共查询到20条相似文献,搜索用时 734 毫秒
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综述了高分子聚合物在生物降解给药系统、前体药物、膜控制剂、骨架制剂、透皮贴剂和药树脂微囊等缓、控释给药系统中的应用. 相似文献
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目的通过对缓释、控释药物的临床应用情况进行观察,分析和总结其应用进展情况。方法通过对2010年4月至2012年10月在我院就诊的150例患者进行问卷调查和病例采集,调查统计缓释、控释的在临床中的使用情况。结果在150例患者中,使用缓释、控释药物的患者有38例,所占比例为25.33%,不使用缓释、控释药物的患者有112例,比例为74.67%,在临床上的使用率并不是很高。但是浪宁、倍他乐克、泰白以及拜新同等缓释、控释药物使用比较多,主要用于治疗呼吸系统疾病、心血管疾病以及糖尿病等。结论缓释、控释药物在临床中的使用范围有限,使用率不高,但是在治疗一些慢性疾病方面具有较大作用。 相似文献
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药用高分子在缓控释制剂中的应用现状 总被引:1,自引:0,他引:1
胡颖 《实用医药杂志(山东)》2008,25(7):861-863
<正>缓控释制剂的发展除与制药设备的不断发展、革新有关外,药用高分子在该类制剂中也是不可分割的重要组成部分。近年来,一些新型高分子材料的研究和应用使缓控释制剂步入了定时、定向、定位、速效、高效、长效的精密化给药阶段,出现了口服渗透泵控释制剂、脉冲式释药系统、环境敏感型定位释药系统、结肠定位给药系统等新型缓控释制剂。辅料的成分、组成与结构对药物的释放性能有很大的影响,因此在缓控释制剂中合理应用新型高分子材料,就具有重要的意义。1药用高分子作为药物载体药用高分子的广泛研究和应用,促进了缓控释制剂的快 相似文献
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当今医药界习惯于将药物剂型分为四代:Ⅰ.普通剂;Ⅱ.缓释剂;Ⅲ.控释剂;Ⅳ.靶向剂.这种分法其实不够科学,割裂了缓释剂、控释剂和靶向剂之间的内在联系,对"控释"的含义模糊不清.药物剂型宜分为两代:Ⅰ.普通剂;Ⅱ.控释剂.控释剂包括速度型控释系统和靶向型控释系统. 相似文献
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介孔二氧化硅纳米粒(MSNs)是一种新型无机纳米材料,因具有独特的网状孔道结构、巨大的比表面积、孔径分布窄且可调节及易于表面修饰等特性,已用于药物控释系统的研究.MSNs载体的药物负载量与其介孔容积相关,表面经修饰后可实现药物的控释和靶向传递.然而,随着MSNs载体与人体接触的机会和时间日益增加,其安全性也受到广泛关注.本文综合近10年来国内外的相关文献,归纳了MSNs在递药系统中的应用,并分析了其生物安全性的影响因素. 相似文献
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Application of artificial neural networks in the design of controlled release drug delivery systems 总被引:6,自引:0,他引:6
Controlled release drug delivery systems offer great advantages over the conventional dosage forms. However, there are great challenges to efficiently develop controlled release drug delivery systems due to the complexity of these delivery systems. Traditional statistic response surface methodology (RSM) is one of the techniques that has been employed to develop and formulate controlled release dosage forms. However, there are some limitations to the RSM technique. Hence, another technique called artificial neural networks (ANN) has recently gained wide popularity in the development of controlled release dosage forms. In this review, the basic ANN structure, the development of the ANN model and an explanation of how to use ANN to design and develop controlled release drug delivery systems are discussed. In addition, the applications of ANN in the design and development of controlled release dosage forms are also summarized in this review. 相似文献
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Patel A Mehta T Patel J Patel M Patel K Patel N 《Recent patents on drug delivery & formulation》2012,6(1):66-72
Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems. The present review is concerned with the study of drug release through asymmetric membrane capsule systems. When these systems are exposed to water, low levels of water soluble additive are leached from polymeric material i.e. the semipermeable membrane and the drug releases in a controlled manner over an extended period of time. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. This patent review is useful in the knowledge of asymmetric membrane capsule osmotic pump for its application. 相似文献
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Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-responsive changes in their structural network and hence, the drug release. Because of large variations in physiological pH at various body sites in normal as well as pathological conditions, pH-responsive polymeric networks have been extensively studied. This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release. 相似文献
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制剂新技术在多肽、蛋白质类药物给药系统研究中的应用 总被引:10,自引:2,他引:8
目的 介绍制剂新技术在多肽、蛋白质类药物给药系统研究中的应用。方法 综述了多肽、蛋白质类药物的性质特点和影响其稳定性的原因;制剂新技术在多肽、蛋白质类药物给药系统中的运用;对LHRH及其类似物和胰岛素两类药物的新型制剂研究进行了概述。结果 脂质体、微乳和复乳、微球、纳米粒、自控式释药技术等制剂新技术广泛应用于多肽、蛋白质类药物给药系统中,取得了较大进展;黄体激素释放激素(LHRH)及其类似物和胰岛素两类药物的新剂型研究具有代表性且引人注目。结论 将制剂新技术用于多肽、蛋白质类药物给药系统的研究,有着广阔的应用前景。 相似文献
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缓控释药物在现今临床使用上已日趋广泛,也是药物制剂学研究的热点内容。本文简要地介绍了缓控释制剂的释药原理,并列举了常用的缓控释药品及正确的使用方法,为临床工作者合理应用提供了必要的依据。 相似文献
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Polymeric drug delivery platforms have been receiving increasing attention in the past decade. The pharmaceutical industry is evaluating modes of delivery for their prized therapeutics at every step of the design cycle. Not only can the drug delivery platform transport drug molecules effectively, it can also improve patient compliance, offer greater patient convenience, and extend product lifecycles as patents expire. A large number of successful drug delivery systems have been developed as a result of an almost arbitrary selection of constituents and configurations. However, the development of advanced drug delivery systems relies on a judicious and careful selection of components, configurations, and geometries, which can be facilitated through mathematical modeling of controlled release systems. Mathematical modeling aids in predicting the drug release rates and diffusion behavior from these systems by the solution of an appropriate model, thereby reducing the number of experiments needed. It also aids in understanding the physics of a particular drug transport phenomenon, thus facilitating the development of new pharmaceutical products. The objective of this article is to review the spectrum of mathematical models that have been developed to describe drug release from polymeric controlled release systems. The mathematical models presented in this article have been grouped under diffusion controlled systems, swelling controlled systems, and erosion controlled systems as proposed by Langer and Peppas. Simple empirical or semi-empirical models and complex mechanistic models that consider diffusion, swelling, and erosion processes simultaneously are presented. 相似文献
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《Expert opinion on drug delivery》2013,10(11):1465-1469
Drug delivery systems for non-specialist uses and application under field conditions are required for medical action in disaster situations and in developing countries. A possible solution for drug delivery under those conditions might be provided by mechanical manipulation of host–guest interactions that could allow drug release control by simple human actions such as hand motion. This editorial article presents recent research developments on control of molecular recognition, capture and release involving macroscopic mechanical motions. In particular, pressure-induced drug release from a cyclodextrin-linked gel has been used to realize controlled release of entrapped drugs upon applying an easy-to-perform mechanical procedure. These easy-action-based drug delivery systems can be applied at will by unskilled staff or patients and are expected to be used to assist medically patients in less-favorable environments anywhere in the world. 相似文献