Treatment for heart failure: good news and bad

Heart failure is a common disorder associated with significant morbidity, mortality and financial burden to health services. The pharmacotherapy of heart failure, including new treatments, will be discussed.     

心脏不好闻闻“草”

"马上就到伏天了,每年一到这个时候我的胸口总是闷得慌,晚上也睡不好。""最近温差小,气压低,我的心脏又有些不舒服了。"这是在广东省中医院的急诊门诊中,有心脏不适的患者提出最多的困惑。     

Recessions are bad for workplace safety

Workplace accidents are an important economic phenomenon. Yet, the pro-cyclical fluctuations in workplace accidents are not well understood. They could be related to fluctuations in effort and working hours, but workplace accidents may also be affected by reporting behavior. Our paper uses unique data on workplace accidents from an Austrian matched worker-firm dataset to study in detail how economic incentives affect workplace accidents. We find that workers who reported an accident in a particular period of time are more likely to be fired later on. And, we find support for the idea that recessions influence the reporting of moderate workplace accidents: if workers think the probability of dismissals at the firm level is high, they are less likely to report a moderate workplace accident.     

Xenobiotic considerations for the development of autoimmune liver diseases: bad genes and bad luck.

The etiologic origins of autoimmune disease remain an enigma. Although considerable information on the mechanisms of immunopathology has been acquired, in part from murine models, such mechanisms have yet to be substantiated in human autoimmune disease. This absence of validation is especially true for organ-specific diseases like those affecting the liver. In this review we focus on the putative role of xenobiotics as inducing agents for autoimmune liver pathology. In particular, we discuss the autoantibody immune response, the humoral hallmark of autoimmune disease, as well as cellular immune responses. We believe that exposure to environmental factors, namely xenobiotics, is the initiating straw that breaks the camel's back, leading to the loss of tolerance to self proteins in genetically susceptible hosts. The end result is a perpetuating process that is determined by the governing features of the genetics of the host and by exposure to the inciting environmental agent. Interestingly, the liver, an organ that plays a major role in immune tolerance, can itself become the target of autoreactivity and immune destruction.     

宝宝睡眠不好的相关疾病

与睡眠相关的疾病和问题 1.佝偻病 佝偻病多见于3个月～2岁的小儿,表现为正处于生长中的骨骼的病变,主要分四期: (1)初期:多见于6个月以内,特别是小于3个月的婴儿,主要表现为神经兴奋性增高,如易激惹、烦恼、夜间啼哭、睡眠不安.