共查询到20条相似文献,搜索用时 15 毫秒
1.
N. A. Agadzhanyan L. V. Sorokin E. P. Tambovtsev V. I. Torshin 《Bulletin of experimental biology and medicine》1995,120(3):878-881
It is shown that the geometric mean of survival time and the deviation of σ from τ are measures of a population's resistance
to acute hypoxia; that a measure of the individual resistance of an animal to such hypoxia is Student's parameter for that
animal; that the distribution of Student's parameter in a population is a lognormal distribution under any conditions; and
that the number of animals with low resistance is always equal to the number of highly resistant animals. The procedure described
makes it possible to limit the number of animals used in an experiment by recording with the requisite accuracy the proposed
measures of resistance to acute hypoxia at the population and individual levels.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 239–241, September, 1995 相似文献
2.
N. A. Agadzhanyan M. L. Khachatur'yan L. A. Panchenko 《Bulletin of experimental biology and medicine》1999,127(6):567-570
The resistance of rats to hypoxia was measured by survival time after exposure to high-altitude (11.5 km) hypoxia. The first
exposure to acute hypoxia caused phasic changes in the survival time: short-term in high-resistant rats (about 24 h) and long-term
in moderate- and lowresistant rats (38–39 days) starting from 1 h and 6–7 days after the first exposure, respectively. Adaptive
reactions were more pronounced in low- and moderate-resistant rats, while disadaptation was typical of high-resistant animals.
In all rats, the adaptive effect dominated until days 22–23. Throughout the testing, the initial type of resistance was retained
in 79% of high-resistant rats, in 41% of low-resistant and in 33% of moderate-resistant rats, i. e., the initially homogenous
groups formed after the first exposure in accordance with the type of resistance became mixed, which reduced the intergroup
differences.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 6, pp. 625–628, June, 1999 相似文献
3.
4.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(1):22-25
Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high
and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are
found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products
is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance
to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming
that oxidation plays a major role in the damaging and lethal effects of acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp 26–29, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
5.
6.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(2):126-131
The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver,
and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of
11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest
in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation
is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in
the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it
is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant
system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 138–143, February, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
7.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1995,120(1):733-736
Lipid peroxidation and the antioxidant system of the myocardium of adult male Wistar rats with low and high resistance to
acute hypoxia tested by “raising” to an altitude of 11.5 km are studied in winter and in summer. It is found that the winter
season is a mild stressor inducing changes in the myocardial antioxidant system and lipid peroxidation which are similar to
those observed at the early stages of catecholamine stress in the summer season. In both cases alterations are more pronounced
in low-resistance than in high-resistance rats. In winter, in low-resistance rats the intensity of lipid peroxidation and
the activity of the antioxidant system are lower, while the ratio of their parameters (chemiluminescence data) is higher.
At the same time, the levels of thiobarbituric acid-reactive substances are higher in winter in both groups. The relationship
between the studied parameters and the resistance of rats to hypoxia is more obvious in winter than in summer, i.e., it is
season-dependent and is also more pronounced in catecholamine stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nolo 7, pp. 87–90, July, 1995
Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences 相似文献
8.
N. V. Sanotskaya D. D. Matsievskii I. A. Tarakanov 《Bulletin of experimental biology and medicine》1999,128(3):906-909
We studied the effects of acute hypoxia on hemodynamics and respiration in cats. The animals were divided into high-, low-
and medium-resistant to hypoxia by the time of respiratory arrest after breathing with 3% O2 gas mixture. In high-resistant animals, hemodynamic indices remained at a high level throughout the hypoxic episode, while
in low-resistant cats they decreased shortly after the onset of hypoxia. It is suggested that the peculiarities of hemodynamic
regulation play an important role in individual resistance to acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 286–290, September, 1999 相似文献
9.
N. A. Bondarenko E. L. Germanova L. D. Luk'yanova 《Bulletin of experimental biology and medicine》2000,130(3):849-851
Locomotor activity in the open field test did not correlate with rat resistance to acute hypobaric hypoxia; there was a correlation
between this resistance and rat behavior during acute stress. Immobility was characteristic of rats with low and particularly
medium resistance to hypoxia; this reaction can be abolished by antidepressants. By contrast, highly resistant rats were mainly
hyperactive. The resistance to hypoxia was associated with extreme parameters of dopaminergic neuron functioning. In low-resistant
rats locomotor stereotypia was maximal, while perioral stereotypia was the minimal; highly resistant rats were characterized
by an opposite pattern, and medium-resistant rats occupied an intermediate position.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 275–278, September, 2000 相似文献
10.
11.
Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation
P. F. Zabrodskii 《Bulletin of experimental biology and medicine》1995,120(2):809-811
Cholinergic stimulation (acetylcholine, aceclidine, armin) is found to improve antiinfectious nonspecific resistance in mice.
The effect depends on the dose of cholinomimetic (armin), is maximal during the first 18 hours of the infectious process,
and is determined by serum antibacterial activity, lysozyme activity, and the function of neutrophils and natural killers.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
. 8, pp. 164–166, August, 1995
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
12.
A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,120(6):1193-1195
After a prolonged (for 30 days) adaptation of rats to intermittent hypoxia, their brains contained lowered levels of mitochondrial
cytochromes, despite an increase in the number of mitochondria in the brain tissue mass, along with similar levels of high-energy
compounds and more protein as compaired to the brains of unadapted controls. A mitochondrial population with novel properties
presumably emerged in the brain. These effects were all more strongly marked in rats with an initially low resistance to hypoxia.
In the liver of hypoxiaadapted animals, unlike in their brain, cytochrome levels in the mitochondrial and microsomal redox
chains were lowered and the biogenesis of mitochondria was much less intensive.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 576–579, December, 1995 相似文献
13.
O. R. Grek Yu. P. Gichev E. O. Guseva V. I. Sharapov 《Bulletin of experimental biology and medicine》1998,126(6):1203-1204
Hepatic monooxygenase activity was studied in rats with various resistance to hypoxia during adaptation to cold. Cold-induced
change in the concentrations of cytochromes P-450 and b5 and the activity of microsomals metabolism of amidopyrine and aniline were shown to be associated with individual resistance
to hypoxia. The content of microsomal cytochromes in highly resistant rats did not change on the fifth day of cold exposure.
However, the intensity of metabolic reactions decreased. In low-resistance rats, a cold-induced decrease in the concentration
of the cytochromes was not accompanied by significant changes in metabolic rates of amidopyrine and aniline.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 631–633, December, 1998 相似文献
14.
Yu. P. Gichev E. O. Guseva O. P. Grek V. I. Sharapov 《Bulletin of experimental biology and medicine》1998,126(5):1098-1099
It is shown that the parameters of antipyrine pharmacokinetics during cold exposure depend on individual resistance to hypoxia.
High-resistant rats are characterized by less intense metabolism and more rapid normalization of pharmacokinetic parameters
than lowresistant rats characterized by shortened elimination half-time corresponding to a more rapid metabolism of xenobiotics
under conditions of cold stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 513–515, November, 1998 相似文献
15.
A study of kinetic parameters of brain respiratory enzymes revealed that the maximal velocity and the Michaelis apparent constant
for NADH-cytochrome C-reductase are significantly lower in low-resistant rats than in rats with a high resistance to hypoxia.
Adaptation to periodic hypoxia increases total resistance only in low-resistant rats. It is accompanied by an increase in
the values of kinetics parameters for NADH-cytochrome C-reductase and cytochrome oxidase. Kinetic parameters for these enzymes
in the brain of high-resistant rats are either unaltered or even decreased. It is suggested that the first enzymatic complex
of the respiratory chain is one of the limiting or regulating links in energy metabolism determining the brain's resistance
to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 252–255, March, 1996. 相似文献
16.
A. A. Korneev I. A. Komissarova Ya. R. Nartsissov 《Bulletin of experimental biology and medicine》1993,116(3):1089-1092
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N
o
9, pp. 261–263, September, 1993 相似文献
17.
18.
M. L. Khachatur'yan L. A. Panchenko E. N. Zanina S. M. Perevertkin N. A. Agadzhanyan 《Bulletin of experimental biology and medicine》1999,127(3):231-235
The resistance to acute hypoxia in male Wistar rats was evaluated by the period of survival after exposure to high-altitude
hypoxia (11.5 km above see level). The study was performed during daytime (13.00–21.00) in autumn. The fatal rat population
was characterized by the log-normal distribution of survival periods. The rats with low and moderate resistance to hypoxia
exhibited similar diurnal variations in it with gradual decrease by the end of daytime more pronounced in low-resistant rats.
The rats with high resistance showed relatively constant resistance to hypoxia which decreased only at 21:00. All groups revealed
a relatively stable resistance to hypoxia from 16:00 to 18:00. These variations in the resistance to hypoxia should be taken
into consideration when planning experimental research.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 256–260, March 1999 相似文献
19.
Rats with low resistance to acute altitude hypoxia did not differ from those with high resistance in the erythron parameters
recorded under normal environmental conditions. After a bilateral carotid glomectomy, significant falls in the red blood cell
count, hemoglobin concentration, packed cell volume, and mean corpuscular hemoglobin were recorded only in the group with
low resistance to acute hypoxia, although the “altitude” resistance was decreased to similar degrees in the two groups.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 12–13, July, 1996 相似文献
20.
L. D. Luk'yanova A. M. Dudchenko V. V. Belousova 《Bulletin of experimental biology and medicine》1994,118(6):1268-1272
It is shown that isolated hepatocytes are capable of perceiving slight changes in the envioronmental oxygen concentration.
A complicated phase dependence exists between adenosine triphosphate and partial oxygen pressure, which differs in cells from
animals with high and low resistance to hypoxia, the former showing a more stable and resistant energy-synthesizing function
than the latter. After long-term adaptation to periodic hypoxia, the resistance of the energy-synthesizing function rises
in hepatocytes from high-resistant animals, and falls in low-resistant animals suggesting a fundamentally different organization
of the emergency compensatory mechanisms of the energy-synthesizing function in hepatocytes of animals of these two types.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 576–581, December, 1994 相似文献