徒手淋巴引流技术对大鼠下肢创伤肿胀后TNF-α影响的研究

目的探讨徒手淋巴引流技术(MLDT)对下肢软组织创伤所致肿胀和肿瘤坏死因子-α(TNF-α)表达的影响。方法将56只Wistar大鼠随机分为组正常组(D)、模型组(M1、M3、M7)、治疗组(T1、T3、T7),每组8只。D组不做任何干预,M组和T组造成软组织创伤模型,T组运用MLDT作用于水肿组织,增加淋巴管与淋巴结的重吸收功能。分别于治疗后第1、3和7天采用容积法测量足爪肿胀程度,观察治疗前后差值变化;ELSIA法检测干预后大鼠血清TNF-α表达变化。结果 M组和T组各时点的下肢体积及血清TNF-α含量与D组比较均有统计学差异(P<0.05);M组与T组在第3和7天的体积和TNF-α含量比较均有统计学差异(P<0.05),但两组在第1天治疗后TNF-α含量无统计学差异(P>0.05),而体积有统计学差异(P<0.05)。结论 (1)MLDT能明显提高肢体软组织创伤后消肿的速度;(2)在血清TNF-α含量于创伤24h达到高峰后,MLDT的干预能明显促进TNF-α的表达恢复正常水平。     

徒手淋巴引流对全膝关节置换术后康复疗效的Meta分析

目的：探讨徒手淋巴引流（MLD）对全膝关节置换术（TKA）后疼痛、肿胀和关节活动功能障碍的治疗效果。方法：检索PubMed、Embase、Web of science、Cochrane Library、Scopus、CNKI、万方数据、VIP、CBM等数据库,筛选出建库至2021年12月发表的关于MLD对TKA术后的随机对照实验（RCT）。由 2 位评审员对纳入研究进行风险质量评估,使用Review manager 5.3进行统计分析。结果：最终纳入7项RCT,共396名患者。结果显示,MLD在改善疼痛［WMD=-0.36,95%CI：-0.58～-0.13,P=0.002］和大腿周径［WMD=-1.25,95%CI：-1.99～-0.50,P=0.001］上差异具有统计学意义（P<0.05）;但在改善膝关节周径 ［WMD=-0.24, 95%CI:-1.30~ 0.83, P=0.66］、小腿周径［WMD=-0.22, 95%CI: -0.86 ~ 0.42, P=0.51］和膝关节被动屈曲关节活动度（PROM）［WMD=1.96, 95%CI:-1.31~ 5.24, P=0.24］上差异无统计学意义。结论：MLD在降低TKA术后的疼痛和大腿肿胀上较常规治疗更有优势,在膝关节肿胀、小腿肿胀以及膝关节屈曲活动度方面则可能存在辅助治疗作用,但仍需更多高质量、大样本RCT来验证。     

负压淋巴回流促进系统和徒手淋巴引流治疗乳腺癌术后上肢淋巴水肿的疗效比较

目的比较负压淋巴回流促进系统(PhysioTouch)与徒手淋巴引流技术对乳腺癌术后上肢淋巴水肿的临床疗效。方法选取符合纳入标准的乳腺癌术后上肢淋巴水肿患者60例,按随机数字表法分为对照组和观察组,每组30例。对照组患者采用徒手淋巴引流治疗(1 h/次,1次/d,5 d/周),观察组患者采用PhysioTouch治疗(20 min/次,1次/d,5 d/周),治疗后2组患者均行低弹力绷带加压治疗、上肢功能训练及皮肤护理,共治疗4周。分别于治疗前和治疗4周后(治疗后),采用上臂臂围测量法评估2组患者的上臂淋巴水肿程度和临床疗效,并采用上肢功能指数(UEFI)、肩关节功能Constant-Murley评分、欧洲癌症研究与治疗组织乳腺癌生活质量调查问卷(EORTC QLQ-BR23)评分对2组患者的上肢功能、肩关节功能及患者生存质量进行评估和比较。结果结果:①治疗后,对照组和观察组患者上臂淋巴水肿程度治疗总有效率分别为70.00%和93.33%,观察组优于对照组(P<0.05)。②治疗后,对照组和观察组患者的UEFI评分分别为(54.87±7.29)和(62.64±8.95)分,明显高于组内治疗前[(18.32±2.29)和(19.06±2.35)分],差异均有统计学意义(P<0.05),且治疗后观察组的UEFI评分明显高于对照组(P<0.05)。③治疗后,2组患者肩关节功能Constant-Murley评分[对照组(89.13±9.62)分,观察组(96.23±11.09)分]均明显高于组内治疗前[对照组(78.13±9.15)分,观察组(79.03±8.26)分],差异有统计学意义(P<0.05);且治疗后观察组的Constant-Murley评分明显高于对照组(P<0.05)。④治疗后,2组患者的生存质量评分[对照组的EORTC QLQ-BR23评分(43.69±5.16)分,观察组(39.51±4.29)分]明显优于组内治疗前[对照组(56.29±5.23)分,观察组(57.72±5.65)分],治疗前后差异有统计学意义(P<0.05),且治疗后观察组明显优于对照组(P<0.05)。结论PhysioTouch与徒手淋巴引流技术结合综合康复治疗均可改善乳腺癌术后上肢淋巴水肿患者的水肿,PhysioTouch在治疗时间、临床疗效、提高患者上肢运动功能和生活质量方面均具有明显优势。     

徒手淋巴引流在乳腺癌术后淋巴水肿中应用效果的Meta分析

目的:评价徒手淋巴引流在乳腺癌患者术后淋巴水肿中的应用效果。方法:计算机检索Cochrane Library、PubMed、Web of Science、EMBASE、中国生物医学文献数据库、中国知网、万方和维普等国内外数据库中有关徒手淋巴引流应用于乳腺癌患者术后淋巴水肿的随机对照试验。经筛选文献,提取资料与评价文献质量后,采用RevMan 5.3软件进行Meta分析。结果:最终纳入11篇随机对照试验,共2524例患者。Meta分析结果显示,徒手淋巴引流可有效预防乳腺癌患者在术后12个月、6个月、3个月发生淋巴水肿[RR=0.35,95%CI(0.17,0.74),P<0.01;RR=0.45,95%CI(0.30,0.68),P<0.01;RR=0.24,95%CI(0.12,0.48),P<0.01],可有效减少乳腺癌患者术后淋巴水肿体积[WMD=-52.35,95%CI(-70.51,-34.19),P<0.01],可有效降低患者术后发生腋窝综合征的风险[RR=0.17,95%CI(0.09,0.34),P<0.01]。结论:徒手淋巴引流能有效预防和治疗乳腺癌患者术后淋巴水肿,以及有效预防腋窝综合征的发生,建议临床推广应用。     

穴位按摩结合自我淋巴引流预防乳腺癌术后上肢淋巴水肿的临床研究

目的 探索穴位按摩结合自我淋巴引流技术预防乳腺癌术后上肢淋巴水肿的临床效果。方法 选取2017年4月至2018年5月在江苏省肿瘤医院乳腺外科行乳腺癌手术的患者68例，按时间段进行分组，36例患者进行自我淋巴引流，32例患者在自我淋巴引流的基础上，配合大陵、内关、外关、尺泽、曲泽等穴位按摩。采用手臂周径测量法评估两组患者术后6个月、12个月、18个月患侧肢体肿胀症状、淋巴水肿是否发生以及发生程度。结果 自我淋巴引流组有6例（16.7%）患者发生轻度水肿，穴位按摩结合自我引流组仅1例（3.1%）患者发生轻度水肿，发生时间在术后6～12个月不等，两组淋巴水肿的发生率差异有统计学意义（P＜0.05）。结论 穴位按摩结合自我淋巴引流技术预防乳腺癌术后上肢淋巴水肿的效果优于单纯实施自我淋巴引流。     

徒手淋巴引流联合功能锻炼在乳腺癌患者术后的应用

总结了个性化徒手淋巴引流手法联合功能锻炼在乳腺癌同步甲状腺癌术后的护理,主要包括功能锻炼及个性化徒手淋巴引流,由乳腺科专科护士在术前一天,麻醉复苏后及术后1d、2d、3d及出院当天指导患者及家属功能锻炼,每次10～15 min,功能锻炼包括手术体位及呼吸功能训练、踝泵运动及术后下床活动、患侧上肢功能锻炼.个性化徒手淋巴引流由淋巴水肿治疗师进行操作,麻醉复苏后即可进行,频次为每天早、中、晚1次,每次10 min.包括开通淋巴通路和淋巴引流两步.患者经功能锻炼及个性化徒手淋巴引流护理后,6例患者伤口肿胀经治疗后3～5d改善,3例患者出现皮瓣发红或及紧绷感明显,治疗后3～5d红肿消退,紧绷感消失,2例患者出现术后患肢急性肿胀,治疗后4～5d消退,4例患者出现伤口疼痛,评分3～6分,治疗1～3d后缓解,评分0分,所有患者出院前顺利拔除引流管.认为对乳腺癌同步甲状腺癌患者使用个性化徒手淋巴引流手法联合功能锻炼,可以有效减轻伤口肿胀、利于伤口愈合和术后皮瓣的恢复,利于改善患者疼痛,利于改善术后患肢急性肿胀和患肢酸痛,促进患者功能的恢复,预防淋巴水肿,促进康复效果.     

徒手淋巴引流结合肌内效贴治疗脑卒中后肩手综合征Ⅰ期的短期疗效观察

目的:观察徒手淋巴引流结合肌肉效贴治疗脑卒中后肩手综合征Ⅰ期的短期疗效。方法:将40例脑卒中后肩手综合征患者随机分为对照组和研究组各20例。对照组接受常规康复治疗,包括正确的体位摆放、气压治疗、冷热水治疗、主动和被动运动及神经发育疗法,研究组在常规康复治疗基础上实行徒手淋巴引流结合肌内效贴治疗,2组均进行4周治疗。治疗前后分别用排水法、视觉模拟评分(VAS)、肩关节功能评价量表、Fugl-Meyer量表(FMA)、巴氏指数(BI)评估患者的水肿及疼痛程度、肩关节功能、上肢运动功能和日常生活活动能力,对采集到的数据进行组间及组内比较。结果:治疗4周后,2组患者水肿及疼痛程度、肩关节功能、上肢运动功能和日常生活活动能力均较治疗前改善(均P0.05),且研究组优于对照组(P0.05)。结论:徒手淋巴引流结合肌内效贴在短期内能进一步改善肩手综合征Ⅰ期患者的水肿及疼痛程度,提高肩关节功能、上肢运动功能以及日常生活活动能力。     

手法淋巴引流结合气压治疗对乳腺癌术后上肢淋巴水肿的预防效果

目的 分析手法淋巴引流结合气压治疗对乳腺癌术后上肢淋巴水肿的预防效果。方法 选取2020年4月-2021年12月我院收治的80例乳腺癌手术患者作为研究对象,采用随机数字表法分为对照组和观察组,每组40例。对照组采用常规护理干预,观察组在对照组的基础上采用手法淋巴引流结合气压治疗干预。比较两组上肢淋巴水肿发生率、水肿程度以及护理干预前后自我效能感水平。结果 观察组术后1、4周上肢淋巴水肿发生率明显低于对照组,术后4周水肿程度轻于对照组(P<0.05);观察组术后4周肩关节功能评分明显高于对照组(P<0.05);观察组术后4周一般自我效能感总分明显高于对照组(P<0.05)。结论 在常规护理的基础上应用手法淋巴引流结合气压治疗,不仅可降低乳腺癌术后上肢淋巴水肿发生率,减轻水肿程度,还可提高患者肩关节功能以及自我效能感水平。     

足部按摩结合穴位按揉对胃肠道术后肠蠕动影响的研究

目的 观察足部按摩结合穴位按揉对胃肠道手术患者肠蠕动恢复的影响.方法 将127例胃肠道术后患者根据手术日单、双号分成两组,观察组除了术后常规护理外给予足部按摩 穴位按揉;对照组给予术后常规护理外指导患者早期活动.比较两组腹胀发生、肠蠕动恢复及肛门排气情况,并作统计学处理.结果 观察组腹胀发生率低、肠蠕动恢复及肛门排气出现早,与对照组比较,统计有高度显著性差异.结论 足部按摩结合穴位按揉能更有效地促进胃肠道术后肠蠕动恢复.     

手法淋巴引流综合疗法对下肢2期淋巴水肿患者的疗效

目的:探讨手法淋巴引流综合疗法对下肢2期淋巴水肿患者的疗效。方法:将70例下肢2期淋巴水肿的患者随机均分为治疗组和对照组各35例,治疗组接受手法淋巴引流综合疗法,对照组接受常规传统压力疗法,治疗1个疗程后采用多频生物电阻人体成分分析仪检测组织水肿,疼痛视觉模拟评分量表评判治疗后疼痛情况,测量肢体周径大小,睡眠状况和下肢运动功能状况来评估最终疗效。结果:治疗1个疗程后,2组患者患侧肢体组织水肿程度显著降低(P0.05),患侧下肢疼痛显著减轻(P0.05),患肢周径的显著缩小(P0.05);睡眠状况和下肢运动功能状况明显好转(P0.05),而且治疗组较对照组效果更明显(P0.05)。结论:下肢2期淋巴水肿患者可以通过手法淋巴引流综合疗法有效地促进滞留组织淋巴水肿的回流,并显著地减轻肢体的肿胀和疼痛,改善睡眠和下肢运动功能,是目前一种非常有效值得推广的治疗手段。     

Manual lymphatic drainage versus exercise in the early postoperative period for breast cancer

Abstract

Objective: To compare the effect of active exercise and manual lymphatic drainage (MLD) on postoperative wound healing complications, shoulder range of motion (ROM) and upper limb (UL) perimetry in women undergoing radical mastectomy for breast cancer. Methods: Controlled non-randomized clinical trial with 89 women undergoing breast cancer surgery with axillary lymph node dissection (Brazilian Registry of Clinical Trials: 906). Women were matched for staging, age and body mass index, with 46 women allocated to the exercise group and 43 in the MLD group, receiving 2 weekly sessions during one month. Assessments were performed in the preoperative and 60?d after surgery, including inspection, palpation, goniometry and perimetry. Results: No significant difference existed between groups relative to individual and clinical surgical characteristics. The incidence of seroma, number of punctures performed, dehiscence and infection was similar in both groups. A comparison of shoulder ROM and UL perimetry between groups, obtained in the preoperative and postoperative period, did not show any significant difference. Conclusion: The performance of active exercise or MLD did not demonstrate difference in wound healing complications, shoulder ROM and UL perimetry at 60?d after surgery, suggesting that these techniques may be employed, according to the complaints or symptoms of each woman and physical therapist experience.     

Manual lymphatic drainage and multilayer compression therapy for vulvar edema: a case series

Abstract

Background and objective: Vulvar edema is a condition rarely reported and without defined treatment that may result in functional limitation. The aim of the report is to describe a case series of patients with disabling vulvar edema of different etiologies that were treated with manual lymphatic drainage (MLD) and multilayer compression therapy (MCT). Case series: Four cases of vulvar edema are described: one in a woman with cervical cancer; one in a woman in the postoperative period of bilateral adrenalectomy for pheocromocytoma; and two in pregnant women with preeclampsia. All cases were treated with MLD and MCT during hospitalization. Outcomes: Total resolution of the edema occurred in 2 to 5 d of treatment. Conclusion: The present case series is the first to report the use of the MLD and MCT in the successful management of female genital edema. This report suggests that the vulvar edemas for these four patients treated with MLD and MCT seem to resolve faster than expected based on previously reported untreated edemas or edemas treated with different therapeutic approaches.     

Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging

Tan I-C, Maus EA, Rasmussen LC, Marshall MV, Adams KE, Fife CE, Smith LA, Chan W, Sevick-Muraca EM. Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging.

Objective

To investigate the feasibility of assessing the efficacy of manual lymphatic drainage (MLD), a method for lymphedema (LE) management, by using near-infrared (NIR) fluorescence imaging.

Design

Exploratory pilot study.

Setting

Primary care unit.

Participants

Subjects (N=10; age, 18–68y) with a diagnosis of grade I or II LE and 12 healthy control subjects (age, 22–59y).

Intervention

Indocyanine green (25 μg in 0.1 mL each) was injected intradermally in bilateral arms or legs of subjects. Diffused excitation light illuminated the limbs, and NIR fluorescence images were collected by using custom-built imaging systems. Subjects received MLD therapy, and imaging was performed pre- and posttherapy.

Main Outcome Measures

Apparent lymph velocities and periods between lymphatic propulsion events were computed from fluorescence images. Data collected pre- and post-MLD were compared and evaluated for differences.

Results

By comparing pre-MLD lymphatic contractile function against post-MLD lymphatic function, results showed that average apparent lymph velocity increased in both the symptomatic (+23%) and asymptomatic (+25%) limbs of subjects with LE and control limbs (+28%) of healthy subjects. The average lymphatic propulsion period decreased in symptomatic (−9%) and asymptomatic (−20%) limbs of subjects with LE, as well as in control limbs (−23%).

Conclusions

We showed that NIR fluorescence imaging could be used to quantify immediate improvement of lymphatic contractile function after MLD.     

早期应用淋巴引流结合持续被动活动对膝关节周围骨折术后康复的影响

目的:探讨早期应用淋巴引流手法结合持续被动活动(CPM)对膝关节周围骨折术后膝关节功能康复的临床疗效。方法:41例膝关节周围骨折术后患者随机分为观察组21例和对照组20例,对照组予常规康复治疗(包括关节松动、肌力训练、冰敷等),观察组在常规康复治疗的基础上应用淋巴引流手法及CPM治疗。治疗前及治疗4周后测量患肢膝关节周径评定水肿情况,采用关节活动度及lysholm膝关节功能评分(LKSS)评定膝关节功能。结果:治疗4周后,2组膝关节周径较治疗前均降低(均P0.01),其中观察组降低更明显(P0.01);2组ROM、LKSS评分较治疗前均提高(均P0.01),其中观察组提高更明显(P0.01)。结论:膝关节周围骨折术后早期应用淋巴引流手法结合CPM能减轻膝关节肿胀、改善膝关节活动度及膝关节功能。     

经阴道低负压引流器预防宫颈癌根治术后盆腔淋巴囊肿形成的研究

目的 研究经阴道低负压引流器预防宫颈癌根治术后盆腔淋巴囊肿形成.方法 将 87例术后阴道引流管直接接引流袋和166例术后阴道引流管接低负压引流器,两组患者术后其他治疗相同.观察两组患者的引流量、淋巴囊肿发生率.结果 患者阴道引流管接低负压引流器较直接接引流袋的日平均引流量多 (121.28 ml/97.50 ml,P<0.01)、淋巴囊肿发生率明显降低 (8.74%/12.64%,P<0.05).结论 经阴道低负压引流对宫颈癌根治术后盆腔淋巴囊肿的形成具有预防价值.