尿病合并幽门螺杆菌感染患者消化性溃疡、反流性食管炎、十二指肠炎及糜烂性胃炎检出率高,且消化性溃疡面积较大。2型糖尿病合并幽门螺旋杆菌患者血糖控制更差。     

循证护理干预对糖尿病合并消化性溃疡患者的影响

目的 分析循证护理干预针对糖尿病合并消化性溃疡患者的护理效果。方法 随机抽取2021年1月—2022年7月于厦门大学附属第一医院接受医疗措施的糖尿病合并消化性溃疡患者60例为研究对象,均分为观察组和对照组;对照组患者采用临床护理路径,观察组患者采用循证护理干预,对比两组患者护理风险发生率,血糖、血脂控制情况以及护理满意度。结果 观察组患者餐后血糖水平和对照组比较,差异无统计学意义(P>0.05),而空腹血糖低于对照组,差异有统计学意义(P<0.05);观察组患者不良反应发生率与对照组比较,差异无统计学意义(P>0.05);观察组患者TC、TG、LDL-C、HDL-C水平与对照组比较,差异无统计学意义(P>0.05);观察组患者的护理满意度较对照组更高,差异有统计学意义(P<0.05)。结论 对糖尿病合并消化性溃疡患者采用循证护理干预可保证护理阶段风险较小、血糖和血脂水平控制良好。     

老年人上消化道出血临床特征及病因分析

目的分析老年人上消化道出血的临床特征、病因及预后。方法回顾性分析2010年10月-2012年10月我院消化科上消化道出血病例246例,分为两组:老年组87例、非老年组159例,对比两组在临床症状、失血严重程度、并存疾病、病因及预后的差异。结果老年组与非老年组呕血或黑便的发生率无明显差异(P>0.05)。老年组收缩压均值高于非老年组,脉搏与休克指数均值低于后者,并存疾病率较后者高,差异有统计学意义(P<0.01)。老年人上消化道出血的前五位病因依次为消化性溃疡(31例,35.6%)、食管胃底静脉曲张(20例,23.0%)、急性胃黏膜病变(17例,19.5%)、胃癌(13例,14.9%)、食管贲门黏膜撕裂综合征(2例,2.3%)。Blatchford评分老年组64例(73.6%)为中高危,与非老年组比较差异无统计学意义(P>0.05)。结论老年组呕血或黑便的发生率与非老年组相近,失血严重程度低于非老年组,并存疾病率高于非老年组。消化性溃疡、食管胃底静脉曲张、急性胃黏膜病变、胃癌、食管贲门黏膜撕裂综合征为老年人前五位的上消化道出血病因。两组预后评估均较差。     

580例健康体检者电子胃镜检查结果分析

目的了解电子胃镜在人体疾病检查中的重要性及对疾病早发现、早治疗的重要意义。方法研究对象选取自我院2015年3月至2016年6月行电子胃镜检查的健康体检者共580例,回顾性分析受检者检查结果。结果 580例健康体检者经电子胃镜检查结果显示有上消化道疾病者共206例,检出率为35.52%,其中慢性萎缩性胃炎(CAG)73例(12.59%),浅表性胃炎61例(10.52%),胃息肉38例(6.55%),胃溃疡15例(2.59%),十二指肠溃疡10例(1.72%),胃癌9例(1.55%)。其中男性萎缩性胃炎(CAG)、浅表性胃炎、胃溃疡、十二指肠溃疡、胃癌三种疾病检出率稍高于女性,但差异均无统计学意义(P0.05),而女性胃息肉检出率显著高于男性,差异具有统计学意义(P0.05)。50~79岁人群CAG、浅表性胃炎、胃息肉、胃溃疡检出率显著高于20~49岁人群(P0.05);50~79岁人群十二指肠溃疡、胃癌检出率高于20~49岁人群,但差异无统计学意义(P0.05);而各年龄段胃癌病理类型比较,差异无统计学意义(P0.05)。胃息肉发病部位从高至低排序为胃底、胃体、胃窦、喷门、胃角;胃溃疡发病部位从高至低排序为胃体、胃角、胃底、胃窦、贲门;胃癌发病部位从高至低排序为胃体、胃底、胃窦、胃角、贲门。结论健康体检者中,CAG、浅表性胃炎、胃溃疡、十二指肠溃疡及胃癌发病率男性略高于女性,而胃息肉好发于女性。≥50岁人群中上消化道疾病检出率明显增加。可见,对健康人群,尤其是年龄≥50岁的上消化道疾病高发人群进行胃镜体检,对上消化道疾病的预防及早期诊断、干预具有重要的临床意义。     

瑞格列奈治疗老年2型糖尿病合并糖尿病肾病的临床研究

目的分析瑞格列奈用于治疗老年2型糖尿病合并糖尿病肾病的临床疗效。方法抽取50例老年2型糖尿病合并糖尿病肾病作为主要对象,其收治时间为2018年7月-2019年7月,根据随机数字表法将其分为两组,其中对照组25例患者采用门冬胰岛素30注射液治疗,观察组25例患者采用瑞格列奈治疗,比较两组患者血糖达标率、低血糖发生率,对比两组患者治疗前后糖化血红蛋白、空腹血糖、餐后2 h血糖。结果治疗后观察组患者血糖达标率明显高于对照组,差异有统计学意义(P<0.05)。住院期间观察组患者低血糖发生率明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者糖化血红蛋白、空腹血糖、餐后2 h血糖较治疗前均明显降低,差异有统计学意义(P<0.05),但组间数据比较差异无统计学意义(P>0.05)。结论瑞格列奈可有效控制老年2型糖尿病合并糖尿病肾病患者血糖,可明显降低低血糖发生率,临床效果较为理想。     

糖尿病性胃病患者胃镜和病理检查及Hp检测分析

目的分析糖尿病性胃病患者胃镜和病理检查及Hp检测结果,为糖尿病性胃病防治提供参考依据。方法随机选择近年来该院门诊收治的伴有慢性上腹部不适症状的糖尿病患者(观察组)和同期收治的具有可比性的非糖尿病患者(对照组)各110例为研究对象,均采用日本富士公司生产的201型电子胃镜进行检查,胃镜检查同时取病变组织行病理检查,应用13C呼气试验检测是否存在Hp感染,比较两组患者相应检查结果之间的差异是否具有统计学意义,分析糖尿病病程与胃十二指肠病变检出率之间的关系。结果观察组胃镜检查胃十二指肠慢性病变、复合性病变、单纯慢性胃炎、单纯胃溃疡、单纯慢性十二指肠炎、单纯十二指肠溃疡,病理检查慢性胃炎的检出率分别为83.64%、20.91%、39.09%、10.91%、9.09%、3.64%和57.27%;对照组分别为69.09%、13.64%、31.82%、9.09%、8.18%、6.36%和38.18%,胃镜胃十二指肠慢性病变和病理检查慢性胃炎总检出率之间的差异有统计学意义(前者χ2=6.45,P0.05;后者χ2=8.03,P0.01),其余项目检出率之间均差异无统计学意义(均P0.05);观察组和对照组Hp感染率分别为84.54%和69.09%,差异有高度统计学意义(χ2=7.38,P0.01);糖尿病病程在5年以下、5~10年和10年以上的胃十二指肠慢性病变检出率分别为69.23%、82.76%和100.00%,差异具有高度统计学意义(χ2=14.75,P0.01),列联系数R=0.34。结论糖尿病患者胃镜胃十二指肠慢性病变和病理检查慢性胃炎总检出率以及Hp感染率高于非糖尿病患者,且糖尿病病程越长,胃十二指肠病变发生率越高。     

糖尿病微血管病变合并高血压患者应用依帕司他治疗的效果分析

目的 探讨糖尿病微血管病变合并高血压患者应用依帕司他治疗的效果。方法 选取2020年5月—2022年5月泉州市台商投资区弘润医院收治的糖尿病微血管病变合并高血压患者60例作为研究对象,根据随机数字表法分成研究组(30例)与对照组(30例),对照组采用常规治疗,研究组采用依帕司他+常规治疗,对两组血糖、血压、血管内皮功能及不良反应进行比较。结果 治疗4周后研究组血糖水平较对照组低,差异有统计学意义(P<0.05);两组血压水平比较差异无统计学意义(P>0.05)。治疗4周后研究组ET、NO较对照组低,eNOS较对照组高,差异有统计学意义(P<0.05)。研究组不良反应发生率(3.33%)较对照组(26.67%)低,差异有统计学意义(P<0.05)。结论 依帕司他应用于糖尿病微血管病变合并高血压患者治疗中,可降低血糖、血压水平,改善血管内皮功能,减少不良反应发生。     

十二指肠球部溃疡伴胃食管反流患者食管动力及胃内pH值监测

目的：探讨胃食管反流(GER)常见于十二指肠球部溃疡的原因。方法：选择近5年我院接受胃食管动力检查并行胃镜检查明确诊断为十二指肠球部溃疡的患者46例。食管pH监测胃食管酸反流阳性或胃镜检查存在反流性食管炎(RE)者为反流组，食管pH值监测胃食管酸反流阴性者为非反流组。比较两组食管下括约肌(IES)、食管体部及食管上括约肌(UES)等功能差别，同时对两组胃pH值监测进行比较。结果：十二指肠球部溃疡患者为GER／RE的高发人群，反流组与非反流组LES长度、功能压、食管体部清除功能、UES静息压比较差异无显著性。反流组每日不同时限胃酸分泌高于非反流组。结论：十二指肠球部溃疡易合并GER／RE与胃酸增高有关，与食管动力变化关系不大。     

泮托拉唑钠粉针剂治疗上消化道出血疗效观察

目的　评价泮托拉唑钠 (诺森 )粉针剂对消化性溃疡所致的上消化道出血的疗效和安全性 ,并与奥美拉唑 (洛赛克 )粉针剂作对照。方法　选择消化性溃疡出血患者 90例 ,泮托拉唑治疗组 60例 ,其中胃溃疡 (GU) 2 4例 ,十二指肠球部溃疡 (DU) 33例 ,糜烂性胃炎 3例。奥美拉唑对照组 30例 ,其中GU 9例 ,DU 1 6例 ,糜烂性胃炎 5例。治疗方法 :分别用泮托拉唑或奥美拉唑 80mg加入 5 %葡萄糖液 2 50ml内 ,静脉滴注 (30～ 60min) ,1次 /d ,共 5d。观察生命体征与出血情况的改变。结果　两组出血情况差异无显著性 (P >0 .0 5)。治疗后 3d内泮托拉唑组有 51例止血 (85 % ) ,奥美拉唑组有 2 4例止血 (80 % ) ;4～ 5d内止血分别为 7例 (1 1 .7% )和 5例 (1 6 .7% )。止血显效率 ,泮托拉唑组为 85 % ,奥美拉唑组为 80 % ,治疗总有效率两组均为 96 .7%。两组各有 1例出现恶心症状 ,不良反应发生率分别为1 .7%和 3 .4%。结论　泮托拉唑钠粉针剂是治疗消化性溃疡出血安全、有效的药物     

食管pH值监测观察酸相关疾病103例

目的 探讨24小时食管pH值监测在诊断上消化道疾病中（尤其胃食管反流病）的临床意义。方法 对2001年4月-2004年5月于我院进行食管pH值监测的103例临床患者，根据有无症状分为两组，无症状组20例为对照组，有症状组83例，其中反流性食管炎（RE）并慢性胃炎的患者30例，占36．1％，然后依次为十二指肠溃疡19例（22．9％）、非糜烂性食管炎13例（15．6％）、单纯反流性食管炎11例（13．3％）及胃溃疡10例（12．0％）。结果 RE并十二指肠溃疡组在各项指标中均高于其他各组（P〈0．05）。结论 RE多合并其他上消化道疾病（尤其酸相关疾病）发生．罹患十二指肠溃疡可能是RE发生和加重的原因之一。     

泮托拉唑四联法不同疗程对胃溃疡合并糖尿病患者的疗效及复发率的影响研究

目的探讨泮托拉唑四联法不同疗程对胃溃疡合并糖尿病患者的疗效及复发率的影响。方法纳入50例2017年5月—2018年5月该院胃溃疡合并糖尿病患者开展研究,所有患者均采用泮托拉唑、克拉霉素、阿莫西林、果胶铋四联法治疗,按随机排列法选出25例列为对照组:1个疗程;剩余25例列为研究组:3个疗程;比较两组对临床疗效及复发率的影响。结果研究组总有效率为92.00%,高于对照组的76.00%,差异有统计学意义(P<0.05);两组治疗结束1个月后Hp阳性率差异无统计学意义(P>0.05),治疗结束1年后研究组Hp阳性率及复发率均低于对照组,差异有统计学意义(P<0.05);两组血糖水平对比,治疗前差异无统计学意义(P>0.05),治疗后,研究组空腹及餐后2 h血糖均低于对照组,差异有统计学意义(P<0.05)。结论在胃溃疡合并糖尿病患者的治疗中,泮托拉唑四联法3个疗程疗效优于1个疗程,可提高临床有效率,降低Hp阳性率及复发率,有效控制患者血糖水平,值得推广。     

Combined Upper and Lower Gastrointestinal Endoscopy: A Prospective Study in Alcoholic and Nonalcoholic Cirrhosis

Upper gastrointestinal hemorrhage is one of the more important complications of cirrhosis. Most of the available data regarding the prevalence of upper and lower gastrointestinal sites of bleeding in cirrhotic patients have been obtained in individuals with alcoholic cirrhosis evaluated in the course of an acute gastrointestinal bleeding episode. Few data exist, however, as to the prevalence of either potential bleeding sites or of normal endoscopic findings in hemodynamically stable individuals with cirrhosis of any etiology. Five hundred ten cirrhotic subjects, who were evaluated for possible liver transplantation (OLTx) between January 1985 and June 1987, were included in this study. Seventy-five had alcoholic cirrhosis and 435 had nonalcoholic cirrhosis of various etiologies. Of these 510 patients, 412 underwent combined upper and lower gastrointestinal endoscopy and 98 underwent upper gastrointestinal endoscopy alone. Gastritis, gastric and duodenal ulcer disease were found significantly (each at least p less than 0.025) more often in patients with alcoholic liver disease than in those with nonalcoholic liver disease. The prevalence of the various lower gastrointestinal lesions in both groups was similar. Of particular interest is the fact that in alcoholic cirrhotics, the prevalence of gastritis, gastric ulcer and duodenal ulcer disease was unrelated to the degree of portal hypertension, whereas in the nonalcoholic cirrhotics the prevalence of gastritis and duodenal ulcer disease but not gastric ulcer disease was associated significantly with the degree of portal hypertension as assessed by the presence or absence of large esophageal varices, ascites, and hepatic encephalopathy.     

消化性溃疡患者血浆内皮素的临床观察

应用特异性放射免疫分析法测定了活动期22例胃溃疡,33例十二指肠球部溃疡患者血浆内皮素水平,结果胃溃疡组为81.2±12.2,球部溃疡组为94.7±28.5,与对照组50.8±7.6比较,均有显著性差异(P<0.001).胃溃疡组与球部溃疡组比较,无明显差异(P<0.05).提示溃疡病患者体内内皮素的合成与分泌增加,内皮素与溃疡病发生有较密切的关系.     

Hpylori infection in patients with Behcet＇s disease

AIM To evaluate endoscopic findings and the prevalence of H pylori in patients with Behcet's disease (BD) who have upper gastrointestinal symptoms.METHODS The patients with BD diagnosed according to the International Study Group and followed up in the Department of Dermatology and other related departments and who had any upper gastrointestinal complaints, were included in this study. Forty-five patients with BD and 40 patients in the control group were evaluated by upper gastrointestinal endoscopy and two biopsied specimens were taken during endoscopy for H pylori. A two-week triple therapy for H pylori eradication was administered to H pylori positive patients. Two months after the treatment, the patients were evaluated by urea-breath test for eradication control.RESULTS Patients with BD had a mean age of 36.2 ± 11.4 years (18-67 years). The mean follow-up time was 35 ± 14 mo (16-84 mo). Aphthous or deep ulcer in esophagus, stomach and duodenum had never been confirmed by endoscopic examination. Most gastric lesions were gastric erosion (40%) and the most duodenal lesions were duodenitis (17.5%) in two groups.H pylori was positive in 33 patients (73.3%) with BD.The two-week triple eradication therapy was successful in 75% of the patients. There was no difference between the groups in respect to prevalence of H pylori(73.3% vs 75%, P ＞ 0.05), and eradication rate (75% vs 70%, P ＞ 0.05).CONCLUSION Endoscopic findings, eradication rate and prevalence of H pylori were similar in patients with BD and control group.     

Fiberoptic Endoscopy of the Gastrointestinal Tract in Infants and Children

Fiberoptic endoscopy of the upper gastrointestinal tract was performed on 53 patients without incident, ranging in age between two months and 18 years, of whom 35 were out patients at the time of examination. Of 27 patients with recurrent abdominal pain and normal upper gastrointestinal series, eight had abnormal findings at endoscopy: a duodenal ulcer in four, a gastric ulcer in two and duodenitis in two. Of 18 patients with hematemesis and/or melena, esophageal varices were demonstrated both by endoscopy and x-ray in two, gastric ulcer by endoscopy in three and x-ray in one, duodenal ulcer by endoscopy in three and by x-ray in two, esophagitis by endoscopy only in one patient, erosive gastritis by endoscopy in five and by x-ray in two and duodenitis by endoscopy in three and by x-ray in two. Of the remaining eight patients with abnormal x-rays findings and other symptomatology, endoscopy demonstrated foreign bodies in two (coins, esophagus and stomach), duodenitis in two, a gastric ulcer in one, a duodenal ulcer in one and normal examination in two. The data indicate that fiberoptic endoscopy significantly improves diagnostic accuracy in the evaluation of disorders of the upper gastrointestinal tract in children and is a safe and effective procedure in ambulatory pediatric patients.     

Does chronic pancreatitis promote duodenal ulcer in men?]

The aims of this study were to assess the prevalence of duodenal ulcer during chronic pancreatitis and the relationship between the occurrence of duodenal ulcer and the course of chronic pancreatitis. The population consisted of 264 men with chronic pancreatitis, 94 percent of which were of alcoholic origin. Duodenal ulcer occurred in 37 patients (14 percent). Fifteen patients with gastric or anastomotic ulcer were excluded. The 37 patients with duodenal ulcer were compared with 212 patients without ulcer. There was no significant difference between the two groups as regards the course of chronic pancreatitis except for insulin-dependent diabetes mellitus which was significantly more frequent in patients without duodenal ulcer (P less than 0.05). Eight patients with duodenal ulcer died but the cause of death was not related to their ulcer. All patients with duodenal ulcer and 92 percent of those without were smokers (not significant). Duodenal ulcer occurred in 25/37 patients (68 percent) before the clinical onset of chronic pancreatitis. The risk of duodenal ulcer occurrence was constant in 17-65 year old patients and independent of the time of chronic pancreatitis onset. We concluded that in men with chronic pancreatitis: a) prevalence of duodenal ulcer is 14 percent; b) duodenal ulcer occurred most often before clinical onset of chronic pancreatitis; c) duodenal ulcer occurs independently of the course of pancreatitis which cannot account for its high prevalence. Smoking may be a promoting factor.     

Distribution of cagG gene in Helicobacter pylori isolates from Chinese patients with different gastroduodenal diseases and its clinical and pathological significance

AIM: To determine the distribution of cagG gene of Helicobacter pylori(Hpylori) isolates cultured from patients with various digestive diseases and its relationship with gastroduodenal diseases.METHODS: cagG was amplified by polymerase chain reaction in 145 H pylori isolates cultured from patients with chronic gastritis (n=72), duodenal ulcer (n=48), gastric ulcer (n=17), or gastric and duodenal ulcer (n=8), and the relationship between cagGstatus and the grade of gastric mucosal inflammation was determined.RESULTS: cagG was present in 91.7% of the 145 H pylori isolates, with the rates were 90.3%, 93.8%, 88.2% and 100.0%, respectively, in those from patients with chronic gastritis, duodenal ulcer, gastric ulcer, and gastric and duodenal ulcer. There was no significant difference among the four groups (P＞0.05). The average grade of gastric mucosal inflammation in the antrum and corpus was 1.819±0.325and 1.768±0.312, respectively in cagG positive patients,whereas the average inflammation grade was 1.649±0.297,1.598±0.278 respectively in cagG negative cases (P＞0.05).CONCLUSION: cagG gene of H pylori was quite conservative,and most H pylori strains in Chinese patients were cagG positive.cagG status was not related to clinical outcome or the degree of gastric mucosal inflammation. Therefore, cagG can notbe used as a single marker for discrimination of H pylori strains with respect to a specific digestive disease.     

成都区域性老年性消化性溃疡内镜特点

目的 根据我院老年性消化性溃疡的检出情况及内镜下特征，探讨老年性消化性溃疡的特点。方法总结我院2004．8—2008．7间经胃镜确诊的4554例消化性溃疡患者，比较老年组和中青年组消化性溃疡的检出率、大小、部位、并发症、Hp阳性率及老年性胃溃疡与溃疡型胃癌的发生部位和大小。结果 老年组和中青年组消化性溃疡的检出率分别为5．98％和4．86％（P〈0．01），且胃溃疡、十二指肠溃疡和复合性溃疡在两组的检出率均有差别（P〈0．01）；两组胃溃疡的发生部位没有差别（P〉0．05），平均溃疡面积分别为1．479±3．737和3．209士7．914（P=0．015）；两组并发症的发生率分别为2．3％和0．89％（P〈0．005），不同类型溃疡的Hp的检出率差异无统计学意义。老年性溃疡型胃癌在胃底的发生率高于胃溃疡（P=0．0005），面积大于胃溃疡（P〈0．005）。结论老年性消化性溃疡的发病随年龄的增加而增加，胃溃疡多好发于胃窦和胃角，并发症发生率高。溃疡性胃癌则好发于胃底，且溃疡的面积大。