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1.
Prism Adaptation Therapy (PAT) is an intervention method in the treatment of the attention disorder neglect (Frassinetti, Angeli, Meneghello, Avanzi, & Ladavas, 2002; Rossetti et al., 1998). The aim of this study was to investigate whether one session of PAT using a computer-attached touchscreen would produce similar after-effects to the conventional box normally used in PAT. In four experiments, 81 healthy subjects and 7 brain-injured patients diagnosed with neglect were subjected to a single session of PAT under two conditions: (1) using the original box, and (2) using a computer-based implementation of PAT. The session of PAT included a pre-exposure step involving pointing at 30 targets without feedback; an exposure step involving pointing at 90 targets with prism goggles and feedback; and a post-exposure step involving pointing at 60 targets, with no goggles and no feedback. The results indicate that the expected similarity in the after-effect produced by the two conditions seems to occur only if subjects receive feedback on pointing precision by seeing their fingertip during the exposure step. Attempts to provide feedback indirectly via icons on the computer screen failed to produce the expected size in the after-effect. The findings have direct implications for computer-based treatment of visuospatial disorders in the future and computer-assisted rehabilitation in general. 相似文献
2.
Background: A number of hypotheses have been formulated to account for comprehension data in agrammatic aphasia. They explain deficits in comprehending specific structures, such as semantically reversible non-canonical sentences, for example, Trace Deletion Hypothesis (TDH, Grodzinsky, 1986, 1990, 1995), or functional categories, for example, Tree Pruning Hypothesis (TPH, e.g., Friedmann, 2006); Tense Underspecification Hypothesis (TUH, Wenzlaff & Clahsen, 2004, 2005); Interpretable Features’ Impairment Hypothesis (IFIH; e.g., Varlokosta et al., 2006). Several studies, however, report evidence contradicting these theories (e.g., Caramazza, Capasso, Capitani, & Miceli, 2005; Dickey, Milman, & Thompson, 2008) and propose new accounts to explain the comprehension deficits in agrammatic aphasia, for example, Distributed Morphology Account (DMA, Dickey et al., 2008). Aims: Against the background above, this study investigates the ability of three Greek-speaking agrammatic individuals to comprehend a wide range of structures and functional categories: semantically reversible (canonical) active and (non-canonical) passive sentences, Complementizer Phrase, subject-verb Agreement, Tense, and Aspect. Methods & Procedures: We administered: (a) two sentence-picture matching tasks to test comprehension of reversible active and passive sentences, and Tense; (b) a sentence grammaticality judgement task to test judgement of Tense, Aspect, and subject-verb Agreement; and (c) a picture-pointing task to test comprehension of Complementizer Phrase. Outcomes & Results: (a) Two of the three agrammatic participants performed at chance on reversible passive sentences and above chance on active sentences. The third participant performed equally high on the two sentence types. Two participants performed at chance on Tense comprehension and one above chance. (b) The three participants were selectively or across-the-board impaired in judgement of Agreement, Tense, and Aspect. One of the two selectively affected participants had chance performance on Aspect and above chance performance on Agreement and Tense. The other one performed at chance on Aspect and Tense, and above chance on Agreement. The third participant's performance was equally poor on all three categories. (c) All three agrammatic participants performed above chance on the comprehension of Complementizer Phrase. Conclusions: In comprehension/judgement, canonical and non-canonical sentences do not dissociate in all agrammatic speakers, while functional categories associated with the verb morphology may be compromised in the face of relatively well-preserved categories that are located higher in the syntactic hierarchy. All three agrammatic participants support the DMA, and two of them support the TDH. Instead, none of them provided support to the TPH, TUH, and IFIH. 相似文献
3.
Michael S. Okun Ramon L. Rodriguez Ania Mikos Kimberly Miller Ida Kellison Lindsey Kirsch-Darrow 《The Clinical neuropsychologist》2013,27(1):162-189
Deep brain stimulation (DBS) now plays an important role in the treatment of Parkinson's disease, tremor, and dystonia. DBS may also have a role in the treatment of other disorders such as obsessive-compulsive disorder, Tourette's syndrome, and depression. The neuropsychologist plays a crucial role in patient selection, follow-up, and management of intra-operative and post-operative effects (Pillon, 2002; Saint-Cyr & Trepanier, 2000). There is now emerging evidence that DBS can induce mood, cognitive, and behavioral changes. These changes can have dramatic effects on patient outcome. There have been methodological problems with many of the studies of DBS on mood, cognition, and behavior. The neuropsychologist needs to be aware of these issues when following up patients, and constructing future studies. Additionally, this article will review all aspects of the DBS procedure that can result in mood, cognitive, and behavioral effects and what role(s) the neuropsychologist should play in screening and follow-up. 相似文献
4.
Heidi Getz Sarah Snider David Brennan Rhonda Friedman 《Neuropsychological rehabilitation》2016,26(4):584-609
A growing body of literature supports the effectiveness of the remote delivery of rehabilitation services, i.e., telerehab. Aphasia treatment is particularly well suited for telerehab because of the verbal and visual nature of speech-language therapy, but scientific research investigating aphasia telerehab is in its infancy. No studies to date have evaluated whether treatment of acquired reading disorders by a live clinician can be feasibly, effectively, or efficiently conducted via telerehab. Here we address this gap in the literature by reporting our success remotely remediating the reading deficits of two participants with phonological alexia. We adapted for the telerehab setting a previously validated treatment for phonological alexia (Friedman, Sample, &; Lott, 2002), which uses a paired-associate design to train reading of problematic words. Both telerehab participants significantly improved their reading of trained words in similar time frames as previous participants (Friedman et al., 2002; Kurland et al., 2008; Lott, Sample, Oliver, Lacey, &; Friedman, 2008); furthermore, both participants reported high satisfaction with the telerehab setting. Although telerehab with alexic patients poses unique challenges, we conclude that treatment for alexia via telerehab is nevertheless feasible, may be equally effective as in-person treatment, and saves substantial resources for participants as well as clinicians. 相似文献
5.
ABSTRACTWe used factor analysis to examine relationships among tasks that have previously shown right hemispheric processing asymmetries. We were interested in whether processing emotion displayed by a face constitutes a distinct perceptual process from processing other facial characteristics. Interest in this topic arose after Boles [1991. Factor analysis and the cerebral hemispheres: Pilot study and parietal functions. Neuropsychologia, 29(1), 59–91] found evidence of a common process underlying face processing and then Boles [1992. Factor analysis and the cerebral hemispheres: Temporal, occipital and frontal functions. Neuropsychologia, 30(11), 963–988] found evidence of a distinct process for the processing of the facial emotion. We used seven tasks that measured both face and non-face perception. Analysis of the asymmetries revealed measures from the five face tasks resulted in a single factor, thus failing to support the hypothesis that emotional face perception would involve a separate process from non-emotional face perception. A second factor revealed a separate process underlying enumeration, and a third factor revealed yet another process underlying line bisection. The results indicate that perceiving facial emotion results in right hemisphere processing, and faces as a whole are responsible for such processing. 相似文献
6.
《Social neuroscience》2013,8(1):69-78
Abstract Guided by influential models of face processing, efforts have been expended to uncover the neural substrates subserving the many facets of face perception. Extending this work, the present study used functional brain imaging (fMRI) to explore the relationship between the operations supporting the explicit extraction of sex and gaze-related information from faces. The brain imaging data showed the right superior temporal sulcus to be preferentially involved during assessments of gaze direction and a region of the left fusiform gyrus to be involved during sex categorization. These results provide support for the distributed face-processing model advanced by Haxby and colleagues (2000). 相似文献
7.
Psychometric properties of Romanian translations of the Behavior Problems Inventory-01 (BPI-01; Rojahn, Matson, Lott, Esbensen, & Smalls, 2001) and the Nisonger Child Behavior Rating Form (NCBRF; Aman, Tassé, Rojahn, & Hammer, 1996) were explored. Respondents completed the instruments for 115 children and adolescents with intellectual disabilities. Internal consistency of both instruments' total scales was good to excellent (Cronbach's α ranging from .88 to .95) and the subscale internal consistencies were fair to excellent (with α ranging from .74 to .94). The results based on bivariate Spearman correlations and multiple regression analyses provided strong convergent and discriminant validity of both instruments. Overall, the Romanian versions of the behavior rating scales had very good reliability (internal consistencies) and convergent and discriminant validity. It is hoped that this study will be a catalyst for Romanian clinicians and researchers as well as for transcultural researchers working with Romanian individuals with intellectual disabilities to continue the exploration of the utility and psychometric quality not only of the BPI-01 and the NCBRF but also of other English language psychopathology assessment instruments. 相似文献
8.
This study was conducted to assess the psychometric properties of 2 assessment instruments, the Behavior Problems Inventory-01 (BPI-01; Rojahn, Matson, Lott, Esbensen, & Smalls, 2001) and the Nisonger Child Behavior Rating Form (NCBRF; Aman, Tassé, Rojahn, & Hammer, 1996). The sample consisted of 237 ethnically diverse children and adolescents with intellectual disabilities who ranged in age from 4 to 22 years. Reliability parameters included internal consistency, interteacher agreement, teacher-parent agreement, and test-retest reliability. Factorial validity was assessed first by bivariate Spearman rank (ρ) correlations and then by examining the factor structure fit via confirmatory factor analysis (CFA). Convergent and discriminant validity was assessed by multiple regression analyses across the 2 instruments. Reliability coefficients (internal consistency, interteacher agreement, and test-retest reliability) of the BPI-01 and of the NCBRF subscales ranged from fair to excellent and from poor to excellent, respectively. The CFA suggested a poor fit between the present and the original BPI-01 and NCBRF factor structures, although item-total correlations were reasonable. Convergent and discriminant validity between the BPI-01 and the NCBRF, however, was strong. Limitations of the study are discussed and recommendations for future studies are presented. 相似文献
9.
Sandra Hanne Irina A. Sekerina Shravan Vasishth Frank Burchert Ria De Bleser 《Aphasiology》2013,27(2):221-244
Background: In addition to the canonical subject-verb-object (SVO) word order, German also allows for non-canonical order (OVS), and the case-marking system supports thematic role interpretation. Previous eye-tracking studies (Kamide et al., 2003; Knoeferle, 2007) have shown that unambiguous case information in non-canonical sentences is processed incrementally. For individuals with agrammatic aphasia, comprehension of non-canonical sentences is at chance level (Burchert et al., 2003). The trace deletion hypothesis (Grodzinsky 1995, 2000) claims that this is due to structural impairments in syntactic representations, which force the individual with aphasia (IWA) to apply a guessing strategy. However, recent studies investigating online sentence processing in aphasia (Caplan et al., 2007; Dickey et al., 2007) found that divergences exist in IWAs' sentence-processing routines depending on whether they comprehended non-canonical sentences correctly or not, pointing rather to a processing deficit explanation. Aims: The aim of the current study was to investigate agrammatic IWAs' online and offline sentence comprehension simultaneously in order to reveal what online sentence-processing strategies they rely on and how these differ from controls' processing routines. We further asked whether IWAs' offline chance performance for non-canonical sentences does indeed result from guessing. Methods & Procedures: We used the visual-world paradigm and measured eye movements (as an index of online sentence processing) of controls (N?=?8) and individuals with aphasia (N?=?7) during a sentence–picture matching task. Additional offline measures were accuracy and reaction times. Outcomes & Results: While the offline accuracy results corresponded to the pattern predicted by the TDH, IWAs' eye movements revealed systematic differences depending on the response accuracy. Conclusions: These findings constitute evidence against attributing IWAs' chance performance for non-canonical structures to mere guessing. Instead, our results support processing deficit explanations and characterise the agrammatic parser as deterministic and inefficient: it is slowed down, affected by intermittent deficiencies in performing syntactic operations, and fails to compute reanalysis even when one is detected. 相似文献
10.
A manual form of the Letter Memory Test (LMT: Orey, Cragar, & Berry, 2000) was compared in neuropsychological evaluees classified as honest (HON: n = 39) or probable cognitive feigners (PCF: n = 10) using results from two well-validated motivational tests. With the exception of lower educational level and higher rate of compensation seeking in the PCF, the groups were equivalent on most important demographic and injury severity parameters. PCF participants scored significantly lower on most neuropsychological tests (median Cohen's d = 1.2), as well as on the manual LMT (Cohen's d = 4.2). Operating characteristics of the manual LMT in the present sample were comparable to those reported in a similar study using the computerized version of the LMT in neuropsychiatric patients (Vagnini et al., 2006). 相似文献
11.
Insular degeneration has been linked to symptoms of frontotemporal dementia (FTD). Presented in this case is a patient exhibiting semantic variant primary progressive aphasia, behavioral disturbance. Upon autopsy, he was found to have severe insular atrophy. In addition, selective serotonin reuptake inhibitors were ineffective in reducing symptoms of obsessive–compulsive behaviors or emotional blunting. This case suggests that Seeley et al.'s (2007, Alzheimer Disease & Associated Disorders, 21, S50) hypothesis that von Economo neurons and fork cell-rich brain regions, particularly in the insula, are targeted in additional subtypes of FTD beyond the behavioral variant. 相似文献
12.
Executive functioning influences a host of other cognitive processes and people who attend neuropsychological services are more likely to display executive dysfunction than any other cognitive deficit (Stuss & Levine, 2002). Impairment in executive functioning disrupts a person's ability to effectively employ their intact areas of functioning, and undermines effective self-management of other areas of dysfunction, hampering attempts to employ compensatory strategies. Therefore, assessment of a person's executive functioning is a high priority as part of a comprehensive neurorehabilitation plan. Guided by the International Classification of Functioning, Disability, and Health model (ICF model; Peterson, 2005), we suggest that an important development in the field is moving to formal assessment of executive performance in functional contexts, in addition to more traditional assessment of executive impairment. We outline a number of existing studies in this area, review current measures that can provide clinicians with useful information on these issues, and discuss how this research could be further advanced. 相似文献
13.
Valantis Fyndanis Christina Manouilidou Eugenia Koufou Spyros Karampekios Eva Maria Tsapakis 《Aphasiology》2013,27(2):178-200
Background: Little research has been conducted on functional categories in probable Alzheimer's disease (pAD). Furthermore, the findings are contradictory, since some studies report ceiling performance on tense and/or subject–verb agreement (Kaprinis & Stavrakaki, 2007; Kavé & Levy, 2003), whereas others report morphosyntactic deficits and agrammatic profiles (e.g., Altmann, Kempler, & Andersen, 2001). Aims: This study investigates the ability of Greek-speaking pAD individuals to produce and judge subject–verb agreement, tense, and aspect. Given pAD individuals have working memory limitations (e.g., Baddeley, 1996), and given the differential processing demands of agreement, tense and aspect (e.g., Fyndanis, Varlokosta, & Tsapkini, 2012a), pAD participants are expected to perform better on agreement than on tense/aspect. Based on the hypothesis that reference to the past is computationally more demanding than reference to the future/present (e.g., Bastiaanse et al., 2011), a within-tense dissociation is expected to emerge. Further, on the assumption that unmarked values of functional categories are less demanding than marked values (e.g., Lapointe, 1985), the imperfective (unmarked) aspect is expected to be better preserved than the perfective (marked) aspect. Methods & Procedures: Ten Greek-speaking mild pAD individuals and six healthy controls participated in a sentence completion task, a grammaticality judgement task, and a sentence–picture matching task. Non-parametric tests were used for analysis of results. Outcomes & Results: PAD participants were found to be significantly more impaired in aspect compared to tense and agreement, in both production and grammaticality judgement/comprehension. Agreement was found significantly better preserved than tense in production. Similar patterns of performance have been attested in agrammatism (e.g., Fyndanis et al., 2012a). Reference to the past and reference to the future did not dissociate, whereas the imperfective aspect was found to be significantly more impaired than the perfective aspect in production. Conclusions: PAD participants' better performance on producing agreement, compared to tense/aspect, is accounted for in terms of the differential demands these categories pose on the processing system. Agreement is computationally less demanding than tense/aspect, because the former involves processing of grammatical information only, whereas the latter involve processing and integration of grammatical and extralinguistic/conceptual information. The preponderance of tense over aspect is attributed to the subjectivity of the latter, which renders it either a category “difficult” to test, or a computationally more demanding condition. The results also show that reference to the past is as demanding as reference to the future. The hypothesis that unmarked values are easier than marked ones is not supported by our data. 相似文献
14.
Developing language treatments that not only improve trained items but also promote generalisation to untrained items is a major focus in aphasia research. This study is a replication and extension of previous work which found that training abstract words in a particular context-category promotes generalisation to concrete words but not vice versa (Kiran, Sandberg, & Abbott, 2009). Twelve persons with aphasia (five female) with varying types and degrees of severity participated in a generative naming treatment based on the Complexity Account of Treatment Efficacy (CATE; Thompson, Shapiro, Kiran, & Sobecks, 2003). All participants were trained to generate abstract words in a particular context-category by analysing the semantic features of the target words. Two other context-categories were used as controls. Ten of the twelve participants improved on the trained abstract words in the trained context-category. Eight of the ten participants who responded to treatment also generalised to concrete words in the same context-category. These results suggest that this treatment is both efficacious and efficient. We discuss possible mechanisms of training and generalisation effects. 相似文献
15.
16.
Over the past 50 years, mental health professionals have come to recognize the enormous benefits that can be derived from involving the families of people with serious mental illness in the treatment enterprise. One of the earliest advocates for this perspective, Robert Liberman, has played a pivotal role in the development of evidence-based practices targeted to improving the outcomes for this population. From his early work starting in the 1970 s with Ian Falloon on behavioral family therapy for schizophrenia, through his influence as director of the UCLA Clinical Research Center in the 1980 s and ‘90 s on colleagues who applied family psychoeducation principles to the treatment of other mental disorders, to his most recent efforts designed to adapt these approaches to people of diverse cultural backgrounds, Liberman has steadfastly championed the value of teaching families the skills required to meet their needs and to enhance the social adjustment and quality of life of individuals with serious mental disorders. 相似文献
17.
Paul R. Lees-Haley M. Frank Greiffenstein Glenn J. Larrabee Edward L. Manning 《The Clinical neuropsychologist》2013,27(3):449-464
Recently, Kaiser (2003) raised concerns over the increase in brain damage claims reportedly due to exposure to welding fumes. In the present article, we discuss methodological problems in conducting neuropsychological research on the effects of welding exposure, using a recent paper by Bowler et al. (2003) as an example to illustrate problems common in the neurotoxicity literature. Our analysis highlights difficulties in conducting such quasi-experimental investigations, including subject selection bias, litigation effects on symptom report and neuropsychological test performance, response bias, and scientifically inadequate casual reasoning. 相似文献
18.
Jayoung L. Choi 《Archives of Suicide Research》2013,17(3):222-235
We examined the cultural validity of the College Student Reasons for Living Inventory (CSRLI) with Asian American College Students (N = 314). Although results did not completely replicate the six factor structure of the CSRLI as identified in Westefeld, Cardin, and Deaton (1992), partial support was found. The content of the five factors that emerged corresponded to five of the original scales. Our factor solution accounted for 50.25% of common variance and demonstrated moderate to high coefficient alphas. Validity of the CSRLI subscales was supported through significant negative relations with measures of depression and hopelessness. Furthermore, the CSRLI subscales accounted for 8% of the variance in suicidal behavior above and beyond that accounted for by the risk factors of depression and hopelessness alone. 相似文献
19.
Jacoba M. Spikman Danielle H.E. Boelen Gerdina H.M. Pijnenborg Marieke E. Timmerman Joukje van der Naalt Luciano Fasotti 《Neuropsychological rehabilitation》2013,23(6):824-845
Deficits in emotion recognition, a crucial aspect of social cognition, are common after serious brain injury, as are executive deficits. Since social cognition and executive function are considered to be separate constructs, our first aim was to examine the presence of emotion recognition problems in brain injury patients with dysexecutive problems. We studied 65 brain injury patients of mixed aetiology participating in a randomised controlled trial evaluating the effects of a multifaceted treatment for executive dysfunction (Spikman, Boelen, Lamberts, Brouwer, & Fasotti, 2010) and 84 matched controls with a test for emotion recognition. Results showed that, in patients with acquired brain injury exhibiting executive deficits, emotion recognition deficits are also present. Male patients are more impaired than female patients, irrespective of aetiology. Our second aim was to investigate whether emotion recognition problems negatively predict the results of the treatment programme. Pre-treatment emotion recognition performance significantly predicted resumption of roles in daily life (Role Resumption List; RRL) and performance on an ecologically valid test for everyday executive functioning (Executive Secretarial Task; EST) post-treatment and, in addition, interfered negatively with treatment condition. Moreover, worse pre-treatment emotion recognition skills affect the learning of compensatory strategies for executive dysfunction negatively, whereas pre-treatment dysexecutive deficits do not. 相似文献
20.
Wim Van der Elst Martin P. J. Van Boxtel Gerard J. P. Van Breukelen Jelle Jolles 《Laterality》2013,18(3):234-254
The effect of handedness on cognitive functioning has been the subject of much controversy. The influential “pathological left-handedness theory” posited by Coren and Halpern (1991) claims that left-handedness is probabilistically related to deviations from the neurological and cognitive norm. Many studies have failed to find negative effects of left-handedness on cognitive functioning, but most of these studies related handedness to cognition at one moment in time. Such studies do not exclude the possibility that sinistrality may be related to a more pronounced age-related longitudinal decline in cognitive functions. This hypothesis was tested in the present study. In a longitudinal study involving a large population sample of cognitively intact people aged at least 50 years at baseline, we evaluated the effect of handedness on age-related decline in four major cognitive domains: speed of information processing, verbal learning, long-term verbal memory, and executive functioning. The results failed to provide support for the hypothesis that sinistrality is associated with a more pronounced age-related cognitive decline. Recommendations for future studies are provided. 相似文献