医专学生SCL-90调查分析

采用症状自评量表（ＳＣＬ－９０），对大同医专８４６名学生进行问卷调查。结果表明，ＳＣＬ－９０各因子分及总分均向于国内常模，其中强迫、人际关系、抑郁及敌对因子≥３分者占５％以上。女生组人际关系、抑郁、恐怖因子分显著高于男生组，而男生组的敌对因子分高于女生组。提示应对医专生加强心理卫生教育。     

不同专业大学生SCL—90检查分析

采用症状自评量表（ＳＣＬ－９０），对内蒙古７所高校４类不同专业学生心理健康状况进行测查，结果发现，４类专业中２８．９４％的学生存在心理问题，其中经济类学生检出率最高，艺术类检出率最低。常见的心理问题为强迫、人际关系敏感、偏执、敌对和抑郁。４类专业学生各因子分均值明显高于国内常模，经济类专业学生各因子分均偏高。     

中考前学生心理健康状况调查

应用症状自评量表（SCL—90），对初中三年级快班118名学生中考前心理健康状况调查，与国内常模比较，发现中考学生的SCL—90总分、总均分高于国内常模，各因子分除躯体化无明显差异外，其余8个因子分呈增高趋势。提示学校和家庭对中考学生除加强文化课的复习准备外，要重视心理健康，加强心理素质的培养。     

抑郁性神经症功能失调状况与临床症状的关系

目的：探讨抑郁性神经症患者的功能失调状况是属于素质性的,还是一种状态依从性的变量。方法：应用功能失调状况评定量表（ＤＳＡ）测评了９０例抑郁性精神症患者,并以９０正常人作对照。另外,将抑郁性神经症的ＤＡＳ总分和因子分与症状自评量表（ＳＣＬ－９０）的总分及因子分进行了相关分析。结果：抑郁性精神症的ＤＡＳ总分及因子分均明显高于正常人;ＤＡＳ得分与ＳＣＬ－９０评分之间的分析提示绝大部分变量间呈现密切正相关     

弱智儿童的父母心理状况调查

本研究采用ＳＣＬ－９０症状自评量表，１１０例弱智儿童的父母进行调查，结果表明，各因子分均高于成年常模，尤其是躯体化、人际关系、抑郁、焦虑和敌对性更为突出。说明这一群体存有明显的心理障碍，提供心理咨询和心理治疗是必要的。     

不同分娩方式对产妇心理影响

本文采用抑郁自评量表（ＳＤＳ），焦虑自评量表（ＳＡＳ）对１５５例孕产妇作了产前、产后心理状况调查，结果显示：产前、产后ＳＡＳ总分值高于常模值；产后ＳＤＳ分值高于产前，剖腹产者ＳＡＳ，ＳＤＳ高于常模值，也高于自然分娩者（均为Ｐ＜０．０１）。ＳＤＳ抑郁严重度指数≥０．５者：剖腹产２５例（３６．７６％），自然分娩者５例（５．２５％）。提示产前产后孕产妇有明显焦虑情绪，剖腹产后有明显抑郁。     

实习期医护生心理健康探讨

为了解实习期医护生的心理健康水平,作者采用ＳＣＬ－９０症状自评量表,对在某医院实习的医疗系大学生和护理中专生进行调查,结果显示,医学生的强迫症状,人际关系敏感等７个因子分均高于国内常模,有显著性差异,护生的人际关系敏感,焦虑等５个因子均高于国内常模,有显著性差异;医学生的强迫症状因子分高于护生,有显著性差异。     

企业下岗职工心理卫生状态初步分析

本文采用症状自评量表（SCL—90）对企业下岗或待岗职工进行了测试，并与园内常模对照分析。结果提示，71．2％存有不同程度的心理问题，尤以躯体化、忧郁、焦虑、人际关系、恐怖等因子分明显高于国内常模资料．因此，重视和加强企业下岗职工的心理保健工作显得十分重要。     

失眠症患者焦虑,抑郁情况分析

本文对３５例门诊失眠症患者进行抑郁自评量表和焦虑自评量表评定，并与我国的常模进行对比，结果表明，二者的评发明显高于正常人，提示失眠者较正常人有较多的抑郁和焦虑情绪。     

精神发育迟滞患儿的父母心理健康状况调查

本研究采用症状自评量表(SCL—90)．对精神发育迟滞患儿的父母进行调查．结果各因子分均显著高于国内常模．其中不同性别及文化程度者存在不同的心理问题。提示加强心理卫生指导,有助于患儿父母心身健康及患儿的康复。     

White matter integrity affected by depressive symptoms in migraine without aura: a tract‐based spatial statistics study

Previous studies have proven that migraine and depression are bidirectionally linked. However, few studies have investigated white matter (WM) integrity affected by depressive symptoms in patients suffering from migraine without aura (MWoA). Forty patients with MWoA were divided into two groups according to their self‐rating depression scale (SDS) score in the present study, including 20 in the SDS (+) (SDS > 49) group and 20 in the SDS (?) (SDS ≤ 49) group. Forty healthy participants were also recruited as the control group. Tract‐based spatial statistics analyses with multiple diffusion tensor imaging‐derived indices [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)] were employed collectively to investigate WM integrity between all patients with MWoA and all healthy controls, between each subgroup (SDS (?) group and SDS (+) group) and healthy controls, and between the SDS (?) and SDS (+) groups. Compared with healthy controls, decreased AD was shown in several WM tracts of the whole MWoA group, SDS (?) group and SDS (+) group. In addition, compared with the SDS (?) group, the SDS (+) group showed decreased FA and increased MD and RD, with conserved AD, including the genu, body and splenium of the corpus callosum, bilateral superior longitudinal fasciculi, the right anterior corona radiata and some other WM tracts, similar to previous findings in depression disorder. Furthermore, mean FA and RD in some of the above‐mentioned WM tracts in the SDS (+) group were correlated significantly with SDS scores, including the genu and splenium of the corpus callosum, the right anterior corona radiata and the superior longitudinal fasciculi. Our results suggest that WM integrity may be affected by both depression symptoms (more sensitive as RD) and migraine (more sensitive as AD). The findings may serve as a sensitive biomarker of depression severity in MWoA. Copyright © 2013 John Wiley & Sons, Ltd.     

Increase in central striatal dopamine transporters in patients with Shwachman–Diamond syndrome: Additional evidence of a brain phenotype

Patients with Shwachman–Diamond syndrome (SDS) do not only experience well‐described physical features like skeletal abnormalities and hematological dysfunctions, but recent studies also suggested attention and working memory deficits in SDS. Indeed, a recent structural magnetic resonance imaging (MRI) study demonstrated smaller brain regions in SDS. Regarding attention and working memory, however, an important role for the neurotransmitter dopamine is well established. Therefore, in this study we assessed in vivo dopamine transporters (DATs; a specific marker of dopaminergic cells expressed in nerve terminals) and performed structural MRI in SDS. In 6 and 5 young SDS patients, respectively, we were able to acquire DAT single photon emission computed tomography (SPECT) and MRI examinations, and the data were compared to age‐matched control data. Striatal DAT binding was significantly increased in SDS patients as compared to controls. In addition, we observed significantly smaller volumes particularly posteriorly and caudally located in the brain: the corpus callosum, brainstem, and cerebellum. Also the thalamus was smaller in SDS patients than in controls. In conclusion, our data replicate earlier findings on smaller brain regions in SDS. In addition, our novel molecular imaging data suggest that SDS patients may have a dysregulated dopaminergic system. These findings may be of relevance to increase our understanding of behavioral and cognitive deficits in SDS. © 2012 Wiley Periodicals, Inc.     

精神障碍患者配偶心理状况调查

目的了解精神障碍患者发病对其配偶心理状况的影响,为患者配偶实施心理干预提供依据。方法采用抑郁自评量表(SDS)、焦虑自评量表(SAS)对68例患者的配偶在患者入院及出院时进行问卷调查。结果精神障碍患者配偶在患者症状活跃期及缓解期SAS、SDS评分均显著高于国内常模(活跃期:t男SDS=3.14、t男SAS=2.85,P<0.05;t女SDS=4.80、t女SAS=4.57,P<0.01;缓解期:t男SDS=2.40、t男SAS=2.65,P<0.05;t女SDS=3.17,P<0.05;t女SAS=3.98,P<0.01),复发组患者配偶评分显著高于首发组(tSDS=2.14、tSAS=1.89,P<0.05),稳定的经济来源也是影响精神障碍患者配偶焦虑的一个重要原因(tSAS=2.77、P<0.05)。结论精神障碍患者配偶心理问题的存在,不仅影响了自身的心理健康,还对患者康复带来一定影响。     

抑郁症抑郁自评量表的因子结构分析及影响因素

目的探讨抑郁自评量表(SDS)在抑郁症患者中的因子结构维度。方法采用相关分析和主成分因子分析法研究819例抑郁症患者及不同性别的SDS因子结构特点。结果抑郁症患者SDS标准分均分显著高于国内常模差异有统计学意义(t=40.98,P<0.001);SDS所有条目得分与SDS总分呈显著性正相关(r=0.73～0.29,P<0.001);因子分析取特征值>1,全部样本和男性样本得4个因子,半数样本和女性样本得5个因子。结论抑郁症患者SDS呈4或5个因子结构,不同人群SDS因子结构有所不同。     

Factors Related to Decreased Bone Mineral Density in Childhood Cancer Survivors

The risk of osteoporosis or osteopenia is known to increase after childhood cancer treatment. The purpose of this study was to evaluate patterns of bone mineral density (BMD) and to identify factors related to the decreased BMD in childhood cancer survivors. We studied 78 patients (34 boys, 44 girls) treated for childhood cancer. Twenty (25.7%) patients had lumbar BMD (LBMD) standard deviation score (SDS) lower than -2. Nineteen (24.4%) patients had femur neck BMD (FNBMD) SDS lower than -2. The patients treated with hematopoietic stem cell transplantation had lower LBMD SDS (-1.17 ± 1.39 vs -0.43 ± 1.33, P = 0.025). The risk of having LBMD SDS < -2 was higher in the patients treated with glucocorticoid (GC) for graft-versus-host disease (GVHD) (36.6% vs 13.5%; odds ratio [OR], 3.7; P = 0.020). In multivariate logistic regression analysis, longer duration of GC treatment for GVHD (OR, 1.12; 95% confidence interval [CI], 1.05-1.20) and lower body mass index (BMI) SDS (OR, 0.59; 95% CI, 0.36-0.95) were associated with decreased LBMD SDS. These findings suggest that prolonged GC use and reduction in BMI are risk factors for decreased BMD in childhood cancer survivors. Anticipatory follow-up and appropriate treatment are necessary, especially for the patients with risk factors.     

Growth Responses During 3 Years of Growth Hormone Treatment in Children and Adolescents With Growth Hormone Deficiency: Comparison Between Idiopathic,Organic and Isolated Growth Hormone Deficiency,and Multiple Pituitary Hormone Deficiency

BackgroundThe study aimed to compare the growth responses to 3 years of growth hormone (GH) treatment in children and adolescents with GH deficiency (GHD) according to idiopathic, organic, isolated (IGHD), and multiple pituitary hormone deficiency (MPHD).MethodsTotal 163 patients aged 2–18 years (100 males and 63 females; 131 idiopathic and 32 organic GHD; 129 IGHD and 34 MPHD) were included from data obtained from the LG Growth Study. Parameters of growth responses and biochemical results were compared during the 3-year GH treatment.ResultsThe baseline age, bone age (BA), height (Ht) standard deviation score (SDS), weight SDS, mid-parental Ht SDS, predicted adult Ht (PAH) SDS, and insulin like growth factor-1 (IGF-1) SDS were significantly higher in the organic GHD patients than in the idiopathic GHD patients, but peak GH on the GH-stimulation test, baseline GH dose, and mean 3-year-GH dosage were higher in the idiopathic GHD patients than in the organic GHD patients. The prevalence of MPHD was higher in the organic GHD patients than in the idiopathic GHD patients. Idiopathic MPHD subgroup showed the largest increase for the ΔHt SDS and ΔPAH SDS during GH treatment, and organic MPHD subgroup had the smallest mean increase after GH treatment, depending on ΔIGF-1 SDS and ΔIGF binding protein-3 (IGFBP-3) SDS. The growth velocity and the parental-adjusted Ht gain were greater in the idiopathic GHD patients than the organic GHD patients during the 3-year GH treatment, which may have been related to the different GH dose, ΔIGF-1 SDS, and ΔIGFBP-3 SDS between two groups. Multiple linear regression analysis revealed that baseline IGF-1 SDS, BA, and MPH SDS in idiopathic group and baseline HT SDS in organic group are the most predictable parameters for favorable 3-year-GH treatment.ConclusionThe 3-year-GH treatment was effective in both idiopathic and organic GHD patients regardless of the presence of MPHD or underlying causes, but their growth outcomes were not constant with each other. Close monitoring along with appropriate dosage of GH and annual growth responses, not specific at baseline, are more important in children and adolescents with GHD for long-term treatment.Trial RegistrationClinicalTrials.gov Identifier: {"type":"clinical-trial","attrs":{"text":"NCT01604395","term_id":"NCT01604395"}}NCT01604395     

血液病患者心理状况及相关因素分析

目的探讨血液病患者的心理状况及相关因素,以指导心理干预,提高生存质量。方法选用焦虑自评量表(SAS)和抑郁自评量表(SDS)评价病人的情绪障碍。利用社会支持量表评定病人的社会支持及主要照顾者SAS评分、SDS评分等作为相关因素。结果血液病患者的SAS、SDS评分明显高于常模;多元回归分析显示：病人的SAS评分与年龄,支持利用负相关,与照顾者SAS评分正相关。SDS评分与支持利用,主观支持负相关,与照顾者SAS评分正相关。结论血液病患者存在明显的焦虑、抑郁,并受多种因素的影响,医护人员应有针对性地给予心理帮助和指导。     

Some cases of common variable immunodeficiency may be due to a mutation in the SBDS gene of Shwachman-Diamond syndrome

Known genetic defects currently account for only a small proportion of patients meeting criteria for 'probable' or 'possible' common variable immunodeficiency (CVID). A 59-year-old male with a 12-year history of CVID on intravenous immunoglobulin (IVIG) is presented who developed bronchiectasis, cytopenias and malabsorption that are recognized complications of CVID. Work-up for his malabsorption suggested the possibility of Shwachman-Diamond syndrome, confirmed by mutation testing. With the identification of the molecular defect in Shwachman-Diamond syndrome (SDS), it is becoming clear that not all SDS patients have the prominent features of neutropenia or pancreatic malabsorption. A meta-analysis of published immunological defects in SDS suggests that four of 14 hypogammaglobulinaemic SDS patients meet criteria for 'possible' CVID. Mutations in the SBDS gene may therefore be the fifth identified molecular defect in CVID.     

102例急性白血病患者焦虑、抑郁调查

目的　探讨急性白血病患者的焦虑和抑郁情绪。方法　采用焦虑自评量表 ( SAS)和抑郁自评量表 ( SDS)对急性白血病病人和健康人进行对照研究。结果　急性白血病患者 SAS和 SDS评分均明显高于健康对照组 ( P<0 .0 1 )。结论　急性白血病患者多伴焦虑和抑郁情绪。临床上在治疗该病同时 ,应给予心理疏导 ,必要时加用抗抑郁剂治疗。     

综合性心理治疗对脑卒中患者心理障碍的干预效应

目的 探讨脑卒中后患者存在的心理障碍,综合性心理治疗对脑卒中后心理障碍的干预效果及其对患者生活质量的影响。方法 采用心理量表对225例卒中患者应用SCL-90、SDS、SAS进行心理评估。将存在,心理障碍的脑卒中患者随机分为实验组及对照组,实验组增加了阶梯式心理治疗。评定与比较两组患者SCL-90、SDS、SAS、SF-36的分值及其临床疗效。结果 70．67％脑卒中患者存在一定程度的心理障碍,以抑郁、焦虑多发。实验组SDS、SAS评分显著低于对照组,其临床疗效及生活质量评分显著高于对照组。结论 脑卒中后患者易出现心理障碍;综合心理治疗能显著改善脑卒中患者的心理障碍,可以提高临床疗效、患者的躯体功能及生活质量。