完壁式乳突根治-鼓室成形术治疗胆脂瘤型中炎的疗效

目的 探讨完壁式乳突根治-鼓室成形术治疗胆脂瘤型中耳炎的临床疗效.方法 回顾性分析72例胆脂瘤性中耳炎病人的临床资料.结果 72例病人均获得干耳.较术前听力气导提高30 dB的占15.3%,20 dB的占41.7%,10 dB的占16.7%,保持原有听力的占26.4%.胆脂瘤复发率为9.7%.结论 完壁式乳突根治-鼓室成形术对全面清除病灶、重建听力、同时保存耳部正常形态有重要意义.且有利于术后清理及观察乳突腔病变,避免复发,提高干耳率.     

乳突三角函数定位投照法

传统的乳突投照法,因操作复杂,难于掌握。我们根据数学三角函数原理投照乳突劳氏位,许氏位、伦氏位,经实践取得了较满意的效果,现介绍如下, 胶片 13×18cm,滤线器:( ),焦点与胶片的距离:90cm。定位患者俯卧于摄影床台上,将被检侧耳廓向前折叠,前缘与床台面上的中心线     

完壁式乳突根治-鼓室成形术治疗胆脂瘤型中耳炎的疗效

目的探讨完壁式乳突根治-鼓室成形术治疗胆脂瘤型中耳炎的临床疗效。方法回顾性分析72例胆脂瘤性中耳炎病人的临床资料。结果72例病人均获得干耳。较术前听力气导提高30dB的占15.3%,20dB的占41.7%,10dB的占16.7%,保持原有听力的占26.4%。胆脂瘤复发率为9.7%。结论完壁式乳突根治-鼓室成形术对全面清除病灶、重建听力、同时保存耳部正常形态有重要意义。且有利于术后清理及观察乳突腔病变,避免复发,提高干耳率。     

44例中耳胆脂瘤双侧乳突的气化状况分析

目的探讨乳突气化不良与中耳胆脂瘤发病的关系。方法对44例中耳胆脂瘤患者和56名无耳疾体检者都作颞骨CT扫描，观察双侧乳突气化程度。结果全部病耳乳突气化不良，其对侧乳突气化不良占52．3％；对照组乳突气化型占83．9％，气化不良型为16．1％。44例患侧气化都受到抑制，对侧乳突气化亦明显受到影响。结论中耳胆脂瘤群体发生乳突气化不良的机会较多。     

鼻内窥镜下咽鼓管导管注药治疗分泌性中耳炎

目的 :探讨鼻内窥镜下咽鼓管导管注药治疗分泌性中耳炎的方法。方法 :回顾分析鼻内窥镜直视下咽鼓管导管注药治疗分泌性中耳炎 36 0例、4 0 0耳的临床资料。结果 :治愈 2 5 2例 ,占 70 % ;好转 90例 ,占2 5 % ;总有效率 95 %。治疗前听力平均损失 4 5 .4± 8.2dBHL ,治疗后平均为 33.0± 8.2dBHL ,差异有高度显著性 (P <0 .0 1)。鼓室功能曲线治疗前B型 32 0耳 ,C型 80耳 ,治疗后转变为A型 30 3耳 ,占 75 .8%。结论 :此法操作简单 ,在直视下进行 ,患者痛苦小 ,不破坏鼓膜的正常生理结构 ,可改善分泌性中耳炎的咽鼓管功能 ,提高听力     

保留或重建部分外耳道后骨壁的乳突根治鼓室成形术

目的 :探讨乳突根治鼓室成形术中保留或重建部分外耳道后骨壁对提高胆脂瘤型中耳炎术后患者的干耳率及听力水平的意义。方法 :保留部分外耳道后壁 2 4例、2 5耳 ,重建外耳道部分后壁 6例、6耳 ,均行I期鼓室成形术。结果 :术后随访 11个月～ 4年 ,术后干耳并提高听力达实用听力 (2 5dB以上 ) 2 3耳 ,治愈率82 .1%;复发 4耳 ,复发率 12 .9%。结论 :在乳突根治鼓室成形术中保留或重建部分外耳道后骨壁有利于增加中耳含气腔 ,提高听力 ;且有利于术后观察乳突腔病变 ,避免胆脂瘤复发 ,提高干耳率。     

完壁式乳突根治并鼓室成形术治疗中耳炎临床观察

目的探讨完壁式乳突根治并鼓室成形术治疗慢性化脓性中耳炎的临床疗效。方法收治45例49耳慢性中耳乳突炎,行完壁式乳突根治并鼓室成形术,并对手术疗效进行分析。结果49耳在2个月内全部干耳,平均1.5月。纯音听力较术前提高≥30dB的为6耳(12.24%),20-29dB的为18耳(36.73%),10-19dB的为11耳(22.45%),听力无改善14耳(28.57%)。胆脂瘤复发3耳(6.12%)。结论完壁式乳突根治并鼓室成形术在清除中耳病灶和重建听骨链的同时,保留了耳部的正常形态,有效提高了患者的听力。     

浅谈改良乳突切除保留骨桥鼓室成形术治疗中耳乳突炎的体会

目的探讨改良乳突切除保留骨桥同期行鼓室成形术治疗慢性化脓性中耳乳突炎患者的临床疗效。方法对83例(83耳)慢性化脓性中耳乳突炎患者(含胆脂瘤型、骨疡型)施行改良乳突切除保留骨桥同期行鼓室成形术的治疗过程进行回顾性分析及总结。结果 83例患者术后观察1个月-4年,鼓膜修补愈合率为95.18%,听力改善有效率为68.67%,无效率31.32%,3个月内全部干耳。听力恢复较好者为长期反复流脓、听力渐进性下降、中耳乳突不可逆病理改变的慢性单纯型中耳乳突炎患者,治疗有效率为95.65%,其次为骨疡型,有效率为85.71%,胆脂瘤型最差,有效率为34.37%。结论长期反复流脓、听力渐进下降的慢性化脓性中耳乳突炎患者,应早日行改良乳突切除保留骨桥同期行鼓室成形术,可获得早日干耳,听力提高,防止听力丧失。对胆脂瘤型、骨疡型中耳乳突炎患者,在清除病灶的基础上尽可能保留乳突气房及骨桥同期行鼓室成形术,亦可早日干耳、提高听力。     

30例听力正常2型糖尿病患者听性脑干反应的特点

目的 通过研究听力正常的2型糖尿病患者听性脑干反应的结果,探讨听力正常的2型糖尿病患者听力改变的特点.方法 选取30位经确诊为2型糖尿病且纯音测听听闻正常的患者(60耳)作为研究组,另选取30位正常人(60耳)作为对照组,分别对其进行听性脑干反应检查.对比两组Ⅰ,Ⅲ,Ⅴ波潜伏期和波间期数值.结果 研究组和对照组听性脑干反应数据进行比较,经t检验,2型糖尿病组Ⅰ波潜伏期延长有统计学意义.结论 听力正常的2型糖尿病患者在出现听力下降以前内耳可能已出现早期病变.     

完壁式乳突根治术并鼓室成形术治疗中耳炎效果观察

目的探讨完壁式乳突根治并鼓室成形术治疗慢性化脓性中耳炎的手术方法、注意事项及疗效。方法选取2011年5月—2012年2月该院住院的84例（92耳）病人作为治疗组,实施完壁式乳突根治并鼓室成形术。术后观察病人情况,随访6个月-1年。结果术后1年,测患者听力,听力提高30 dB的为14例,占16.7%。提高20 dB的40例占47.6%。提高15 dB的24例占28.6%,术后听力改善率为93.2%（78/84）,听力无改善率7.14%（6/84）。92耳切口均I期愈合,干耳时间为1-3个月。干耳时间平均8周。继发性感染2例,复发1例,并发症及复发率为3.6%。结论完璧式乳突根治术并鼓室成形术符合清除病灶并保存听力的耳外科原则。对于慢性中耳乳突炎具有良好的治疗效果,可以有效保留原中耳乳突解剖结构和改善听力,提高患者生活质量,应予优先选择。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.