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Sirtuins蛋白家族是一类高度保守的组蛋白去乙酰化酶,在哺乳动物中有7个家族成员(Sirt1-7).他们各自在肿瘤中发挥不同的作用,且有越来越多的证据表明,他们与肿瘤的化疗耐药密切相关,可能成为临床抑制甚至逆转肿瘤化疗耐药的靶点.本文就Sirtuin蛋白家族在肿瘤化疗耐药中的作用、靶点、分子机制进行探讨. 相似文献
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近几年Calponin家族在肿瘤的发生发展过程中的作用受到广泛关注,以往的研究着重在作为一种钙调节蛋白参与细胞的收缩作用方面,认为Calponin主要通过研究抑制原肌浆蛋白MgATPase发挥在平滑肌中收缩的作用[1,2],但随着SEREX(Serological identification of antigens by recombinant expression cloning)等技术的发展,发现Calponin家族中H1-Calponin和H2-Calponin在肿瘤的发生发展过程中起到一定的抑制作用,深入了解Calponin家族在肿瘤转移过程中的抑制作用机制有助于更好的理解肿瘤的晚期转移,将肿瘤限制在局部,从而为患者争取手术的机会,对已发生转移的患者可以阻止肿瘤的继续转移,改善患者的预后. 相似文献
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目的:探讨HMGA1与肿瘤细胞的关系。方法:参考国内外相关文献,进行整理综述。结果:HMGA1的高表达可以促进肿瘤细胞的增殖和分化,与众多肿瘤的发生、发展密切相关。结论:通过对HMGA1的研究,为肿瘤的早期诊断和治疗提供一个新的思路和依据。 相似文献
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肿瘤转移是导致肿瘤患者死亡的主要原因,也是肿瘤难以治疗的关键所在。肿瘤转移过程包括肿瘤细胞穿越肿瘤组织的血管内皮细胞从原发部位迁出、肿瘤细胞随血液运行以及肿瘤细胞在转移部位的植入三个主要环节,转移过程涉及多种细胞黏附分子、细胞外基质以及其他血细胞间的相互作用。研究发现血小板能够促进肿瘤转移,血小板数目增多与肿瘤转移具有正相关性,而降低血小板数目或者抑制其功能可以明显抑制肿瘤转移。虽然已证实血小板可参与肿瘤转移,但其具体作用机制目前还不十分明确。近年来的研究结果揭示, 相似文献
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肿瘤细胞对多种化疗药物产生交叉耐药性称为多药耐药(multidrug resistance, MDR),是造成肿瘤耐药化疗失败的主要原因。经过20余年国内外诸多实验室通过诱导耐药细胞株及对动物模型耐药表型的研究,发现多药耐药的发生存在多机制,多环节。针对不同耐药机制,已经发现一系列逆转剂。因此,对MDR机制研究和逆转MDR成为肿瘤治疗亟待解决的问题 相似文献
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摘要干扰素-α(IFN-α)具有广谱的抗病毒、抗肿瘤及免疫调节作用,是临床上治疗病毒性疾病及肿瘤的首选药物,但仍有相当一部分患者未能达到满意的疗效,存在不同程度的耐药现象,严重制约了人类的生活质量。近年来,IFN—α耐药机制及其耐药机制的逆转成为国内外研究的热点之一,研究表明,宿主因素在IFN—α耐药机制中可能发挥了重要的作用,影响着IFN—α的临床疗效。 相似文献
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肿瘤多药耐药(MDR)是目前临床肿瘤化疗失败的主要原因之一.关于肿瘤多药耐药产生的机制有多种,针对这些不同的机制来研发相应的逆转药物则是目前解决临床耐药现象的主要途径.就目前国内外肿瘤多药耐药机制的研究进展作一综述. 相似文献
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钱阳阳 《国际病理科学与临床杂志》2017,37(8)
传统观念认为癌症的进展仅仅是由癌细胞基因和表型变化的多个过程所致.但最近20年的研究显示肿瘤微环境(tumor microenvironment,TME)对于肿瘤行为的影响是同等重要的.TME的组成包括局部的基质细胞,如定植的成纤维细胞(cancer-associated fibroblasts,CAF)和巨噬细胞,远处招募的细胞如内皮细胞、免疫细胞包括髓系和淋巴系细胞、骨髓来源的前体细胞和循环中的血小板.TME能够分泌影响并调控肿瘤表型的分子,如能揭示成瘤细胞与微环境之间的关系,必定能够为肿瘤的发生发展及治疗等一系列难题提供全新的视角. 相似文献
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In recent decades, extensive studies have indicated that IL-17A plays an important role in tumor progression and metastasis, but the underlying mechanisms are not immediately clear. In this review, we examined the literature from the recent years concerning the study of IL-17A in four kinds of tumor transfer paths, including hematogenous metastasis, lymphatic metastasis, local invasion and transcoelomic metastasis, to summarize the roles and underlying mechanisms of IL-17A on tumor metastasis. 相似文献
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R. I. Abdryashitov A. A. Stavrovskaya 《Bulletin of experimental biology and medicine》1989,108(4):1496-1498
Laboratory of Genetics of Tumor Cells, All-Union Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by, Academician of the Academy of Medical Sciences of the USSR N. I. Trapeznikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 108, No. 10, pp. 490–492, October, 1989. 相似文献
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This report describes a 40-year-old man with a remote history of testicular mixed nonseminomatous germ cell tumor (NSGCT) treated by surgery and chemotherapy. He presented 10 years later with shortness of breath and was found to have a mass occupying the right atrium, based high in the superior vena cava. He also had multiple pulmonary emboli. The sarcomatous and myxomatous histological appearance of the neoplasm closely resembled a primary cardiac sarcoma. However, immunohistochemical studies confirmed the diagnosis of metatstatic sarcomatoid germ cell tumor. Metastatic spindle cell tumors have been reported in patients with NSGCTs. These neoplasms are thought to arise from the spindle cell component of the yolk sac tumor that is resistant to chemotherapy. 相似文献
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皮细胞间质转型 (epithelial-mesenchymal transitions,EMT)是具有极性的上皮细胞转换成为具有活动能力的间质细胞并获得侵袭和迁移能力的过程,它存在于人体多个生理和病理过程中。EMT的发生涉及到多个信号转导通路和复杂的分子机制,与钙连接素、生长因子、转录因子、微环境等有关。EMT与肿瘤细胞的侵袭和转移关系密切。 相似文献
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骨骼是除肝脏和肺脏外恶性肿瘤最常见的转移部位.骨转移(bone metastasis)被认为是临床严重的并发症之一.有文献显示超过70%的各类癌症晚期患者会发生骨转移,骨转移会诱发骨痛、病理性骨折、脊髓压迫和高钙血症等,因其导致的死亡率和致残率分别为20%和45%.在保证治疗原发肿瘤的基础上,怎样最大限度的治疗骨转移瘤和诱发最小的副作用是目前医学界研究的热点.靶向给药体系(targeted drug delivery system)包括双磷酸盐类、四环素类、单克隆抗体、聚乙烯亚胺等,它能有效的抑制骨转移,旨在为治疗骨转移提供更有效的策略. 相似文献
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He‐da Zhang Lin‐hong Jiang Shan‐liang Zhong Jian Li Da‐wei Sun Jun‐chen Hou Dan‐dan Wang Si‐ying Zhou Jin‐hai Tang 《Clinical genetics》2021,99(1):84-92
Long non‐coding RNAs (lncRNAs), a class of long RNAs, are longer than 200 nucleotides in length but lack protein‐coding capacity. LncRNAs, as critical genomic regulators, are involved in genomic imprinting regulation, histone modification and gene expression regulation as well as tumor initiation and progression. However, it is also found that lncRNAs are associated with drug resistance in several types of cancer. Drug resistance is an important reason for clinical chemotherapy failure, and the molecular mechanism of tumor resistance is complex, which is a process of multi‐cause, multi‐gene and multi‐signal transduction pathway interaction. Then comprehending the mechanisms of chemoresistance will help find ways to control the tumor progression effectively. Therefore, in this review, we will construct lncRNAs /drug resistance interaction network and shed light on the role of lncRNAs in drug resistance. 相似文献
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Recent studies have identified a family of glycoproteins which moulate cellular transport of antibiotics, alkaloids and drugs used in cancer chemotherapy. By facilitating efflux of drugs from the intracellular domain, these proteins reduce cytotoxicity and thus confer drug resistance. With the availability of antibodies raised against these phenotypic markers of drug resistance, immunohistochemistry and flow cytometry has been used to study their distribution and expression in normal and tumor cells. As some of the drugs used in cancer chemotherapy and other dyes which are substrates for this efflux pump are fluorescent, laser flow cytometry can be used for rapid quantitation of cellular retention, efflux and heterogeneity in drug transport of a tumor cell population. This method can also be used to screen drugs which may block efflux of a chemotherpeutic drug and thus increase chemosensitivity of a drug resistant tumor. In the present report flow cytometric methods for the study of drug transport and its modulation in tumor cells are discussed. 相似文献