708例泌尿生殖道支原体感染状况及药敏分析

目的 了解临沧市泌尿生殖道解脲支原体(UU)和人型支原体(MH)感染及药敏情况以指导临床合理用药.方法 使用支原体分离培养药敏试剂盒,对2010年6月～2011年12月我院可疑支原体感染708例患者的泌尿生殖道标本进行UU和MH检测,并测定其对12种抗生素的敏感性.结果 708例样本中,UU阳性者675例,MH阳性者206例,两者同时阳性者174例.UU最敏感的抗生素是强力霉素,其次是美满霉素和交沙霉素,耐药最高的是红霉素和环丙沙星;MH最敏感的是强力霉素和美满霉素,MH耐药最高的是罗红霉素和红霉素.结论 临床用药应该充分考虑本地区耐药株的流行情况,最好是按照药敏结果给予合理用药.     

泌尿生殖道解脲支原体和人型支原体感染及对抗生素敏感性调查分析

目的:了解本地区泌尿生殖道解脲支原体(UU)和人型支原体(MH)感染情况以及对抗生素的耐药性,指导临床合理用药。方法:采用珠海浪峰生物技术公司生产的支原体培养、鉴定、计数药敏试剂盒对1000例标本进行培养、鉴定和药敏试验。结果:支原体总阳性感染率为40.5%(405/1000),其中UU305株,阳性率为30.5%;MH18株,阳性率为1.8%;UU和MH混合感染82株,阳性率为8.2%。对抗生素耐药情况,喹诺酮类药物耐药性最高(环丙沙星79.0%、司帕沙星60.7%、可乐必妥52.8%),大环内酯类药物耐药率在3%-31%(交沙霉素3.2%、阿齐霉素14.3%、克拉霉素19.7%、罗红霉素27.1%、环酯红霉素17.2%、红霉素30.6%),四环素类药物耐药率最低在1%-5%(强力霉素为1.7%、美满霉素3.4%)。结论:对泌尿生殖道UU和MH感染患者,四环素和大环内酯类几种抗生素耐药性较低,仍可作本地区一线抗UU和MH药物。     

牡丹江地区某性病门诊女性患者泌尿生殖道支原体培养及药敏分析

目的了解牡丹江地区性病门诊女性患者的泌尿生殖道解脲支原体(UU)和人型支原体(MH)感染及耐药情况,指导临床合理用药。方法对509例疑为非淋菌性宫颈炎患者的生殖道标本进行UU和MH培养及药敏鉴定。结果生殖道支原体感染235例,感染率为46.17%。其中单纯UU阳性202例(39.69%)、MH阳性11例(2.16%),UU和MH同时阳性22例(4.32%)。8种抗生素的敏感程度依次为交沙霉素、强力霉素、克拉霉素、四环素、阿奇霉素、红霉素、氧氟沙星、环丙沙星。结论 UU是本地区性病门诊女性患者生殖道支原体感染的主要病原体,治疗上首选交沙霉素、强力霉素、克拉霉素。加强支原体的培养与药敏检测研究,将有助于指导临床诊断及合理用药。     

泌尿生殖道感染者支原体检测及药敏分析

目的检测我院门诊泌尿生殖道支原体感染情况及支原体培养加药敏试验分析。方法采用微量肉汤稀释法,对3 263例泌尿生殖道感染者解脲支原体(UU)和人型支原体(MH)进行8种抗生素的药敏试验。结果检出支原体1 142例,阳性率为35%,女性患者(42%)明显高于男性患者(30%),且UU感染(25%)明显高于MH感染(1%)和UU MH混合感染(8%)。UU药敏分析对红霉素、罗红霉素、交沙霉素、阿齐霉素、强力霉素、美满霉素、氧氟沙星、环丙沙星的敏感率分别为60%、68%、74%、86%、55%、40%、25%、2%;UU MH混合感染对8种抗生素均出现不同程度的耐药菌株。结论泌尿生殖道感染者中,支原体感染处于国内较高水平,且对不同种类抗生素有较高的耐药性,特别是UU MH混合感染,临床上做支原体培养加药敏试验,对指导临床合理用药很有必要。     

阴道炎患者536例支原体感染及耐药分析

目的了解本地区女性阴道炎患者的支原体感染情况及耐药现状,为临床合理应用抗生素提供参考。方法采用支原体培养鉴定药敏试剂盒进行支原体培养鉴定及药敏试验。结果536例阴道炎患者中支原体阳性215例,阳性率为40.1%。其中UU阳性161例(30.0%);MH阳性17例(3.2%);UU和MH混合感染37例(6.9%)。对强力霉素、交沙霉素、美满霉素、罗红霉素、氧氟沙星、阿奇霉素、克林霉素耐药率分别为14.0%,15.8%,19.5%,30.2%,34.4%,43.7%,45.6%。结论阴道炎患者支原体感染率为40.1%,UU是支原体感染的主要病原体,临床治疗首选强力霉素、交沙霉素和美满霉素。     

泌尿生殖道支原体感染1045例临床资料及药敏分析

目的为了解泌尿生殖道解脲脲原体(UU)和人型支原体(MH)的感染情况及其对抗生素的敏感性,以指导临床用药。方法应用支原体培养、鉴定、药敏试剂盒,对3602例可疑泌尿生殖道感染患者的泌尿生殖道标本进行UU和MH的检测,并测定其对9种常用抗生素的敏感性。结果检出1045例支原体阳性者,检出率为29.01%,其中UU,MH,UU+MH检出率分别为23.96%,0.58%及4.47%;UU对米诺环素最敏感,其次为多西环素和克拉霉素。结论支原体引起的泌尿生殖道感染以UU感染为主;结合支原体药敏结果合理选择抗生素则更高效。     

2003年我院门诊泌尿生殖道支原体感染状况及药敏分析

目的为了解来我院诊治的泌尿生殖道解脲支原体(UU)和人型支原体(MH)的感染状况及其对抗生素的敏感性.方法应用支原体培养、鉴定、药敏试剂盒,对2003年2305例可疑支原体感染患者的泌尿生殖道标本进行UU和MH的检测,并测定其对9种常用抗生素的敏感性.结果检出830例支原体阳性者,检出率为36.01%,其中UU、MH及UU、MH混合感染者分别占90.84%、1.33%及7.83%.UU对交沙霉素最敏感,其次为米诺环素及多西环素,MH对交沙霉素最敏感,其次为多西环素、克林霉素及米诺环素,UU合并MH感染者对9种抗生素均存在不同程度耐药.结论昆明地区UU、MH对抗生素的敏感性已发生了较大的变迁,UU合并MH混合感染者已出现多重耐药.     

泌尿生殖道支原体培养及药敏结果分析

目的了解本地区泌尿道患者支原体的培养及药敏情况。方法用男性尿道拭子、女性宫颈拭子取分泌物进行UU和MH检测及药敏试验。结果 254例样本中,UU阳性者215例,MH阳性者49例,UU与MH同时阳性者24例。UU最敏感的抗生素是交沙霉素,其次强力霉素与美满霉素;MH最敏感的是强力霉素与美满霉素。UU耐药最高的是螺旋霉素与环丙沙星,其次氧氟沙星;耐药最低的是交沙霉素;MH耐药性最高的是罗红霉素,其次是司帕沙星;耐药最低的是强力霉素。结论临床用药应该考虑地区耐药菌株的流行情况,最好按照药敏试验结果合理用药。     

女性支原体感染情况及耐药分析

当前支原体感染已成为常见的性传播疾病,由于治疗不当,滥用抗生素,混合感染、反复感染等原因,使支原体对抗生素的耐药力逐步升高,受到临床普遍关注。能引起泌尿生殖道感染的支原体有：解脲支原体（UU）、人型支原体（MH）、生殖支原体（MG）。其中UU及MH主要通过分离培养来检测。为了解女性支原体感染及耐药情况,本文采用支原体培养法对我院2003年1-12月间,921份宫颈分泌物进行了培养、鉴定和药敏分析,结果如下。     

1599例前列腺液标本支原体感染检测及药敏结果分析

目的：回顾本地区男性泌尿生殖道患者感染解脲支原体（UU）、人型支原体（MH）的分布状况,了解支原体对12种抗生素体外药物敏感试验的现状。方法：对1599例男性泌尿生殖道感染患者前列腺液标本进行支原体（Uu、MH）培养及药敏试验。结果：1599例检测标本中,总感染率为23.08％,单纯UU阳性277例（75.07％）,UU －Mh 阳性81例（21.95％）,单纯 Mh 阳性11例（2.98％）。MH 对强力霉素（DOX）、交沙霉素（JOS）、美满霉素（MIN）全部敏感,UU 对JOS、MIN、DOX、环酯红霉素（ECC）、克拉霉素（CLA）均非常敏感,UU－MH混合感染的耐药率明显高于单纯UU或MH感染。结论：临床治疗支原体感染时应尽量根据药敏结果选择敏感药物,DOX、MIN和JOS可作为本地区临床经验用药的首选药物。     

Dermatology in private practice in France in 2000

OBJECTIVES: Data regarding French dermatological practice are scarce. Our objective was to identify the skin disorders most commonly diagnosed by office-based dermatologists. We also documented the severity of these skin disorders, as reflected by the repercussions on patient's everyday life, and the way physicians managed patients. DESIGN: We carried out a one-day survey of visits to a randomly selected sample of 900 French office-based dermatologists. The randomization was stratified according to the five French different dialing area codes. RESULTS: Office-based dermatologists saw 6411 patients with 7839 skin disorders during the survey. The daily number of visits to French dermatologists was estimated at 47 000 and the annual number between 12 and 14 millions. Office-based dermatologists mostly managed warts, acne, nevus, dermatitis, malignancies and pre-malignancies, fungal infection and psoriasis. Repercussions on patients'everyday life were assessed by physicians as important or very important in 28 p. 100 of cases. Half of the patients received topical treatment, 20.5 p. 100 a systemic drug and 40 p. 100 a minor surgical procedure (including cryotherapy). CONCLUSION: Although dermatologists frequently see benign skin disorders such as warts or nevus, more severe diseases represent an important part of their activity.     

Pentoxifylline in reactions in leprosy

A study was conducted to assess the response of reactions in leprosy to pentoxifylline therapy. Ten cases were studied; 8 cases had type 2 reaction and 2 cases had type 1 reaction. Pentoxifylline was given orally 400 mg three times daily. In patients with type 2 reaction, good response was observed within one week. There was near complete regression of ENL lesions within one month. Cases with type 1 reaction did not respond to pentoxifylline.     

Leukocyte migration in vivo and in vitro in patients with psoriasis

Leukocyte migration in vivo was studied with a skin chamber technique in 21 patients with active psoriasis vulgaris and 18 with cleared psoriasis vulgaris. Measuring over 24 h, no difference was found between healthy volunteers and most patients with active psoriasis, although a subgroup of patients with long-lasting relapses showed subnormal migration values. In patients with cleared psoriasis on the other hand the in vivo leukocyte migration values were increased. In addition, leukocyte migration in vitro under agarose was studied, but no difference was found between healthy controls and patients with psoriasis, active or cleared.     

Decrease in neutrophils observed in vivo in psoriatics after PUVA therapy

Summary In 56 patients leucocyte and differential counts were done before and at weekly intervals during PUVA treatment of chronic recalcitrant psoriasis. A statistical significant (P<0.01) decrease in the percentage of neutrophils was observed during the first week of the PUVA therapy. This observation could be closely related to the clinical clearing of psoriasis (P=0.02).The effect of PUVA therapy in psoriasis may be due to a decrease in the number of immunocompetent neutrophils demonstrated in psoriatic lesions.