The role of anticipated regret and health beliefs in HPV vaccination intentions among young adults

Although cognitions have predicted young adults’ human papillomavirus (HPV) vaccine decision-making, emotion-based theories of healthcare decision-making suggest that anticipatory emotions may be more predictive. This study examined whether anticipated regret was associated with young adults’ intentions to receive the HPV vaccine above and beyond the effects of commonly studied cognitions. Unvaccinated undergraduates (N = 233) completed a survey assessing Health Belief Model (HBM) variables (i.e., perceived severity of HPV-related diseases, perceived risk of developing these diseases, and perceived benefits of HPV vaccination), anticipatory emotions (i.e., anticipated regret if one were unvaccinated and later developed genital warts or HPV-related cancer), and HPV vaccine intentions. Anticipated regret was associated with HPV vaccine intentions above and beyond the effects of HBM variables among men. Among women, neither anticipated regret nor HBM variables showed consistent associations with HPV vaccine intentions. Findings suggest that anticipatory emotions should be considered when designing interventions to increase HPV vaccination among college men.     

Changing adolescents' sexual behaviour: perceived risk,self-efficacy and anticipated regret

This article focuses on determinants of adolescent AIDS-related behaviour. First, we will focus on the perception of risk for AIDS and possible optimistic biases in perceived risk. The behavioural consequences of optimism or perceived invulnerability will be briefly discussed. Next, we will focus on other determinants of sexual risk behaviour, i.e. self-efficacy and anticipated regret. Gender differences in the predictive power of these factors will be discussed. Finally, we will summarize the results of a series of studies investigating the role of anticipated regret as a determinant of adolescent sexual risk behaviour. The possible contribution of stressing anticipated regret in prevention programs aiming adolescents to adopt safer sex practices will be discussed.     

Role of anticipated regret,intentions and intention stability in adolescent smoking initiation

Objectives To examine the impact of anticipated regret within the theory of planned behaviour (TPB) on intentions of adolescents to initiate smoking. To examine the moderating role of anticipated regret and intention stability on the relationship between intentions and smoking initiation in adolescents. Methods We conducted two studies measuring anticipated regret within the TPB applied to adolescent smoking initiation. In the first study, 347 non‐smoking adolescents (between 11 and 12 years of age) completed the TPB and anticipated regret measures about smoking initiation. In the second study, 675 non‐smoking adolescents (between 11 and 12 years of age) completed the TPB, anticipated regret, and intention stability measures in relation to smoking initiation. Smoking was assessed objectively by carbon monoxide breath monitor 9 months later. Results In Studies 1 and 2, regret significantly added to predictions of intentions over and above components of the TPB (p <.001). In Study 2, smoking behaviour was predicted by intentions and the relationship of intentions to behaviour was moderated by regret and intention stability. Conclusions Regret and intention stability were shown to be important variables within the TPB in understanding intentions and behaviour of smoking initiation in adolescents.     

The role of the vagus nerve in cardiac adaptation to exercise

Summary Ten dogs were subjected to bilateral removal of thoracic sympathetic chains so as sympathetically to denervate the heart while leaving vagal control intact (so-called Vagal Dogs). Their cardiac output was then estimated at different levels of exercise. The estimation was repeated on eight of these same animals about a year later with almost identical results. Comparing these results with cardiac exercise outputs of seven normal dogs, it emerges that possession of the vagus alone allows normal cardiac response during exercise. Surprisingly, cutting both vagi in these vagal dogs resulted in practically no immediate deterioration of their cardiac response to exercise. These recently vagotomized animals were then contrasted with a group of eight dogs whose hearts had been completely denervated some months previously. The latter had relatively poor cardiac adaptation to exercise.It was concluded that in the sympathectomized dogs even the recent possession of the vagus confers almost full power of cardiac adaptation to exercise. It is suggested that the recent possession of the vagus has trophic influence on the heart enabling it to retain mitochondria essential to normal function.     

The role of voluntary exercise in enriched rearing: a behavioral analysis

The effects of postweaning enriched rearing and home cage voluntary wheel-running exercise in adulthood were contrasted on a comprehensive battery of tests designed to assess mnemonic, attentional, emotional, and motor functions. In a 2 x 2 factorial design, female C57BL/6 mice were housed in groups in either standard or enriched cages, which were equipped with either a running or a locked wheel. They were maintained in the corresponding housing conditions for 2 months postweaning prior to, and throughout, testing. Enriched rearing was associated with anxiogenesis, hypolocomotor activity, enhanced motor skills, retarded extinction of conditioned responding, and improved water maze performance. Exercise as such enhanced motor coordination and facilitated extinction of contextual conditioning. Evidence for an interaction between enrichment and exercise was apparent in the open field test, conditioned freezing to a tone stimulus, prepulse inhibition, and acquisition of water maze reference memory. Hence, care should be taken to control for the unique contribution of wheel-running exercise when it is included as an integral component of the enrichment procedure.     

Deciding when to intervene: a Markov decision process approach

The aim of this paper is to point out the difference between static and dynamic approaches to choosing the optimal time for intervention. The paper demonstrates that classical approaches, such as decision trees and influence diagrams, hardly cope with dynamic problems: they cannot simulate all the real-world strategies and consequently can only calculate suboptimal solutions. A dynamic formalism based on Markov decision processes (MPPs) is then proposed and applied to a medical problem: the prophylactic surgery in mild hereditary spherocytosis. The paper compares the proposed approach with a static approach on the same medical problem. The policy provided by the dynamic approach achieved significant gain over the static policy by delaying the intervention time in some categories of patients. The calculations are carried out with DT-Planner, a graphical decision aid specifically built for dealing with dynamic decision processes.     

The role of sports and exercise in allergic disease: drawbacks and benefits

Although training and exercise have several benefits, overdoing it might not necessarily be a good thing. For instance, elite athletes have an increased risk for asthma and allergy. Several mechanisms can be implicated for this risk, which include the interplay between environmental training factors and athlete’s personal risk factors, such as genetic susceptibility, neurogenic-mediated inflammation, and epithelial sensitivity. However, an overwhelming amount of scientific evidence shows the positive effects of sports as part of a healthy lifestyle. Training reduces breathlessness and asthma symptoms and attenuates Th2-mediated inflammatory responses. Taken together, the benefits far outweigh the potential hazards of training. An easily administered therapeutic healthy lifestyle intervention, which could be used alongside current treatment, must be developed.     

The role of exercise in the management of rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with significant functional impairment and increased risk for cardiovascular disease. Along with pharmacological therapy, exercise seems to be a very promising intervention to improve disease-related outcomes, including functional ability and systemic manifestations, such as the increased cardiovascular risk. In this review, we discuss the physiological mechanisms by which exercise improves inflammation, cardiovascular risk and psychological health in patients with rheumatoid arthritis (RA) and describe in detail how exercise can be incorporated in the management of this disease using real examples from our clinical practice.     

The processing of anticipated and unanticipated fearful faces: An ERP study

This study examined the processing of fearful and neutral expressions, which could either be anticipated or not from a prime word (i.e., 'fear' or 'neutral') with or without predictive value. In total, data from 17 participants (i.e., reaction times; ERP waveforms) were analyzed. ERP data showed that the expression effect (fearful vs. neutral faces) was different between predictable and unpredictable trials in early components (N1, N170 and P2) after face onset. However, the expression effect was essentially the same between predictable and unpredictable trials in late components (N300 and P3) after face onset. These results revealed that emotion processing of anticipated vs. non-anticipated stimuli differs mainly in the early stage of neural activity after face onset.     

Escaping homelessness: anticipated and perceived facilitators

One study with two distinct sections was conducted to identify factors facilitating escape from homelessness. In Section 1, 58 homeless individuals rated possible facilitators of escape (factors they believed would help them become more independent and self‐sufficient). In Section 2, 80 participants who had already exited homelessness rated the same facilitators (factors that would have helped them become more independent and self‐sufficient) and the importance of actual factors that facilitated escape. When rating factors in the hypothetical, both groups rated obtaining housing as being particularly important for facilitating movement toward independence. People formerly homeless who reported perceived facilitators of escape, however, also reported that their escape was facilitated by realization of their own abilities and potential to offer something to the world. The findings have implications for the design of community interventions helping individuals who are homeless. © 2009 Wiley Periodicals, Inc.     

The role of central command in ventilatory control during static exercise

The role of central command in the respiratory response to 15 min of rhythmic-static (isometric) exercise was studied in humans. Voluntary exercise (VE) was compared with electrically induced exercise (EE) at three different work intensities, i.e. 5%, 15% and 25% of maximal voluntary contraction. A group of 12 volunteers participated in the study and each of them performed six sessions. A session consisted of at least 5 min rest, 15 min rhythmic-static single leg exercise (4 s contraction/12 s relaxation) and at least 5 min recovery. Force, minute ventilation (V _E) and oxygen uptake (VO₂) were measured. In EE, both V _E and VO₂ increased continuously during the entire exercise period after an initial rapid increase at all three work intensities. Correlation between VE and VO₂ was highly significant during EE. During all three work intensities of VE, VE and VO₂ achieved a steady-state after the initial increase. During VE, VE did not correlate as closely with VO₂ as during EE. All these findings indicate that central command was not imperative for an adequate ventilatory response to exercise within all three work intensities investigated. Without the influence of central command, correlation between VE and VO₂ was even better than during VE.     

The VO2 response to exhaustive square wave exercise: influence of exercise intensity and mode

We investigated the oxygen uptake (O₂) response to exhaustive square wave exercise of approximately 2, 5 and 8 min duration in cycling and running. Nine males completed a ramp test and three square wave tests on a motorised treadmill and the same four tests on a cycle ergometer, throughout which gas exchange was assessed (Douglas bag method). The peak O₂ from the ramp test was higher for running than for cycling [mean (SD): 58.4 (2.8) vs. 55.9 (3.7) ml.kg^–1.min^–1; P=0.04]. However O_2max (defined as the highest O₂ achieved in any of the four tests) did not differ between running and cycling [60.0 (2.9) vs. 58.5 (3.3) ml.kg^–1.min^–1; P=0.15]. The peak O₂ was similar (P>0.1) for the 5 and 8 min square wave tests [98.5 (1.8) and 99.2 (2.3) %O_2max for running; 97.0 (4.2) and 97.5 (2.0) %O_2max for cycling] but lower (P<0.001) for the 2-min test [91.8 (2.5) and 89.9 (5.5) %O_2max for running and cycling respectively]. O₂ increased over the final two 30-s collection periods of the 2-min test for cycling [O₂=0.18 (0.15) l.min^–1; P<0.01] but not running [O₂=0.00 (0.09) l.min^–1; P=0.98]. We conclude that in the aerobically fit the peak O₂ for square wave running or cycling at an intensity severe enough to result in exhaustion in approximately 2 min is below O_2max. In running, O₂ plateaus at this sub-maximal rate.     

The role of exercising muscle length in the protective adaptation to a single bout of eccentric exercise

The purpose of this study was to determine if the protective adaptation to a single bout of eccentric exercise (repeated bout effect) is dependent on the muscle length at which the eccentric contractions are performed. Ten subjects (six men, four women) performed two bouts of 120 isokinetic eccentric contractions separated by 2 weeks (target intensity was 90% of maximum isometric strength at 70°). In the initial bout one limb exercised from 30° to 70° of knee flexion (short initial bout; SIB) and the contralateral limb exercised from 70° to 110° (long initial bout; LIB). For the repeated bout 2 weeks later, the limb that initially exercised at a short length now exercised at a long length (long repeated bout; LRB) and the limb that initially exercised at a long length now exercised at a short length (short repeated bout; SRB). Isometric strength and pain (scale 0–10) were assessed immediately post exercise and on the next 3 days. Strength loss and pain were greater following LIB versus SIB (strength loss P<0.01; pain P<0.001) and following LRB versus SRB (strength loss P<0.01; pain P<0.001). Strength loss and pain were not different between LIB and LRB. Pain was significantly greater following SIB compared with SRB (P<0.05). Strength loss was not different between SIB and SRB. These results confirm that the symptoms of muscle damage are highly dependent on exercising muscle length and also demonstrate that the repeated bout effect is dependent on muscle length. Performing an initial bout of eccentric exercise at a shortened muscle length did not protect against strength loss and pain following a repeated bout at a longer muscle length. Data are given as mean (SE) unless otherwise stated.     

The role of exercise capacity in the health and longevity of centenarians

Ageing is a continuum of biological processes characterized by progressive adaptations which can be influenced by both genetic and physiological factors. In terms of human maturation, physically and cognitively functional centenarians certainly represent an impressive example of successful healthy ageing. However, even in these unique individuals, with the passage of time, declining lung function and sarcopenia lead to a progressive fall in maximal strength, maximal oxygen uptake, and therefore reduced exercise capacity. The subsequent mobility limitation can initiate a viscous downward spiral of reduced physical function and health. Emerging literature has shed some light on this multi-factorial decline in function associated with aging and the positive role that exercise and physical capacity can play in the elderly. Recognizing the multiple factors that influence ageing, the aim of this review is to highlight the recently elucidated limitations to physical function of the extremely old and therefore evaluate the role of exercise capacity in the health and longevity of centenarians.     

The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing

Mitochondria are the hub for energy production within living cells. They can undergo morphological changes in response to nutrient availability and cellular stress. Here, we review how exercise chronically and acutely affects mitochondrial dynamics. Moreover, we discuss whether mitochondrial dysfunction observed in elderly subjects is due to the ageing process per se or due to the associated sedentary state. Finally, we study how endurance exercise can improve mitochondrial dynamics in older subjects, thereby improving their overall health and likely limiting muscle waste.     

The possible role of acetate in exercise hyperemia in dog skeletal muscle

The possible role of acetate in the genesis of exercise hyperemia was studied in five series of dogs. Intraarterial infusion of an isomotic solution of sodium acetate at 0.76 ml/min in the dog forelimb decreased the resistance to flow through skeletal muscle by 48%, primarily by decreasing resistance to flow through small vessels. Skin lymph flow and lymph protein concentration were unaffected. The hindlimb of the conscious dog took up acetate at rest (A-V difference, _58.3±19.6 nmoles/ml) and put out acetate during treadmill exercise (A-V difference, –105.6±20.12 nmoles/ml); femoral venous blood acetate concentration increased by 145 nmoles/ml (control 195 nmoles/ml). In the gracilis muscle of the anesthetized dog, simulated exercise at 0.5, 1.0 or 2.0 Hz increased acetate tissue content (72, 248 and 442 nmoles/g, respectively), output (18,899, and 1,830 nmoles/100 g/min, respectively) and venous cencentration (82, 49 and 39 nmoles/ml, respectively) and changes in tissue acetate content correlated with changes in vascular resistancer=0.75,P<0.001. Intraarterial infusion of an isosmotic solution of sodium acetate in the quiescent gracilis muscle perfused at constant flow produced a significant (6%) decrease in resistance when arterial blood acetate was increased by a calculated 96 nmoles/ml. These studies suggest that acetate might be included among those metabolites that contribute to exercise hyperemia.Supported by grants CO7610 and CO7635 from the Uniformed Services University. Preliminary communications included Physiologist 21:115, 1978, Federation Procedings 39:270, 1980 and Physiologist 23:156, 1980